Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001071.1:
Cluster 1Polyketide159320

BGC0001071, nosperin biosynthetic gene cluster from Nostoc sp. 'Peltigera. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: nosperin
SMILES string: Copy to clipboard
Molecular formula: C26H43N3O9
Exact molecular mass: 564.2897 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I / Trans-AT type I
Starter unit:
Acetyl-CoA
ADA69247.1
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
ADA69237.1
Module 0
AT specificity: Acetyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None
Module 1
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module 2
Scaffold-modifying domain: Other
Module 3
KR stereochemistry: Unknown
Scaffold-modifying domain: Other

ADA69239.2
Module 4
Scaffold-modifying domain: None
Module is non-elongating
Evidence for non-elongation: Unknown
Module 6
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module 7
Scaffold-modifying domain: None
Module is non-elongating
Evidence for non-elongation: Unknown
Module 8
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module 9
Scaffold-modifying domain: None
Module is non-elongating
Evidence for non-elongation: Unknown

ADA69241.1
Module 11
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Gene cluster description

nosperin (BGC0001071). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank GQ979609, positions 1-59320. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Eric J. N. Helfrich (Institute of Microbiology, Eidgenoessische Technische Hochschule (ETH) Zurich, Piel lab)

Literature references

1. Kampa A et al. (2013) Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses. Proc Natl Acad Sci U S A 110(33):E3129-37. doi: