BGC0001071: nosperin biosynthetic gene cluster from Nostoc sp. 'Peltigera membranacea cyanobiont'
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Location: 1 - 59,320 nt. (total: 59,320 nt).
This entry is originally from NCBI GenBank GQ979609.2.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001071
Short description nosperin biosynthetic gene cluster from Nostoc sp. 'Peltigera membranacea cyanobiont'
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • NRP
Loci NCBI GenBank: GQ979609.2
Compounds
  • nosperin
Species Nostoc sp. 'Peltigera membranacea cyanobiont' [taxonomy]
References
Chemical products information
nosperin
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C26H43N3O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADA69237.1
 1 - 15963 (+) trans-AT polyketide synthase
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  • ADA69238.1
 15976 - 17091 (+) flavin-dependent oxygenase
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  • ADA69239.2
 17094 - 41852 (+) trans-AT hybrid polyketide synthase-NRPS
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  • ADA69241.1
 41860 - 48480 (+) cis-AT polyketide synthase
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  • ADA69242.1
 48491 - 49915 (-) MatE efflux transporter
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  • ADA69243.1
 50025 - 50882 (+) O-methyltrasferase
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  • ADA71314.1
 50911 - 51171 (+) acyl carrier protein
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  • ADA69244.1
 51149 - 52384 (+) beta-ketoacyl synthase
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  • ADA69245.1
 52398 - 53660 (+) hydroxymethylglutaryl-CoA synthase
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  • ADA69246.1
 53648 - 54436 (+) enoyl-CoA hydratase
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  • ADA69247.1
 54474 - 55802 (+) acyl transferase
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  • ADA69248.1
 55911 - 57305 (+) cytochrome P450 monooxygenase
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  • ADA69249.1
 57377 - 59320 (+) asparagine synthase
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
ADA69241.1
+
ADA69237.1
+
ADA69247.1
+
ADA69239.2 		Synthase subclass: Modular type I/Trans-AT type I
Trans-acyltansferases: ADA69247.1
Module 0
Specificity: Acetyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADA69237.1
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Genes: ADA69237.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 2
Genes: ADA69237.1
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Module 3
Genes: ADA69237.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Genes: ADA69239.2
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: ADA69239.2
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 7
Genes: ADA69239.2
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 8
Genes: ADA69239.2
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 9
Genes: ADA69239.2
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 11
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADA69241.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Enoylreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ADA69239.2
Module 10
Specificity: proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 5
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new NPAtlas id for nosperin (npatlas:NPA020215)
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed amino acid substrates to lower case
Detailed domain annotation
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