BGC0001075 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001075 (Rhodococcus erythropolis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	arylpolyene,terpene-precursor	1	17,525	High	aurachin RE	terpene+PKS

BGC0001075 - Region 1 - arylpolyene,terpene-precursor

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Location: 1 - 17,525 nt. (total: 17,525 nt) Show pHMM detection rules used

Region on contig edge.

arylpolyene: (APE_KS1 or APE_KS2)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Terpene

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 17,526
Label		BGC0001075

Tailoring functions

Oxidoreductases: oxygenase

rauA: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Ligases: ligase synthase synthetase

rauD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rauF: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

rauI: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001075.5	2.00	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0002099.3	0.47	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0002084.4	0.47	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002631.2	0.40	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0001224.5	0.30	other (other)	reductasporine	uncultured bacterium
BGC0002591.2	0.26	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0001605.3	0.25	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000678.5	0.25	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001456.3	0.24	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.24	terpene	carotenoid	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001075.5	1.00	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0002099.3	0.57	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0001224.5	0.45	other (other)	reductasporine	uncultured bacterium
BGC0002591.2	0.41	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0001605.3	0.41	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000678.5	0.41	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001456.3	0.40	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.39	terpene	carotenoid	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

rauI: PT_FPPS_like

Domain 1 (43 - 264): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Terpene

NRPS/PKS substrate predictions

rauF: X

AMP-binding (32..380): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GGNAVAGIVK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate