LOCUS       BGC0001078             27448 bp    DNA     linear   BCT 04-FEB-2006
DEFINITION  Streptomyces sp. KO-3988 furaquinocin A biosynthetic gene cluster,
            complete cds.
ACCESSION   BGC0001078
VERSION     BGC0001078
KEYWORDS    .
SOURCE      Streptomyces sp. KO-3988
  ORGANISM  Streptomyces sp. KO-3988
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:50:41
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 27448
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..27448
                     /db_xref="taxon:285219"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. KO-3988"
                     /strain="KO-3988"
     protocluster    1..27448
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[7424:8348]"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7425..8348
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="1"
     protocluster    1..27448
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[694:16178]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      695..16178
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="2"
     cand_cluster    1..27448
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /detection_rules="(LmbU or Neocarzinostat or bcpB or frbD
                     or mitE or vlmB or prnB or CaiA or bacilysin or
                     orf2_PTase)"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="interleaved"
                     /product="T3PKS"
                     /product="other"
                     /product="terpene"
                     /protoclusters="2"
                     /protoclusters="1"
                     /protoclusters="3"
                     /tool="antismash"
     subregion       1..27448
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001078"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..27448
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="T3PKS"
                     /product="other"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /rules="(LmbU or Neocarzinostat or bcpB or frbD or mitE or
                     vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            695..1765
                     /gene="pks"
     CDS             695..1765
                     /codon_start=1
                     /gene="pks"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_C"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:chalcone and stilbene synthase domain protein
                     (Score: 349.8; E-value: 2.1e-106)"
                     /gene_kind="biosynthetic"
                     /product="Probable Type III PKS"
                     /protein_id="BAE78969.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 9.6e-18,
                     bitscore: 55.0, seeds: 21, tool: rule-based-clusters)"
                     /sec_met_domain="Chal_sti_synt_C (E-value: 4.6e-16,
                     bitscore: 49.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRLCKPAMNAPEHVITVEETLEFAARAHAGKPQLGLALRLIRNT
                     GVKKRHIVQPIEKTLHHPGLEERNRIYEVESKKRTPRVIEEALAHAELKARDIDAIIYV
                     SCTGFLMPSLTAWLINHMGFRSDTRQIPIAQLGCAAGGAAINRAHDFCMAHPASNVLIV
                     SCELCSPCYQPDADDIGSLLSDGLCGDAVAAAVVRGEGCVGIELERNASYLIPGTEEWF
                     SYAVKDTGFHFQLDRRVPGTMEPLAPVLREPAKDHSWDVGKLDFYIVHAGGPRILDDLA
                     RFLEVDREVFRHSWSTLHEFGNIASAVVLEAARGLFEEDALAPGATGLSAGVGPGITAE
                     RALGSGAAEGVPQTFA"
     CDS             1776..2363
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAE78970.1"
                     /transl_table=11
                     /translation="MRGGRSYDRPHHPGRRRATPVTPAQEVTFKATQETGSAVSIFEVV
                     VPPGFDVGAHVHHRSQEFFYVLEGELDLLCFEPTERTPDTWHHWESPKGDRVVRAGEGS
                     CMFVPPGTPHAFRNATDKPVKMLFQSYPSPEHEAYFEEIAEIWSRGGPVDPAAVEAMRR
                     RYDVGQLTPLRFEPPADAATPGREPHAQRNER"
     CDS             2360..3526
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     317.3; E-value: 2.4e-96)"
                     /gene_kind="biosynthetic-additional"
                     /product="hypothetical protein"
                     /protein_id="BAE78971.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.7e-93,
                     bitscore: 301.9, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7e-07, bitscore:
                     19.2, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAMEPIPLVRASLGQQELAAVAEVFASGWPAGQGPRGKALEAQL
                     VKRYGAGDAVAMCNAGAALHVSLLALGVKPGDEVIVADYGFPAPAHAVRYLDAVPVCAD
                     VRADTGTVDPQAVADLITARTVGIIAVDTVGIPADYVELQAIADRHGLFVVEDAACAVG
                     ATYQGREAGSLAEVGVLSFHGRKGATSGEGGALLAADPKIGADARLRSSFGIGSIFDMG
                     KVVGLPIPEFTRIGHNYKLSDIAAAILQVQLERIDELLARRDAVAVQYSELLADEELLT
                     VPYVPDDRTHAWQTYMVKLDPRVDRAAVATELRAQGIGCGHGTFATHIQPVFESKHTCP
                     VSAELVQRHLAIPMHAELDADQVERVVDALRTAVRTHAAPTPSPGGAA"
     CDS             3523..4518
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 189.4; E-value:
                     1.7e-57)"
                     /gene_kind="biosynthetic-additional"
                     /product="Probable methyltransferase"
                     /protein_id="BAE78972.1"
                     /transl_table=11
                     /translation="MTDHQPTPDGVLRLINGYWATGVVGAAAAHSLFTHLENGAGTVAE
                     LAERAEIAEAGAQTLLDGLLGVGLVELHEGRYRNTPEASLYLVDGKPTSLSSFARLKLK
                     HMGGLTALPDVVRAGGPIQHATTEVADNPHWEEIVPAIAAQSVPAAQVAAQALGLAEAG
                     PVSILDVGGGSGVYSAIWLAANPAARSTQLDWEPINVIARRLVAEQGVGDRFTTVAGDF
                     HTTDFGTGEYDIALYSHIAHQEAPEDNIAVLSRLREALKPGGALVVCDYVVEDDRSGPA
                     FPLIFAAEMLLKSKQGGTWRRSDYHNWLVKAGFTTVSFHSAPPATLVIAR"
     CDS             4553..6139
                     /NRPS_PKS="Domain: AMP-binding (44-432). E-value: 1.3e-43.
                     Score: 140.9. Matches aSDomain:
                     nrpspksdomains_BAE78973.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     165.3; E-value: 2.9e-50)"
                     /gene_kind="biosynthetic-additional"
                     /product="fatty-acid-CoA ligase homolog"
                     /protein_id="BAE78973.1"
                     /sec_met_domain="AMP-binding (E-value: 8.3e-42, bitscore:
                     133.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGSVAYRTIQKRGLHIGLLPAMAAAVDETTPITLDHDLDVLPEV
                     GRQLTVSRLADLVDDLAARLWAAGVRPDEHIVVHKKANADVWVLACAASRIGAVPVLLA
                     PSLDAVTVGALLQRVDRPNLLTDEHKLDVLGELPLPELTKQVIIVSGARPGTVSLGALA
                     GAPRVKPVVRPIDEAAVITHTSGTTGVAKLVVHTPRTQGLRLKPQWRLLSLMRKREKVA
                     INIPFVHSRNVAAMALALLKEMPVLLMNESAPETVAELFLENRPGLVEALPNSLMAWEN
                     LAADPRKPFASVKYFSSTFDAIHPGTMSRLLKSSQRKGALFFQIYGQSEVGPAVGRAYL
                     RRSAHKANGRCVGWRMPVGSAKVRVVSRDGSPADGQNPGRIQVAWPALAKTYFGEQERY
                     DSNRDGDWWGTGDVGYFTRFGCLHMLDRQVDMIDGVRSSLEIEDLVLAELPELSELVVV
                     HGPDAEAVPVVCTHGDRPLDPGRWRAAVADFPQLADPVQIPEAELPRTGTLKVQRLALA
                     DRLKDKRKGRE"
     aSDomain        4685..5848
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BAE78973.1_AMP-binding.1"
                     /evalue="1.30E-43"
                     /label="BAE78973.1_AMP-binding.1"
                     /locus_tag="BAE78973.1"
                     /protein_end="432"
                     /protein_start="44"
