BGC0001080: endophenazine A biosynthetic gene cluster from Streptomyces anulatus
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Location: 1 - 17,804 nt. (total: 17,804 nt).
This entry is originally from NCBI GenBank FN178498.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001080
Short description endophenazine A biosynthetic gene cluster from Streptomyces anulatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (phenazine)
Loci
FN178498.1
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • endophenazine A
  • endophenazine B
Species Streptomyces anulatus [taxonomy]
References
Chemical products information
endophenazine A Evidence:
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C18H16N2O2
Chemical database entries
NPAtlas
PubCHEM
endophenazine B Evidence:
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C19H18N2O3
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAX48655.1
  • ppzP
 1 - 900 (+) 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase (dihydro-PCA prenyltransferase)
  • Tailoring
  • Activity assay
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  • CAX48656.1
  • mk
 1009 - 2046 (+) mevalonate kinase
  • Precursor biosynthesis
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  • CAX48657.1
  • mdpd
 2036 - 3091 (+) diphosphomevalonate decarboxylase
  • Precursor biosynthesis
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  • CAX48658.1
  • pmk
 3088 - 4203 (+) phosphomevalonate kinase
  • Precursor biosynthesis
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  • CAX48659.1
  • ippi
 4200 - 5291 (+) type II isopentenyl diphosphate delta isomerase
  • Precursor biosynthesis
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  • CAX48660.1
  • hmgr
 5288 - 6349 (+) 3-hydroxy-3-methylglutaryl-CoA reductase
  • Precursor biosynthesis
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  • CAX48661.1
  • hmgs
 6353 - 7528 (+) 3-hydroxy-3-methylglutaryl-CoA synthase
  • Precursor biosynthesis
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  • CAX48662.1
  • ppzT
 7587 - 8570 (+) 3-oxoacyl-[acyl-carrier-protein] synthase
  • Precursor biosynthesis
  • Knock-out
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  • CAX48663.1
  • ppzU
 8628 - 9353 (+) Flavodoxin
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    • CAX48664.1
    • ppzV
    		 9501 - 10121 (-) conserved hypothetical protein ovmZ-like
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      • CAX48665.1
      • ppzM
      		 10210 - 11232 (-) phenazine N-methyltransferase
      • Tailoring
      • Knock-out
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      • CAX48666.1
      • ppzB
      		 11292 - 11798 (-) Phenazine biosynthesis protein PhzB
      • Scaffold biosynthesis
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      • CAX48667.1
      • ppzG
      		 11834 - 12535 (-) FMN-dependent oxidase
      • Scaffold biosynthesis
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      • CAX48668.1
      • ppzF
      		 12528 - 13367 (-) trans-2,3-dihydro-3-hydroxyanthranilate isomerase
      • Scaffold biosynthesis
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      • CAX48669.1
      • ppzE
      		 13464 - 15404 (-) 2-amino-2-desoxy-isochorismate synthase
      • Scaffold biosynthesis
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      • CAX48670.1
      • ppzD
      		 15401 - 16024 (-) 2,3-dihydro-3-hydroxy-anthranilate synthase
      • Scaffold biosynthesis
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      • CAX48671.1
      • ppzC
      		 16103 - 17281 (-) 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase
      • Scaffold biosynthesis
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      • CAX48672.1
      • ppzA
      		 17316 - 17804 (-) Phenazine biosynthesis protein PhzA
      • Scaffold biosynthesis
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      Biosynthesis information
      Annotation changelog

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Updated bioactivity data
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (MIBiG Annotathon)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: 6BNBMTTKZLI3ZE3JTCJWEZIV)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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