LOCUS       BGC0001080             17804 bp    DNA     linear   BCT 28-MAY-2009
DEFINITION  Streptomyces anulatus phenazine gene cluster, strain 9663.
ACCESSION   BGC0001080
VERSION     BGC0001080
KEYWORDS    .
SOURCE      Streptomyces anulatus
  ORGANISM  Streptomyces anulatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:50:58
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17804
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..900
                     /gene="ppzP"
     CDS             1..900
                     /codon_start=1
                     /db_xref="GOA:C4PWA1"
                     /db_xref="InterPro:IPR020965"
                     /db_xref="UniProtKB/TrEMBL:C4PWA1"
                     /gene="ppzP"
                     /gene_functions="biosynthetic (rule-based-clusters) other:
                     orf2_PTase"
                     /gene_kind="biosynthetic"
                     /product="5,10-dihydrophenazine-1-carboxylate
                     9-dimethylallyltransferase (dihydro-PCA prenyltransferase)"
                     /protein_id="CAX48655.1"
                     /sec_met_domain="orf2_PTase (E-value: 1e-126, bitscore:
                     412.2, seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESAELTELYSAIEETTRVVGAPCRRDTVRPILTAYEDVIAQSV
                     ISFRVQTGTSDAGDLDCRFTLLPKDMDPYATALSNGLTAKTDHPVGSLLEEVHRQFPVD
                     CYGIDFGAVGGFKKAWSFFRPDSLQSASDLAALPSMPSGVSENLGLFDRYGMTDTVSVV
                     GFDYAKRSVNLYFTGASPESFEPRGIQAILRECGLPEPSDELLRFGEEAFAIYVTLSWD
                     SQKIERVTYSVNTPDPMALPVRIDTRIEQLVKDAPLGSAGHRYVYGVTATPKGEYHKIQ
                     KYFQWQSRVEKMLTADAG"
     source          1..17804
                     /db_xref="taxon:1892"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces anulatus"
                     /strain="9663"
     protocluster    1..17804
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[6352:7528]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6353..7528
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     protocluster    1..17804
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[0:900]"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..900
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="2"
     cand_cluster    1..17804
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /detection_rules="(LmbU or Neocarzinostat or bcpB or frbD
                     or mitE or vlmB or prnB or CaiA or bacilysin or
                     orf2_PTase)"
                     /detection_rules="phzB"
                     /kind="neighbouring"
                     /product="T3PKS"
                     /product="other"
                     /product="phenazine"
                     /protoclusters="1"
                     /protoclusters="2"
                     /protoclusters="3"
                     /tool="antismash"
     subregion       1..17804
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001080"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17804
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="T3PKS"
                     /product="other"
                     /product="phenazine"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /rules="(LmbU or Neocarzinostat or bcpB or frbD or mitE or
                     vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /rules="phzB"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1009..2046
                     /gene="mk"
     CDS             1009..2046
                     /codon_start=1
                     /db_xref="GOA:C4PWA2"
                     /db_xref="InterPro:IPR006203"
                     /db_xref="InterPro:IPR006204"
                     /db_xref="InterPro:IPR006205"
                     /db_xref="InterPro:IPR006206"
                     /db_xref="InterPro:IPR013750"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="UniProtKB/TrEMBL:C4PWA2"
                     /gene="mk"
                     /product="putative mevalonate kinase"
                     /protein_id="CAX48656.1"
                     /transl_table=11
                     /translation="MQKRQAELSVLIPPNSAKGLSKSHRARSVGIGRAHAKAILLGEHA
                     VVYGAPALALPIPQLTATASVGWSPHSPDGPHDMSLTMTGSASRPMVTQASESLRRLTA
                     EFRASMGVTDRLHLDMVIDCAIPPGRGLGSSAACARAVVLALADLFDREISQSTAFDLV
                     QTAENVTHGRASGVDAMAVGASVPLLFQAGGAQELAVGCEGLFIIADSGVVGRTKDAVE
                     LLREGFLRHPGSQERFVRRASVLTEEARHAFADGRPEELGSRLTDYHELLRTAGLSIDR
                     IDTLVEAARTAGALGAKMTGGGMGGCMIALTRSWQASEVTRKLHEAGAVQTWVLPLRRL
                     AGHAP"
     misc_feature    1066..1068
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     protocluster    1292..17804
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[11291:17804]"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      11292..17804
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="3"
     cand_cluster    1292..17804
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="phzB"
                     /kind="single"
                     /product="phenazine"
                     /protoclusters="3"
                     /tool="antismash"
     misc_feature    1678..1680
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2036..3091
                     /gene="mdpd"
     CDS             2036..3091
                     /codon_start=1
                     /db_xref="GOA:C4PWA3"
                     /db_xref="InterPro:IPR005935"
                     /db_xref="InterPro:IPR006204"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="UniProtKB/TrEMBL:C4PWA3"
                     /gene="mdpd"
                     /product="putative diphosphomevalonate decarboxylase"
                     /protein_id="CAX48657.1"