                     /score="140.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VGRQLTVSRLADLVDDLAARLWAAGVRPDEHIVVHKKANADVWVL
                     ACAASRIGAVPVLLAPSLDAVTVGALLQRVDRPNLLTDEHKLDVLGELPLPELTKQVII
                     VSGARPGTVSLGALAGAPRVKPVVRPIDEAAVITHTSGTTGVAKLVVHTPRTQGLRLKP
                     QWRLLSLMRKREKVAINIPFVHSRNVAAMALALLKEMPVLLMNESAPETVAELFLENRP
                     GLVEALPNSLMAWENLAADPRKPFASVKYFSSTFDAIHPGTMSRLLKSSQRKGALFFQI
                     YGQSEVGPAVGRAYLRRSAHKANGRCVGWRMPVGSAKVRVVSRDGSPADGQNPGRIQVA
                     WPALAKTYFGEQERYDSNRDGDWWGTGDVGYFTRFGCLHMLDRQVDMI"
     CDS_motif       5087..5140
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BAE78973.1_0001"
                     /evalue="1.30E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="BAE78973.1"
                     /protein_end="196"
                     /protein_start="178"
                     /score="11.9"
                     /tool="antismash"
                     /translation="AVITHTSGTTGVAKLVVH"
     CDS             6136..7272
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 174.3; E-value:
                     6.6e-53)"
                     /gene_kind="biosynthetic-additional"
                     /product="Probable methyltransferase"
                     /protein_id="BAE78974.1"
                     /transl_table=11
                     /translation="MTSDQPAATAVENPLPERDEPMTSEATLARFREYMVGPSRFMTLL
                     SCFELGLVDQIRDNPGLTAAELGEAIGAKADAVEQLLLLLVKEGFVAHDEASGAYVLDG
                     LADVAAGDLKRALAYMNMIKVVALRQLFHLTESAQTGTLVGLKELYGVTEGTLYGAVAE
                     HRDLRDAWSNLMNTVTANIDPWFFGNVDVPAGARVLDLAGNTGLGAIHTVAHKASPGLQ
                     VTTFDLPEKEQEALANFKAHGVAESCSFIGGDVFDGVPKGFDIVLIKHFLDMFDKDDVI
                     RILQGVNQALEVGGQVNIMVPVYPEDITDTDNYNVDFFPAFFIGCTMGQGGPQKLSAYQ
                     SWLEECGFKVTKAITKNAAEVPPDVIPVQAIISATKVV"
     CDS             7425..8348
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) other:
                     orf2_PTase"
                     /gene_kind="biosynthetic"
                     /product="cloQ homologue"
                     /protein_id="BAE78975.1"
                     /sec_met_domain="orf2_PTase (E-value: 3.9e-122, bitscore:
                     397.6, seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGTDDVAVDVASVYSAIEKSAGLLDVTAAREVVWPVLTAFEDVL
                     EQAVIAFRVATNARHEGDFDVRFTVPEEVDPYAVALSRSLIAKTDHPVGSLLSDIQQLC
                     SVDTYGVDLGVKSGFKKVWVYFPAGEHETLARLTGLTSMPGSLAGNVDFFTRYGLADKV
                     DVIGIDYRSRTMNVYFAAPSECFERETVLAMHRDIGLPSPSEQMFKFCENSFGLYTTLN
                     WDTMEIERISYGVKTENPMTFFARLGTKVEHFVKNVPYGVDTQKMVYAAVTSSGEEYYK
                     LQSYYRWRSVSRLNAAYIAARDKEST"
     gene            8345..9649
                     /gene="p450"
     CDS             8345..9649
                     /codon_start=1
                     /gene="p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 291.8; E-value: 1.6e-88)"
                     /gene_kind="biosynthetic-additional"
                     /product="P450"
                     /protein_id="BAE78976.1"
                     /sec_met_domain="p450 (E-value: 1.5e-53, bitscore: 172.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSRMKPARAAEEHDSPEFQFSLMENLLRGRALRHLTVDGVDAVF
                     VRDPVLVRTILVNESKNYGKGELFRKARNLSRVGMLSDDEAMHRHYRRLASPYLRSSSV
                     DAYVPAMRDIVRVHASSWRAGDPVDIQSEMCRITCAIVVGTLIEGLPPETTQALSERLS
                     RLAWEMIRKPLYGKSAARAARPGASRRLSKARTEFRELLAACIADLLNSPESTIGYLSA
                     LLADSDDQGNRVLTAEEVCEEAVMMLTAATVTTASVMSWSLHVLSQDSSVEERLLKDLT
                     QRRSGNRANGHDASSYTLRFLMEILRLYPPVWISCRKTLSDVALGDHLLPAGTNVVFSS
                     YLLHRDPEHYPDPRRFDPDRWLSINPSKADASYIPFGIGSKGCIGEVFAWEQLEAILDV
                     VTQEWKLSTEPDRQVRTAPETTLHPRRLLLVPQPR"
     CDS             9709..10716
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /product="mevalonate kinase"
                     /protein_id="BAE78977.1"
                     /transl_table=11
                     /translation="MTVSTSAEGVSEDRRPRSVGIGRAHAKAILLGEHAVVYGAPALAL
                     PVPQLAVTARAHRSGRESDGPGDVSFTMAGSPPRPMATQASDGLRRLIAEFTAALGTDA
                     APHLDVTVDGAIPPGRGLGSSAACARAVVHALADLHGREVTESETFDLVQTAENVAHGR
                     SSGVDARTVGASAPLLFCRGEVQELSIGCYDLLVIADSGVLGRTKDAVELLREGFQRHD
                     GAQERFVQRATRLTEGARRALADGRPQELGARLTDYHDLLRAAGLSTRRIDALVDAALA
                     AGSLGAKITGGGLGGCVIALTREEQAGEVIQQLHGAGAVQTWVVPLRGLAENAL"
     CDS             10790..11719
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /product="mevalonate diphosphate decarboxylase"
                     /protein_id="BAE78978.1"
                     /transl_table=11
                     /translation="MLPRVDSLSMTLDVLPTTTRVRRAPEAGQDEVTLDGRPAEGEALR
                     RVVAFLDLVRERAGLADRAVVDTANTVATGAGLASSASGFAALAVAAAAAYGLDLDATA
                     LSRLARRGSGSASRSIFGGFAVWHAGLHSGAAAEADLSSYAEPVPVGDLDPALVVAVVD
                     AGPKAVSSRAAMRRTVDTSPLYEPWAVSSGDDLVDMRAALLAGDIEAVGEIAERNALGM
                     HATMLAARPAVRYLAPATLTVLDSVLGLRRDGVPAYATMDAGPNVKVLCRSADAERVAK
                     TLRVAVPDGTVLVARPGPGDRLLHGDVR"
     CDS             11716..12855
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /product="phosphomevalonate kinase"
                     /protein_id="BAE78979.1"
                     /transl_table=11
                     /translation="MTGRRTVVRRAPGKLFVVGEYAVVEPGNPAVLVAVDRYVTVTVTG
                     PVEPGVAAGVEPGVEISSDLGPRGERRRWRDGRLVPYDAHDGPDARAGLAHVLSAIETV
                     ARLLAERGLPAPEFSLSVVSGLHDGGTKYGLGSSAAVTVATVAAVAAFCGLTPTDEERF
                     RLALLATAEIDPKGSGGDLAAGVWGGWIAYRAPDRAAVLALARAHGVEAALRAPWPGFA
                     VRRLPPPAGLALEVGWTGDPASTTALLSDLHRRPCRGTAAHRRFVSTTTDCASAAIAAL
                     EGGDGRRLLDQIRRARRELALLDEEVALGVFTPRLTALCEAAEAVGGAAKPSGAGGGDC
                     GIALLDAGAPQDIARLRERWESAGVVPLPIRPVAEGNEK"
     protocluster    11736..27448
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[21735:22794]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      21736..22794
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="3"
     cand_cluster    11736..27448
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="3"
                     /tool="antismash"
     CDS             12852..13943
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /product="Type II isopentenyl diphosphate isomerase"
                     /protein_id="BAE78980.1"
                     /transl_table=11
                     /translation="MIAQRKDDHVQLAVEQQQQHSGRNQFDDVSFVHHALAGIDRPDVR
                     LATSFAGLSWQAPLYINAMTGGSEKTGIINRDLGIAARETGVPIASGSMSAYFKDPDCA
                     DTFSVLRKENPDGFVLANVNATASVDRARRAVDLIRADALQIHVNTVQETVMPEGDRSF
                     SSWVPQIEKIAAGVDVPVIVKEVGFGLSRETVRLLESLGVRAADLGGRGGTDFARIENG
                     RRPLGDYAFLHGWGQSTAACLLDAQDAPIPVLASGGVRHPLDVARALALGASGVGVSGT
                     FLRTLLDDGVAALIARISTWLDQLAALLTLLGARTPADLSRCDLLINGELRDFCADRGI
                     DPRPFARRSGGLDVPHEMTGSTR"
     CDS             13940..14998
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /product="3-hydroxy-3-methylglutaryl-CoA reductase"
                     /protein_id="BAE78981.1"
                     /transl_table=11
                     /translation="MTDDTSAGVPMRWVGPLRISGNVAVTETQVPLATYESPLWPSVGR
