Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001076.1:
Cluster 1Other129709

BGC0001076, liposidomycin biosynthetic gene cluster from Streptomyces sp. SN-1061M. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Liposidomycin B
PubChem ID: 90658650
SMILES string: Copy to clipboard
Molecular formula: C43H67N5O21S-2
Average molecular mass: 1022.083 Da
Molecular activity: Antibacterial, Inhibitor
Molecular target: translocase I

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Nucleoside

Gene cluster description

liposidomycin (BGC0001076). Gene Cluster 1. Biosynthetic class = Other. GenBank GU219978, positions 1-29709. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Comments:Liposidomycins are a mixture of derivatives with different chain length, saturation and branching of the fatty acyl moiety.
Contact for this cluster:Leonard Kaysser (Eberhard Karls University Tuebingen)

Literature references

1. Kaysser L et al. (2010) Analysis of the liposidomycin gene cluster leads to the identification of new caprazamycin derivatives. Chembiochem 11(2):191-6. doi: 10.1002/cbic.200900637.
2. Brandish PE et al. (1996) Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli. Antimicrob Agents Chemother 40(7):1640-4.