BGC0001095: fengycin biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1,921,412 - 1,970,953 nt. (total: 49,542 nt).
This entry is originally from NCBI GenBank CP000560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001095
Short description fengycin biosynthetic gene cluster from Bacillus velezensis FZB42
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CP000560.1
Compounds
  • fengycin
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
fengycin [synonyms: Fengycin C, Fengymycin]
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C72H110N12O20
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBAM_018330
  • ABS74196.1
  • yngE
 1921412 - 1922941 (-) YngE
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  • RBAM_018340
  • ABS74197.1
  • yngF
 1922959 - 1923738 (-) YngF
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  • RBAM_018350
  • ABS74198.1
  • yngG
 1923752 - 1924651 (-) YngG
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  • RBAM_018360
  • ABS74199.1
 1924667 - 1924879 (-) hypothetical protein
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  • RBAM_018370
  • ABS74200.1
  • yngH
 1924876 - 1926225 (-) YngH
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  • RBAM_018380
  • ABS74201.1
  • yngI
 1926247 - 1927887 (-) YngI
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  • RBAM_018390
  • ABS74202.1
  • yngJ
 1927933 - 1929075 (-) YngJ
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  • RBAM_018400
  • ABS74203.1
  • yngK
 1929215 - 1930753 (-) YngK
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  • RBAM_018410
  • ABS74204.1
  • yngL
 1930875 - 1931306 (-) YngL
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  • RBAM_018420
  • ABS74205.1
  • fenE
 1931328 - 1935131 (-) fengycin synthetase E
  • Scaffold biosynthesis
Sequence-based prediction
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  • RBAM_018430
  • ABS74206.1
  • fenD
 1935150 - 1945925 (-) fengycin synthetase D
  • Scaffold biosynthesis
Sequence-based prediction
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  • RBAM_018440
  • ABS74207.1
  • fenC
 1945951 - 1953600 (-) fengycin synthetase C
  • Scaffold biosynthesis
Sequence-based prediction
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  • RBAM_018450
  • ABS74208.1
  • fenB
 1953616 - 1961313 (-) fengycin synthetase B
  • Scaffold biosynthesis
Sequence-based prediction
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  • RBAM_018460
  • ABS74209.1
  • fenA
 1961339 - 1968997 (-) fengycin synthetase A
  • Scaffold biosynthesis
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  • RBAM_018470
  • ABS74210.1
  • dacC
 1969478 - 1970953 (-) DacC
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
fenA
Module 1
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 2
Specificity: ornithine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
fenB
Module 3
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 4
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
fenC
Module 5
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 6
Specificity: valine / alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
fenD
Module 7
Specificity: proline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 8
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 9
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
fenE
Module 10
Specificity: isoleucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FICEQDRJCNKWHHGNCRVDDP5D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Update compound information for Fengycin
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Cleaned up synonym list
  • Linked new NPAtlas id for fengycin (npatlas:NPA020186)
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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