                     GAKVSMLSERGIAATLVDERMTRSVLVEATDAQTAYTAARAIEARIEELRAVVRTCSRF
                     AELLQVRHEIAGNLLFVRFEFSTGDASGHNMATLASDALLAHLLQTIPGISYGSISGNY
                     CTDKKATAINGILGRGKNVVTELVVEREVVERVLHTTAAKIVELNIRKNLLGTLLAGGI
                     RSANAHYANMLLGFYLATGQDAANIVEGSQGVTLAEDRDGDLYFSCNLPNLIVGTVGNG
                     KGLEFVETNLNRLGCREDRAPGENARRLAVIAAATVLCGELSLLAAQTNPGELMRAHVQ
                     LERDHTTAKAGV"
     CDS             15003..16178
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 463.2;
                     E-value: 1.1e-140)"
                     /gene_kind="biosynthetic"
                     /product="3-hydroxy-3-methylglutaryl-CoA synthase"
                     /protein_id="BAE78982.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 1e-11, bitscore:
                     35.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNDSAIGIHDLSFATTEFVLPHTALAEHNGADIGKYHQGIGQRS
                     MSVPAADEDIVTMGAAAAAPLIARHGGDGIRTIIFATESSIDQAKSAGVYVHSLLGLSS
                     ATRVVELKQACYAATAGLQFAIGLVRRDPAQRVLVVASDVSKYEPDSPGEATQGAAAVA
                     MLVGADPALVEIEEPSGVFTADVMDFWRPNYREAALVDGQESIGAYLLAVEGSWKDYTE
                     QGGRSLDEFAAFCYHQPFTKMAYKAHRHLLNYSGHDLDEDRVARDLGLTTAYNNVVGNS
                     YTASVYLALAALLDQADDLSGQAVGFLSYGSGSVAEAFAGRVVPGYREHLRTEAHRAAI
                     DRRKPVDFARYRELHAYSFPADGGDHRTPAQTTGPYRLAALRGHKRIYTAR"
     CDS             16259..17233
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 343.3; E-value: 2.1e-104)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 3-oxoacyl-[acyl-carrier-protein]"
                     /protein_id="BAE78983.1"
                     /sec_met_domain="fabH (E-value: 2.4e-88, bitscore: 286.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEVGILGTGAQVPDRVVSNDEAGAAAGVDDAWVVRKTAIRERRW
                     AAPEQATSDLAAAAGSAALRSAGITPDQLSVIVVATSTPDRPQPPTAAYVQQLLGAVGA
                     AAFDVNAVCSGEVFALAAAEGILTRRGGHALVIGADVYSRILNPADRRTVVLFGDGAGA
                     MVLGPGRGARVRNLALHTFGELAGLIEVPAGGSRRPADQAALDAGLQYFTMDGRAVRSF
                     VEDRLPLLTKQFLHDSGVGPDDIRHFVPHQANGVMLDALFAELALNRAVMHRTLTHYGN
                     TGAASIPITLAEAARSGAFRPGDLILLAGFGGGMAVGFALVEW"
     CDS             17230..19278
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAE78984.1"
                     /transl_table=11
                     /translation="MRPAPARSLVGRPSSPRPALCSLTSAETGTMTTRHCTVGLIGSGP
                     RGLSVVERLCANARSQPESSTVHVHVVDPYPPGSGKVWRTDQSRHLLMNTWAGQISVFT
                     DASVDLQGPLEPGPSLHEWAVALFAXRFGDDCPAEVLDEARGLGPDVYPTRAFYGRYLQ
                     WAYQRIVEGAPAGLTVTVHAALAVTLDDDPDAEDGSLQRVVLDDGTVLAGLHAVILCQG
                     HLPARADAAQRSFASRARKAGLVHIPPANPADVDLDVLAPGAHVLLRGLGLNFFDYMAG
                     LTLGRGGSFTRTAGGLVYHPGGQEPRLYAGSRRGIPYQARGDNEKGAHGRHEPLLLTAD
                     RVAELRHAHEHTGLDFRTDVWPLISREVETVYYRTLLASRGHPARAEQFQDDFLTAGAG
                     ERERDAVLAAYGIGEKYRWDWELIARPYRDREFAGPSDFTDWLLDHLRKDVAEARCGNV
                     SGPLKAALDVLRDLRNEVRLAVDHGGLHGDSHRADLDDWYTPLNAFASIGPPAQRVEEM
                     IALIEAGVLTVVGPGLRAAVDGAGYTAGSPLVPGSEVRVDALVEARLPDITLRRTDDPL
                     LRHLLATGQCTVHRIRTRSGGAHESDGLAVTGRPFHLIDAEGKAHPRRFAFGVPTESVH
                     WVTAAGIRPGVNSVTLTDSDALARAALACGDEGGQEAHTGRGLTYAQ"
     CDS             19268..20722
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 193.9; E-value: 8.6e-59)"
                     /gene_kind="biosynthetic-additional"
                     /product="3-carboxy-cis,cis-muconate cycloisomerase
                     homologue"
                     /protein_id="BAE78985.1"
                     /transl_table=11
                     /translation="MPNDTSLTADVGLLSPVWADTPVVAAVSDGAWLQAMLDAEAALSR
                     AQARLGTVPASAARVITDAARADRLDLVALARQARESANPVVALVREFTARVADLDPAA
                     AAYVHRGSTSQDILDTATVLVVDRALRLVRADLACVEEALAVLAREHRDTLIAGRTLAL
                     HAVPTTFGLKAAGWRHLVLDAVHKLDALAEGLPVQLGGAAGTLAGYLACAPEADPARYV
                     PELTEAFAAELGLTAPLVPWHVLRTPVVDTAVAAAFLCGALGKIAVDVLSLTRTEVAEV
                     HEPAPRGRGASSAMPHKRNPVLATAVRSAALQAPQLAATVLGCLPSEDERSAGAWHAEW
                     EPLRALLRLAGGAAHQARELVCELSVDPRRMRANTRITGGQIVSERIAVVLAPLLGKAW
                     ARDLLNEASARSARTGEPLAEVLRQDGRASAVVADARLADLFEPEAYTGAAALLTDRAL
                     SRPLPPPGARTRTAAGPSAVVASRSA"
     CDS             complement(20870..21499)
                     /codon_start=1
                     /product="ovmZ homologue"
                     /protein_id="BAE78986.1"
                     /transl_table=11
                     /translation="MELNACRKTPRQEPGEATESVLGAARIRQLEGNLLALPGLYRESL
                     HHIAPISREVRHTRVSGSRSSDRLNMSALDTRHNILAILESWAEFVADGLGGIAPTRSV
                     PHLANFLLRNLEWLTEQPPAIDFADEIAGLRLELLRTIDPEPAECHVLTWDCVVADCTG
                     KITTSAQHGRTTDGRSIRCSSGHSWEMREWITLRPLMQRHGKAVGS"
     misc_feature    complement(21083..21085)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             21736..22794
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: NapT7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 217.4; E-value:
                     3.7e-66)"
                     /gene_kind="biosynthetic"
                     /product="Probable geranyl diphosphate synthase"
                     /protein_id="BAE78987.1"
                     /sec_met_domain="NapT7 (E-value: 9.7e-216, bitscore: 705.7,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDTGQDAVGLARRTGADLLHRVEDRLRSLLAVERDAWAAVHEQ
                     AVVPVDALSELIASGGKRIRPAFCITGYLAAGGDPAEPGIVAAGAALEMLHLSALVHDD
                     VLDDSSSRRGVPTVHTQAMALHESSGWQGEPRRYGEGVAILVGDLALVYSEELMAEAPR
                     RVLPEWNKLRSEVMIGQYMDVHAAAEFSVDPRSSRLIARIKSGRYTIHRPLVVGAKRGR
                     GRGDLAPALEEYGEAVGEAFQLRDDLLDASATPAETGKPTGLDFTQHKMTLLLGWAMQR
                     DEHIHTLVTEPGHTPDEVRRRLLDTGVPADVERHIAGLVERGCKAIADAPVDQVWRGEL
                     AAMAGRVAYRTA"
     CDS             22869..23717
                     /codon_start=1
                     /product="Probable short-chain Z-isoprenyl diphosphate
                     synthase"
                     /protein_id="BAE78988.1"
                     /transl_table=11
                     /translation="MAEAPRGAIRWPSPAVGGDEGTGHVALRAVRSALEAVYVRRLARK
                     LEGRPRPRHVAVMLDGNRRWARGAGHDDVREGYRVGGAKVGDFLRWCDASDIEHVTLWM
                     LSDDNLSAPPAELGPLLEIIEETVASICAADEDWQIEVIGALDLLPGETARTLKDAVAR
                     TTGRSGLKVDVAVGYGGRREVVDAVKSAFDKHIAGGGDPRELAENFDLQHITDNLYSPA
                     GHDTDFIIRTSGEQRLSGFLLWQSAYAEVHFVEVLWPAFRQIDLLRALRSYADRDRRYG
                     R"
     CDS             23736..24932
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 197.4; E-value:
                     6.1e-60)"
                     /gene_kind="biosynthetic-additional"
                     /product="Probable methyltransferase"
                     /protein_id="BAE78989.1"
                     /transl_table=11
                     /translation="MSRRAVVAGAPLHRHSSSPADTRWPGGWGRAPPGLPTEGILVSNP
                     EAVLARMREYMVGPTRFMNLYTCFELGIVDALRKEAGLTAAELGAAVGAKADAVEQLLY
                     LLLKEGFVARDEATGGYTLDALADVPETDLQRALTFMGMIKTGMLRQLYHLADSVSSGS
                     VVGLKELYGFDGTMFEAAAEVAEVRAAWGPLAQNETASVYPWFFRSFDVPAGARVLDVR
                     GGNGLGAIMTCQTKASPGLRVTTLDRPALEAECLRNCEAHGVAEQCSCVGGEVLDALPG
                     GFDVLLLKHFVDMYDKDDVLTMFRNAHRALEPGGQIVVLAPVYPEDVRDADDYQADFFP
                     AYILGCVMGRGGLQKASTYGSWLEECGFEVTRTTAKEPADIPADAIINRVVICATKRD"
     CDS             complement(25035..26066)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     317.5; E-value: 3.8e-96)"
                     /gene_kind="regulatory"
                     /product="Putative transcriptional regulator"
                     /protein_id="BAE78990.1"
                     /transl_table=11
                     /translation="MDHTGGPTQHRNDPAKPDGCRHRTLGGPMSETGGASAPTESGYRR
                     VRHAGRRPAATLSIAERDSTRCGGKVKIQVLGTLYAEVNGQSIVPTAGKPRQILSLLAL
                     HPGRVVPVPTLMEELWGTKPPQSALATLQTYIPQLRRRLGSAMGPDAPGTAKEVLATRH
                     NGYVMEIPAESVDVHAYERMATEGRSAFRAGDDVVAADRSRQALMLWQGPALVDVRVGP
                     ALKIEVMRLEESRLGTVERRIDAALRLGRHTELLPELTELTARHPQHEGLHSQAMVALY
                     RSGRQATALDVYRKLRIRLIEELGVEPSPQVQRLHQAMLVVDPQLDVVAGPRRISTFDL
                     YAA"
     misc_feature    complement(25830..25832)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(25839..25841)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(25896..25898)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(26139..27170)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149:LuxR family
                     transcriptional regulator (Score: 130.2; E-value: 1.4e-39)"
                     /gene_kind="regulatory"
                     /product="Putative transcriptional regulator"
                     /protein_id="BAE78991.1"
                     /transl_table=11
                     /translation="MVTVSGEPGIGKTSLLRRFAELADGAPVLWGACPTHVATPPLWPW
                     RQVLGMAGSHYPRRPVPDAVAEVLHGETRQPRDDADADAATLRQFEAIVHYLTGASQAA
                     PLVIVLDHLHQADPSSLRLLAHLAESVPTSRLLVAVSYRSDKAAILAETAAALARAEMT
                     RVELSGLNVAETRALASAMLHREVSGTTAEDLRHRTGGNPFYLRELIKVLDCEERAGRG
                     RIAPVPAPVREVVLGRVAQLGPTAVELLSVASIAGLTFAIDVVAEASSIEIEEALRVVD
                     AIVAAGLIGEDHRRLGWYSFTHALTAEVLFHTMGRLRRVHLLRRIRAAAARPRRGAVGS
                     AAE"
ORIGIN
        1 gcggccgctg cgtcggcatg acggcggagt ccaccgccca tcagtacccc cggcccggcg
       61 tcgtctaccg cccggtccgt gacgccgaac ccatcgccgt acgtctcgcc tggtggcgcg
      121 acgacccgca ccccgccacc caggcggcga tcgagctgct gaccgcgctg taccgcagcg
      181 gctgaccggc ggccggcgac cggcgatctt cgctgtgacc tgagtcactc gatggttttc
      241 ttggtgcgag ggcccctcgt gtgtcacgat ttccgcacac cttccctgcc cgaaaacagc
      301 tacgaggcaa aaacagctac gaggcagtgg atcgaccgcc gtccgccgat ctccgcaggc
      361 gagaccgagc cccccccgtg atccaccgca gccggctgcg tcctccgggc agctgaagcc
      421 ccttccccag aaggacaggc acgactcgcc gtcgacggtc cccgtccgac cggccgccac
      481 agcacacgct ttcgtcccgt agcccggcca cggccgtggt cggtgctgcc cggccgggag
      541 ccgttctccg cccgcccgat ccgtcggcgg gcatgtcagg ccaccgtgaa gcactcgtca
      601 acgaccgcag cgggacggcg gctcagaggt tccgccgtcc ccgcaacgcc ccactgccct
      661 tgccgtcgag actctgagga agtggacccc aggtatgccg aggctatgca agccggcgat
      721 gaacgcccct gagcacgtca tcaccgtcga agagactctg gaattcgccg cacgagccca
      781 tgccggcaag ccgcaactcg gtctggcgct ccgtctgatc cggaacaccg gcgtcaagaa
      841 gcggcacatc gtccagccca tcgagaagac gctccaccac ccgggcctgg aggagcgcaa
      901 ccgcatctac gaggtcgagt ccaagaagcg cacgccccgg gtcatcgaag aggccctggc
      961 ccacgccgaa ctgaaagccc gtgacatcga cgcgatcatc tacgtgtcgt gcaccggctt
     1021 cctgatgccg tccctgacgg catggctgat caaccacatg ggcttccgct ccgacacccg
     1081 gcagataccc atcgcccagc tgggctgcgc ggccggcgga gcggcgatca accgggccca
     1141 cgacttctgc atggcgcacc ccgccagcaa cgtcctgatc gtgtcctgcg aactgtgctc
     1201 gccctgctac cagcccgacg cggacgacat cggctcgctg ctctcggacg gcctgtgcgg
     1261 cgacgcggtc gccgccgccg tcgtacgggg cgaaggatgc gtcggcatcg agctggagcg
     1321 caacgcctcc tacctcatcc cgggcaccga ggagtggttc tcctacgcgg tcaaggacac
     1381 cggcttccac ttccagctgg accgccgggt gcccggcacc atggagccgc tcgctccggt
     1441 cctgcgcgag ccggccaagg accacagctg ggacgtcggc aagctcgact tctacatcgt
     1501 ccacgccggc ggtccgcgca tcctcgacga cctcgcgagg ttcctcgagg tcgaccgcga
     1561 ggtgttccgg cacagctggt cgaccctgca cgagttcggc aacatcgcca gcgccgtcgt
     1621 cctcgaggcc gcccgcgggc tgttcgagga ggacgccctg gcacccggtg cgaccggtct
     1681 gagcgcgggc gtcggtcccg gcatcaccgc cgagagggcg ctcggcagcg gggcggccga
     1741 gggcgtcccg cagaccttcg cctgagcgcg cccgcgtgcg gggggggcgg agttatgacc
     1801 gacctcatca tcccggccgg cgtcgggcga caccggtcac cccggcacag gaggtgacgt
     1861 tcaaggccac ccaggagacg ggatccgccg tctcgatctt cgaggtggtc gtcccccccg
     1921 gattcgacgt cggggcgcat gtccaccacc gctcccagga gttcttctac gtcctggagg
     1981 gcgagctgga cctgctgtgc ttcgagccca ccgagcgcac gcccgacacc tggcaccact
     2041 gggagtcccc caagggcgac cgggtcgtcc gcgccggcga aggcagctgc atgttcgtgc
     2101 cccccggcac cccgcacgcc ttccgcaacg ccaccgacaa gccggtgaag atgctcttcc
     2161 agagctaccc ctcgcccgag cacgaggcct acttcgagga gatcgccgag atctggtcgc
     2221 gcggcggccc ggtggacccc gctgccgtgg aggcgatgcg ccggcgctac gacgtcggcc
     2281 agctcacgcc gctgcgcttc gaaccgccgg ccgacgccgc gacgcccggc cgcgaaccgc
     2341 acgcgcagcg gaacgagagg tgaccgcgat ggaaccgatt cccctggtcc gcgccagcct
     2401 cggacaacag gaacttgccg ccgtcgccga ggtgttcgcc tccggctggc cggccggaca
     2461 gggcccgcgg ggcaaggccc tggaagccca gctggtcaag cgctacgggg ccggcgacgc
     2521 cgtggcgatg tgcaacgccg gcgccgcgct ccatgtctcc ctgctcgccc tcggggtcaa
     2581 gccgggcgac gaggtgatcg tcgccgacta cggcttcccg gcgcccgccc acgccgtgcg
     2641 ctacctcgac gcggtccccg tctgcgccga cgtgcgcgcc gacaccggaa ccgtcgaccc
     2701 gcaggcggtg gccgacctga tcaccgcgcg caccgtcgga atcatcgcgg tggacaccgt
     2761 cggcatcccc gccgactacg tcgaactcca ggccatagcc gaccgccacg gcctgttcgt
     2821 cgtcgaggac gccgcctgcg ccgtcggcgc gacgtaccag ggccgcgagg cgggctcgct
     2881 cgccgaggtg ggcgtcctgt ccttccacgg acgcaagggc gccaccagcg gcgagggcgg
     2941 cgcgctgctc gccgccgacc cgaagatcgg cgcggacgcc cgactgcgct cctccttcgg
     3001 catcggcagc atcttcgaca tgggcaaggt cgtcggcctg cccatcccgg agttcacccg
     3061 gatcggccac aactacaagc tgtccgacat cgccgcggcc atcctccagg tgcagctgga
     3121 gcggatcgac gaactgctgg cgcgtcgcga cgccgtcgcc gtccagtact ccgagctgct
     3181 cgccgacgag gagctgctga cggtgccgta cgtgccggac gaccgcaccc acgcctggca
     3241 gacgtacatg gtgaaactgg acccgcgggt ggaccgcgcg gccgtcgcga ccgagctgcg
     3301 cgcccagggc atcggctgcg gacacggcac cttcgcgacc cacatccagc cggtgttcga
     3361 gtccaagcac acctgcccgg tgtcggcgga gctcgtccag cgccacctcg ccataccgat
     3421 gcacgcggaa ctcgacgccg accaggtcga acgggtcgtg gacgccctgc gcacggcggt
     3481 ccggacccac gccgcgccca ccccgagccc aggaggggca gcatgacgga ccaccagccg
     3541 actccggacg gggtcctgcg gctgatcaac ggctactggg ccaccggcgt cgtcggcgcc
     3601 gcggccgccc actcgctgtt cacccacctg gagaacgggg cgggcacggt cgcggagctg
     3661 gccgagcgcg cggagatcgc ggaggcgggc gcgcagaccc tcctcgacgg cctcctcggc
     3721 gtgggcctgg tcgaactgca cgagggccgc taccgcaaca cccccgaggc gtccctctac
     3781 ctggtcgacg gcaagcccac ctccctcagc agcttcgccc ggctgaagct gaagcacatg
     3841 ggcggcctga ccgccctgcc ggacgtggtc cgggccgggg ggccgatcca gcacgcgacg
     3901 accgaggtgg ccgacaaccc gcactgggag gagatcgttc cggccatcgc cgcccagtcg
     3961 gtgcccgccg cccaggtcgc cgcccaggcg ctcggactgg ccgaggccgg cccggtctcc
     4021 atcctcgacg tgggcggcgg ctcgggcgtc tactcggcca tctggctcgc ggccaacccg
     4081 gcggcccgct ccacccagct cgactgggag ccgatcaacg tgatcgcccg ccgactggtg
     4141 gcggagcagg gagtgggcga ccggttcacc accgtcgccg gcgacttcca caccaccgac
     4201 ttcggcaccg gcgagtacga catcgcgctg tactcccaca tcgcccacca ggaggcgccc
     4261 gaggacaaca tcgcggtcct ctcgcgtctg cgcgaggcgc tcaagcccgg cggcgccctg
     4321 gtggtctgcg actacgtcgt cgaggacgac cgcagcggtc ccgccttccc gctgatcttc
     4381 gccgcggaaa tgctgctcaa gagcaagcag ggcggcacct ggcggcgctc cgactaccac
     4441 aactggctgg tcaaggccgg tttcacgacg gtgtcgttcc actccgcgcc gcccgccacc
     4501 ctggtcatcg cccggtgagc gggcgagacc ccgccgtaaa ggagaccgcc ggatgaacgg
     4561 ctcagtggcc tatcgcacga tacagaaacg cggactgcac ataggcctgc tcccggccat
     4621 ggccgcggcc gtcgacgaga cgacgcccat caccctcgac cacgacctgg acgtcctccc
     4681 cgaggtgggc aggcagctga cggtctcccg gctcgccgat ctggtcgacg acctggcggc
     4741 ccggctgtgg gccgccggag tgcggcccga cgagcacatc gtcgtccaca agaaggccaa
     4801 cgccgacgta tgggtgcttg cctgcgcggc gtcccggatc ggcgcggtgc ccgtgctgct
     4861 cgcgcccagc ctggacgcgg tgaccgtcgg cgccctgctc cagcgcgtcg accggcccaa
     4921 cctgctcacc gacgagcaca agctggacgt gctgggcgag ctgccgctgc cggagctcac
     4981 caagcaggtg atcatcgtgt ccggcgcccg gccggggacc gtgtcgctgg gcgcgctggc
     5041 cggggcgccg cgggtcaagc cggtggtgcg gcccatcgac gaggccgccg tgatcaccca
     5101 cacctccggg accaccggag tggccaagct ggtcgtgcac acgccccgca cccagggact
     5161 gcgcctcaag ccgcagtggc ggctgctgtc cctcatgcgc aagcgcgaga aggtcgcgat
     5221 caacatcccg ttcgtgcact cgcgcaacgt cgcggcgatg gccctggccc tcctcaagga
     5281 gatgccggtg ctgctcatga acgagtcggc ccccgagacc gtcgccgaac tgttcctcga
     5341 gaaccggccc ggcctcgtcg aggcgctgcc caactcgctg atggcgtggg agaacctggc
     5401 cgcggacccg cgcaagccct tcgcctcggt gaagtacttc agcagcacct tcgacgcgat
     5461 ccaccccggg acgatgagcc gactgctgaa gtcgtcccag cgcaagggcg ctctgttctt
     5521 ccagatctac gggcagagcg aggtcggccc cgccgtcggc cgcgcctatc tgcgccgctc
     5581 cgcgcacaag gccaacggcc gctgcgtcgg ctggcggatg ccggtgggct ccgcgaaggt
     5641 ccgcgtcgtc agccgcgacg gatcgccggc cgacggccag aaccccggcc gcatccaggt
     5701 cgcctggccg gcgctggcca agacgtactt cggcgagcag gagcgctacg acagcaaccg
     5761 ggacggcgac tggtggggca ccggggacgt cggctacttc acccggttcg gctgcctgca
     5821 catgctcgac cgccaggtcg acatgatcga cggggtccgc agctccctcg agatcgagga
     5881 cctggtcctc gccgagctgc cggagctgag cgagctggtc gtggtccacg gccccgacgc
     5941 cgaggccgtt ccggtggtct gcacccacgg cgaccggccg ctggaccccg gccgctggcg
     6001 cgcggcggtc gccgacttcc cccagctggc cgatccggtc cagatccccg aggccgaact
     6061 gccgcgcacc ggcaccctca aggtccagcg cctcgcgctg gccgaccggc tcaaggacaa
     6121 gcgcaagggc cgggagtgac gtctgaccag ccggccgcca cggcggtgga aaaccctcta
     6181 cccgaaagag acgagcccat gacgtcggaa gccacgcttg cccgattccg tgagtacatg
     6241 gtgggcccct cgcggttcat gaccctgctg tcctgcttcg aactcggcct cgtcgaccag
     6301 attcgggaca acccgggcct gaccgcggcc gagttgggcg aggcgatcgg cgccaaggcc
     6361 gacgccgtgg agcagctgct tctcctcctg gtcaaggagg gcttcgtcgc gcacgacgag
     6421 gcgtccggcg cgtacgtcct cgacggcctc gccgacgtcg ccgccggcga tctgaagcgc
     6481 gcgctcgcct atatgaacat gatcaaggtg gtggcgctgc ggcagctgtt ccacctcacc
     6541 gagagcgcgc agaccggcac cctcgtcggc ctgaaggagc tgtacggggt gaccgagggc
     6601 accttgtacg gcgcggtcgc cgagcaccgg gatctgcgcg acgcctggtc gaacctgatg
     6661 aacacggtca ccgccaacat cgacccctgg ttcttcggca acgtggacgt ccccgccggc
     6721 gcccgggtgc tcgacctggc cggcaacacc ggcctcgggg cgatccacac ggtcgcgcac
     6781 aaggcgtctc ccgggttgca ggtcaccacc ttcgacctgc cggagaagga gcaggaggcg
     6841 ctggccaact tcaaggccca cggggtggcg gagagctgct ccttcatcgg cggcgacgtc
     6901 ttcgacgggg tgcccaaggg cttcgacatc gtcctgatca agcacttcct ggacatgttc
     6961 gacaaggacg acgtgatcag gatcctccag ggcgtcaacc aggccctgga ggtcggcggc
     7021 caggtcaaca tcatggtgcc ggtgtatccg gaggacatca cggacaccga caactacaac
     7081 gtcgacttct tcccggcctt cttcatcggc tgcacgatgg gccagggcgg cccgcagaag
     7141 ctgtcggcct atcagagctg gctggaggag tgcgggttca aggtgacgaa ggcgatcacc
     7201 aagaacgccg ccgaggttcc gccggacgtc atcccggtcc aggccattat ctccgcgacc
     7261 aaggtcgtgt gaccggacga ggcccacggg tcggtaggcc cgttccgagc gcgcggggcg
     7321 tgcggccgat gtccgcgcgc cccgcccgca gtggtgcgtc ggcgcggaac agcgtgagag
     7381 cccgacgtga gtcatgcaca caggaaccga ttcttggagt aacgatgccg ggtacggacg
     7441 atgtcgctgt cgatgtggca agtgtctact cagccattga gaagtcagcc ggcctgctgg
     7501 acgtgaccgc cgcgcgcgag gtcgtctggc ccgtcctcac cgcgttcgag gacgtgctgg
     7561 agcaggccgt gatcgccttc agggtggcca ccaacgcgcg gcacgaaggg gacttcgacg
     7621 ttcgcttcac cgttcccgaa gaggtcgacc cgtacgccgt ggccctgtcg aggagcctga
     7681 tcgcgaagac ggaccacccc gtcggcagtc tgctgtcgga catccagcag ctctgctccg
     7741 tcgacaccta cggcgtcgac ctcggggtca agtccgggtt caagaaggtc tgggtgtact
     7801 tcccggccgg agagcacgag acgctggccc ggctgaccgg tctgacgtcg atgccgggga
     7861 gcctggccgg caacgtcgac ttcttcaccc gctacggcct ggccgacaag gtcgacgtga
     7921 tcgggatcga ctatcgcagc cgaacgatga acgtgtactt cgcggccccc tcggagtgtt
     7981 tcgagcggga gaccgtcctg gcgatgcacc gggacatcgg gctgccgagc cccagtgagc
     8041 agatgttcaa gttctgcgag aactcgttcg ggctctacac caccctgaac tgggacacga
     8101 tggagatcga gcgaatctcc tacggtgtga agacagagaa tccgatgacg ttcttcgccc
     8161 gactgggaac caaggtcgag cacttcgtga agaacgttcc ctacggtgtc gacactcaga
     8221 agatggtgta cgccgccgtg acgtccagcg gggaagagta ctacaaactc cagtcgtact
     8281 atcgctggcg ttccgtcagc cggttgaacg ccgcctacat cgcagctcgc gacaaggagt
     8341 cgacatgacg agtcggatga aaccggcgcg tgctgcagaa gagcacgaca gcccggaatt
     8401 ccagttcagt ctgatggaga acctcctgcg cgggcgcgcg ctgcgccatc tgacggtgga
     8461 cggcgtcgac gcggtgttcg tgcgggatcc ggtcctggtg cgcaccattt tggtgaacga
     8521 gagcaagaac tacggaaaag gcgaactctt ccgcaaagcc agaaacctca gcagggtggg
     8581 aatgctgtcg gacgacgagg ccatgcaccg gcactatcgg cggctggcca gtccctatct
     8641 gcggtcgtcg agcgtcgacg cgtacgtccc ggccatgcgg gacatcgtgc gggtccacgc
     8701 gtcctcctgg cgggccggcg atcccgtgga catccagtcc gagatgtgcc ggatcacctg
     8761 cgcgatcgtc gtgggcacgc tcatcgaggg gctgccgccc gagaccacgc aggcgctgag
     8821 cgagcgcctc tcccggctgg cctgggagat gatcagaaag ccgctctacg ggaagtcggc
     8881 ggcccgagcg gcacggcccg gcgcgtcgag gcggctgtcc aaggcgcgca ccgaattccg
     8941 ggaactgctc gcggcctgca tagccgatct cctgaattcc cccgagtcga cgatcggtta
     9001 cctctcggcg cttctggccg actccgacga ccagggaaac cgggtcctga cggcggagga
     9061 ggtgtgcgag gaggcggtca tgatgctgac cgcggccacc gtcaccaccg cctcggtcat
     9121 gtcctggtcg ctgcatgtgc tctcccagga ctcctcggtc gaggaaagac ttctcaagga
     9181 cctgacgcag cggcgcagcg gaaaccgcgc caacggccac gacgcgtcca gctataccct
     9241 ccggtttctg atggagattc tgcggctcta tccgccggtc tggatatcgt gccgaaagac
     9301 cctttcggac gtcgcgctcg gtgaccattt gctccccgcg ggcacgaacg tggtgttcag
     9361 ttcgtatctc ctgcaccggg accccgagca ctatccggat ccgcgtcggt tcgatcccga
     9421 ccgctggctc tccatcaacc cgagcaaggc cgacgcctcc tacattccct tcggaatcgg
     9481 atcgaagggg tgcatcggag aggtgttcgc ctgggagcag ctcgaggcca ttctcgacgt
     9541 ggtgacgcag gaatggaagc tgagcaccga gcccgatcgc caggtccgca ccgcgccgga
     9601 gaccacgctc catccgcgcc gcctgctcct ggtcccccag ccgcggtgac cagtgggccg
     9661 ccgggcgatg cgatctcacc gtaggaacga caaggggagt tgagtgctgt gacggtgtcg
     9721 acctcggcgg agggggtgtc agaggaccgt cggcctcgtt ccgtcggcat cggtcgcgcc
     9781 cacgcgaaag ccattctgct cggggagcac gccgtcgtgt acggggcccc ggcgctcgct
     9841 ctgcccgttc cgcagctggc ggtcaccgcg agagcccacc ggtccggccg cgagagcgac
     9901 ggaccgggcg atgtgtcctt cacgatggcc ggctccccgc cgcggccgat ggcgacgcag
