BGC0001072: simocyclinone D8 biosynthetic gene cluster from Streptomyces antibioticus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 75,379 nt. (total: 75,379 nt).
This entry is originally from NCBI GenBank AF324838.2.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001072
Short description simocyclinone D8 biosynthetic gene cluster from Streptomyces antibioticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
  • saccharide (None)
  • other (aminocoumarin)
Loci
AF324838.2
via Knock-out studies
Compounds
  • simocyclinone D8
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
simocyclinone D8 Evidence:
Copy SMILES
C46H42Cl1N1O18
Chemical database entries
NPAtlas
PubCHEM
ChEMBL
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEU17883.1
 1227 - 1475 (+) putative acyl carrier protein
    copy AA seq
    copy Nt seq
    • AEU17884.1
    		 1472 - 2551 (+) 3-oxo-ACP synthase II
      copy AA seq
      copy Nt seq
      • AEU17885.1
      		 2602 - 3843 (+) 3-oxo-ACP synthase II
        copy AA seq
        copy Nt seq
        • AEU17886.1
        • simB7
        		 4212 - 5369 (+) putative glycosyl transferase
          copy AA seq
          copy Nt seq
          • AEU17887.1
          • simB5
          		 5376 - 6137 (+) putative 4-ketoreductase
            copy AA seq
            copy Nt seq
            • AEU17888.1
            • simB4
            		 6134 - 7102 (+) putative 3-ketoreductase
              copy AA seq
              copy Nt seq
              • AEU17889.1
              • simX5
              		 7106 - 8059 (+) putative 3-oxo-ACP synthase
                copy AA seq
                copy Nt seq
                • AEU17890.1
                • simX7
                		 8085 - 8855 (+) hypothetical protein
                  copy AA seq
                  copy Nt seq
                  • AEU17891.1
                  • simReg3
                  		 8866 - 9330 (+) putative regulator MarR/SlyA family
                    copy AA seq
                    copy Nt seq
                    • AEU17892.1
                    • simC7
                    		 9344 - 10198 (+) putative hydroxylase/dehydratase
                    • Tailoring
                    • Heterologous expression
                    copy AA seq
                    copy Nt seq
                    • AEU17893.1
                    • simX3
                    		 10750 - 10863 (+) hypothetical protein
                      copy AA seq
                      copy Nt seq
                      • AEU17894.1
                      • simC6
                      		 10947 - 12410 (+) putative halogenase
                        copy AA seq
                        copy Nt seq
                        • AEU17895.1
                        • simEx2
                        		 12945 - 14186 (+) putative Na/H antiporter
                          copy AA seq
                          copy Nt seq
                          • AEU17896.1
                          • simA13
                          		 14573 - 15829 (+) putative P450 oxygenase
                            copy AA seq
                            copy Nt seq
                            • AEU17897.1
                            • simC1B
                            		 15910 - 22506 (+) putative type I PKS
                              copy AA seq
                              copy Nt seq
                              • AEU17898.1
                              • simC1C
                              		 22560 - 26555 (+) putative type I PKS
                                copy AA seq
                                copy Nt seq
                                • AEU17899.1
                                • simC1A
                                		 26623 - 39741 (+) putative type I PKS
                                  copy AA seq
                                  copy Nt seq
                                  • AEU17900.1
                                  • simC2
                                  		 39958 - 40788 (+) putative thioesterase
                                    copy AA seq
                                    copy Nt seq
                                    • AEU17901.1
                                    • simX8
                                    		 41215 - 41457 (+) hypothetical protein
                                      copy AA seq
                                      copy Nt seq
                                      • AAK06782.1
                                      • simA7
                                      		 41847 - 43322 (+) putative oxygenase SimA7
                                        copy AA seq
                                        copy Nt seq
                                        • AAK06783.1
                                        • simA4
                                        		 43372 - 43698 (+) putative cyclase SimA4
                                          copy AA seq
                                          copy Nt seq
                                          • AAK06784.1
                                          • simA1
                                          		 43695 - 44963 (+) putative ketosynthase SimA1
                                            copy AA seq
                                            copy Nt seq
                                            • AAK06785.1
                                            • simA2
                                            		 44960 - 46174 (+) putative ketosynthase SimA2
                                              copy AA seq
                                              copy Nt seq
                                              • AAK06786.1
                                              • simA3
                                              		 46223 - 46489 (+) putative acyl carrier protein SimA3
                                                copy AA seq
                                                copy Nt seq
                                                • AAK06787.1
                                                • simA6
                                                		 46509 - 47294 (+) putative ketoreductase SimA6
                                                  copy AA seq
                                                  copy Nt seq
                                                  • AAK06788.1
                                                  • simA5
                                                  		 47320 - 48267 (+) putative cyclase/dehydrase SimA5
                                                    copy AA seq
                                                    copy Nt seq
                                                    • AAK06789.1
                                                    • simA8
                                                    		 48273 - 49757 (+) putative oxygenase SimA8
                                                      copy AA seq
                                                      copy Nt seq
                                                      • AAK06790.1
                                                      • simA9
                                                      		 49836 - 50600 (+) putative reductase SimA9
                                                        copy AA seq
                                                        copy Nt seq
                                                        • AAK06791.1
                                                        • simA10
                                                        		 50731 - 51303 (+) putative reductase SimA10
                                                          copy AA seq
                                                          copy Nt seq
                                                          • AAK06792.1
                                                          • simA11
                                                          		 51311 - 51976 (+) putative phosphopantheine-transferase SimA11
                                                            copy AA seq
                                                            copy Nt seq
                                                            • AAK06793.1
                                                            • simA12
                                                            		 51989 - 53575 (+) putative decarboxylase SimA12
                                                              copy AA seq
                                                              copy Nt seq
                                                              • AAK06794.1
                                                              • simX2
                                                              		 53572 - 53808 (+) SimX2
                                                                copy AA seq
                                                                copy Nt seq
                                                                • AAK06795.1
                                                                • simC3
                                                                		 53850 - 54623 (+) putative thioesterase SimC3
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • AAK06796.1
                                                                  • simC4
                                                                  		 54620 - 55990 (+) putative dioxygenase SimC4
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • AAK06797.1
                                                                    • simC5
                                                                    		 56007 - 57347 (+) putative alcohol dehydrogenase SimC5
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • AAK06798.1
                                                                      • simReg2
                                                                      		 57298 - 58083 (-) transcriptional repressor of transporter SimX
                                                                      • Regulation
                                                                      • Other in vivo study Activity assay
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • AAK06799.1
                                                                      • simEx
                                                                      		 58180 - 59784 (+) simocyclinone-specific efflux pump
                                                                      • Transport
                                                                      • Other in vivo study
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • AAK06800.1
                                                                      • simX4
                                                                      		 59996 - 60877 (+) SimX4
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • AAK06801.1
                                                                        • simC8
                                                                        		 60874 - 61536 (+) putative phosphopantetheinyl transferase SimC8
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • AAK06802.1
                                                                          • simD3
                                                                          		 61682 - 62392 (+) putative 3-keto-acyl-reductase SimD3
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • AAK06803.1
                                                                            • simD5
                                                                            		 62429 - 63988 (+) aminocoumarin ligase
                                                                            • Scaffold biosynthesis
                                                                            • Knock-out Activity assay
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • AAK06804.1
                                                                            • simD6
                                                                            		 63978 - 67010 (+) Tyroxyl-AMP-forming enzyme
                                                                            • Precursor biosynthesis
                                                                            • Activity assay
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • AAK06805.1
                                                                            • simD1
                                                                            		 67007 - 68272 (+) putative cytochrome P450 oxidase SimD1
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • AAK06806.1
                                                                              • simX1
                                                                              		 68309 - 68521 (+) MbtH-like protein
                                                                              • Precursor biosynthesis
                                                                              • Activity assay
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • AAK06807.1
                                                                              • simD2
                                                                              		 68532 - 69353 (+) putative 3-keto-acyl-reductase SimD2
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • AAK06808.1
                                                                                • simReg1
                                                                                		 69523 - 70278 (+) regulator
                                                                                • Regulation
                                                                                • Knock-out Other in vivo study
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • AAK06809.1
                                                                                • simD4
                                                                                		 70601 - 71341 (+) putative 3-keto-acyl-reductase SimD4
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • AAK06810.1
                                                                                  • simB3
                                                                                  		 71408 - 72856 (+) putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase SimB3
                                                                                  • Scaffold biosynthesis
                                                                                  • Knock-out
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • AAK06811.1
                                                                                  • simB6
                                                                                  		 72853 - 74253 (+) putative acetyl transferase SimB6
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    • AAK06812.1
                                                                                    • simX6
                                                                                    		 74332 - 74610 (+) SimX6
                                                                                      copy AA seq
                                                                                      copy Nt seq
                                                                                      Biosynthesis information

                                                                                      Biosynthetic modules

                                                                                      Name
                                                                                      0
                                                                                      Type
                                                                                      pks-modular
                                                                                      Genes
                                                                                      simC1A
                                                                                      Substrates
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                                      Name
                                                                                      1
                                                                                      Type
                                                                                      pks-modular
                                                                                      Genes
                                                                                      simC1A
                                                                                      Substrates
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                      Name
                                                                                      2
                                                                                      Type
                                                                                      pks-modular
                                                                                      Genes
                                                                                      simC1A
                                                                                      Substrates
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                      Name
                                                                                      3
                                                                                      Type
                                                                                      pks-modular
                                                                                      Genes
                                                                                      simC1B
                                                                                      Substrates
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                                                      Name
                                                                                      4
                                                                                      Type
                                                                                      pks-modular
                                                                                      Genes
                                                                                      simC1C
                                                                                      Substrates
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                                      Annotation changelog

                                                                                      Entry version: 4

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-10-07
                                                                                      Update chemical activity to schema version 2.11
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 3

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-09-15
                                                                                      Remove duplicated citations
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Corrected polyketide synthase gene entries
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 2

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2019-10-16
                                                                                      Migrated from v1.4
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2019-10-16
                                                                                      Updated compound(s) information (NPAtlas curation)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 1

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2015-06-12
                                                                                      Submitted
                                                                                      • (ID: LPHAMZXQ3BT6INJWOLKUYGWU)
                                                                                      • (ID: 4UPPKTA43BL72GR2GNMXZQQK)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      Detailed domain annotation
                                                                                      Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                      A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                      Selected features only
                                                                                      Show module domains
                                                                                      Similar known gene clusters from MIBiG 4.0
                                                                                      Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                      Click on reference genes to show details of similarities to genes within the current region.
                                                                                      Click on an accession to open that entry in the MiBIG database.