Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001069.1:
Cluster 1NRP / Polyketide196547

BGC0001069, chivosazole biosynthetic gene cluster from Sorangium cellulosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Chivosazol
SMILES string: Copy to clipboard
Molecular formula: C49H71N1O12
Exact molecular mass: 866.5049 Da ([M+H]+)
Molecular activity: Cytotoxic
Molecular target: polymerizes actin

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
chiD (AAY89051.1)
Module 9
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AAY89049.1
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
chiB (AAY89049.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 2
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 3
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation

chiC (AAY89050.1)
Module 4
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 5
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 6
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 7
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 8
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation

chiD (AAY89051.1)
Module 10
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 11
AT specificity: None
Evidence for specificity: Unknown

chiE (AAY89052.1)
Module 11
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 12
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 13
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation

chiF (AAY89053.1)
Module 14
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 15
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 16
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation
Module 17
AT specificity: None
Evidence for specificity: Unknown

Gene cluster description

chivosazole (BGC0001069). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank DQ065771, positions 1-96547. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Perlova O et al. (2006) Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. J Biotechnol 121(2):174-91. doi: 10.1016/j.jbiotec.2005.10.011. Epub