Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001090.1:
Cluster 1NRP144647

BGC0001090, bacillomycin biosynthetic gene cluster from Bacillus amyloliquefaciens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: bacillomycin D
PubChem ID: 3086563
SMILES string: Copy to clipboard
Molecular formula: C52H84N12O14
Average molecular mass: 1101.314 Da
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP
Other lipopeptide (cyclic)
Thioesterase type:
None
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
bmyA (ABS74181)
Module 1
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Other
Module 3
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Other
Scaffold-modifying domain: Amination
Module 4
A specificity: Asparagine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 5
A specificity: Unknown
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: DCL
bmyB (ABS74180)
Module 5
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Module 6
A specificity: Asparagine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: DCL
Module 7
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 8
A specificity: Glutamate
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 9
A specificity: Unknown
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: DCL
bmyC (ABS74179)
Module 10
A specificity: Threonine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 9
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: N/A

Gene cluster description

bacillomycin (BGC0001090). Gene Cluster 1. Biosynthetic class = NRP. GenBank CP000560, positions 1908422-1871172. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Rainer Borriss (Humboldt University Berlin)

Literature references

1. Koumoutsi A et al. (2004) Structural and functional characterization of gene clusters directing nonribosomal synthesis of bioactive cyclic lipopeptides in Bacillus amyloliquefaciens strain FZB42. J Bacteriol 186(4):1084-96.