BGC0001074: cosmomycin D biosynthetic gene cluster from Streptomyces olindensis
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Location: 297,513 - 339,455 nt. (total: 41,943 nt).
This entry is originally from NCBI GenBank JJOH01000002.1.

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core biosynthetic genes
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General
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001074
Short description cosmomycin D biosynthetic gene cluster from Streptomyces olindensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
  • PKS (Unknown)
Loci
JJOH01000002.1
297513 - 339455
via
Compounds
  • cosmomycin D
Species Streptomyces olindensis [taxonomy]
References
Chemical products information
cosmomycin D Evidence:
Copy SMILES
C60H88N2O22
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DF19_23380
  • KDN80036.1
 297513 - 298367 (+) oxidoreductase
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    • DF19_23385
    • KDN80037.1
    		 298430 - 299305 (-) glucose-1-phosphate thymidylyltransferase
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      • DF19_23390
      • KDN80038.1
      		 299592 - 299846 (+) actinorhodin polyketide synthase acyl carrier protein
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        • DF19_23395
        • KDN80039.1
        		 300044 - 300886 (+) transcriptional regulator
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          • DF19_23400
          • KDN80040.1
          		 300973 - 301830 (-) methyltransferase
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            • DF19_23405
            • KDN80041.1
            		 302018 - 302455 (+) ester cyclase
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              • DF19_23410
              • KDN80042.1
              		 302497 - 303600 (+) methyltransferase
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                • DF19_23415
                • KDN80043.1
                		 303605 - 304501 (+) alpha/beta hydrolase
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                  • DF19_23420
                  • KDN80044.1
                  		 304534 - 305247 (+) SAM-dependent methyltransferase
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                    • DF19_23425
                    • KDN80045.1
                    		 305291 - 306886 (+) FAD-dependent oxidoreductase
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                      • DF19_23430
                      • KDN80046.1
                      		 307143 - 308144 (-) oxidoreductase
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                        • DF19_23435
                        • KDN80047.1
                        		 308340 - 309479 (+) hypothetical protein
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                          • DF19_23440
                          • KDN80048.1
                          		 309476 - 310795 (+) glycosyl transferase
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                            • DF19_23445
                            • KDN80049.1
                            		 310807 - 312108 (+) lipopolysaccharide biosynthesis protein RfbH
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                              • DF19_23450
                              • KDN80050.1
                              		 312116 - 312901 (+) ketoacyl reductase
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                                • DF19_23455
                                • KDN80051.1
                                		 312910 - 314268 (+) actinorhodin polyketide synthase
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                                  • DF19_23460
                                  • KDN80052.1
                                  		 314356 - 315087 (-) ketoreductase
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                                    • DF19_23465
                                    • KDN80053.1
                                    		 315112 - 315549 (-) hydroxylacyl-CoA dehydrogenase
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                                      • DF19_23470
                                      • KDN80054.1
                                      		 315698 - 316477 (+) cyclase
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                                        • DF19_23475
                                        • KDN80055.1
                                        		 316548 - 317276 (+) SAM-dependent methyltransferase
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                                          • DF19_23480
                                          • KDN80056.1
                                          		 317273 - 318382 (+) daunorubicin biosynthesis sensory transduction protein DnrJ
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                                            • DF19_23485
                                            • KDN80057.1
                                            		 318469 - 319914 (-) NDP-hexose 2,3-dehydratase
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                                              • DF19_23490
                                              • KDN80058.1
                                              		 319911 - 320915 (-) NAD-dependent epimerase
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                                                • DF19_23495
                                                • KDN80059.1
                                                		 320882 - 321508 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                                  • DF19_23500
                                                  • KDN80060.1
                                                  		 321582 - 322874 (-) glycosyl transferase family 28
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                                                    • DF19_23505
                                                    • KDN80061.1
                                                    		 323121 - 323684 (+) transcriptional regulator
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                                                      • DF19_23510
                                                      • KDN80062.1
                                                      		 323792 - 324769 (+) hypothetical protein
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                                                        • DF19_23520
                                                        • KDN80063.1
                                                        		 324886 - 325221 (+) antibiotic biosynthesis monooxygenase
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                                                          • DF19_23525
                                                          • KDN80064.1
                                                          		 325218 - 326486 (+) beta-ACP synthase
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                                                            • DF19_23530
                                                            • KDN80065.1
                                                            		 326483 - 327727 (+) beta-ketoacyl synthase
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                                                              • DF19_23535
                                                              • KDN80066.1
                                                              		 327724 - 328758 (+) 3-oxoacyl-ACP synthase
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                                                                • DF19_23540
                                                                • KDN80067.1
                                                                		 328755 - 329804 (+) polyketide synthase
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                                                                  • DF19_23545
                                                                  • KDN80068.1
                                                                  		 329948 - 331198 (+) cytochrome P450
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                                                                    • DF19_23550
                                                                    • KDN80069.1
                                                                    		 331233 - 332513 (+) glycosyl transferase family 28
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                                                                      • DF19_23555
                                                                      • KDN80070.1
                                                                      		 332536 - 333519 (+) dTDP-glucose 4,6-dehydratase
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                                                                        • DF19_23560
                                                                        • KDN80071.1
                                                                        		 333595 - 334584 (+) ABC transporter
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                                                                          • DF19_23565
                                                                          • KDN80072.1
                                                                          		 334581 - 335411 (+) multidrug ABC transporter permease
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                                                                            • DF19_23570
                                                                            • KDN80073.1
                                                                            		 335580 - 336062 (+) glutathione peroxidase
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                                                                              • DF19_23575
                                                                              • KDN80074.1
                                                                              		 336116 - 338401 (+) daunorubicin resistance protein DrrC
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                                                                                • DF19_23580
                                                                                • KDN80075.1
                                                                                		 338625 - 339455 (+) 3-ketoacyl-ACP reductase
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                                                                                  Biosynthesis information
                                                                                  Annotation changelog

                                                                                  Entry version: 4

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-10-07
                                                                                  Update chemical activity to schema version 2.11
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 3

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-09-15
                                                                                  Updated bioactivity data
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 2

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2019-10-16
                                                                                  Migrated from v1.4
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2019-10-16
                                                                                  Updated compound(s) information (NPAtlas curation)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 1

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2015-06-12
                                                                                  Submitted
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  Detailed domain annotation
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