BGC0001090: bacillomycin D biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1,867,976 - 1,912,622 nt. (total: 44,647 nt).
This entry is originally from NCBI GenBank CP000560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001090
Short description bacillomycin D biosynthetic gene cluster from Bacillus velezensis FZB42
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP000560.1
1867976 - 1912622
via Knock-out studies
Compounds
  • bacillomycin D
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
bacillomycin D Evidence:
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C49H76N10O15
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBAM_018140
  • ABS74177.1
  • ynfF
 1867976 - 1869247 (-) YnfF
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    • RBAM_018150
    • ABS74178.1
    • xynD
    		 1869309 - 1870847 (-) XynD
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      • RBAM_018160
      • ABS74179.1
      • bmyC
      		 1871172 - 1879031 (-) bacillomycin D synthetase C
      • Scaffold biosynthesis
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      • RBAM_018170
      • ABS74180.1
      • bmyB
      		 1879116 - 1895207 (-) bacillomycin D synthetase B
      • Scaffold biosynthesis
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      • RBAM_018180
      • ABS74181.1
      • bmyA
      		 1895252 - 1907200 (-) bacillomycin D synthetase A
      • Scaffold biosynthesis
      • Knock-out
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      • RBAM_018190
      • ABS74182.1
      • bmyD
      		 1907220 - 1908422 (-) malonyl-CoA transacylase
      • Scaffold biosynthesis
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      • RBAM_018200
      • ABS74183.1
      • yxjF
      		 1908982 - 1909767 (-) YxjF
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        • RBAM_018210
        • ABS74184.1
        • scoB
        		 1909780 - 1910442 (-) ScoB
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          • RBAM_018220
          • ABS74185.1
          • scoA
          		 1910460 - 1911161 (-) ScoA
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            • RBAM_018230
            • ABS74186.1
            • yxjC
            		 1911186 - 1912622 (-) YxjC
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              Biosynthesis information

              Biosynthetic modules

              Name
              4
              Type
              nrps-type1
              Genes
              bmyA
              Substrates
              asparagine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              5
              Type
              nrps-type1
              Genes
              bmyB
              Substrates
              tyrosine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              adenylation
              Name
              6
              Type
              nrps-type1
              Genes
              bmyB
              Substrates
              asparagine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (DCL), adenylation, epimerase
              Name
              7
              Type
              nrps-type1
              Genes
              bmyB
              Substrates
              proline (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              8
              Type
              nrps-type1
              Genes
              bmyB
              Substrates
              glutamic acid (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              10
              Type
              nrps-type1
              Genes
              bmyC
              Substrates
              threonine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              9
              Type
              nrps-type1
              Genes
              bmyC
              Substrates
              serine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              adenylation
              Name
              None
              Type
              pks-modular-starter
              Genes
              bmyD
              Substrates
              Integrated Monomers
              Domains
              acyltransferase
              Name
              2
              Type
              pks-trans-at
              Genes
              bmyA
              Substrates
              Integrated Monomers
              Domains
              ketosynthase, carrier (ACP)
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Corrected NRP module activity
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Removed ketoreductase stereochemistry annotation from modules without ketoreductases
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Corrected gene identifiers
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2019-10-16
              Updated compound(s) information (NPAtlas curation)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: FICEQDRJCNKWHHGNCRVDDP5D)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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