BGC0001076: liposidomycin B biosynthetic gene cluster from Streptomyces sp. SN-1061M
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Location: 1 - 29,709 nt. (total: 29,709 nt).
This entry is originally from NCBI GenBank GU219978.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001076
Short description liposidomycin B biosynthetic gene cluster from Streptomyces sp. SN-1061M
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Liposidomycins are a mixture of derivatives with different chain length, saturation and branching of the fatty acyl moiety."
Biosynthetic class(es)
  • other (nucleoside)
Loci
GU219978.1
via Heterologous expression
Compounds
  • liposidomycin B
  • liposidomycin A
  • liposidomycin C
  • liposidomycin Z
  • liposidomycin H
  • liposidomycin G
  • liposidomycin L
  • liposidomycin M
  • liposidomycin K
  • liposidomycin N
Species Streptomyces sp. SN-1061M [taxonomy]
References
Chemical products information
liposidomycin B Evidence:
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C43H68N5O21S1
Chemical database entries
PubCHEM
liposidomycin A Evidence:
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C45H68N5O21S1
Chemical database entries
NPAtlas
liposidomycin C Evidence:
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C43H68N5O21S1
liposidomycin Z Evidence:
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C43H66N5O21S1
liposidomycin H Evidence:
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C43H66N5O21S1
liposidomycin G Evidence:
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C45H70N5O21S1
liposidomycin L Evidence:
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C45H72N5O21S1
liposidomycin M Evidence:
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C45H72N5O21S1
liposidomycin K Evidence:
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C46H68N5O21S1
liposidomycin N Evidence:
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C47H74N5O21S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADC96649.1
  • lpmA
 1 - 1176 (-) HMG-CoA syntahse
  • Precursor biosynthesis
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  • ADC96650.1
  • lpmB
 1229 - 2467 (-) sulfotransferase
  • Tailoring
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  • ADC96651.1
  • lpmC
 2531 - 3271 (-) hypothetical protein
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    • ADC96652.1
    • lpmD
    		 3703 - 4752 (+) type III PKS
    • Precursor biosynthesis
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    • ADC96653.1
    • lpmE
    		 4757 - 5539 (+) PAPS 3'-phosphatase
    • Precursor biosynthesis
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    • ADC96654.1
    • lpmF
    		 5536 - 6174 (+) sulfotransferase
    • Precursor biosynthesis
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    • ADC96655.1
    • lpmG
    		 6434 - 7444 (+) AraC-like regulator
    • Regulation
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    • ADC96656.1
    • lpmH
    		 7573 - 8094 (+) beta-hydroxylase
    • Scaffold biosynthesis
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    • ADC96657.1
    • lpmI
    		 8114 - 8755 (+) SAM-dependent methyltransferase
    • Tailoring
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    • ADC96658.1
    • lpmJ
    		 8752 - 9309 (+) kinase
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      • ADC96659.1
      • lpmK
      		 9319 - 10644 (+) amino-carboxypropyl transferase
      • Scaffold biosynthesis
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      • ADC96660.1
      • lpmL
      		 10649 - 11923 (+) transaldolase
      • Scaffold biosynthesis
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      • ADC96661.1
      • lpmM
      		 12006 - 12836 (+) Fe(II)-dependent UMP dioxygenase
      • Scaffold biosynthesis
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      • ADC96662.1
      • lpmN
      		 12833 - 13534 (+) nucleotidyltransferase
      • Scaffold biosynthesis
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      • ADC96663.1
      • lpmO
      		 13534 - 14667 (+) glycosyltransferase
      • Scaffold biosynthesis
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      • ADC96664.1
      • lpmP
      		 14664 - 15938 (+) aminotransferase
      • Scaffold biosynthesis
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      • ADC96665.1
      • lpmQ
      		 15949 - 17322 (+) pyrimidine phosphorylase
      • Scaffold biosynthesis
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      • ADC96666.1
      • lpmR
      		 17315 - 18379 (+) acyl-CoA synthase
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        • ADC96667.1
        • lpmS
        		 18379 - 19866 (+) acyltransferase
        • Scaffold biosynthesis
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        • ADC96668.1
        • lpmT
        		 19863 - 23576 (+) ABC transporter
        • Transport
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        • ADC96669.1
        • lpmU
        		 23573 - 24607 (+) acyltransferase
        • Scaffold biosynthesis
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        • ADC96670.1
        • lpmV
        		 24894 - 26693 (+) hypothetical protein
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          • ADC96671.1
          • lpmW
          		 26778 - 27806 (+) acyl-CoA dehydrogenase
          • Scaffold biosynthesis
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          • ADC96672.1
          • lpmX
          		 27868 - 29121 (+) SAM-dependent methyltransferase
          • Tailoring
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          • ADC96673.1
          • lpmY
          		 29152 - 29709 (+) kinase
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            Biosynthesis information
            Annotation changelog

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Update compound structure (SMILES) for liposidomycin A
            • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated bioactivity data
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2019-10-16
            Updated compound(s) information (NPAtlas curation)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: MQCAQSV425YQGLSERITRLP7K)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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