BGC0001095: fengycin biosynthetic gene cluster from Bacillus velezensis FZB42
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,921,412 - 1,970,953 nt. (total: 49,542 nt).
This entry is originally from NCBI GenBank CP000560.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001095
Short description fengycin biosynthetic gene cluster from Bacillus velezensis FZB42
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP000560.1
1921412 - 1970953
via Knock-out studies
Compounds
  • fengycin
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
fengycin Evidence:
Copy SMILES
C72H110N12O20
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBAM_018330
  • ABS74196.1
  • yngE
 1921412 - 1922941 (-) YngE
    copy AA seq
    copy Nt seq
    • RBAM_018340
    • ABS74197.1
    • yngF
    		 1922959 - 1923738 (-) YngF
      copy AA seq
      copy Nt seq
      • RBAM_018350
      • ABS74198.1
      • yngG
      		 1923752 - 1924651 (-) YngG
        copy AA seq
        copy Nt seq
        • RBAM_018360
        • ABS74199.1
        		 1924667 - 1924879 (-) hypothetical protein
          copy AA seq
          copy Nt seq
          • RBAM_018370
          • ABS74200.1
          • yngH
          		 1924876 - 1926225 (-) YngH
            copy AA seq
            copy Nt seq
            • RBAM_018380
            • ABS74201.1
            • yngI
            		 1926247 - 1927887 (-) YngI
              copy AA seq
              copy Nt seq
              • RBAM_018390
              • ABS74202.1
              • yngJ
              		 1927933 - 1929075 (-) YngJ
                copy AA seq
                copy Nt seq
                • RBAM_018400
                • ABS74203.1
                • yngK
                		 1929215 - 1930753 (-) YngK
                  copy AA seq
                  copy Nt seq
                  • RBAM_018410
                  • ABS74204.1
                  • yngL
                  		 1930875 - 1931306 (-) YngL
                    copy AA seq
                    copy Nt seq
                    • RBAM_018420
                    • ABS74205.1
                    • fenE
                    		 1931328 - 1935131 (-) fengycin synthetase E
                    • Scaffold biosynthesis
                    copy AA seq
                    copy Nt seq
                    • RBAM_018430
                    • ABS74206.1
                    • fenD
                    		 1935150 - 1945925 (-) fengycin synthetase D
                    • Scaffold biosynthesis
                    copy AA seq
                    copy Nt seq
                    • RBAM_018440
                    • ABS74207.1
                    • fenC
                    		 1945951 - 1953600 (-) fengycin synthetase C
                    • Scaffold biosynthesis
                    copy AA seq
                    copy Nt seq
                    • RBAM_018450
                    • ABS74208.1
                    • fenB
                    		 1953616 - 1961313 (-) fengycin synthetase B
                    • Scaffold biosynthesis
                    copy AA seq
                    copy Nt seq
                    • RBAM_018460
                    • ABS74209.1
                    • fenA
                    		 1961339 - 1968997 (-) fengycin synthetase A
                    • Scaffold biosynthesis
                    • Knock-out
                    copy AA seq
                    copy Nt seq
                    • RBAM_018470
                    • ABS74210.1
                    • dacC
                    		 1969478 - 1970953 (-) DacC
                      copy AA seq
                      copy Nt seq
                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      1
                      Type
                      nrps-type1
                      Genes
                      fenA
                      Substrates
                      glutamic acid (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      condensation (LCL), adenylation
                      Name
                      2
                      Type
                      nrps-type1
                      Genes
                      fenA
                      Substrates
                      ornithine (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      condensation (DCL), adenylation, epimerase
                      Name
                      3
                      Type
                      nrps-type1
                      Genes
                      fenB
                      Substrates
                      tyrosine (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (LCL), adenylation
                      Name
                      4
                      Type
                      nrps-type1
                      Genes
                      fenB
                      Substrates
                      threonine (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (DCL), adenylation, epimerase
                      Name
                      5
                      Type
                      nrps-type1
                      Genes
                      fenC
                      Substrates
                      glutamic acid (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (LCL), adenylation
                      Name
                      6
                      Type
                      nrps-type1
                      Genes
                      fenC
                      Substrates
                      valine, alanine (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (DCL), adenylation, epimerase
                      Name
                      7
                      Type
                      nrps-type1
                      Genes
                      fenD
                      Substrates
                      proline (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (LCL), adenylation
                      Name
                      8
                      Type
                      nrps-type1
                      Genes
                      fenD
                      Substrates
                      glutamine (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (LCL), adenylation
                      Name
                      9
                      Type
                      nrps-type1
                      Genes
                      fenD
                      Substrates
                      tyrosine (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (DCL), adenylation, epimerase
                      Name
                      10
                      Type
                      nrps-type1
                      Genes
                      fenE
                      Substrates
                      isoleucine (evidence: Structure-based inference [1], [2])
                      Integrated Monomers
                      Domains
                      condensation (LCL), adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Cleaned up synonym list
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Linked new NPAtlas id for fengycin (npatlas:NPA020186)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Corrected NRP module activity
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Corrected gene identifiers
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Update compound information for Fengycin
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: FICEQDRJCNKWHHGNCRVDDP5D)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
                      Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                      A domain glossary is available here, and an explanation of the visualisation is available here.
                      Selected features only
                      Show module domains
                      Similar known gene clusters from MIBiG 4.0
                      Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                      Click on reference genes to show details of similarities to genes within the current region.
                      Click on an accession to open that entry in the MiBIG database.