BGC0001076: liposidomycin B biosynthetic gene cluster from Streptomyces sp. SN-1061M
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Location: 1 - 29,709 nt. (total: 29,709 nt).
This entry is originally from NCBI GenBank GU219978.1.

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core biosynthetic genes
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001076
Short description liposidomycin B biosynthetic gene cluster from Streptomyces sp. SN-1061M
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Liposidomycins are a mixture of derivatives with different chain length, saturation and branching of the fatty acyl moiety."
Biosynthetic class(es)
  • Other (Nucleoside)
Loci NCBI GenBank: GU219978.1
Compounds
  • liposidomycin B
  • liposidomycin A
  • liposidomycin C
  • liposidomycin Z
  • liposidomycin H
  • liposidomycin G
  • liposidomycin L
  • liposidomycin M
  • liposidomycin K
  • liposidomycin N
Species Streptomyces sp. SN-1061M [taxonomy]
References
Chemical products information
liposidomycin B
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C43H68N5O21S1
Chemical database entries
PubCHEM
liposidomycin A
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C45H68N5O21S1
Chemical database entries
NPAtlas
liposidomycin C
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C43H68N5O21S1
liposidomycin Z
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C43H66N5O21S1
liposidomycin H
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C43H66N5O21S1
liposidomycin G
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C45H70N5O21S1
liposidomycin L
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C45H72N5O21S1
liposidomycin M
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C45H72N5O21S1
liposidomycin K
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C46H68N5O21S1
liposidomycin N
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C47H74N5O21S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADC96649.1
  • lpmA
 1 - 1176 (-) HMG-CoA syntahse
  • Precursor biosynthesis
Sequence-based prediction
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  • ADC96650.1
  • lpmB
 1229 - 2467 (-) sulfotransferase
  • Tailoring (Sulfation)
Sequence-based prediction
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  • ADC96651.1
  • lpmC
 2531 - 3271 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ADC96652.1
  • lpmD
 3703 - 4752 (+) type III PKS
  • Precursor biosynthesis
Sequence-based prediction
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  • ADC96653.1
  • lpmE
 4757 - 5539 (+) PAPS 3'-phosphatase
  • Precursor biosynthesis
Sequence-based prediction
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  • ADC96654.1
  • lpmF
 5536 - 6174 (+) sulfotransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • ADC96655.1
  • lpmG
 6434 - 7444 (+) AraC-like regulator
  • Regulation
Sequence-based prediction
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  • ADC96656.1
  • lpmH
 7573 - 8094 (+) beta-hydroxylase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96657.1
  • lpmI
 8114 - 8755 (+) SAM-dependent methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • ADC96658.1
  • lpmJ
 8752 - 9309 (+) kinase
  • Unknown
Sequence-based prediction
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  • ADC96659.1
  • lpmK
 9319 - 10644 (+) amino-carboxypropyl transferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96660.1
  • lpmL
 10649 - 11923 (+) transaldolase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96661.1
  • lpmM
 12006 - 12836 (+) Fe(II)-dependent UMP dioxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96662.1
  • lpmN
 12833 - 13534 (+) nucleotidyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96663.1
  • lpmO
 13534 - 14667 (+) glycosyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96664.1
  • lpmP
 14664 - 15938 (+) aminotransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96665.1
  • lpmQ
 15949 - 17322 (+) pyrimidine phosphorylase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96666.1
  • lpmR
 17315 - 18379 (+) acyl-CoA synthase
  • Unknown
Sequence-based prediction
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  • ADC96667.1
  • lpmS
 18379 - 19866 (+) acyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96668.1
  • lpmT
 19863 - 23576 (+) ABC transporter
  • Transport
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  • ADC96669.1
  • lpmU
 23573 - 24607 (+) acyltransferase
  • Scaffold biosynthesis
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  • ADC96670.1
  • lpmV
 24894 - 26693 (+) hypothetical protein
  • Unknown
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  • ADC96671.1
  • lpmW
 26778 - 27806 (+) acyl-CoA dehydrogenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADC96672.1
  • lpmX
 27868 - 29121 (+) SAM-dependent methyltransferase
  • Tailoring (Methylation)
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  • ADC96673.1
  • lpmY
 29152 - 29709 (+) kinase
  • Unknown
Sequence-based prediction
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: MQCAQSV425YQGLSERITRLP7K, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for liposidomycin A
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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