BGC0001079: napyradiomycin A80915C biosynthetic gene cluster from Streptomyces aculeolatus
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Location: 1 - 43,410 nt. (total: 43,410 nt).
This entry is originally from NCBI GenBank EF397638.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001079
Short description napyradiomycin A80915C biosynthetic gene cluster from Streptomyces aculeolatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type III)
  • terpene (Monoterpene)
Loci
EF397638.1
via Enzymatic assays, Heterologous expression
Compounds
  • napyradiomycin A80915C
  • napyradiomycin 2
  • napyradiomycin 3
  • napyradiomycin 4
Species Streptomyces aculeolatus [taxonomy]
References
Chemical products information
napyradiomycin A80915C Evidence:
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C26H33Cl3O6
napyradiomycin 2 Evidence:
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C26H32Cl2O6
napyradiomycin 3 Evidence:
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C26H34Cl2O6
napyradiomycin 4 Evidence:
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C26H34Cl2O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABS50443.1
  • napT1
 1 - 1170 (-) putative HMG-CoA synthase
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    • ABS50444.1
    • napT2
    		 1174 - 2235 (-) putative HMG-CoA reductase
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      • ABS50445.1
      • napT3
      		 2232 - 3374 (-) putative type 2 IPP isomerase
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        • ABS50446.1
        • napT4
        		 3371 - 4609 (-) putative phosphomevalonate kinase
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          • ABS50447.1
          • napT5
          		 4606 - 5742 (-) putative mevalonate decarboxylase
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            • ABS50448.1
            • napT6
            		 5756 - 6739 (-) putative mevalonate kinase
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              • ABS50449.1
              • napU1
              		 7628 - 8305 (-) hypothetical protein
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                • ABS50450.1
                • napU2
                		 8545 - 9339 (+) hypothetical protein
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                  • ABS50451.1
                  • napB1
                  		 9397 - 10464 (+) putative THN synthase
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                    • ABS50452.1
                    • napB2
                    		 10535 - 11089 (+) putative monooxygenase
                    • Oxidation
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                    • ABS50453.1
                    • napB4
                    		 12426 - 14015 (+) putative acyl-CoA synthase
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                      • ABS50454.1
                      • napT7
                      		 14113 - 15186 (+) putative polyprenyl synthase
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                        • ABS50455.1
                        • napR1
                        		 15463 - 16509 (+) putative regulatory protein
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                          • ABS50456.1
                          • napR2
                          		 16404 - 17675 (+) putative sodium transporter
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                            • ABS50457.1
                            • napR3
                            		 17824 - 18486 (+) putative transcription regulator
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                              • ABS50458.1
                              • napH1
                              		 18638 - 20224 (-) putative vanadium chloroperoxidase
                              • Halogenation
                              • Heterocyclization
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                              • ABS50459.1
                              • napU3
                              		 20779 - 21399 (+) hypothetical protein
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                                • ABS50460.1
                                • napH2
                                		 21698 - 23038 (+) putative FADH2 dependent halogenase
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                                  • ABS50461.1
                                  • napT8
                                  		 23985 - 24878 (-) putative prenyltransferase
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                                    • ABS50462.1
                                    • napT9
                                    		 25104 - 26087 (+) putative prenyltransferase
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                                      • ABS50463.1
                                      • napH3
                                      		 26195 - 27520 (+) putative vanadium chloroperoxidase
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                                        • ABS50464.1
                                        • napH4
                                        		 27700 - 29271 (+) putative vanadium chloroperoxidase
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                                          • ABS50465.1
                                          • napB5
                                          		 29716 - 30789 (+) putative methyltransferase
                                          • Methylation
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                                          • ABS50466.1
                                          • napR4
                                          		 31119 - 32510 (+) putative transporter
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                                            • ABS50467.1
                                            • napR5
                                            		 32976 - 34583 (+) putative efflux protein
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                                              • ABS50468.1
                                              • napR6
                                              		 34888 - 36495 (+) putative efflux protein
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                                                • ABS50469.1
                                                • napR7
                                                		 36492 - 37151 (+) putative transcription regulator
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                                                  • ABS50470.1
                                                  • napR8
                                                  		 38225 - 39376 (-) putative regulatory protein
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                                                    • ABS50471.1
                                                    • napU4
                                                    		 39319 - 40032 (-) hypothetical protein
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                                                      • ABS50472.1
                                                      		 40336 - 41673 (+) putative transposase
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                                                        • ABS50473.1
                                                        • napR9
                                                        		 42205 - 43410 (+) putative efflux transporter
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                                                          Biosynthesis information

                                                          Biosynthetic modules

                                                          Name
                                                          1
                                                          Type
                                                          pks-trans-at
                                                          Genes
                                                          napB1
                                                          Substrates
                                                          Integrated Monomers
                                                          Domains
                                                          ketosynthase
                                                          Annotation changelog

                                                          Entry version: 5

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2024-05-06
                                                          MIBiG v4 annotathon
                                                          • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 4

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Update compound structure (SMILES) for napyradiomycin A80915C
                                                          • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Add new compound: napyradiomycin 2
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Add new compound: napyradiomycin 3
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Add new compound: napyradiomycin 4
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Fixed incorrect terpene synthase/cyclase gene names
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Removed duplicated alternative name of gene in polyketide synthase
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Migrated from v1.4
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2015-06-12
                                                          Submitted
                                                          • (ID: 7PXJSJT7IBMNIYLGG3GUM5VC)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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