Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001084.1:
Cluster 1NRP / Terpene / Alkaloid142456

BGC0001084, notoamide / stephacidin biosynthetic gene cluster from Aspergillus sp. MF297-2. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: notoamide A
SMILES string: Copy to clipboard
Molecular formula: C26H29N3O5
Exact molecular mass: 463.2107 Da ([M+H]+)
Molecular activity: Cytotoxic, Inhibitor

Class-specific details

Biosynthetic class(es):
NRP / Terpene / Alkaloid
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
ADM34138.1
Module 1
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 2
A specificity: Tryptophan
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Terpene subclass:
Other
Terpene subclass by size:
Hemiterpene
Final isoprenoid precursor:
DMAPP
Terpene synthase/cyclase-encoding genes:
Prenyltransferase-encoding genes:
HM622670, ADM34136.1, NOTC, HM622670, ADM34138.1, NOTF
Alkaloid subclass:
Pyrrole/pyrrolidine

Gene cluster description

notoamide / stephacidin (BGC0001084). Gene Cluster 1. Biosynthetic class = NRP/Terpene/Alkaloid. GenBank HM622670, positions 1-42456. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Ding Y et al. (2010) Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. J Am Chem Soc 132(36):12733-40. doi: 10.1021/ja1049302.