Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001095.1:
Cluster 1Other / NRP149542

BGC0001095, fengycin biosynthetic gene cluster from Bacillus amyloliquefaciens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: fengycin
PubChem ID: 14197
SMILES string: Copy to clipboard
Molecular formula: C23H32O4
Average molecular mass: 372.505 Da
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
Other / NRP
Nonribosomal peptide synthetases:
fenA (YP001421440)
Module 1
A specificity: Glutamate
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 2
A specificity: Ornithine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: DCL
fenB (YP001421439)
Module 3
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 4
A specificity: Threonine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: DCL
fenC (YP001421438)
Module 5
A specificity: Glutamate
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 6
A specificity: Valine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: DCL
fenD (YP001421437)
Module 7
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 8
A specificity: Glutamate
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 9
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: DCL
fenE (YP001421436)
Module 10
A specificity: Isoleucine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Other biosynthetic class:
None

Gene cluster description

fengycin (BGC0001095). Gene Cluster 1. Biosynthetic class = Other/NRP. GenBank CP000560, positions 1968997-1931328. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Rainer Borriss (Humboldt University Berlin)

Literature references

1. Koumoutsi A et al. (2004) Structural and functional characterization of gene clusters directing nonribosomal synthesis of bioactive cyclic lipopeptides in Bacillus amyloliquefaciens strain FZB42. J Bacteriol 186(4):1084-96.
2. Chen XH et al. (2007) Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Nat Biotechnol 25(9):1007-14. doi: 10.1038/nbt1325. Epub 2007 Aug 19.