BGC0001084: notoamide A biosynthetic gene cluster from Aspergillus sp. MF297-2
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Location: 1,293 - 42,030 nt. (total: 40,738 nt).
This entry is originally from NCBI GenBank HM622670.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001084
Short description notoamide A biosynthetic gene cluster from Aspergillus sp. MF297-2
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • terpene (Hemiterpene)
  • other (other)
Loci
HM622670.1
1293 - 42030
via Gene expression correlated with compound production
Compounds
  • notoamide A
Species Aspergillus sp. MF297-2 [taxonomy]
References
Chemical products information
notoamide A Evidence:
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C26H29N3O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADM34134.1
 1293 - 2491 (-) NmrA family protein
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    • ADM34135.1
    		 3486 - 4829 (+) FAD binding domain protein
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      • ADM34136.1
      		 5819 - 7168 (+) aromatic prenyl-transferase
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        • ADM34137.1
        		 8012 - 10036 (+) oxidoreductase
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          • ADM34138.1
          		 10787 - 17509 (+) non-ribosomal peptide synthetase
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            • ADM34139.1
            		 17924 - 19354 (-) aromatic prenyl-transferase
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              • ADM34140.1
              		 19899 - 21799 (-) P450
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                • ADM34141.1
                		 22422 - 24257 (+) P450
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                  • ADM34142.1
                  		 24803 - 26225 (+) FAD binding domain protein
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                    • ADM34143.1
                    		 26390 - 27502 (-) hypothetical protein
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                      • ADM34144.1
                      		 28771 - 30621 (-) efflux pump
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                        • ADM34145.1
                        		 31789 - 33243 (+) trancriptional activator
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                          • ADM34146.1
                          		 33816 - 35080 (+) hypothetical protein
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                            • ADM34147.1
                            		 35192 - 36317 (-) dehydrogenase
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                              • ADM34148.1
                              		 36520 - 37512 (-) short-chain dehydrogenase/reductase
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                                • ADM34149.1
                                		 37770 - 38789 (+) metallo-beta-lactamase domain protein
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                                  • ADM34150.1
                                  		 39871 - 40439 (+) hypothetical protein
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                                    • ADM34151.1
                                    		 40514 - 42030 (-) hypothetical protein
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      1
                                      Type
                                      nrps-type1
                                      Genes
                                      ADM34138.1
                                      Substrates
                                      proline (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Name
                                      2
                                      Type
                                      nrps-type1
                                      Genes
                                      ADM34138.1
                                      Substrates
                                      tryptophan (evidence: Structure-based inference, Homology)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Corrected NRP module activity
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Removed duplicate prenyltransferase
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Removed invalid prenyltransferase identifiers
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Fixed incorrect prenyltransferase gene
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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