Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001080.1:
Cluster 1Other117804

BGC0001080, phenazine biosynthetic gene cluster from Streptomyces anulatus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Endophenazine A
PubChem ID: 10039975
SMILES string: Copy to clipboard
Molecular formula: C18H16N2O2
Average molecular mass: 292.338 Da
Molecular activity: Antibacterial, Antifungal

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Phenazine

Gene cluster description

phenazine (BGC0001080). Gene Cluster 1. Biosynthetic class = Other. GenBank FN178498. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Alexander Kristian Apel (Eberhard Karls Universitaet Tuebingen)

Literature references

1. Saleh O et al. (2012 TI) Mutational analysis of a phenazine biosynthetic gene cluster in Streptomyces anulatus 9663. Beilstein J Org Chem 8:501-13. doi: 10.3762/bjoc.8.57. Epub 2012 Apr 4.
2. Saleh O et al. (2009) Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus. J Biol Chem 284(21):14439-47. doi: 10.1074/jbc.M901312200. Epub 2009
3. Krastel P et al. (2002) Endophenazines A-D, new phenazine antibiotics from the athropod associated endosymbiont Streptomyces anulatus II. Structure elucidation. J Antibiot (Tokyo) 55(9):801-6.
4. Gebhardt K et al. (2002) Endophenazines A-D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo) 55(9):794-800.