Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001089.1:
Cluster 1Other172494

BGC0001089, bacillaene biosynthetic gene cluster from Bacillus amyloliquefaciens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: bacillaene
PubChem ID: 44227768
SMILES string: Copy to clipboard
Molecular formula: C34H50N2O6
Average molecular mass: 582.782 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Other biosynthetic class:

Gene cluster description

bacillaene (BGC0001089). Gene Cluster 1. Biosynthetic class = Other. GenBank AJ634060. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Rainer Borriss (Humboldt University Berlin)

Literature references

1. Chen XH et al. (2006) Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. J Bacteriol 188(11):4024-36. doi: 10.1128/JB.00052-06.
2. Chen XH et al. (2007) Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Nat Biotechnol 25(9):1007-14. doi: 10.1038/nbt1325. Epub 2007 Aug 19.
3. Moldenhauer J et al. (2007 TI) Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family. Angew Chem Int Ed Engl 46(43):8195-7. doi: 10.1002/anie.200703386.
4. Moldenhauer J et al. (2010) The final steps of bacillaene biosynthesis in Bacillus amyloliquefaciens FZB42: direct evidence for beta,gamma dehydration by a trans-acyltransferase polyketide synthase. Angew Chem Int Ed Engl 49(8):1465-7. doi: 10.1002/anie.200905468.