                     /transl_table=11
                     /translation="MRPDHPHAPDRSREHGAAGGATAVAHPNIALIKYWGKRDERLVLP
                     RTDSLSMTLDILPTTTHVRLDPEAEHDEVTLDGVPLEGGPRQRVITFLELVRERAGSSR
                     RAAVDSRNTVPTGAGLASSASGFAALAVAASAAYGLGLDATALSRLARRGSGSASRSIF
                     GDFAIWHAGRPTGSATDADLGSYAEPVPAAEFDPALVIAVVNAGPKDVSSREAMRRTVE
                     TSPLYGPWAASSEGDLVDMRVALRRGDLDAVGEIAERNALGMHATMLAARPAVRYLSAP
                     TLDVLDSVLRLRRDGVPAYATMDAGPNVKVLCHRTDADRVAQVVRSAAPGGSVLVAGRG
                     PGARLLAEGER"
     gene            3088..4203
                     /gene="pmk"
     CDS             3088..4203
                     /codon_start=1
                     /db_xref="GOA:C4PWA4"
                     /db_xref="InterPro:IPR005917"
                     /db_xref="InterPro:IPR006204"
                     /db_xref="InterPro:IPR006206"
                     /db_xref="InterPro:IPR013750"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="UniProtKB/TrEMBL:C4PWA4"
                     /gene="pmk"
                     /product="putative phosphomevalonate kinase"
                     /protein_id="CAX48658.1"
                     /transl_table=11
                     /translation="MTRQHTVVRRAPGKLFVAGEYAVVEPGNQAILVAVDRHITVTVSG
                     RGSGAGGADVVISSDLVPEQGRWRWHDGRLSGCGPAPGGLKHVVSAIEVMGRLLAGRGL
                     PPPSLSVSVSSRLHDNGTKFGLGSSGAVVVATVAAVAALHDLELPPDTRFRLAMLATAG
                     IDSRASGGDLAAGTWGGWIAYRAPDRAAVLDLARRRGVEEALRAPWPGFEVRRLPPLPR
                     GLALEVGWTGEPASTTSLVSGLDRRTWRGGASHRRFMETTSDCVRASITAFRLGDGPGL
                     LHQIRRARRELARLDDELGLGIFTPGLTALCDAAEAVGGAAKPSGAGGGDCGIALLDAG
                     APSDISLVRERWAAAGVRPLPVRPTMEGNEK"
     gene            4200..5291
                     /gene="ippi"
     CDS             4200..5291
                     /codon_start=1
                     /db_xref="GOA:C4PWA5"
                     /db_xref="InterPro:IPR000262"
                     /db_xref="InterPro:IPR011179"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="UniProtKB/TrEMBL:C4PWA5"
                     /gene="ippi"
                     /product="putative type II isopentenyl diphosphate delta
                     isomerase"
                     /protein_id="CAX48659.1"
                     /transl_table=11
                     /translation="MISQRKDDHVRLAVEQQQALDGRNQFDEVSFVHHALAGIDRPDVS
                     LATTFAGIAWQVPLYINAMTGGSTHTGAINRDLAIAARETGVPIASGSMSAYFKDPSCA
                     DTFRVLRQENPDGFVMANINATASVDKARRAIGLLEADALQIHINTVQETVMPEGDRSF
                     SSWVPQIERITAAVDVPVIVKEVGFGLSRETVLTLRNLGVRVADLGGRGGTDFARIENG
                     RRELADYAYLHGWGLSTAACLLDARDPGIPVLASGGVRHPLDVVRALALGASGVGVSGG
                     FLRTLMDGGVTALVAQISTWLDQLGALQTMLGSRTPAGLTGCDLQIHGTLRDFCADRGI
                     DTGRLALRSSSFDALHEMTGSTR"
     gene            5288..6349
                     /gene="hmgr"
     CDS             5288..6349
                     /codon_start=1
                     /db_xref="GOA:C4PWA6"
                     /db_xref="InterPro:IPR002202"
                     /db_xref="InterPro:IPR009029"
                     /db_xref="InterPro:IPR023074"
                     /db_xref="UniProtKB/TrEMBL:C4PWA6"
                     /gene="hmgr"
                     /product="putative 3-hydroxy-3-methylglutaryl-CoA
                     reductase"
                     /protein_id="CAX48660.1"
                     /transl_table=11
                     /translation="MTDTHAIAGVPMKWVGPLRLSGNTATTETHVPLATYESPLWPSVG
                     RGAKISMLVEQGIVATLVDERMTRSVLVEATDAQTAYLAARDVDARFDELREVVRTGSR
                     YAELIGVRHEITANLLFIRFEFTTGDASGHNMATLASDALLKHLLQTVPGITYGSISGN
                     YCTDKKATAINGILGRGKNVVTELLVPRDVVADVLHTSAARIVQLNIRKNMLGTLLAGG
                     IRSANAHFANMLLGFYLATGQDAANIVEGSQGVTMAEDRDGDLYFSCTLPNLIVGTVGN
                     GKGLEFVETNLTRLGCTVDRAPGENARRLAVIAAATVLCGELSLLAAQTNPGELMRAHV
                     QLERGKTTAKVGV"
     gene            6353..7528
                     /gene="hmgs"
     CDS             6353..7528
                     /codon_start=1
                     /db_xref="GOA:C4PWA7"
                     /db_xref="InterPro:IPR011554"
                     /db_xref="InterPro:IPR013528"
                     /db_xref="InterPro:IPR013746"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:C4PWA7"
                     /gene="hmgs"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 479.3;
                     E-value: 1.4e-145)"
                     /gene_kind="biosynthetic"
                     /product="putative 3-hydroxy-3-methylglutaryl-CoA synthase"
                     /protein_id="CAX48661.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 3.4e-11,
                     bitscore: 33.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGETAVGIHDLSFATTEFVLPHTALADHNGTDIGKYHRGIGQRS
                     MSVPAADEDIVTMGAAAAAPIIARHGFDRIRTVVLATESSVDQAKSAGVYVHSLLGLPS
                     ATRVVELKQACYGATAALQFAIGLVHRDPAQQVLVVASDISKYELDSPGEATQGAAAVA
                     MLVGSDPALLRVEEPSGLFTADVMDFWRPNYRDAALVDGQESITAYLQAVEGTWKDYTE
                     RGGRALDAFSAFCYHQPFTKMAYKAHRALLNSCGYDTDEAEVARAIGRTTAYNAVLGNS
                     YTASVYLGLASLLDGADDLAGQCVGLLSYGSGSVAEFFAGTVAPGYRDHLRTAEHREAI
                     DRRKPVGYARYRELHERSFPTDGGDHPTPSETTGPFRLAALRGHKRVYEVR"
     gene            7587..8570
                     /gene="ppzT"
     CDS             7587..8570
                     /codon_start=1
                     /db_xref="GOA:C4PWA8"
                     /db_xref="InterPro:IPR004655"
                     /db_xref="InterPro:IPR013747"
                     /db_xref="InterPro:IPR013751"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:C4PWA8"
                     /gene="ppzT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 356.6; E-value: 1.9e-108)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 3-oxoacyl-[acyl-carrier-protein]
                     synthase"
                     /protein_id="CAX48662.1"
                     /sec_met_domain="fabH (E-value: 8.8e-95, bitscore: 307.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRMSDLGILGTGAYVPDRVVSNDDVGAAAGVDDAWIRRKTAIRER
                     RWAAPGQATSDLAAAAGRAALRSAGITADQLSVIVVATSTPDRPQPPTAAYVQHGLGAA
                     GAAAFDVNAVCSGSVFALAVAEGLLAGRGGHALVIGADLYSRILNPADRRTVVLFGDGA
                     GALVLGPAAQGPRVRHLALHTFGELAGLIEVPAGGSRLPGDRAALEAGLQYFAMDGREV
                     RRFVAEQLPRLTKQFLHEAGVVPDDIGHFVPHQANGVLLDAVTADLGLPRAASHRTLAH
                     YGNTGAASIPITLDTAARAGAFRPGDLILLAGFGGGMSAGLALVEW"
     gene            8628..9353
                     /gene="ppzU"
     CDS             8628..9353
                     /codon_start=1
                     /db_xref="GOA:C4PWA9"
                     /db_xref="InterPro:IPR005025"
                     /db_xref="InterPro:IPR008254"
                     /db_xref="UniProtKB/TrEMBL:C4PWA9"
                     /gene="ppzU"
                     /product="putative WrbA NAD(P)H:quinone oxidoreductase"
                     /protein_id="CAX48663.1"
                     /transl_table=11
                     /translation="MGVPVKDDRTSLVHPETDTTVKVAVIYHSATGHVADIARELSDAA
                     EKAGAEVRLRKVAELEPLRSVASLPARVANATATADISVAAVGDVLWADAVLLGSPARF
                     GNIAAQLARFIESLGGAWKRGALADKIYSGFTSTASAHGGNEATLLALMNSFHHFGGIV
                     VTPGFTHPDKFVDGNPYGTAHHDGSGTLPVGDVTRNAARVQAERVVRLAGVLRAASVRP
                     TAHRRAASRLSTGAAERSA"
     gene            complement(9501..10121)
                     /gene="ppzV"
     CDS             complement(9501..10121)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:C4PWB0"
                     /gene="ppzV"
                     /product="conserved hypothetical protein ovmZ-like"
                     /protein_id="CAX48664.1"
                     /transl_table=11
                     /translation="MAPHSCPRNHTRDIAAGPALCKPCVGQLEHQLRALPGLHQDCLHH
                     VLSTSRRRNPTKVSGSRKRDHLNVAALDARNDLIPVLTSWSGLVAERLGTVVPHRSVVH
                     LADFLLLNLEWLTAHPSAADFAEEIEDLHTELLRAIDPDAGDRPPPATECVVDACTGTI
                     NASPKSTGKAGTRSISCSAGHAWEMREWLTLRYLMDRRRKDAA"
     gene            complement(10210..11232)
                     /gene="ppzM"
     CDS             complement(10210..11232)
                     /codon_start=1
                     /db_xref="GOA:C4PWB1"
                     /db_xref="InterPro:IPR001077"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR016461"
                     /db_xref="UniProtKB/TrEMBL:C4PWB1"
                     /gene="ppzM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 299.1; E-value:
                     7.1e-91)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative phenazine N-methyltransferase"
                     /protein_id="CAX48665.1"
                     /transl_table=11
                     /translation="MSTDIAPGAARATLDLVTAAWRTQSVYAAAKLGLPDLIAAGHTAA
                     PDLARAAGADEDAVQRLLRLLVRLDVFTWDEDGGYGNTEVGDLLRDRPGSLRDVCLLYG
                     EEFYQAWGHAIETARTGKPGFEVAYGQSLVSYLHDDADAANRFQRVMRAQADNFAFEAV
                     PREIDFSADRHVVDIAGGSGQLLSTVLATAPGARGTLLDLEHTIPIARAHLERTVGCDR
                     VGLVAGDMFTSPLPGEADTYLLSRVLGDWPDDDCVRLLGNVREVMAKHSRLVVIELVVQ
                     DGHAGLLAPLWDLHLMVVNGGHQRSFGEYTELAARTGLAVERSVRLPMEATALVLTPAG
                     "
     gene            complement(11292..11798)
                     /gene="ppzB"
     CDS             complement(11292..11798)
                     /codon_start=1
                     /db_xref="GOA:C4PWB2"
                     /db_xref="InterPro:IPR004964"
                     /db_xref="UniProtKB/TrEMBL:C4PWB2"
                     /gene="ppzB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phenazine: phzB"
                     /gene_kind="biosynthetic"
                     /product="putative enzyme of phenazine biosynthesis"
                     /protein_id="CAX48666.1"
                     /sec_met_domain="phzB (E-value: 2.1e-55, bitscore: 178.1,
                     seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPLPSEPHAAAPVFTDHHDLRERNRRAVEQYMVTGPEARLSRY
                     TLYTEDGTASLFNTDIGRPITVKGRDNLKRHNELSLDVLPDWEWTDVHLYETQDPAVIW
                     VECDGEGTIRFPGYPEGRYRNHFIHGFTLRDGRIAASREYTNPIEHMRALGIETPNIER
                     DWIPS"
     gene            complement(11834..12535)
                     /gene="ppzG"
     CDS             complement(11834..12535)
                     /codon_start=1
                     /db_xref="GOA:C4PWB3"
                     /db_xref="InterPro:IPR000659"
                     /db_xref="InterPro:IPR009002"
                     /db_xref="InterPro:IPR011576"
                     /db_xref="InterPro:IPR012349"
                     /db_xref="InterPro:IPR019576"
                     /db_xref="InterPro:IPR019740"
                     /db_xref="UniProtKB/TrEMBL:C4PWB3"
                     /gene="ppzG"
                     /product="putative FMN-dependent oxidase"
                     /protein_id="CAX48667.1"
                     /transl_table=11
                     /translation="MSDLPHADGISDGASEGREGAARSESLTGTDEVDFPEFLAPPPEP
                     LGLLVSWLETSSAHGVREARALALATADARGRSSSRIVVLNSVTEAGIVFATHADSRKG
                     RELAENPWASGVLYWRETSQQITLAGPVSRLPDAEAEVLWSARPPFTHAMSTASRQSRP
                     LDGLDHVARLRATARELGEPERPLPRPSSYVVYQLALSSVEFWANGTDRLHERLCYERA
                     GCGWTITRLQP"
     gene            complement(12528..13367)
                     /gene="ppzF"
     CDS             complement(12528..13367)
                     /codon_start=1
                     /db_xref="GOA:C4PWB4"
                     /db_xref="InterPro:IPR003719"
                     /db_xref="UniProtKB/TrEMBL:C4PWB4"
                     /gene="ppzF"
                     /product="putative trans-2,3-dihydro-3-hydroxyanthranilate
                     isomerase"
                     /protein_id="CAX48668.1"
                     /transl_table=11
                     /translation="MHSYVVVDAFARRPLTGNPVAVFFDSDDLAAEQMQRIAREMNLSE
                     TTFVLRPRQDGDVHVRIFTPVNELPFAGHPLLGTAIALGGRTDADRLRIETAMGTIPFE
                     LEREHGEKVVAASMRQPVPVWEPFDRAEELLDALGVRESTLPVEIYRNGPRHVLVGFES
                     IEALSKADPDHRALAAFPDMATNCIAGHGSSWRNRMFSPAYGVVEDAATGSAAGPIAIH
                     LARHGLAAYGQRVEITQGVEIGRPSPMRALVHGEGDRVDTVEVSGHGVVSIEGVLHV"
     misc_feature    complement(13140..13142)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13464..15404)
                     /gene="ppzE"
     CDS             complement(13464..15404)
                     /codon_start=1
                     /db_xref="GOA:C4PWB5"
                     /db_xref="InterPro:IPR000991"
                     /db_xref="InterPro:IPR001317"
                     /db_xref="InterPro:IPR005801"
                     /db_xref="InterPro:IPR006220"
                     /db_xref="InterPro:IPR011702"
                     /db_xref="InterPro:IPR015890"
                     /db_xref="InterPro:IPR017926"
                     /db_xref="UniProtKB/TrEMBL:C4PWB5"
                     /gene="ppzE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 327.1; E-value:
                     4e-99)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 2-amino-2-desoxy-isochorismate synthase"
                     /protein_id="CAX48669.1"
                     /transl_table=11
                     /translation="MTYGPRGNPGAPRDPRPGDLLDHVLHTEGEAYALLHRPGAAGRDV
                     VEVLTGSVSLPGTLADIPLPPRPAPGAGARHEVLVLVPYRQLAERGFDCADDGTPLVAM
                     TVTDTQQLPLDAALARLPDVPTPLAGESFDVDDEAYENVVRRIVKEMIGTGEGANFVIK
                     RTFVADITDYGPQSAPALFRRLLERESGAHWTFLIHTGTRTLVGASPERHISLQGGTAV
                     MNPISGTYRYPPSGPTLSGVLDFLSDRKETDELYMVLDEELKMMARICATGGRVVGPYL
                     KEMARVAHTEYFIEGRTDRDVRDILRETMFAPTVTGSPLESACRIIQQYEPGGRGFYSG
                     AAVLIGRDDEGERAMDSAILIRTADISREGHIAIGVGATIVRHSDPASEAAETRAKAAG
                     LVAALRGDEKERFAQHASVRRALELRNDSIADFWLSDAEARASALPGLAGRSVLVLDAE
                     DTFTSMIDQQLRSLGLRVTVRRYDEPYAFEGYDLVVMGPGPGDPQEAAHPKMRHLRTAV
                     GTLLSQRRPFLAVCLSHQVLGLHIGLPLRRRAVPNQGVQKDIDLFGATERVGFYNTFAL
                     VGEDDTFVADGVGPVRVSRDPVTGEVHALRGPGFASLQFHPESVLTREGPRIVGTALGG
                     LLAPARTPGSA"
     gene            complement(15401..16024)
                     /gene="ppzD"
     CDS             complement(15401..16024)
                     /codon_start=1
                     /db_xref="GOA:C4PWB6"
                     /db_xref="InterPro:IPR000868"
                     /db_xref="InterPro:IPR016291"
                     /db_xref="UniProtKB/TrEMBL:C4PWB6"
                     /gene="ppzD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 289.5; E-value: 3.2e-88)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 2,3-dihydro-3-hydroxy-anthranilate
                     synthase"
                     /protein_id="CAX48670.1"
                     /transl_table=11
                     /translation="MTGIPAIHSYPLPTEGDLPPARVTWTAEADRSVLLVHDMQRYFLQ
                     PFPGSMSQELTGNAARLRDRCAELGVPVAYTAQPGGMTEEQRGLLKDFWGPGMRPEPED
                     RQVVDALAPAEQDWMLTKWRYSAFFKTDLLRRMRAAGRDQLVLCGVYAHVGVLATAVEA
                     FTHDIQPFFVADATADFSEHYHRSALTYAAERCARVTTVKGLFA"
     misc_feature    complement(15839..15841)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16103..17281)
                     /gene="ppzC"
     CDS             complement(16103..17281)
                     /codon_start=1
                     /db_xref="GOA:C4PWB7"
                     /db_xref="InterPro:IPR002480"
                     /db_xref="UniProtKB/TrEMBL:C4PWB7"
                     /gene="ppzC"
                     /product="putative 3-deoxy-D-arabino-heptulosonic acid
                     7-phosphate synthase"
                     /protein_id="CAX48671.1"
                     /transl_table=11
                     /translation="MEDVIREIRIRGASQQPEWSDLLQLSRVAEALGARPTLVQADDVA
                     TLRTLLGKVALGEAMVLQSGDCAEDPQECTRPHVARKAALLDLLAGSLGLITGKPVVRA
                     GRIAGQFAKPRSKPTEFVDGVELPVFRGHMVNGPEPDRERRQADPLRILTGYMAALDIV
                     GHMGWRDRAEGRDAVEPLVWTSHEALLLDYEMPMLRTDAKGRLFLGSTHWPWIGERTRQ
                     VEGAHVALLAEVSNPVACKVGPSMEPDELLALCERLDRWRDPGRLTLIARMGADAVADR
                     LPRLVEAVRGAGHPVVWLSDPMHGNTVTAPGGHKTRLVETVSLEVTRFVEAVRSAGGIA
                     GGLHLETTPDDVTECVLDASELASVGDRYTSHCDPRLTPSQALSVVSAWTAS"
     gene            complement(17316..17804)
                     /gene="ppzA"
     CDS             complement(17316..17804)
                     /codon_start=1
                     /db_xref="GOA:C4PWB8"
                     /db_xref="InterPro:IPR004964"
                     /db_xref="UniProtKB/TrEMBL:C4PWB8"
                     /gene="ppzA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phenazine: phzB"
                     /gene_kind="biosynthetic"
                     /product="putative enzyme of phenazine biosynthesis"
                     /protein_id="CAX48672.1"
                     /sec_met_domain="phzB (E-value: 1.4e-78, bitscore: 254.4,
                     seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDSLPNQGFSDAAELRRINRATVEKYMHTKGQDRLRRHELFTED
                     GSGGLWTTDTGSPIATHGKARLAEHAVWSLECFPDWEWHNIRIFETQDPNHFWVECDGR
                     GKIRFGDYPEGYYENHFLHSFELENGKIKQNREFMNPFQQLRALGIPVPEIKRQGIPT"
ORIGIN
        1 atgtcagaat ccgctgagct gacagagctc tactcggcca tcgaggaaac gacccgggtg
       61 gtcggcgcac cctgccggcg cgacacggtc cggcccattc tgaccgcgta cgaagacgtg
      121 atcgcgcagt ccgtcatttc tttccgggtc cagacgggca cgagtgacgc gggagatctc
      181 gactgccgtt tcaccctgct tcccaaggac atggatccgt atgccacagc actgtcgaac
      241 ggcctcacgg caaagacgga ccacccggtc ggcagtctcc tcgaagaagt ccaccggcag
      301 tttcccgtcg actgctacgg cattgacttc ggagccgtcg gcggcttcaa gaaggcctgg
      361 tccttcttcc gcccggacag cctccagtcg gcgtccgatc tcgccgccct tccgtcgatg
      421 ccgagcggcg tctccgagaa cctcggcctg ttcgacaggt acggcatgac cgacacggtc
      481 agcgtcgtcg ggttcgacta cgcgaagcga tcggtcaatc tgtacttcac cggcgcctcg
      541 cccgaaagct tcgagccccg aggcatccag gcgatcctcc gggagtgcgg cctgccggag
      601 ccgagcgacg agctgctgag gttcggcgag gaggcgttcg ccatatacgt caccctgagc
      661 tgggattcgc agaagatcga gcgggtcacc tactccgtca acacgccgga tcccatggcg
      721 cttcccgttc gtatcgatac caggatcgag cagctggtga aggatgctcc gctcggttcc
      781 gccggccacc ggtacgtcta cggcgtcacg gcgacgccca agggcgaata ccacaagatc
      841 cagaagtact tccagtggca gtcccgggtg gagaagatgc tgaccgccga tgccggatag
      901 cgcctcaccc gtcggcatgt gaaggacaag ggcttgcggg gaaatgcaca ccgcgattcc
      961 ccgcaagccc tttccgccct ttccagaaaa ctggatgatg cgattccgat gcagaaacga
     1021 caagcggagc tgagtgtgtt gattccaccg aactcagcga aggggttatc gaaaagccac
     1081 cgggctcgct cggtcggcat cggccgtgct cacgccaagg caattctgct gggcgaacac
     1141 gcggtcgtct acggagctcc ggcgctcgct cttccgattc cgcaactgac cgccacggca
     1201 agcgtcggat ggtcccccca ctcccccgac ggcccgcacg acatgtcgct cacgatgacc
     1261 ggttcggcgt cgaggccgat ggtgacgcaa gcctccgaga gcctgcggcg gctcaccgcc
     1321 gaattcaggg cctccatggg tgtgaccgac cggctgcacc tcgacatggt catcgactgt
     1381 gcgatcccgc ccggccgggg gctcggttcc agcgcggcgt gcgcgcgcgc ggtcgtgctg
     1441 gccctggccg atctcttcga ccgcgagatc tcgcagagca ccgccttcga cctggtccag
     1501 acggcggaga acgtgacgca cggccgggcc agcggcgtcg acgccatggc cgtcggggcc
     1561 tcggtcccgc tgctgttcca ggcgggcggg gcccaggaac tggccgtcgg ctgcgagggg
     1621 ttgttcatca tcgcggacag cggcgtcgtg ggcaggacca aggacgcggt cgagctgtta
     1681 cgggaggggt tcctgcgtca tcccggatcg caggagagat tcgtgcgccg ggcgtcggtc
     1741 ctgaccgagg aggccaggca cgccttcgcc gacggcaggc cggaggagct cggctcacgg
     1801 ctcacggact accacgaact gctccgtacg gcaggcctca gcatcgaccg gatcgacacg
     1861 ctggtggagg ccgcccgcac cgccggcgct ctcggagcca agatgaccgg gggcggcatg
     1921 ggcggctgca tgatcgccct gacccggtcg tggcaggcga gcgaggtcac ccggaagctg
     1981 cacgaggccg gcgccgtgca gacgtgggtg ctgccgctga ggaggctcgc cggccatgcg
     2041 ccctgaccac ccgcacgctc cggaccggag ccgggagcac ggtgccgcgg ggggtgccac
     2101 cgccgtcgcg cacccgaaca tcgcgctgat caagtactgg ggcaaacggg acgagcggct
     2161 cgtcctcccc cggacggaca gcctgtcgat gaccctggac atcctcccga ccaccaccca
     2221 cgtccggctc gaccccgagg cggaacatga cgaggtgacg ctcgacggcg tccccctgga
     2281 gggcgggccg aggcaacgcg tcatcacctt cctggaactg gtgcgggagc gggcgggcag
     2341 ctcccggcgc gctgccgtcg actcccggaa caccgttccc accggggccg ggctcgcgtc
     2401 ctccgcgagc gggttcgccg ccctcgccgt cgccgcgtcc gccgcgtacg gtctcggtct
     2461 cgacgcgacc gcgctgtcac ggctggcccg gcgaggatcg ggatcggcgt cgcggtcgat
     2521 cttcggtgac ttcgcgatct ggcacgccgg ccggcccacc ggatcggcca cggacgcgga
     2581 cctgggctca tacgccgaac cggtacccgc ggcggagttc gaccccgccc tggtcatcgc
     2641 ggtggtcaac gccgggccca aggacgtgtc cagccgggag gccatgcggc ggaccgtcga
     2701 gacctcgccg ctgtacgggc cgtgggcagc ctccagcgag ggcgacctcg tcgacatgcg
     2761 ggtggcgttg cgacggggcg atctcgatgc ggtgggagag atcgcggagc ggaacgcgct
     2821 cggcatgcac gcgacgatgc tggcggctcg ccctgcggtg cgctatctgt cggcgcccac
     2881 gctcgacgtg ctcgacagcg tgctgcggct caggcgggac ggggtcccgg cctacgcgac
     2941 catggacgcc ggaccgaacg tcaaggtgct ctgccatcgc acggacgcgg accgggtggc
     3001 ccaggtggtg cgaagtgccg ccccgggcgg ctcggtgctc gtcgccgggc ggggaccggg
     3061 cgcccgtctg ctggccgagg gcgagcgatg acccggcagc acaccgtcgt gcgacgggcg
     3121 cccggcaagc tgttcgtcgc gggcgagtac gccgtggtgg agccgggcaa ccaggcgatc
     3181 ctggtggcgg tcgaccggca tatcaccgtc accgtgtccg gccgcggctc cggcgccggt
     3241 ggcgccgacg tcgtgatctc ctccgacctc gttccggaac aggggcggtg gcgatggcac
     3301 gacggacggc tcagcggctg cgggcctgct cccggcggcc tgaagcacgt ggtgtcggcg
     3361 atcgaggtca tgggccgact gctggccgga cgcggtcttc ccccgccctc gctgagtgtc
     3421 tcggtcagca gccgtctgca cgacaacgga acgaagttcg gtctgggttc gagcggcgcg
     3481 gtggtggtgg cgaccgtcgc ggcggtggcc gcgctccacg acctggagct gccccccgac
     3541 acccggttcc ggctggccat gctcgcgacg gccggcatcg acagcagggc ctccggcggt
     3601 gatctcgccg ccggcacctg gggcggctgg atcgcgtacc gggcgcccga ccgggccgcc
     3661 gtgctcgacc tggcccggcg ccggggcgtc gaggaggctc tccgcgctcc ctggccgggc
     3721 ttcgaggtac gccgactgcc gccgctgccc cgcggcctcg cgctggaggt cggctggacc
     3781 ggcgaacccg cctccaccac gtccctcgtg tccggcctgg accgccgtac ctggcggggc
     3841 ggcgcgtccc acaggaggtt catggagacc acgtccgact gtgtgcgcgc ctcgatcacc
     3901 gcattccggc tgggcgacgg ccccggcctc ctgcatcaga tccgccgcgc ccgacgggag
     3961 ctggcccggc tggacgacga gctcgggctg gggatcttca cccccgggct gacggccctg
     4021 tgcgacgccg ccgaagccgt cggcggcgcg gccaaaccct cgggggcggg gggcggcgac
     4081 tgcggcatcg ccctgctgga cgccggagcc ccctcggaca tctcactcgt acgggagcgg
     4141 tgggcagcgg cgggggtacg gcccctgccc gtccgcccca ccatggaagg gaacgagaaa
     4201 tgatctccca acgcaaggac gaccacgtca ggctcgccgt cgaacagcag caggcactcg
     4261 acggaaggaa ccagttcgac gaggtgtcgt tcgtccacca cgcgctggcc ggcatcgacc
     4321 ggccggatgt ctccctggcc acgacgttcg ccggcatcgc ctggcaggtc ccgctgtaca
     4381 tcaacgcgat gaccggcggc agcacgcaca ccggcgccat caaccgggac ctggccatcg
     4441 ccgcccggga gacgggggtg cccatcgcgt cgggatccat gagcgcgtac ttcaaggacc
     4501 cctcgtgtgc cgacacgttc cgcgtgctgc gccaggagaa ccccgacggc ttcgtcatgg
     4561 cgaacatcaa cgcgacggcc tcggtagaca aggcgcggcg ggccatcggc ctcctggagg
     4621 ccgacgccct gcagatccac atcaacacgg tgcaggagac ggtgatgccc gagggggacc
     4681 ggtcgttctc ctcctgggtc ccgcagatcg agaggatcac ggcggccgtc gacgtcccgg
     4741 tgatcgtcaa ggaggtcggc ttcgggctga gccgtgaaac cgtcctgact ctgcggaacc
     4801 tgggcgtgcg ggtggcggac ctcggcggcc ggggcggcac ggacttcgcc cggatcgaga
     4861 acggcaggag ggagctcgcc gactacgcgt acctccacgg ctggggactg tccaccgccg
     4921 cctgtctcct ggacgcgcgg gaccccggga tccccgtgct cgcctccgga ggcgtccgcc
     4981 acccgctcga cgtcgtacgc gcgctggcgc tcggcgcgtc cggcgtcggg gtgtccgggg
     5041 ggttcctccg cacgctgatg gacggcggtg tcaccgcact ggtcgcgcag atctcgacct
     5101 ggctcgacca actgggagcc ctgcagacca tgctcggctc ccgcaccccg gccgggctga
     5161 cgggatgcga tctgcagatc cacggcaccc tccgcgactt ctgcgccgac cggggcatcg
     5221 acaccggccg gctcgccctg cgctccagct ccttcgacgc cctccacgag atgacgggaa
     5281 gcactcgatg accgacacac acgccatagc aggtgttccg atgaagtggg tggggcccct
     5341 tcgtctgtcg gggaacaccg ccaccaccga gacccatgtc ccgctcgcca cctacgagtc
     5401 gccgctgtgg ccctcggtgg gccgtggagc caagatctcc atgctggtcg agcagggcat
     5461 cgtcgccacc ctcgtcgacg aacggatgac ccgctccgta ctcgtcgagg ccacggacgc
     5521 acagaccgcg tacctggccg cacgggacgt cgacgcccgg ttcgacgagc tccgcgaggt
     5581 ggtgcgcacc ggcagcaggt acgcggagct gatcggcgtc cggcacgaga tcacggccaa
     5641 cctgctgttc atccgtttcg agttcaccac cggcgacgcc tccgggcaca acatggcgac
     5701 actggcgtcc gacgcgctcc tcaagcacct gctgcagacc gtcccgggca tcacctacgg
     5761 gtcgatctcg gggaactact gcacggacaa gaaggcgacc gcgatcaacg gcatcctcgg
     5821 tcgcggcaag aacgtggtca cggaactgct cgtaccgcgt gacgtggtcg ccgacgtact
     5881 gcacacgtcg gctgccagga tcgtccagct gaacatccgc aagaacatgc tcggcaccct
     5941 gctcgccgga ggcatccgct cggccaacgc ccacttcgcg aacatgctgc tcgggttcta
     6001 cctggccacg ggccaggacg cggccaacat cgtcgaaggg tcccagggcg tcaccatggc
     6061 cgaggaccgg gacggcgacc tctacttctc ctgcacgctg ccgaacctga tcgtgggcac
     6121 ggtgggcaac ggcaaggggc tcgaattcgt ggagaccaac ctgacccggc tcgggtgcac
     6181 ggtcgaccgc gcccccggcg agaacgcccg ccgtctcgcc gtcatcgcgg cggcgacggt
     6241 gctgtgcggt gagctgtcac tccttgccgc gcagacgaac ccgggtgaac tcatgcgcgc
     6301 tcacgtccag ttggaacgtg gcaagacgac agcgaaggtt ggtgtgtagg gcatggccgg
     6361 cgagaccgcg gtcggaatcc acgacctctc gttcgcgacg accgagttcg tcctgccgca
     6421 cacggcactg gccgaccaca acggcaccga catcggcaag taccaccggg gcatcggcca
     6481 gcggtcgatg agcgtgcccg ccgccgacga ggacatcgtg accatgggcg cggccgccgc
     6541 cgcgcccatc atcgcccggc acggcttcga ccggatccgg acggtcgtcc tcgcgacgga
     6601 gtcgtcggtc gaccaggcga agtcggccgg tgtgtacgtg cattcgctgc tcgggctgcc
     6661 gtcggccacc agggtcgtcg agctgaagca ggcctgttac ggggcgacgg cggccctgca
     6721 gttcgccatc ggcctcgtgc accgtgaccc ggcgcagcag gtcctcgtgg tcgcgagcga
     6781 catctccaag tacgagctgg acagcccggg cgaggcgacc cagggcgcgg cggcggtggc
     6841 gatgctggtc gggtcggacc cggctctgct gcgcgtcgag gagccgtcgg gcctgttcac
     6901 cgccgacgtc atggacttct ggcggccgaa ctaccgcgac gccgcgctgg tcgacggaca
     6961 ggagtcgatc accgcgtatc tgcaggcggt ggagggcacc tggaaggact acacggagcg
     7021 gggtggccgc gcgctggacg cgttcagcgc gttctgctat caccagccgt tcacgaagat
     7081 ggcctacaag gcgcatcgcg ccctgctgaa ctcctgcggg tacgacaccg acgaggcgga
     7141 ggtcgcgcgc gccatcgggc ggaccaccgc ctacaacgcc gtcctgggca acagctacac
     7201 cgcgtcggtg tacctcggcc tcgcctccct gctggacggg gcggacgacc tggccggaca
     7261 gtgtgtcggt ctcctcagct acggctccgg cagcgtcgcc gagttcttcg ccgggaccgt
     7321 ggcgcccggc taccgcgacc acctgcggac cgcggagcac cgcgaggcga tcgaccggag
     7381 gaagccggtc ggctacgccc gctaccgcga actgcacgag cgctcctttc cgaccgacgg
     7441 cggcgaccac cccactcctt cggagaccac cgggccgttc cggctggccg ctctccgcgg
     7501 ccacaagcgc gtctacgaag tgcgctgagg gctgtcgggc cagcccttgg ccccgttttc
     7561 ccgttcactt cttcccagag gggggcatgc gcatgagcga cctagggatc ctcggtacgg
     7621 gtgcctatgt gccggaccgg gtcgtctcca acgacgacgt cggtgcggcg gccggagtcg
     7681 acgacgcctg gatcaggcgc aagacggcga tccgggagcg ccgctgggcc gcccccggcc
     7741 aggcgacctc ggatctggcc gcggctgccg ggcgggccgc gttgcggtcg gccggcatca
     7801 ccgcggacca actgtccgtg atcgtggtcg ccacctccac accggaccgc ccccagccgc
     7861 ccacagcggc ctatgtgcag cacggactcg gagcggcggg cgctgccgcg ttcgacgtca
     7921 acgccgtctg ttcgggcagc gtgttcgccc tggccgtggc cgagggcctc ctcgccggtc
     7981 ggggcggcca cgcgctggtc atcggcgccg acctctactc acgcatcctg aacccggccg
     8041 accgccggac ggtcgtgctg ttcggggacg gcgccggcgc cctggtcctg ggtccggccg
     8101 cgcagggccc gcgcgtccgg catctggcac tgcacacgtt cggcgagctg gccggcctga
     8161 tcgaggttcc cgcgggcggc agccggctgc ccggcgaccg ggccgccctc gaggccggtc
     8221 tgcagtactt cgcgatggac gggcgggagg tgcgccgatt cgtcgcggag caactgccgc
     8281 ggctgaccaa acagttcctc catgaggccg gtgtcgtacc cgacgacatc ggccacttcg
     8341 tcccgcatca ggccaacggc gtcctgctcg acgcggtgac cgcggacctc ggtctgcccc
     8401 gtgccgcctc gcaccggacc ctggcgcact acggcaacac gggagccgct tcgatcccca
     8461 tcaccctgga cacggccgcc cgcgcgggcg ccttccgccc cggggacctg atcctcctgg
     8521 cgggcttcgg cggcggcatg tcggcgggtc tcgcgctggt cgagtggtga agaccgtcaa
     8581 gacgacaccg gggccggcgc ctgtggcgcc ggccccggcc gagaccgatg ggagtacctg
     8641 tgaaggacga tcgcacgtcc ctcgtccacc cggagacgga caccaccgtg aaggtcgccg
     8701 tcatctacca ctccgccacc ggccatgtcg cggacatcgc ccgcgaactc tccgatgccg
     8761 ccgagaaggc cggtgccgag gtacggctgc gcaaggtcgc ggagctcgaa ccgctgcggt
     8821 ccgtcgcctc cctgcccgcc cgggtggcca acgccacggc gaccgctgac atatccgtcg
     8881 ccgcggtggg ggacgtcctg tgggccgatg ccgtgctgct ggggtcgccg gcccggttcg
     8941 ggaacatcgc ggcccagctc gcccggttca tcgagtcctt gggcggagcg tggaagaggg
     9001 gcgcgctggc cgacaagatc tacagcggct tcacctccac cgcgagcgcc cacgggggca
     9061 acgaggcgac cctcctcgcc ctcatgaact ccttccacca cttcggtggc atcgtcgtca
     9121 cccccggttt cacccatccg gacaagttcg tcgacggcaa tccgtacggc accgcgcacc
     9181 atgacgggag cggcaccctc ccggtcggcg acgtcacacg gaacgcggcc cgcgtgcagg
     9241 ccgagcgcgt ggtgcgcctg gccggggtcc tgagggccgc gtccgtccgc cccaccgccc
     9301 accggcgcgc cgcgtcccgt ctcagcaccg gcgccgcaga gcgatctgcg tgagttcctc
     9361 tatgtcgaac tccgagcggc ccggagtgcc gtagcgcgtg atcttcccgc ggctcaccca
     9421 cttccggatg gtcgcttcgg acacgcccgc cgcgagggcg gccacgttcg tcggcacgag
     9481 tctgtggcgg ggcagcctgg tcatgcggcg tccttccgtc gccgatccat gaggtaccgc
     9541 agggtgagcc actcgcgcat ctcccacgca tgccccgcgg aacagctgat gctcctcgtg
     9601 ccggcttttc cggtgctctt cggcgaggcg ttgatcgtcc ccgtgcaggc atccacgaca
     9661 cactccgtgg cgggcggcgg gcgatcaccg gcatcggggt cgatcgcacg gagcagttcc
     9721 gtgtggaggt cctcgatctc ctccgcgaag tcggcggccg aggggtgggc ggtgagccac
     9781 tcgagattga ggaggagaaa gtccgccagg tggacgacgg agcgatgcgg tacgacggtc
     9841 ccgagcctct cggcgaccag tcccgaccag gaggtcagga ccgggatcag gtcgttgcgg
     9901 gcgtcgagcg cggcgacgtt gaggtgatcc cgcttgcggc tgccggacac tttcgtcgga
     9961 ttccttcgcc gggatgtcga tagcacgtgg tgcaggcagt cctggtggag accgggaagt
    10021 gcgcgcagtt ggtgttccag ctgtccgacg cagggcttgc agagagcggg accggccgcg
    10081 atgtcccgtg tgtggtttct ggggcatgag tggggtgcca tggagtctcc ttcatgagat
    10141 gacctgttcc agtgatggat cgcgtgtccc ggcgggagga tccggtcgcc ggccgtcggc
    10201 acgtcatggt cagccggccg gggtcaggac cagcgccgtg gcctccatcg gaaggcgtac
    10261 cgaccgctcg acggcgaggc cggtgcgtgc ggccagctcg gtgtattcgc cgaaggagcg
    10321 ctggtggccg ccgttgacga ccatcaggtg caggtcccac agcggagcca gcagaccggc
    10381 gtggccgtcc tggacgacca gctcgatgac cacgagccga gagtgcttcg ccatgacctc
    10441 gcgtacgttg cccaggagac gtacgcagtc gtcgtccggc cagtcgccga ggacccggga
    10501 cagcagatag gtgtccgcct ccccggggag gggactggtg aacatgtcgc cggccaccag
    10561 gccgacgcgg tcgcagccca ccgtccgctc caggtgtgcg cgggcgatgg gaatcgtgtg
    10621 ttcgaggtcg aggagggtgc cccgggcccc gggtgccgtg gccagcacgg tggacagcag
    10681 ctggccgctg ccaccggcta tgtcgacgac gtgccggtcg gcgctgaagt cgatctcccg
    10741 ggggaccgct tcgaaggcga agttgtccgc ctgtgcccgc atgacccgct ggaagcggtt
    10801 cgccgcatcg gcgtcgtcgt gcaggtagga gacgagcgac tgtccgtacg ccacctcgaa
    10861 cccgggtttg ccggtgcggg ccgtctcgat ggcgtgcccc cacgcctggt agaactcctc
    10921 gccgtacagc aggcacacgt cgcgcagcga gccgggccgg tcccgcagca ggtcgcccac
    10981 ctcggtgttg ccgtacccgc cgtcctcgtc ccacgtgaac acgtcgaggc gtacgagcag
    11041 ccgcagcagg cgctgcacgg cgtcctcgtc cgcgccggct gcccgggcga ggtccggcgc
    11101 cgcggtgtgc cctgccgcga tgaggtccgg caggcccagc ttggccgccg cgtagacgga
    11161 ctgggtccgc caggcggcgg tgacgagatc gagggtggcg cgggctgctc cgggtgcgat
    11221 gtcggtactc atggcctgtc tcctcatggg cgggtgcggg cgggcggggc ggtccctgtc
    11281 gggcgcgggg ctcaggaggg gatccagtcc cgctcgatgt tcggcgtctc gatgccgagg
    11341 gcgcgcatgt gctcgatcgg gttggtgtac tcgcggctgg cggcgatccg cccgtcgcgc
    11401 agcgtgaaac cgtggatgaa gtggttgcgg tagcggccct cgggatagcc ggggaaccgg
    11461 atcgtgccct cgccgtcgca ctcgacccag atgacggcgg ggtcctgcgt ctcgtagagg
    11521 tggacgtcgg tccactccca gtcggggagt acgtcgaggg agagttcgtt gtgccgcttc
    11581 aggttgtccc ggcccttgac ggtgatgggc cggccgatgt cggtgttgaa gagggacgcg
    11641 gtgccgtcct cggtgtagag ggtgtaccgg ctcagccggg cctcggggcc cgtcaccatg
    11701 tactgctcga cggctcgtcg attgcgttcc cgcaggtcgt ggtggtcggt gaagaccggc
    11761 gcggcggcgt ggggttcgga gggcagcggc gaggtcattg gtgtctcccg gaggttcggc
    11821 ggcggggtgg gggtcacggc tggagcctgg tgatggtcca gccgcagccg gcgcgttcgt
    11881 agcagagccg ttcgtgcagc cggtccgtgc cgttggccca gaactcgacc gaggagagcg
    11941 cgagttggta caccacgtac gacgaggggc ggggcagcgg ccgctccggt tcgcctagtt
    12001 cccgggccgt ggcccgcagc cgggcgacgt ggtcgaggcc gtccaggggc cggctctgcc
    12061 gggaggcggt gctcatggcg tgggtgaagg ggggccgtgc ggaccacagg acctccgcct
    12121 cggcgtcggg cagccgggac acggggcccg ccagcgtgat ctgctggctg gtctcccgcc
    12181 agtacaggac gcccgaagcc caggggttct cggccagttc ccgccccttg cggctgtcgg
    12241 cgtgggtggc gaagacgatc cccgcttcgg tcaccgagtt gagcaccacg atgcgggagg
    12301 agcttctgcc ccgggcgtcg gccgtggcca gggccagggc gcgcgcctcc cggaccccgt
    12361 gggcgctgct ggtctccagc cacgagacca gcagccccag cggctcgggg ggcggcgcga
    12421 ggaactcggg gaagtccacc tcgtcggtac cggtgagcga ctcggagcgg gcggcgcctt
    12481 cgcggccctc ggaggcgccg tcggagatcc cgtcggcgtg gggcaggtca gacatgcagc
    12541 actccttcga tggagacgac gccgtgtccc gacacttcga cggtgtcgac ccggtcgccc
    12601 tcgccgtgca cgagcgccct catgggtgag gggcggccga tctcgacgcc ctgggtgatc
    12661 tcgacgcgct gcccgtacgc ggcgaggccg tgccgggcga ggtgaatggc gatgggcccg
    12721 gcggcggagc cggtcgcggc gtcctccacc actccgtacg cgggcgagaa catccggttg
    12781 cgccaggaac tcccgtgacc ggctatgcag ttggtcgcca tgtccggaaa cgcggccaag
    12841 gcccggtggt cggggtcggc cttcgacagg gcttcgatgc tctcgaaacc gacgaggacg
    12901 tgccgggggc cgttgcggta gatctccacc ggcagcgtcg actcgcgcac ccccagtgcg
    12961 tccaggagct cctcggcgcg gtcgaacggt tcccacacgg ggaccggctg gcgcatgctc
    13021 gccgcgacga ccttctcccc gtgctcgcgt tccagctcga aggggatggt ccccatggcc
    13081 gtctcgatcc gcaaccggtc cgcgtcggtc cgtccgccca gtgcgatggc ggtgccgagt
    13141 aacgggtgtc cggcgaaagg cagttcgttg accggggtga agatccgcac gtgtacgtcc
    13201 ccgtcctggc ggggccggag cacgaacgtg gtctccgaga ggttcatctc ccgcgcgatg
    13261 cgctgcatct gctccgcggc gaggtcgtca ctgtcgaaga acaccgccac ggggttgccg
    13321 gtgagcggtc gtcgcgcgaa cgcgtcgacg acgacatagc tgtgcatctg ttctcccttg
    13381 gatcatgagg gtggccgggc cggcgcgggg gatggcaccg gcccggcggt tcattggggg
    13441 gcggatccga cggacgggac ggatcaggcg gagccgggcg tgcgggccgg cgcgagcaga
    13501 ccgcccagtg ccgtgcccac gatgcggggc ccttctcggg tgagtaccga ttcggggtgg
    13561 aactgcaggg aggcgaagcc cgggccgcgc agcgcgtgga cctccccggt gaccgggtcc
    13621 cggctgaccc ggaccggccc cactccgtcg gcgacgaacg tgtcgtcctc gccgaccagg
    13681 gcgaaggtgt tgtagaagcc gacgcgttcg gtggcgccga acaggtcgat gtccttctgc
    13741 accccttggt tgggcaccgc cctgcggcgc agcggcagcc cgatgtggag tccgaggacc
    13801 tggtggctga ggcagacggc gaggaagggc cgacgttggc tcagcagtgt gccgaccgcc
    13861 gtgcgcaggt gccgcatctt ggggtgcgcg gcctcctggg gatccccggg gcccggcccc
    13921 atcacgacca ggtcgtaccc ctcgaaggcg tacggctcgt cgtaccggcg gacggtcacc
    13981 cgcagtccca gggaccgcag ttgctggtcg atcatcgacg tgaaggtgtc ctcggcgtcc
    14041 aggacgagga cgctgcgccc ggccagtccg ggcagcgccg acgcgcgcgc ctcggcgtcg
    14101 gacaaccaga agtcggcgat ggagtcgttg cggagctcca gtgcgcggcg cacgctcgca
    14161 tgctgagcga aacgttcctt ctcgtctccc cggagggcgg cgacgagtcc ggccgccttg
    14221 gcgcgggtct ccgcggcctc ggaggccggg tcggagtgcc gcacgatggt ggcgccgaca
    14281 ccgatggcga tgtggccctc acggctgatg tcggcggtgc ggatcaggat ggccgagtcc
    14341 atggcccgct ccccttcgtc gtcccgtccg atgagcacgg cggcgccgct gtagaagcca
    14401 cgcccgccgg gctcgtactg ctggatgatg cggcaggcgc tctccagcgg gctcccggtg
    14461 accgtcgggg cgaacatcgt ctcgcgcagg atgtcgcgca catcccggtc cgtgcgtccc
    14521 tcgatgaagt actcggtgtg cgcgaccctg gccatctcct tgagataggg gcccaccaca
    14581 cggccccccg tcgcacagat ccgggccatc atcttgagtt cctcgtcgag gaccatgtac
    14641 agctcgtcgg tctccttccg gtcgctcagg aagtccagca cgcccgacag ggtggggccc
    14701 gagggcgggt agcggtacgt gccgctgatg gggttcatga cggccgtccc gccctggagg
    14761 ctgatgtgcc gctcgggcga ggcgccgacc agggtccggg tgcccgtgtg gatcaggaac
    14821 gtccagtggg cgccggactc gcgttcgagg agccgccgga acagcgcggg ggcactctgc
    14881 ggcccgtagt ccgtgatgtc ggcgacgaag gtgcgcttga tgacgaagtt cgcgccctct
    14941 ccggtaccga tcatctcctt gacgatgcgg cgcaccacgt tctcgtacgc ctcgtcatcg
    15001 acgtcgaagc tctctccggc cagcggggtc ggcacatcgg gaagccgtgc caacgccgcg
    15061 tcgagcggca gctgttgggt gtccgtgacc gtcatcgcca ccaggggcgt cccgtcgtcg
    15121 gcgcagtcga agccgcgctc ggcgagctgc cggtagggga cgaggacgag cacctcgtgg
    15181 cgcgcgccgg ctccgggggc gggtcgcggc ggcagcggga tgtcggccag cgtgccgggc
    15241 agggacaccg atccggtcag gacttccacg acgtcccgcc cggccgctcc gggccggtgc
    15301 agcagggcgt acgcctcccc ctccgtgtgc agcacgtggt cgagcagatc gccgggcctg
    15361 gggtcccggg gggcgccggg gtttcctcgc ggaccgtacg tcatgcgaac agccccttga
    15421 ccgtggtgac gcgggcacag cgctcggcgg cgtaggtcag tgccgagcgg tggtagtgct
    15481 ccgagaagtc ggccgtggcg tccgcgacga agaagggctg gatgtcgtgg gtgaaggcct
    15541 cgaccgcggt ggccagcaca ccgacgtggg cgtagacgcc gcacaggacg agctggtcgc
    15601 ggcccgcggc gcgcatgcgc cggagcaggt cggtcttgaa gaaggcgctg tagcgccact
    15661 tggtgagcat ccagtcctgc tcggccggcg cgagggcgtc gaccacctgg cggtcctcgg
    15721 gttccggtcg catgccgggg ccccagaagt ccttgagcag accgcgctgt tcctcggtca
    15781 tgccgcccgg ctgggcggtg taggcgaccg ggacgccgag ctccgcgcag cggtcgcgta
    15841 atcgtgcggc gttgccggtc agttcctggc tcatggagcc cgggaacggc tggagaaagt
    15901 accgctgcat gtcatggacg agaagcaccg accggtcggc ttcggcggtc caggtcacgc
    15961 gggcgggagg caggtcgccc tcggtgggca gggggtagga atgaatggcg ggtattccgg
    16021 tcatggctcc agttcctggc ttgttgcagg cgtgcttggt gcaggcgtgc tcggcgcgca
    16081 gagcagagag gagcgtgcga tgtcaggagg cggtccaggc cgagaccacg gagagcgcct
    16141 gtgacggagt gagacgggga tcgcagtgcg aggtgtagcg gtccccgacg gaggcgagct
    16201 cggacgcgtc gaggacgcac tcggtgacgt cgtccggcgt ggtctccagg tgcagtccgc
    16261 cggcgatacc gcccgcggag cgcacggcct cgacgaagcg ggtgacctcc agcgacaccg
    16321 tctccacgag ccgcgtcttg tggccgccgg gcgccgtgac ggtgttgccg tgcatggggt
    16381 cgctgagcca gacgacgggg tggcccgcgc cgcgtacggc ttcgacgagg cgcggcagcc
    16441 ggtcggcgac ggcgtcggct cccatgcgcg cgatgagagt gagccgcccg gggtcgcgcc
    16501 accggtcgag tcgctcgcac agggcgagca gttcgtccgg ctccatggag gggccgacct
    16561 tgcacgccac cgggttgctc acctcggcga gcagggcgac gtgggcgccc tcgacctggc
    16621 gggtgcgctc gccgatccac ggccagtggg tcgaacccag gaacagccgg cccttggcgt
    16681 ccgtgcggag catgggcatc tcgtagtcga ggaggagcgc ctcgtgactg gtccacacca
    16741 ggggctccac ggcgtcacgc ccttcggccc ggtcgcgcca gcccatgtgt ccgacgatgt
    16801 cgagggcggc catgtagccg gtgaggatcc gaagagggtc ggcctgccgc cgctcgcggt
    16861 ccggctcggg gccgttgacc atgtgaccgc ggaagacggg aagttcgacg ccgtcgacga
    16921 attcggtggg cttggaacga ggcttggcga actgcccggc gatacgtcct gccctcacga
    16981 cgggcttgcc ggtgatcaga ccgagcgacc cggcgagcag gtcgagcagc gcggccttgc
    17041 gtgccacgtg gggacgtgtg cactcctgcg ggtcctcggc gcagtccccg gactgcagca
    17101 ccatggcctc tccgagcgcc accttgccca gcagagtgcg cagcgtcgcc acatcgtcgg
    17161 cctgtacgag ggtggggcgt gcgccgagcg cctcggccac ccggctcagc tgtaggagat
    17221 cgctccactc gggttgctgt gatgccccgc ggatacgaat ctcccgtatg acgtcttcca
    17281 tgacgtgctc cgatccagcg gtgatattct gcttttcagg tgggtattcc ctggcgcttg
    17341 atttctggca ccggaatgcc gagcgcgcgc agttgctgga acgggttcat gaactcacga
    17401 ttctgcttga tcttcccatt ctcgagctcg aacgagtgga ggaagtggtt ctcgtagtaa
    17461 ccctcggggt agtcaccgaa gcgaatcttc ccacgcccgt cgcactccac ccagaagtga
    17521 ttggggtcct gggtctcgaa tatccggatg ttgtgccatt cccagtcggg gaagcactcc
    17581 agcgaccaga cagcgtgttc ggcgagacgc gccttgccgt gggtggcgat cggcgagccg
    17641 gtgtccgtgg tccacaggcc accactgccg tcctcggtga acagctcgtg gcgacgcagt
    17701 cggtcctgcc ccttggtgtg catgtacttc tcgacggtgg cccggttgat ccggcgcagt
    17761 tcggccgcgt cggagaatcc ctggttcggc aatgaatcag gcat
//
