Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001083.1:
Cluster 1Polyketide / Terpene160157

BGC0001083, merochlorin biosynthetic gene cluster from Streptomyces sp. CNH189. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: merochlorin A
SMILES string: Copy to clipboard
Molecular formula: C25H29ClO4
Exact molecular mass: 427.1682 Da ([M-H]-)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide / Terpene
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type III
Starter unit:
Malonamyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
MCL17,AGH68902.1

Modular polyketide synthases:
mcl17 (AGH68902.1)
Module 1
Scaffold-modifying domain: None

Terpene subclass:
Other
Terpene subclass by size:
Sesquiterpene
Final isoprenoid precursor:
DMAPP
Terpene synthase/cyclase-encoding genes:
MCL22, AGH68907.1
Prenyltransferase-encoding genes:
MCL23, AGH68908.1

Gene cluster description

merochlorin (BGC0001083). Gene Cluster 1. Biosynthetic class = Polyketide/Terpene. GenBank JX186999, positions 1-57523. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Comments:An unusual terpene cyclization catalyzed by chloroperoxidases not by classic terpene synthase/cyclases
Contact for this cluster:Stefan Diethelm, Leonard Kaysser (Scripps Institution of Oceanography, Eberhard Karls University Tuebingen)

Literature references

1. Kaysser L et al. (2012) Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. J Am Chem Soc 134(29):11988-91. doi: 10.1021/ja305665f. Epub 2012