BGC0001079: napyradiomycin A80915C biosynthetic gene cluster from Streptomyces aculeolatus
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Location: 1 - 43,410 nt. (total: 43,410 nt).
This entry is originally from NCBI GenBank EF397638.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
Terpene
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001079
Short description napyradiomycin A80915C biosynthetic gene cluster from Streptomyces aculeolatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Terpene (Monoterpene/Unknown)
Loci NCBI GenBank: EF397638.1
Compounds
  • napyradiomycin A80915C
  • napyradiomycin 2
  • napyradiomycin 3
  • napyradiomycin 4
Species Streptomyces aculeolatus [taxonomy]
References
Chemical products information
napyradiomycin A80915C
Copy SMILES
C26H33Cl3O6
napyradiomycin 2
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C26H32Cl2O6
napyradiomycin 3
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C26H34Cl2O6
napyradiomycin 4
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C26H34Cl2O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABS50443.1
  • napT1
 1 - 1170 (-) putative HMG-CoA synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • ABS50444.1
  • napT2
 1174 - 2235 (-) putative HMG-CoA reductase
  • Precursor biosynthesis
Sequence-based prediction
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  • ABS50445.1
  • napT3
 2232 - 3374 (-) putative type 2 IPP isomerase
  • Precursor biosynthesis
Sequence-based prediction
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  • ABS50446.1
  • napT4
 3371 - 4609 (-) putative phosphomevalonate kinase
  • Precursor biosynthesis
Sequence-based prediction
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  • ABS50447.1
  • napT5
 4606 - 5742 (-) putative mevalonate decarboxylase
  • Precursor biosynthesis
Sequence-based prediction
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  • ABS50448.1
  • napT6
 5756 - 6739 (-) putative mevalonate kinase
  • Precursor biosynthesis
Sequence-based prediction
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  • ABS50449.1
  • napU1
 7628 - 8305 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ABS50450.1
  • napU2
 8545 - 9339 (+) hypothetical protein
  • Unknown
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  • ABS50451.1
  • napB1
 9397 - 10464 (+) putative THN synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABS50452.1
  • napB2
 10535 - 11089 (+) putative monooxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • ABS50453.1
  • napB4
 12426 - 14015 (+) putative acyl-CoA synthase
  • Unknown
Sequence-based prediction
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  • ABS50454.1
  • napT7
 14113 - 15186 (+) putative polyprenyl synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • ABS50455.1
  • napR1
 15463 - 16509 (+) putative regulatory protein
  • Regulation
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  • ABS50456.1
  • napR2
 16404 - 17675 (+) putative sodium transporter
  • Transport
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  • ABS50457.1
  • napR3
 17824 - 18486 (+) putative transcription regulator
  • Regulation
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  • ABS50458.1
  • napH1
 18638 - 20224 (-) putative vanadium chloroperoxidase
  • Tailoring (Halogenation)
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  • ABS50459.1
  • napU3
 20779 - 21399 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ABS50460.1
  • napH2
 21698 - 23038 (+) putative FADH2 dependent halogenase
  • Tailoring (Halogenation)
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  • ABS50461.1
  • napT8
 23985 - 24878 (-) putative prenyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABS50462.1
  • napT9
 25104 - 26087 (+) putative prenyltransferase
  • Scaffold biosynthesis
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  • ABS50463.1
  • napH3
 26195 - 27520 (+) putative vanadium chloroperoxidase
  • Unknown
Sequence-based prediction
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  • ABS50464.1
  • napH4
 27700 - 29271 (+) putative vanadium chloroperoxidase
  • Tailoring (Halogenation)
Sequence-based prediction
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  • ABS50465.1
  • napB5
 29716 - 30789 (+) putative methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • ABS50466.1
  • napR4
 31119 - 32510 (+) putative transporter
  • Transport
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  • ABS50467.1
  • napR5
 32976 - 34583 (+) putative efflux protein
  • Transport
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  • ABS50468.1
  • napR6
 34888 - 36495 (+) putative efflux protein
  • Transport
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  • ABS50469.1
  • napR7
 36492 - 37151 (+) putative transcription regulator
  • Regulation
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  • ABS50470.1
  • napR8
 38225 - 39376 (-) putative regulatory protein
  • Regulation
Sequence-based prediction
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  • ABS50471.1
  • napU4
 39319 - 40032 (-) hypothetical protein
  • Unknown
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  • ABS50472.1
 40336 - 41673 (+) putative transposase
  • Unknown
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  • ABS50473.1
  • napR9
 42205 - 43410 (+) putative efflux transporter
  • Transport
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Ketide length 5
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
napB1 Synthase subclass: Type III
Module 1
Genes: napB1
Core domains: Ketosynthase
Terpene-specific information
Carbon count subclass Monoterpene
Structural subclass Unknown
Isoprenoid precursor DMAPP
Prenyltransferases napT8, napT9
Terpene synthases/cyclases napT1, napT2, napT3, napT4, napT5, napT6, napT7
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7PXJSJT7IBMNIYLGG3GUM5VC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for napyradiomycin A80915C
  • Add new compound: napyradiomycin 2
  • Add new compound: napyradiomycin 3
  • Add new compound: napyradiomycin 4
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Fixed incorrect terpene synthase/cyclase gene names
  • Removed duplicated alternative name of gene in polyketide synthase
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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