     9961 gcgtccgacg gccttcgccg gctgatcgcc gagttcaccg cggccctggg cacggacgcc
    10021 gccccgcatc tcgacgtgac cgtcgacggc gcgataccgc ccggccgcgg gctcggctcc
    10081 agcgccgcct gtgcccgggc ggtcgtccac gccctcgccg atctgcacgg ccgcgaggtc
    10141 accgagagcg agacgttcga cctggtccag acggccgaga acgtggcgca cggccgctcc
    10201 agcggcgtcg acgcgcgcac cgtcggcgcg tccgccccgc tgctgttctg caggggcgag
    10261 gtccaggagc tgagcatcgg ctgctacgac ctgctcgtca tcgccgacag cggcgtcctg
    10321 ggccgtacca aggacgcggt cgagctgctg cgcgaaggat tccagcggca cgacggagcg
    10381 caggagagat tcgtgcagcg cgcgacgcgg ctgaccgagg gggcccggcg cgccctcgcc
    10441 gacggcaggc cgcaggagct cggcgcgcgg ctgacggact accacgatct gctgagggcc
    10501 gccgggctca gcacccggcg catcgacgcg ctcgtcgacg ccgcgctcgc cgcgggcagc
    10561 ctcggagcga agatcaccgg cggcggcctc ggcggctgcg tcatcgccct gacccgagag
    10621 gaacaggccg gagaggtcat ccagcagctt catggcgcag gcgccgtgca gacctgggtc
    10681 gtgccgctga gagggcttgc cgagaatgca ctctgaacac ccggtcaccg gcgtcgcgta
    10741 cccgaacatc gcgctgatca agtactgggg caagcgggac gaacacctga tgctgccccg
    10801 cgtcgacagc ctgtcgatga ccctggacgt cctcccgacg accacccgcg tccgccgcgc
    10861 ccccgaggcc gggcaggacg aggtgaccct cgacggccgg cccgccgagg gcgaggcgct
    10921 gcgccgcgtc gtcgccttcc tcgacctggt gcgggaacgc gccgggctcg cggaccgggc
    10981 cgtcgtggac accgccaaca ccgtcgccac cggggcgggg ctggcctcgt cggcgagcgg
    11041 cttcgccgcc ctcgcggtcg ccgcggcggc cgcgtacggg ctcgacctcg acgccaccgc
    11101 cctgtcgcgg ctggcccggc gcggctccgg gtcggcgtcc cggtcgatct tcggcgggtt
    11161 cgcggtgtgg cacgcgggcc tgcactccgg cgccgccgcg gaggccgacc tcagctccta
    11221 cgccgagccc gtgcccgtgg gcgacctcga tccggcgctg gtcgtcgccg tggtcgacgc
    11281 gggcccgaag gccgtgtcca gcagggcggc catgcggcgg accgtggaca cctccccgct
    11341 gtacgagccc tgggccgtct ccagcgggga cgacctggtc gacatgcggg cggccctgct
    11401 cgccggcgac atcgaggcgg tcggggagat cgcggagcgc aacgcgctcg gcatgcacgc
    11461 gaccatgctg gcggcccggc cggccgtgcg ctacctggcg ccggccacgc tcaccgtcct
    11521 cgacagcgtg ctcgggctgc gccgggacgg cgtcccggcg tacgccacca tggacgccgg
    11581 acccaacgtc aaggtgctgt gccgcagcgc ggacgccgag cgggtcgcca agacgctgcg
    11641 cgtcgccgtc ccggacggca cggtgctcgt cgcccggccg gggcccgggg accgcctgct
    11701 gcacggggac gtgcgatgac cggtcggcgg accgtcgtcc gccgcgcgcc gggcaagttg
    11761 ttcgtggtcg gggagtacgc ggtggtcgag cccggcaacc cggcggtcct cgtcgcggtc
    11821 gaccggtacg tcaccgtcac cgtgaccggc cccgtcgagc cgggcgtcgc agcgggcgtc
    11881 gagccgggcg tcgagatctc ctccgacctc ggcccgcgcg gcgagcgccg acggtggcgg
    11941 gacggccggc tcgtcccgta cgacgcgcac gacggtccgg acgcgcgcgc gggcctcgcc
    12001 catgtgctgt ccgcgatcga gaccgtggcc cggctgctgg ccgaacgcgg ccttcccgca
    12061 ccggagttca gcctgtcggt cgtcagcgga ctgcacgacg gcggcaccaa gtacggcctc
    12121 ggctccagcg ccgcggtgac cgtggcgacg gtggccgccg tcgccgcgtt ctgcggcctc
    12181 accccgaccg acgaggagcg gttccgcctc gccctgctgg ccaccgccga gatcgacccc
    12241 aaagggtccg gcggcgacct cgccgccggc gtctggggcg gctggatcgc ctaccgggcg
    12301 cccgaccggg ccgccgtcct ggccctcgcc cgcgcccacg gcgtcgaggc ggcgctgcgc
    12361 gcgccctggc ccgggttcgc ggtacgacgg ctgccgccgc ccgcgggcct ggcgctggag
    12421 gtcggctgga ccggagaccc ggcctccacc acggccctgc tgtccgacct gcaccggcgg
    12481 ccctgtcgcg gcaccgccgc ccaccggagg ttcgtgtcca ccaccaccga ctgcgcgagc
    12541 gcggcgatcg ccgcgctcga ggggggagac ggccgacggc tcctcgacca gatccggcgg
    12601 gcccggcggg aactggccct gctggacgag gaggtcgcgc tgggagtctt cacgccccgg
    12661 ctgaccgcgc tgtgcgaggc cgccgaagcc gtcggaggcg cggccaagcc ctccggggcg
    12721 ggcggcggcg actgcggcat cgcgctgctg gacgccggag ccccccagga catcgcccga
    12781 ctgcgcgaac ggtgggagtc ggccggggtg gtgcccctgc cgatccgtcc cgtcgccgaa
    12841 gggaacgaga aatgatcgct caacgcaagg acgaccacgt ccagctcgct gtcgagcagc
    12901 agcaacagca cagcgggcgc aaccagttcg acgacgtgtc gttcgtccac cacgccctgg
    12961 ccgggatcga ccggcccgac gtccgtctcg ccacctcctt cgccggcctc tcctggcagg
    13021 cgccgctcta catcaacgcg atgaccggcg gcagcgagaa gaccggaatc atcaaccgcg
    13081 acctgggcat cgccgcccgc gagaccggcg tccccatcgc ctccgggtcg atgagcgcct
    13141 acttcaagga cccggactgc gccgacacct tcagcgtgct gcgcaaggag aacccggacg
    13201 ggttcgtcct cgccaacgtc aacgcgaccg cctccgtcga ccgggcgcgg cgggccgtcg
    13261 acctgatccg ggccgacgcc ctccagatcc acgtgaacac cgtgcaggag acggtgatgc
    13321 cggagggcga ccggtcgttc tcgtcctggg tcccgcagat cgagaagatc gcggccggcg
    13381 tcgacgtccc cgtgatcgtc aaggaggtcg gcttcgggct gagccgggag acggtccgcc
    13441 tgctggagag cctgggcgtg cgcgccgccg acctcggcgg ccggggcggc accgacttcg
    13501 cccgcatcga gaacggccgg cgcccgctcg gcgactacgc cttcctccac ggctggggcc
    13561 agtccaccgc cgcctgcctg ctggacgcgc aggacgcccc gatccccgtc ctcgcctccg
    13621 gcggggtgcg ccatccgctc gacgtggccc gcgcgctggc gctcggcgcg tccggcgtcg
    13681 gcgtctccgg caccttcctg cgcacgctgc tcgacgacgg ggtggccgcg ctgatcgccc
    13741 ggatatcgac ctggctcgac caactggccg cgctcctgac gctgttgggc gcacgcaccc
    13801 ccgccgacct gtcccgctgc gatctgctga tcaacggcga gctgcgcgac ttctgcgccg
    13861 accgggggat cgacccccgg ccgttcgccc gtcgctccgg cggccttgac gtaccccatg
    13921 agatgacggg aagcacacga tgaccgacga cacgagtgcg ggggttccga tgaggtgggt
    13981 gggccccctt cgcatctcgg ggaacgtcgc cgtcaccgag acccaggtcc cgctcgccac
    14041 ctacgagtcg ccgctgtggc cttccgtggg ccggggcgcg aaggtgtcca tgctgtccga
    14101 gcggggcatt gccgcgaccc tcgtcgacga gcggatgacc cgctcggtgc tggtcgaggc
    14161 gaccgacgcc cagaccgcgt acacggccgc ccgcgccatc gaggcgcgga tcgaggaact
    14221 gcgcgccgtg gtccgcacct gcagccggtt cgccgagctg ctccaggtcc ggcacgagat
    14281 cgcgggcaac ctgctgttcg tccgcttcga gttcagcacc ggcgacgcct ccggccacaa
    14341 catggccacc ctcgcctccg acgcgctgct ggcgcatctg ctgcagacga tcccgggcat
    14401 ctcctacggc tcgatctccg ggaactactg cacggacaag aaggcgaccg cgatcaacgg
    14461 catcctcggc cgcggcaaga acgtggtcac cgagctggtc gtggagcgcg aggtggtgga
    14521 acgcgtcctg cacaccacgg ccgccaagat cgtcgagctg aacatccgca agaacctgct
    14581 cggcaccctg ctcgccggcg gcatccgctc ggccaacgcc cactacgcca acatgctgct
    14641 cggcttctac ctggccaccg gccaggacgc ggccaacatc gtcgagggct cccagggcgt
    14701 caccctggcg gaggaccgcg acggcgacct ctacttctcc tgcaacctgc ccaacctcat
    14761 cgtcggcacc gtgggcaacg gcaagggcct ggagttcgtg gagacgaacc tgaaccgcct
    14821 cggctgccgc gaagaccgcg cccccggcga gaacgcccgc cggctcgccg tcatcgcagc
    14881 ggcgacggtc ctctgcggcg agctctccct tctcgcggcc cagaccaacc cgggcgaact
    14941 catgcgcgcg cacgtccagt tggaacgcga ccacacgaca gcaaaggctg gtgtctaggg
    15001 aaatgaccaa cgattccgcc ataggaattc atgatctgtc cttcgcgacg accgagttcg
    15061 tcctgccgca cacggccctc gccgagcaca acggcgccga catcggcaag taccaccagg
    15121 gcatcggcca gcggtcgatg agcgtgcccg ccgccgacga ggacatcgtg accatgggcg
    15181 cggccgccgc cgcgcccctc atcgcccggc acggcggcga cggcatccgg acgatcatct
    15241 tcgccacgga gtcctcgatc gaccaggcga agtcggccgg cgtctacgtc cactccctgc
    15301 tcggactgtc ctcggccacc cgggtcgtcg aactcaagca ggcctgttac gcggcgacgg
    15361 cgggcctgca gttcgccatc ggcctggtgc gccgcgaccc ggcgcaacgg gtcctggtgg
    15421 tggcctccga cgtctccaag tacgagccgg acagcccggg cgaggccacc cagggcgcgg
    15481 ccgccgtggc catgctggtg ggcgccgatc ccgcgctggt ggagatcgag gagccctcgg
    15541 gcgtgttcac cgccgacgtc atggacttct ggcggcccaa ctaccgcgag gccgccctgg
    15601 tcgacggaca ggagtcgatc ggcgcgtatc tgctggcggt ggagggcagc tggaaggact
    15661 acaccgagca gggcgggcgc tcgctcgacg agttcgccgc gttctgctac caccagccgt
    15721 tcaccaagat ggcctacaag gcacaccgtc acctgctcaa ctacagcggg cacgacctcg
