BGC0001084 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001084 (Aspergillus sp. MF297-2)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,indole	1	42,030	High	notoamide A	NRPS:Type I+terpene:Hemiterpene+other:other

BGC0001084 - Region 1 - NRPS,indole

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Location: 1 - 42,030 nt. (total: 42,030 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,031
Label		BGC0001084

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

ADM34137.1: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

ADM34140.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ADM34141.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ADM34147.1: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: methyltransferase

ADM34151.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

ADM34149.1: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 73.30%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydrolase

ADM34149.1: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 73.30%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: ligase

ADM34138.1: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001084.5	1.66	NRPS, other (other), terpene	notoamide A	Aspergillus sp. MF297-2
BGC0000818.5	1.06	NRPS	notoamide A	Aspergillus versicolor
BGC0001249.5	0.87	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002254.3	0.78	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001261.3	0.76	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti
BGC0002164.2	0.70	NRPS	peramine	Epichloe festucae
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.65	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001084.5	0.99	NRPS, other (other), terpene	notoamide A	Aspergillus sp. MF297-2
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000818.5	0.72	NRPS	notoamide A	Aspergillus versicolor
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.66	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.66	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37509:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ADM34138.1: Pro - Trp

Search NORINE for peptide: strict or relaxed

AMP-binding (84..484): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVMMIGAVNK
Nearest Stachelhaus code(s):: Pro DVMMIGAVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1165..1564): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVYFVGGICK
Nearest Stachelhaus code(s):: Trp DVYFVGGICK (100% 8Å match); Trp or Pro DVYFVGGICK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor