BGC0001098: iturin biosynthetic gene cluster from Bacillus subtilis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 41,599 nt. (total: 41,599 nt).
This entry is originally from NCBI GenBank AB050629.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001098
Short description iturin biosynthetic gene cluster from Bacillus subtilis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AB050629.1
via
Compounds
  • iturin
Species Bacillus subtilis [taxonomy]
References
Chemical products information
iturin Evidence:
Copy SMILES
C48H74N12O14
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAB69693.1
  • yxjC
 1 - 1167 (+)
    copy AA seq
    copy Nt seq
    • BAB69694.1
    • yxjD
    		 1192 - 1893 (+)
      copy AA seq
      copy Nt seq
      • BAB69695.1
      • yxjE
      		 1911 - 2573 (+)
        copy AA seq
        copy Nt seq
        • BAB69696.1
        • yxjF
        		 2586 - 3371 (+)
          copy AA seq
          copy Nt seq
          • BAB69697.1
          • ituD
          		 3930 - 5132 (+) putative malonyl-CoA transacylase
            copy AA seq
            copy Nt seq
            • BAB69698.1
            • ituA
            		 5152 - 17100 (+) iturin A synthetase A
              copy AA seq
              copy Nt seq
              • BAB69699.1
              • ituB
              		 17145 - 33233 (+) iturin A synthetase B
                copy AA seq
                copy Nt seq
                • BAB69700.1
                • ituC
                		 33322 - 41178 (+) iturin A synthetase C
                  copy AA seq
                  copy Nt seq
                  • BAB69701.1
                  • xynD
                  		 41487 - >41599 (+)
                    copy AA seq
                    copy Nt seq
                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    ituA
                    Substrates
                    asparagine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    ituB
                    Substrates
                    tyrosine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    ituB
                    Substrates
                    asparagine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    ituB
                    Substrates
                    glutamine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    ituB
                    Substrates
                    proline (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    ituC
                    Substrates
                    asparagine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk07
                    Type
                    nrps-type1
                    Genes
                    ituC
                    Substrates
                    serine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
                    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                    A domain glossary is available here, and an explanation of the visualisation is available here.
                    Selected features only
                    Show module domains
                    Similar known gene clusters from MIBiG 4.0
                    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                    Click on reference genes to show details of similarities to genes within the current region.
                    Click on an accession to open that entry in the MiBIG database.