Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001099.1:
Cluster 1NRP / Polyketide177317

BGC0001099, kalimantacin / batumin biosynthetic gene cluster from Pseudomonas fluorescens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Kalimantacin A
PubChem ID: 197707
SMILES string: Copy to clipboard
Molecular formula: C30H48N2O7
Average molecular mass: 548.721 Da
Molecular activity: Antibacterial
Molecular target: FabI

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
bat2 (ADD82940.1)
Module 2
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: Unknown
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I / Trans-AT type I
Starter unit:
Acetyl-CoA
ADD82949.1, ADD82951.1
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
bat1 (ADD82939.1)
Module 0
Module 1
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation

bat2 (ADD82940.1)
Module 3
KR stereochemistry: B-group
Module 4
KR stereochemistry: B-group
Module 5
Scaffold-modifying domain: Beta-branching
Module 6
KR stereochemistry: B-group
Module 7
KR stereochemistry: A-group

bat3 (ADD82941.1)
Module 8
KR stereochemistry: B-group
Module 9
Scaffold-modifying domain: Beta-branching
Module 10
Scaffold-modifying domain: Beta-branching
Module 11
Scaffold-modifying domain: Beta-branching

Gene cluster description

kalimantacin / batumin (BGC0001099). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank GU479979, positions 1-61224. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Rob Lavigne (KU Leuven)

Literature references

1. Mattheus W et al. (2010) Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster. Chem Biol 17(2):149-59. doi: 10.1016/j.chembiol.2010.01.014.
2. Mattheus W et al. (2010) The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target. Chem Biol 17(10):1067-71. doi: 10.1016/j.chembiol.2010.07.015.