    15781 acgaggaccg cgtcgcccgg gacctcgggc tgaccacggc ctacaacaac gtcgtcggca
    15841 acagctacac cgcctcggtg tacctggccc tcgccgcgct cctggaccag gccgacgacc
    15901 tgtccggcca ggccgtcggc ttcctcagct acggctccgg cagcgtcgcc gaggccttcg
    15961 ccggccgcgt cgtccccggc taccgggagc acctgcgcac cgaggcgcac cgcgcggcga
    16021 tcgaccggcg caagcccgtc gacttcgccc gctaccgcga gctgcacgcg tactccttcc
    16081 cggcggacgg cggggaccac cgcaccccgg cgcagaccac gggtccctac cggctggcgg
    16141 ccctgcgcgg ccacaagcgc atctacacgg cgcgctagtc catgcagaag tacctgcaca
    16201 agtccctgca gaccgaccgt ccaagaccgt ccaagtccag gtgagggaag gcgggcgcat
    16261 gaccgaagtc gggattctcg gcacgggtgc tcaggtgccc gatcgagtcg tctccaacga
    16321 cgaggccgga gcggcggcgg gcgtcgacga cgcctgggtc gtccgcaaga ccgcgatccg
    16381 ggaacggcgt tgggccgccc ccgagcaggc cacctccgac ctggccgcag ccgcggggag
    16441 cgccgcgctg cggtcggccg ggatcacccc ggaccagctg tccgtgatcg tcgtcgccac
    16501 ctccacgccc gaccggcccc aaccgcccac cgccgcctat gtgcagcagc tgctcggggc
    16561 cgtaggcgcg gccgccttcg acgtcaacgc cgtctgctcc ggcgaggtgt tcgcgctcgc
    16621 cgcggccgag gggatcctca cccgacgggg cggccacgcg ctggtcatcg gggccgacgt
    16681 gtactcgcgc atcctgaacc cggccgaccg caggacggtc gtcctgttcg gcgacggcgc
    16741 cggtgcgatg gtcctgggcc cggggcgggg cgcacgcgtc cgcaacctcg ccctgcacac
    16801 cttcggcgag ctggcgggcc tgatcgaggt gcccgccggc ggcagccgac ggcccgccga
    16861 ccaggccgcc ctcgacgccg gactgcagta cttcacgatg gacggccggg cggtgcgcag
    16921 cttcgtcgag gaccgtctgc cgctgctgac caagcagttc ctccacgaca gcggcgtcgg
    16981 ccccgacgac atccgccact tcgtgccgca ccaggccaac ggcgtcatgc tcgacgccct
    17041 cttcgcggaa ctggcgctga acagggccgt gatgcaccgc acgctgacgc actacggcaa
    17101 cacgggagcc gcctccatcc cgatcaccct ggccgaagcc gcccgctcgg gagccttccg
    17161 accgggcgac ctgatcctcc tggccggatt cggcggaggc atggcggtgg gattcgcgct
    17221 ggtcgagtgg tgaggccggc gcccgctcgg agcctggtcg gccgcccgtc gtcaccgcgg
    17281 cccgcgctgt gttccctgac ctcggcagaa acaggaacca tgacaacgag acactgcacc
    17341 gtgggcctga taggcagcgg cccgcgcggg ctctcggtgg tcgaacggct ctgcgccaac
    17401 gcccgctcgc agcccgagag cagcactgtc cacgtccatg tggtcgaccc ctacccgccc
    17461 ggctccggca aggtgtggcg caccgaccag tcccgtcacc tgctcatgaa cacctgggcc
    17521 ggacagatct cggtgttcac cgacgcctcc gtggacctcc agggtccgct ggaacccggg
    17581 ccgagcctgc acgagtgggc cgtggcgctg ttcgcggncc ggttcggcga cgactgtccc
    17641 gcagaggtcc tcgacgaagc tcgcgggctg ggacccgacg tctacccgac ccgcgcgttc
    17701 tacggccggt acctgcagtg ggcgtaccag cgcatcgtcg agggcgcgcc cgcggggctg
    17761 accgtcaccg tgcacgccgc cctcgcggtc accctggacg acgatcccga cgccgaggac
    17821 ggatccctgc aacgggtcgt gctcgacgac gggactgtgc tcgccggcct gcacgccgtg
    17881 atcctgtgcc agggccacct gccggcccgc gccgacgccg cccagcggtc gttcgcctcc
    17941 cgggcccgca aggcgggact ggtccacatc ccgccggcca accccgcgga cgtcgacctg
    18001 gacgtgctgg cccccggcgc tcacgtgctg ctgcgcggac tcgggctgaa cttcttcgac
    18061 tacatggccg ggctcaccct cggccgcggc ggctccttca cccggaccgc cggggggctc
    18121 gtctaccacc ccggcgggca ggagccgcgc ctctacgccg gatcccggcg cggcatcccc
    18181 taccaggccc gcggcgacaa cgagaagggc gcgcacggcc ggcacgagcc gctgctgctc
    18241 accgccgacc gcgtcgccga actgcgccac gcccacgagc acaccggcct cgacttcagg
    18301 acggacgtgt ggccgctgat ctcccgggag gtcgagaccg tctactaccg gacgctgctc
    18361 gcctcgcggg ggcaccccgc ccgggccgag cagttccagg acgacttcct gacggccgga
    18421 gcgggggagc gggagcggga cgccgtcctc gcggcgtacg gcatcggcga gaagtaccgc
    18481 tgggactggg agctgatcgc ccgcccgtac cgggaccggg agttcgccgg cccgtcggac
    18541 ttcaccgact ggctcctcga ccatctgcgc aaggacgtcg cggaagccag gtgcggcaat
    18601 gtcagcggcc cgctcaaggc cgccctcgac gtcctgcggg acctgcgcaa cgaggtccgc
    18661 ctcgcggtcg accacggggg cctgcacggc gactcgcacc gcgccgacct ggacgactgg
    18721 tacaccccgc tcaacgcgtt cgcgtcgatc gggccgcccg cccagcgcgt cgaggagatg
    18781 atcgccctga tcgaggccgg cgtgctgacc gtggtcggcc ccggactgcg ggcggcggtc
    18841 gacggcgccg ggtacaccgc cggctcgccg ctggtgcccg gctccgaggt ccgggtggac
    18901 gcgctggtcg aggcccggct gcccgacatc accctgcgcc ggacggacga tccgctgctg
    18961 cgccatctgc tggccaccgg gcagtgcacc gtccaccgca tccgcacccg ctccggcggc
    19021 gcccacgaaa gcgacggact ggccgtcacc gggcggccgt tccatctgat cgacgcggaa
    19081 gggaaggcgc atccgcgccg cttcgcgttc ggcgtgccca cggagtcggt gcactgggtg
    19141 acggccgcgg gcatccggcc cggcgtcaac tcggtgacgc tcacggactc cgacgccctc
    19201 gcccgcgcgg ccctcgcctg cggcgacgag ggcggacagg aagctcacac aggacgagga
    19261 ctcacctatg cccaatgaca ccagcctcac cgcggacgtc ggtctgctgt ccccggtctg
    19321 ggcggacacc ccggtcgtcg ccgcggtgtc cgacggggcc tggctgcagg ccatgctgga
    19381 cgccgaggcg gcgctgagcc gggcgcaggc ccggctcggc accgtgcccg cgagcgccgc
    19441 ccgggtcatc accgacgccg cgcgggctga ccggctcgac ctggtcgccc tggcccggca
    19501 ggcgcgcgag tccgccaatc cggtggtggc gctggtgcgg gagttcaccg cacgggtggc
    19561 ggacctggac ccggcggcgg ccgcgtatgt gcaccggggc tcgacgagcc aggacatcct
    19621 cgacacggcg accgtcctgg tcgtcgaccg ggccctgcgg ctcgtccgcg ccgacctcgc
    19681 ctgcgtcgag gaggcgctgg ccgtactcgc cagggaacac cgggacaccc tgatcgcggg
    19741 ccgcaccctg gccctgcacg cggtgcccac gaccttcggc ctcaaagcgg ccggctggcg
    19801 ccatctcgtc ctggacgcgg tgcacaagct cgacgcgctc gccgagggac tgcccgtcca
    19861 actcgggggc gccgcaggca ccttggccgg gtatctggcc tgtgcgccgg aggccgaccc
    19921 ggcccgctac gtcccggagc tgacggaggc gttcgcggcg gaactggggc tgaccgcccc
    19981 cctcgtgccc tggcatgtgc tgcgcacgcc cgtggtggac accgccgtgg ccgccgcctt
    20041 cctgtgcgga gccctcggca agatcgccgt cgatgtgctg tccctgaccc gcaccgaggt
    20101 cgccgaggtg cacgagccgg cgccccgcgg ccggggcgcg tcctcggcga tgccgcacaa
    20161 acgcaacccc gtgctggcga cggccgtccg ctcggccgca cttcaggcgc cgcagctcgc
    20221 cgcgacggtg ttgggctgtc tgccgagcga ggacgagcgg tccgccggcg cctggcacgc
    20281 cgagtgggag ccgctgcgcg ccctgctgcg gctggccggg ggcgcggcgc accaggcgcg
    20341 tgaactcgtc tgcgaactgt cggtggaccc gcggcggatg cgcgccaaca cccggatcac
    20401 cggagggcag atcgtctccg agcggatcgc cgtcgtgctc gccccgctgc tcggcaaggc
    20461 ctgggcacgc gacctgctga acgaggcgtc cgcccgctcg gcgcgcaccg gggagccgct
    20521 ggccgaggtc ctgcggcagg acggccgggc gtccgcggtc gtcgccgacg cccggctggc
    20581 cgacctgttc gagccggagg cgtacaccgg ggccgcggcc ctgctcaccg accgcgcgct
    20641 gtcccgcccg ctgcccccgc ccggagcccg cacccggacg gccgcaggcc ctagcgccgt
    20701 cgttgcatca cgatctgcgt gagctcgtcg atgtcgaact cggaccggcc gggcgtcccg
    20761 tagcgggtga tcttcccgcg gctcacccac ttgcggatcg tcgcctcgga gacgcctgcg
    20821 gcgagcgcgg ccacccgggt gggcagcagt cggtggcgtg gcggtttcgt catgagccga
    20881 cagccttccc gtgccgttgc atgagcggtc gcagagtgat ccattcgcgc atttcccagc
    20941 tgtggcccga cgaacaccga atgcttctgc cgtccgtggt cctgccgtgc tgcgccgacg
    21001 tcgtgatctt tcccgtgcag tcggccacca cgcaatccca ggtgagcaca tggcattccg
    21061 cgggttccgg atctatcgtc cgtaaaagtt ccagccgaag accggcgatc tcgtccgcga
    21121 aatcgatcgc gggcggctgt tcggtgagcc actccaggtt gcgcagcagg aaattcgcca
    21181 gatgcggaac agagcgcgtg ggggcgatcc cgccgagccc gtcggcgacg aactcggccc
    21241 atgactcgag aatggcgagg atgttgtgcc gggtgtcgag cgcggacatg ttcagacgat
    21301 cgctgctgcg gctcccggac acacgcgtgt ggcgcacttc tctggatata ggtgcaatat
    21361 ggtgcaggct ctcccggtac agccccggga gcgccagcag gttgccctcc agctgccgga
    21421 tccgcgcggc gccgaggacg gattccgtcg cctctccggg ttcctggcgc ggagttttgc
    21481 ggcaggcgtt caactccatt cgatcccctt tctggggtgg attgaccgac gcccgtcacg
    21541 gacgacgttt tcctgcttcg gacgttgccc gttcaatttt cgacccgacg cacagggaga
