BGC0001084: notoamide A biosynthetic gene cluster from Aspergillus sp. MF297-2
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Location: 1,293 - 42,030 nt. (total: 40,738 nt).
This entry is originally from NCBI GenBank HM622670.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
Terpene
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001084
Short description notoamide A biosynthetic gene cluster from Aspergillus sp. MF297-2
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Terpene (Hemiterpene/Unknown)
  • Alkaloid (Pyrrole/pyrrolidine)
Loci NCBI GenBank: HM622670.1
Compounds
  • notoamide A
Species Aspergillus sp. MF297-2 [taxonomy]
References
Chemical products information
notoamide A
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C26H29N3O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADM34134.1
 1293 - 2491 (-) NmrA family protein
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  • ADM34135.1
 3486 - 4829 (+) FAD binding domain protein
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  • ADM34136.1
 5819 - 7168 (+) aromatic prenyl-transferase
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  • ADM34137.1
 8012 - 10036 (+) oxidoreductase
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  • ADM34138.1
 10787 - 17509 (+) non-ribosomal peptide synthetase
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  • ADM34139.1
 17924 - 19354 (-) aromatic prenyl-transferase
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  • ADM34140.1
 19899 - 21799 (-) P450
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  • ADM34141.1
 22422 - 24257 (+) P450
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  • ADM34142.1
 24803 - 26225 (+) FAD binding domain protein
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  • ADM34143.1
 26390 - 27502 (-) hypothetical protein
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  • ADM34144.1
 28771 - 30621 (-) efflux pump
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  • ADM34145.1
 31789 - 33243 (+) trancriptional activator
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  • ADM34146.1
 33816 - 35080 (+) hypothetical protein
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  • ADM34147.1
 35192 - 36317 (-) dehydrogenase
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  • ADM34148.1
 36520 - 37512 (-) short-chain dehydrogenase/reductase
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  • ADM34149.1
 37770 - 38789 (+) metallo-beta-lactamase domain protein
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  • ADM34150.1
 39871 - 40439 (+) hypothetical protein
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  • ADM34151.1
 40514 - 42030 (-) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
ADM34138.1
Module 1
Specificity: proline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 2
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Homology
Condensation domain type: LCL
Terpene-specific information
Carbon count subclass Hemiterpene
Structural subclass Unknown
Isoprenoid precursor DMAPP
Prenyltransferases ADM34136.1, ADM34139.1
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed duplicate prenyltransferase
  • Removed invalid prenyltransferase identifiers
  • Fixed incorrect prenyltransferase gene
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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