Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001079.1:
Cluster 1Polyketide / Terpene143410

BGC0001079, napyradiomycin biosynthetic gene cluster from Streptomyces aculeolatus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Napyradiomycin A80915C
SMILES string: Copy to clipboard
Molecular formula: C26H33Cl3O6
Exact molecular mass: 547.1415 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide / Terpene
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type III
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
NAPB1

Modular polyketide synthases:
napB1 (ABS50451.1)
Module 1
Scaffold-modifying domain: None

Terpene subclass:
Other
Terpene subclass by size:
Monoterpene
Final isoprenoid precursor:
DMAPP
Terpene synthase/cyclase-encoding genes:
NAPT1-7
Prenyltransferase-encoding genes:
NAPT8, NAPT9

Gene cluster description

napyradiomycin (BGC0001079). Gene Cluster 1. Biosynthetic class = Polyketide/Terpene. GenBank EF397638. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Stefan Diethelm (Scripps Institution of Oceanography)

Literature references

1. Winter JM et al. (2007) Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem 282(22):16362-8. doi: 10.1074/jbc.M611046200. Epub 2007
2. Bernhardt P et al. (2011) A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis. J Am Chem Soc 133(12):4268-70. doi: 10.1021/ja201088k. Epub 2011 Mar