BGC0001069: chivosazol biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 96,547 nt. (total: 96,547 nt).
This entry is originally from NCBI GenBank DQ065771.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001069
Short description chivosazol biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
DQ065771.1
via Knock-out studies
Compounds
  • chivosazol
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
chivosazol Evidence:
Copy SMILES
C49H71N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAY89055.1
 1 - 825 (-) hypothetical protein
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    • AAY89048.1
    • chiA
    		 2572 - 4992 (+) acyltransferase/oxidoreductase
    • Activation / processing
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    • AAY89049.1
    • chiB
    		 5072 - 22603 (+) polyketide synthase
    • Scaffold biosynthesis
    • Knock-out
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    • AAY89050.1
    • chiC
    		 22603 - 47856 (+) polyketide synthase
    • Scaffold biosynthesis
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    • AAY89051.1
    • chiD
    		 47872 - 61797 (+) hybrid nonribosomal peptide synthetase/polyketide synthase
    • Scaffold biosynthesis
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    • AAY89052.1
    • chiE
    		 61825 - 76344 (+) polyketide synthase
    • Scaffold biosynthesis
    • Knock-out
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    • AAY89053.1
    • chiF
    		 76341 - 93941 (+) polyketide synthase
    • Scaffold biosynthesis
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    • AAY89054.1
    • chiG
    		 94012 - 94950 (-) methyltransferase
    • Tailoring
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    • AAY89056.1
    		 95993 - 96547 (-) hypothetical protein
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      Biosynthesis information

      Biosynthetic modules

      Name
      9
      Type
      nrps-type1
      Genes
      chiD
      Substrates
      serine (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (Heterocyclization), adenylation
      Name
      1
      Type
      pks-modular
      Genes
      chiB
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
      Name
      2
      Type
      pks-trans-at
      Genes
      chiB
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
      Name
      3
      Type
      pks-trans-at
      Genes
      chiB
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
      Name
      4
      Type
      pks-trans-at
      Genes
      chiC
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, dehydratase, carrier (ACP)
      Name
      5
      Type
      pks-trans-at
      Genes
      chiC
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, dehydratase, carrier (ACP)
      Name
      6
      Type
      pks-trans-at
      Genes
      chiC
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, dehydratase, carrier (ACP)
      Name
      7
      Type
      pks-trans-at
      Genes
      chiC
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, carrier (ACP)
      Name
      8
      Type
      pks-trans-at
      Genes
      chiC
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, methyltransferase
      Name
      10
      Type
      pks-trans-at
      Genes
      chiD
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, carrier (ACP)
      Name
      11
      Type
      pks-trans-at
      Genes
      chiD chiE
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, dehydratase, carrier (ACP)
      Name
      12
      Type
      pks-trans-at
      Genes
      chiE
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
      Name
      13
      Type
      pks-trans-at
      Genes
      chiE
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
      Name
      14
      Type
      pks-trans-at
      Genes
      chiF
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, carrier (ACP)
      Name
      15
      Type
      pks-trans-at
      Genes
      chiF
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, dehydratase, carrier (ACP)
      Name
      16
      Type
      pks-trans-at
      Genes
      chiF
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
      Name
      17
      Type
      pks-trans-at
      Genes
      chiF
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, carrier (ACP)
      Annotation changelog

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Merged cross-CDS PKS modules
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Updated bioactivity data
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Updated NRP substrate specificities
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
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