    21601 tttccacggg acggttcagg gtgtcaacgt tcaccattca tcgtcgaccg tccctaaagg
    21661 gggactccag aatcgaagcg ctcccgctca agtgcccctc catctgaacc cgaggagatt
    21721 cccgtgactt cggacatgac caccgacacc ggccaggacg ccgtcggcct cgcccgccgc
    21781 accggcgccg atctgctgca ccgcgtggag gaccggctgc gctccctcct cgcggtcgag
    21841 cgcgacgcct gggccgcggt gcacgaacag gcggtcgtcc ccgtcgacgc gctgtccgag
    21901 ctgatcgcgt cgggcggcaa gcgcatccgg ccggccttct gcatcaccgg ctatctcgcg
    21961 gccggcggcg atcccgccga gcccgggatc gtggcggccg gcgcggctct ggagatgctc
    22021 cacctgtcgg ccctcgtcca cgacgacgtc ctcgacgact ccagcagccg gcgcggagtg
    22081 ccgaccgtgc acacacaggc catggcgctg cacgagagca gcggatggca gggcgagccg
    22141 cgcaggtacg gcgagggcgt ggcgatcctc gtcggcgacc tcgcgctcgt ctactccgag
    22201 gaactgatgg ccgaggcgcc gcggcgggtg ctcccggagt ggaacaagct gcgctccgaa
    22261 gtgatgatcg gccagtacat ggacgtccac gcggccgccg agttctcggt cgacccccga
    22321 agctcccgac tgatcgccag gatcaagtcc ggccgctaca ccatccaccg gcccctcgtg
    22381 gtgggcgcga aacgcgggcg gggccgaggc gacctcgccc ccgccctgga ggagtacggc
    22441 gaggcggtcg gcgaggcgtt ccagctccgc gacgacctgc tggacgcttc ggcgactccc
    22501 gcggagaccg gcaagcccac cggcctcgac ttcacccagc acaagatgac gctgctgctg
    22561 ggctgggcga tgcagcgcga cgagcacatc cacaccctcg tcacggagcc gggccacacc
    22621 cccgacgagg tgcgccgccg cctcctggac acgggcgttc ccgccgacgt cgaacggcac
    22681 atcgcgggcc tcgtcgagcg gggctgcaag gccatcgccg acgcgcccgt cgaccaggtg
    22741 tggcgcggcg aactggcggc catggccgga cgggtcgcct accgcaccgc ctgaacccgg
    22801 ctcccggcag cggcccggcc ccgaagacgg cgcccgtgcc ccggcgcctg ccgcacggac
    22861 ctgcgtcgat ggctgaggct ccgcgcgggg cgatacggtg gccctcgcca gccgttggtg
    22921 gggacgaagg gacagggcac gtggcattga gggccgttcg ctcggcgttg gaggccgtgt
    22981 acgtcaggcg cctggcgcgc aaactggaag gcaggccccg gccacggcat gtcgccgtca
    23041 tgctggacgg caaccgccga tgggcccgcg gagccgggca cgacgacgtc cgcgagggct
    23101 accgcgtcgg cggcgccaag gtcggcgact tcctgcgctg gtgcgacgcc tcggacatcg
    23161 agcacgtcac cctgtggatg ctgtccgacg acaacctcag cgcgccgccg gccgagctcg
    23221 ggccgctgct ggagatcatc gaggagaccg tggcgagcat ctgcgcggcc gacgaggact
    23281 ggcagatcga ggtcatcggc gcgctggacc tgctgccggg ggagaccgcg cggaccctga
    23341 aggacgccgt cgcgcgcacc accggccgga gcggcctcaa ggtcgacgtg gcggtcggct
    23401 acggcgggcg ccgcgaggtc gtcgacgcgg tcaagtccgc cttcgacaag cacatcgccg
    23461 gcggcggcga cccgcgcgaa ctggccgaga acttcgacct ccagcacatc accgacaacc
    23521 tctactcacc ggcgggccac gacaccgact tcatcatccg cacctcgggc gagcagcggc
    23581 tctccggctt cctgctctgg cagtccgcct acgccgaggt gcacttcgtg gaagtcctgt
    23641 ggcccgcctt ccggcagata gacctgctgc gcgcgctgcg ctcgtacgcc gaccgggacc
    23701 gccgttacgg caggtgacgg gtgacctgag gccgggtgtc ccggcgcgcg gtcgtcgcgg
    23761 gagcaccgct ccaccggcac tccagcagcc ctgccgatac tcggtggccc gggggctggg
    23821 gccgagcccc gcccggactg ccgaccgaag ggatactcgt gtccaacccc gaagccgtac
    23881 tcgcccggat gcgtgagtac atggtgggac ccacgcggtt catgaacctc tacacctgct
    23941 tcgagctcgg catcgtcgac gcgctgcgca aggaggccgg cctgaccgcg gccgaactcg
    24001 gcgcggccgt gggcgcgaag gccgacgcgg tggaacaact gctgtacctg ctgctgaagg
    24061 agggcttcgt cgcccgggac gaggccaccg gcggttacac cctcgacgcg ctcgcggacg
    24121 tccccgagac cgacctccag cgcgccctga ccttcatggg catgatcaag acgggcatgc
    24181 tgcggcagct gtaccacctc gccgacagcg tgtcgagcgg cagcgtggtc ggtctgaagg
    24241 agctctacgg cttcgacggc acgatgttcg aggcggcggc cgaggtcgcg gaggtgcgcg
    24301 ccgcctgggg gccgctggcc cagaacgaga ccgcgagcgt ctatccctgg ttcttccgca
    24361 gcttcgacgt cccggccggg gcacgggtgc tcgacgtgcg gggcggcaac gggctcgggg
    24421 cgatcatgac ctgccagacg aaggcgtcgc caggactgcg ggtgaccacc ctcgaccggc
    24481 ccgccctgga agccgagtgc ctgcgcaact gcgaggcgca cggtgtggcg gagcagtgct
    24541 cgtgcgtggg cggcgaggtc ctggacgccc tgccgggcgg gttcgacgtg ctgctgctca
    24601 agcacttcgt ggacatgtac gacaaggacg acgtgctcac catgttccgc aacgcccacc
    24661 gggcgctgga gcccggcggg cagatcgtcg tcctcgcccc ggtgtacccc gaggacgtcc
    24721 gggacgccga cgactaccag gccgacttct tcccggccta catcctcggc tgtgtgatgg
    24781 gacgcggcgg cctgcagaag gcgtccacgt acgggagttg gctcgaggag tgcgggttcg
    24841 aggtcaccag gacgaccgcc aaggagcccg ccgacatccc ggcggacgcc atcatcaacc
    24901 gggtggtgat ctgcgcgacg aagcgggact gagccgtccg caggcctcgt ccgcggaggc
    24961 cgtgccgggg cgggggcggg cgttccgccg tcgcccggca cgacctgggc gagccacagg
    25021 ccccggggag ggcctcaggc ggcgtagagg tcgaacgtcg agatgcgccg cggtccggcg
    25081 acgacgtcca gttgggggtc gacgaccaac atcgcctggt gcagtcgctg cacctggggc
    25141 gagggctcga cgcccagctc ctcgatcagc cggatgcgca gcttgcggta gacgtcgagg
    25201 gccgtcgcct gccgccccga tcggtacaac gccaccatgg cctgcgagtg caggccctcg
    25261 tgctgggggt gacgtgccgt cagctccgtg agttccggga ggagttcggt gtgccggccg
    25321 agccgcagag cggcgtcgat ccgccgctcg acggtgccca ggcgactctc ctccagacgc
    25381 atgacctcga tcttcagagc cggcccgacc cgaacgtcga ccagggccgg cccctgccac
    25441 aacatgaggg cctgccggga gcggtcggcc gcgacgacgt cgtcgccggc cctgaaggcc
    25501 gaccggccct ccgtcgccat gcgttcatag gcgtgcacgt cgacgctctc ggcgggtatc
    25561 tccatcacat agccgttgtg ccgggtggcg agcacctcct tggcggtgcc gggggcgtcg
    25621 ggccccatgg cgctgccgag gcgccggcgc agctgaggga tgtaggtctg cagggtggcg
    25681 agcgcgctct gcggcggctt ggtgccccac agttcctcca tgagcgtggg gacggggacg
    25741 acccgtccgg gatggagagc gagcagagac agaatctgcc gcggcttccc ggccgtcggg
    25801 acgatcgact gcccgttgac ctcggcgtat aacgtgccta agacctgtat cttcactttt
    25861 cccccgcacc tcgtcgagtc cctctcagcg attgataacg ttgccgcggg tctccttccg
    25921 gcatgacgta cgcggcggta cccggattcc gtcggcgccg acgcgccccc cgtctcggac
    25981 atcggtcctc caagtgtcct gtgccgacag ccgtccggct tggccggatc attccggtgc
    26041 tgcgtaggcc caccagtgtg gtccatgcga cttgagcggg actgttcgcc gacttggcgt
    26101 cggcttggcg gctgctcggc aggggcctgt gcgacggctc actcggcggc gctgccgacg
    26161 gcgccccgcc ggggccgtgc ggccgcggcg cggatccggc gcagcagatg gacccggcgc
    26221 agccgcccca tggtgtggaa cagcacctcg gcggtcaggg catgggtgaa ggagtaccag
    26281 cccagccgcc ggtggtcctc gccgatcagc cctgccgcga cgatggcgtc gacgaccctc
    26341 agcgcctcct cgatctcgat cgaggaggcc tcggcgacga cgtcgatggc gaacgtgagg
    26401 ccggcgatgg aggcgacgga cagcaactcg acggccgtcg ggccgagttg cgcgacgcgt
    26461 cccagcacca cctcgcgcac cggggccggc accggggcga tacggccccg gccggcgcgc
    26521 tcctcgcagt ccaggacctt gatcagttcg cgtaggtaga acgggttgcc cccggtgcgg
    26581 tgccgcagat cctctgcggt ggtcccgctc acctcccgat ggagcatcgc gctcgccaga
    26641 gcccgggtct ccgcgacgtt caggccgctc agctctaccc gcgtcatctc cgcgcgggcc
    26701 agcgcggccg cagtctcggc caggatcgcc gccttgtcgg aacggtagga cacggccacc
    26761 agcagccgac tcgtcggcac cgactcggcc aggtgggcca gcagccgcag cgagctgggg
    26821 tccgcctgat gcaggtgatc gagcacgatc accagcggcg cggcctggga cgcgccggtc
    26881 aggtagtgga cgatcgcctc gaactgccgc agggtggcgg cgtccgcgtc cgcgtcgtcc
    26941 cgcggctgcc gggtctcccc gtggagcacc tcggccaccg cgtccggaac cggacgtcgc
    27001 gggtagtggc tgcccgccat gcccaacacc tgccgccagg gccacagcgg cggtgtggcg
    27061 acatgggtgg ggcaggcgcc ccacagcacc ggcgcgccgt ccgccagctc ggcgaaccgt
    27121 cgcagcaggc tggtcttgcc gatgcccggt tcgccggaca ccgtcaccac ccgcccccgg
    27181 ccggccgccg ccccggccgc gaccgccgac aggtgccgca gggcccctcg cggccgacga
    27241 aggcgtccgc ctccgcggcc ggtctggacc gcggcggggt gggcgagcgg acctgtggcg
    27301 ggatctccgg cctgcccggc gccgtcgggc cgcggccggc cggggccgtc agggcagggc
    27361 cggtcagggt cgggccggtc aggttcgggc cggccggggt cggacgccag tccagcgcgg
    27421 gtgcgtgacg caggatctcg cgctcgag
//
