BGC0001069: chivosazol biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 96,547 nt. (total: 96,547 nt).
This entry is originally from NCBI GenBank DQ065771.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001069
Short description chivosazol biosynthetic gene cluster from Sorangium cellulosum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Macrolide)
Loci NCBI GenBank: DQ065771.1
Compounds
  • chivosazol
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
chivosazol
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C49H71N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAY89055.1
 1 - 825 (-) hypothetical protein
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  • AAY89048.1
  • chiA
 2572 - 4992 (+) acyltransferase/oxidoreductase
  • Activation / processing
Sequence-based prediction
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  • AAY89049.1
  • chiB
 5072 - 22603 (+) polyketide synthase
  • Scaffold biosynthesis
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  • AAY89050.1
  • chiC
 22603 - 47856 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAY89051.1
  • chiD
 47872 - 61797 (+) hybrid nonribosomal peptide synthetase/polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAY89052.1
  • chiE
 61825 - 76344 (+) polyketide synthase
  • Scaffold biosynthesis
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  • AAY89053.1
  • chiF
 76341 - 93941 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAY89054.1
  • chiG
 94012 - 94950 (-) methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AAY89056.1
 95993 - 96547 (-) hypothetical protein
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Polyketide-specific information
Subclass Macrolide
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
chiF
+
chiF
+
chiB
+
chiB
+
chiE
+
chiC
+
chiD 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: chiB
Thioesterases:
  • chiF (Type I)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: chiB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Genes: chiB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 3
Genes: chiB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 4
Genes: chiC
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Genes: chiC
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Genes: chiC
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: chiC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 8
Genes: chiC
Core domains: Ketosynthase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 10
Genes: chiD
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: chiD, chiE
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 12
Genes: chiE
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 13
Genes: chiE
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 14
Genes: chiF
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 15
Genes: chiF
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 16
Genes: chiF
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 17
Genes: chiF
Core domains: Ketosynthase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
chiD
Module 9
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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