BGC0001071: nosperin biosynthetic gene cluster from Nostoc sp. 'Peltigera membranacea cyanobiont'
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Location: 1 - 59,320 nt. (total: 59,320 nt).
This entry is originally from NCBI GenBank GQ979609.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
Operons
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001071
Short description nosperin biosynthetic gene cluster from Nostoc sp. 'Peltigera membranacea cyanobiont'
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
  • NRPS (Type I)
Loci
GQ979609.2
via Gene expression correlated with compound production
Compounds
  • nosperin
Species Nostoc sp. 'Peltigera membranacea cyanobiont' [taxonomy]
References
Chemical products information
nosperin Evidence: NMR [1]
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C26H43N3O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADA69237.1
 1 - 15963 (+) trans-AT polyketide synthase
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    • ADA69238.1
    		 15976 - 17091 (+) flavin-dependent oxygenase
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      • ADA69239.2
      		 17094 - 41852 (+) trans-AT hybrid polyketide synthase-NRPS
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        • ADA69241.1
        		 41860 - 48480 (+) cis-AT polyketide synthase
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          • ADA69242.1
          		 48491 - 49915 (-) MatE efflux transporter
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            • ADA69243.1
            		 50025 - 50882 (+) O-methyltransferase
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              • ADA71314.1
              		 50911 - 51171 (+) acyl carrier protein
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                • ADA69244.1
                		 51149 - 52384 (+) beta-ketoacyl synthase
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                  • ADA69245.1
                  		 52398 - 53660 (+) hydroxymethylglutaryl-CoA synthase
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                    • ADA69246.1
                    		 53648 - 54436 (+) enoyl-CoA hydratase
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                      • ADA69247.1
                      		 54474 - 55802 (+) Acyl transferase
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                        • ADA69248.1
                        		 55911 - 57305 (+) cytochrome p450
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                          • ADA69249.1
                          		 57377 - 59320 (+) asparagine synthase
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            0
                            Type
                            pks-modular-starter
                            Genes
                            ADA69237.1
                            Substrates
                            Integrated Monomers
                            Domains
                            acyltransferase, carrier (ACP)
                            Name
                            1
                            Type
                            pks-trans-at
                            Genes
                            ADA69237.1
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                            Name
                            2
                            Type
                            pks-trans-at
                            Genes
                            ADA69237.1
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, carrier (ACP), carrier (ACP)
                            Name
                            3
                            Type
                            pks-trans-at
                            Genes
                            ADA69237.1
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, carrier (ACP), carrier (ACP)
                            Name
                            4
                            Type
                            pks-trans-at
                            Genes
                            ADA69239.2
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, carrier (ACP)
                            Name
                            6
                            Type
                            pks-trans-at
                            Genes
                            ADA69239.2
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                            Name
                            7
                            Type
                            pks-trans-at
                            Genes
                            ADA69239.2
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, carrier (ACP)
                            Name
                            8
                            Type
                            pks-trans-at
                            Genes
                            ADA69239.2
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                            Name
                            9
                            Type
                            pks-trans-at
                            Genes
                            ADA69239.2
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, carrier (ACP)
                            Name
                            11
                            Type
                            pks-modular
                            Genes
                            ADA69241.1
                            Substrates
                            Integrated Monomers
                            Domains
                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, enoylreductase, thioesterase, carrier (ACP)
                            Name
                            10
                            Type
                            nrps-type1
                            Genes
                            ADA69239.2
                            Substrates
                            proline (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            5
                            Type
                            nrps-type1
                            Genes
                            ADA69239.2
                            Substrates
                            glycine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Operons
                            Genes Evidence
                            nspB, nspA, nspD, nspC
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-05-23
                            MIBiG v4 annotathon
                            • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                            • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Linked new NPAtlas id for nosperin (npatlas:NPA020215)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed amino acid substrates to lower case
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: CUIZDUBUBVAF27VHF4OZXTI3)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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