BGC0001078 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001078 (Streptomyces sp. KO-3988)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T3PKS,other,terpene-precursor	1	27,448	High	furaquinocin B	terpene+PKS

BGC0001078 - Region 1 - T3PKS,other,terpene-precursor

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Location: 1 - 27,448 nt. (total: 27,448 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Terpene

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 27,449
Label		BGC0001078

Tailoring functions

Oxidoreductases: Oxidation oxygenase

BAE78970.1: Oxidation

MITE: MITE0000084Oxidation (identity: 73.40%)

p450: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: aminotransferase methyltransferase

BAE78971.1: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

BAE78972.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

BAE78974.1: Methylation

MITE: MITE0000085Methylation (identity: 70.10%)
smcogs: SMCOG1042: O-methyltransferase

BAE78989.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Lyases: lyase

BAE78985.1: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase synthetase

BAE78973.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

BAE78982.1: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

BAE78983.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

BAE78987.1: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

pks: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001078.5	2.47	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0002458.3	1.12	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0001080.5	0.78	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.77	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0002561.3	0.67	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000673.3	0.66	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0002127.3	0.60	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0002397.2	0.58	terpene	astallatene	Arabidopsis thaliana
BGC0000282.3	0.57	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000902.4	0.57	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001078.5	1.00	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0002458.3	0.72	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0002127.3	0.63	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.62	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0001310.5	0.62	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001080.5	0.62	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.62	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000285.5	0.57	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002561.3	0.56	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000673.3	0.55	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

BAE78987.1: PT_FPPS_like

Domain 1 (55 - 304): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Terpene

NRPS/PKS substrate predictions

BAE78973.1: X

AMP-binding (44..432): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SRAESTIPAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate