LOCUS BGC0001100 30960 bp DNA linear BCT 26-JUL-2016 DEFINITION Streptomyces rochei plasmid pSLA2-L DNA, complete sequence. ACCESSION BGC0001100 VERSION BGC0001100 KEYWORDS . SOURCE Streptomyces rochei ORGANISM Streptomyces rochei Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces rochei group. COMMENT On Mar 14, 2008 this sequence version replaced AB088224.1. The nucleotide sequence has been determined by using restriction fragments and nested deletion fragments of the ordered cosmid library of pSLA2-L. pSLA2-L is 210,614 bp long with G+C content of 72.8 % and carries 143 ORFs. Gene prediction was based on the unique codon usage in Streptomyces (Bibb et al., Gene 30:157-66 (1984)) using the FramePlot program of Ishikawa and Hotta (FEMS Microbiol Lett 174: 251-253 (1999)) as implemented at http://www.nih.go.jp/~jun/cgi-bin/frameplot.pl. Where possible we chose an initiation codon (atg, gtg, ctg or ttg) which is preceded by an upstream ribosome binding site sequence (optimally 5-13 bp before the initiation codon). If this could not be identified we chose the most upstream initiation codon. Three-fourths of the pSLA2-L DNA are occupied by biosynthetic genes (three PKS gene clusters for lankacidin, lankamycin and an unknown type II polyketide, a carotenoid biosynthetic gene cluster, many regulatory genes and others). The range of each biosynthetic gene cluster has been deduced by comparison with similar gene clusters in most cases and may be revised in future. ##antiSMASH-Data-START## Version :: False Run date :: 2022-11-07 22:59:59 NOTE: This is a single region extracted from a larger record! Orig. start :: 4921 Orig. end :: 35881 ##antiSMASH-Data-END## FEATURES Location/Qualifiers gene complement(1..891) /gene="lkcO" CDS complement(1..891) /codon_start=1 /gene="lkcO" /note="ORF4 (296 aa), lankacidin biosynthesis protein; similar to AE004625-4 Pseudomonas aeruginosa pyrroloquinoline quinone biosynthesis protein B (304 aa)" /product="pyrroloquinoline quinone biosynthesis protein B" /protein_id="BAC76462.1" /transl_table=11 /translation="MILLGTAAGGGFPQWNCACALCARGRRGELPARSQECVAVSGDGR DWWLLNASPDIRTQLLAAPALTPGPGPRDTPVRGVLLTDAEVDHALGLAVLRGATGLTV YAAPPVRGALSAELPVRGLLDRYAPWDWRDATAPGGFAVAGGLTVTAHPVGTKAPKYAH APDPDAPWVCAYRIEDPATGGALVYAPCLATWPDGFDDLLASATCALLDGTFFSAGELG TATSSAGAGQSLMGHLPVAGPGGSLAALARHRGLRRIYTHLNNTNPLLDPSSAAHAAVR EAGVEVLPDGSELVL" subregion 1..30960 /aStool="mibig" /contig_edge="False" /label="NRP, Polyketide" /subregion_number="1" /tool="antismash" region 1..30960 /contig_edge="False" /product="unknown" /region_number="1" /subregion_numbers="1" /tool="antismash" gene complement(894..1988) /gene="lkcN" CDS complement(894..1988) /codon_start=1 /gene="lkcN" /gene_functions="biosynthetic (rule-based-clusters) redox-cofactor: SPASM" /gene_functions="biosynthetic (rule-based-clusters) redox-cofactor: PF04055" /gene_functions="biosynthetic (rule-based-clusters) redox-cofactor: TIGR04085" /gene_functions="biosynthetic-additional (rule-based-clusters) Fer4_12" /gene_kind="biosynthetic" /note="ORF5 (364 aa), lankacidin biosynthesis protein; similar to AJ277117-5 Gluconobacter oxydans putative pqqE protein (359 aa)" /product="pyrroloquinoline quinone biosynthesis protein E" /protein_id="BAC76463.1" /sec_met_domain="PF04055 (E-value: 3.9e-26, bitscore: 82.4, seeds: 518, tool: rule-based-clusters)" /sec_met_domain="Fer4_12 (E-value: 3e-08, bitscore: 24.0, seeds: 84, tool: rule-based-clusters)" /sec_met_domain="TIGR04085 (E-value: 6.5e-12, bitscore: 35.8, seeds: 281, tool: rule-based-clusters)" /sec_met_domain="SPASM (E-value: 1.3e-10, bitscore: 31.8, seeds: 166, tool: rule-based-clusters)" /transl_table=11 /translation="MADPAVGAPAGMLIELTHRCPLHCPYCSNPLELVRREAELTCEQW TDILTQARELGVVQMHFSGGEPLARPDLPDLVGHARRLGAYVNLVTSGVGLTAERAHDL ARRGVDHVQLSLQDADPAAGQAIAGARVHTAKLEAARAVTAAGLPLTVNIVLHRGNIDR TGRMVDLAVDLGADRIELANTQYYGWGLRNRAALMPTAAQLAAAREAVRHARTRYAGGP ELVYVAADYYDDRPKPCMDGWGSTQLTVTPAGDVLPCPAAYAITTLPVENALRRPLSEI WYASRSFNAYRGTGWMREPCRTCPERHADHGGCRCQAFQLTGDAAATDPACGLSPHRSL VDAALAEVTDGPVPAFVPRGPVPA" gene complement(1981..2253) /gene="lkcM" CDS complement(1981..2253) /codon_start=1 /gene="lkcM" /gene_functions="biosynthetic (rule-based-clusters) redox-cofactor: PqqD_RRE" /gene_functions="biosynthetic-additional (rule-based-clusters) PF05402" /gene_kind="biosynthetic" /note="ORF6 (90 aa), lankacidin biosynthesis protein; similar to AL603642-200 Sinorhizobium meliloti putative pyrroloquinoline quinone biosynthesis protein D (98 aa)" /product="pyrroloquinoline quinone biosynthesis protein D" /protein_id="BAC76464.1" /sec_met_domain="PF05402 (E-value: 3.1e-14, bitscore: 43.2, seeds: 461, tool: rule-based-clusters)" /sec_met_domain="PqqD_RRE (E-value: 1.2e-22, bitscore: 69.5, seeds: 9, tool: rule-based-clusters)" /transl_table=11 /translation="MTGLPEPTVPRLRPGVRLTRDPARGELALLPERVVVLNDTAAAVL AHCDGTTSLAGIVERLAEEYEGVSAEDVRELLLRLAQRRVVDLHG" gene complement(2250..2978) /gene="lkcL" CDS complement(2250..2978) /codon_start=1 /gene="lkcL" /gene_functions="biosynthetic (rule-based-clusters) redox-cofactor: TIGR02111" /gene_kind="biosynthetic" /note="ORF7 (242 aa), lankacidin biosynthesis protein; similar to AE004625-5 Pseudomonas aeruginosa pyrroloquinoline quinone biosynthesis protein C (250 aa)" /product="pyrroloquinoline quinone biosynthesis protein C" /protein_id="BAC76465.1" /sec_met_domain="TIGR02111 (E-value: 9.5e-81, bitscore: 260.6, seeds: 5, tool: rule-based-clusters)" /transl_table=11 /translation="MSMSVTREVAAPWSEAEFRQRLHALESSYWDRHPFHRRMHEGLLD EGELRLWAANRWYYQRCLPQKDAAIVANCPLPEVRRQWLSRIVYHDGADACAGGAEKWL RLAEAVGLRRDEVHDERLVLAGTRFAVDAYVDFARRRPWLEAAASGLTELFSPGLLAHR LGRLREHYPWIAEEGFEYFTARIEVVGPEGRSLLDLVARHAVSREQQEACVRALAFKCR VLNAVLDSLDYHTGNGATRS" gene complement(3005..3109) /gene="lkcK" CDS complement(3005..3109) /codon_start=1 /gene="lkcK" /note="ORF8 (34 aa), lankacidin biosynthesis protein; similar to AL603642-197 Sinorhizobium meliloti putative pyrroloquinoline quinone biosynthesis protein A (31 aa)" /product="pyrroloquinoline quinone biosynthesis protein A" /protein_id="BAC76466.1" /transl_table=11 /translation="MRTSGKELPAKKAWHRPDFVTIDTGMEVTAYFSR" gene 3499..5136 /gene="lkcJ" CDS 3499..5136 /codon_start=1 /gene="lkcJ" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 133.9; E-value: 1.2e-40)" /gene_kind="transport" /note="ORF9 (545 aa), possible lankacidin resistance protein; similar to AL133424-19 Streptomyces coelicolor putative ABC transporter ATP-binding protein (544 aa)" /product="putative ABC transporter protein" /protein_id="BAC76467.1" /transl_table=11 /translation="MTDASIVCSNLSFSWPDGTPVFHDLSWSVGEGHTGLVAPNGAGKS TLLKLITGALRPNRGSVTVQGLVGYLPQTLPLTGDLTVAEVLGIAPVIEALDAIASGDV SEEHFATIGDDWDIEERSRAQLDRLGLGDIALTRRLHDLSGGQVVSLGLATQLLKRPDV LLLDEPTNNLDLDARRRLYQVLESFGGCLLVVSHDRALLDLMDTIAELESGEMRLYGGN YTDYEEAVRAEQETAEKNIRTAEQQVKREKREMQQARERAVRRAGIGARAYRKGSMSKM AAGTLKRRAQESAGKSNDTHGQRLADAKARLDDASRMLRDDRRIALELPDTNVPAGRTV FLGEGINVRYGGREIFAGDGVSLTIRGPERIALTGSNGVGKSTLLRVISGELEADRGEF KRADGRIAYLSQRLDTLPLDRTVAQCLADYAPLKPEAERMNLLARFLFRGAAAHLPVGA LSGGERLRATLACVLGAEPAPQLLLLDEPTNNLDLDSVEQLEGALNSYEGAFIVVSHDE RFVKEIGVDRWLRLADGRLLETGGPADE" gene 5129..6838 /gene="lkcI" CDS 5129..6838 /codon_start=1 /gene="lkcI" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 109.2; E-value: 4.3e-33)" /gene_kind="transport" /note="ORF10 (569 aa), possible lankacidin resistance protein; similar to X63451-1 Streptomyces ambofaciens spiramycin resistance protein, SrmB (550 aa)" /product="putative ABC transporter protein" /protein_id="BAC76468.1" /transl_table=11 /translation="MSDAPAPPDHGQDVLSADHRSAHLLAEDLRCVLGDRVVLHDVSLS VSRGERVGLIGENGRGKSTLLRALAGELAPQRGRVVRAVTGRVGFLAQQPDFPPGSTIE DVLAQATAEFRELSARMHAAEERMSSESGDLDAVMEEYGRLQEEFTRRGGWELGARVGE VLDVFGLAGLDRDRRIGTLSGGERARLALACLVLDEPAGLLLDEPTNHLDDRAVDWLVR WLAAYQGPCLIASHDRALLDTAVTAIVDLDGPSGATVRYGGGYRDYLAERAAAQERWWQ RYREWSREVAEARRRLERAHAGGRVFAGRADNDKLSYNAMGSAAEAAVARRTRAAQQHL RELLGEAVPRPPEPLDFAPPAPDQETDGVAEPAGGVLLRAAGLLAGEVLRGAELTLAAG SRYVISGPNGAGKSTLLSVLAGEREPDAGVVERAPGLRIGYLPQDSDFGAERRGLLEAF AARRETHLDDAAAELTRFGLFAPRDFATPANRLSVGQWRRLDLALLFARRPHLLLLDEP TNHLSLVLVEQLLAAVERFTGPVVMVTHDRALRERHRDRLLELAGGRLVPSG" gene complement(6894..7448) /gene="lkcH" CDS complement(6894..7448) /codon_start=1 /gene="lkcH" /note="ORF11 (184 aa), lankacidin biosynthesis protein; similar to AE004802-2 Pseudomonas aeruginosa hypothetical protein (180 aa)" /product="probable isochorismatase" /protein_id="BAC76469.1" /transl_table=11 /translation="MLVRADKTAVVLFDMQLELIPLLLEGTQLLHNTCWVAEVAREFDL PLLLTEHKKLGGLSLSLHEAAEDAPRLPKEHFDFLREEPIARHVADTGREQYVLAGAET HVVVLQSALSLLEQGKTVFVLADTVSARNQADHELGLARLRQLGVHLITREMFFFELIR NSEDGRYLELAKKYLDGRYIR" gene complement(7513..10293) /gene="lkcG" CDS complement(7513..10293) /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (13-417). E-value: 4.3e-125. Score: 409.7. Matches aSDomain: nrpspksdomains_lkcG_PKS_KS.1" /NRPS_PKS="Domain: PKS_PP (578-657). E-value: 2.6e-11. Score: 35.6. Matches aSDomain: nrpspksdomains_lkcG_PKS_PP.1" /NRPS_PKS="Domain: Thioesterase (711-830). E-value: 2.5e-10. Score: 33.0. Matches aSDomain: nrpspksdomains_lkcG_Thioesterase.1" /codon_start=1 /gene="lkcG" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: tra_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1022:Beta-ketoacyl synthase (Score: 219.4; E-value: 1.4e-66)" /gene_kind="biosynthetic" /note="ORF12 (926 aa), lankacidin biosynthesis protein; similar to AL021409-12 Streptomyces coelicolor polyketide synthase (2297 aa)" /product="type I polyketide synthase LkcG" /protein_id="BAC76470.1" /sec_met_domain="PP-binding (E-value: 1.7e-10, bitscore: 31.3, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="tra_KS (E-value: 3.6e-136, bitscore: 444.3, seeds: 44, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 5.5e-15, bitscore: 46.5, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MGMDELLEDDTPVVVGMACRFAGSDGLGEYWERLRLGRSALGTTG RWTEEEDAGSFTGGFLDGHQEFDARFFRISPNEAQCMDPQQRILLQTVQHAVDDGYLTA ADLRDLDCGVFAAGLPGDYRTLVARRADLVYGTHSFLGNAPSTLSGRISYFYDVNGPSL TLDSACSSSLAALHEAALNIRAGQCRAAIVGAVSVFSTPEVLRFAQRSRMSSPEGASLP FTDAADGFVPAEGAAALVVMRHDEARARGLRVYGAVQATGTNHNGTTNGLMAPSSKAQS RLIAELYDREKIDASQIAYLETHGTGTPLGDPIELEGLRSAFRRAGADGCHLGAVKPLI GHTLVASGLASVVKALLAFHHATIPPVAAAGEAVSYLDVAPFKVNREPLPWPEDKPLCA ISAFGFTGSNGHVVLRRLPDAPPTADAVDRRPGRALPFCLSAESPDSLAALADRCRTLV AELPGDRLWDLSQLLLRRPRLAHESVVVARTRDELGTALEALAHGGSEGPAPRSADTAR LDDDLRELVTRWRAQDMPAVQRRLDAPADLARITLPAYPFDGRRHWLTGEAPEPAAPPV PDAPEAATDALARELCARLSALLGYDEDSDQVVPGTRIASLGLDSLSAVQLLSPYQKAG SAIKAHDLFRHETVADLAAAIGGRPLAPPPTPPAREPGTTRRGGAGPDHAPLIRWSAYG DAGRPTLLLPPLNCDERAWAQQIPALLRAGRTVYVPEYPGHNDTPFDEERFSFEALADE VAGFLRDTADGPADLVGWSLGGCVSTLTALRHPERVASLALVSCAPRYGEDAFERTLDL REELRLHGGLLEAVFGEGGNLAEKFGGNASMDVLRCYYTDLTAFDVVDRLPDITADCLV LRGVGDCVLDAEAVELYSRIPGVRVREFEDHGHYVPLTAARAVNRTLAAFWAGRG" aSDomain complement(7804..8160) /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcG_Thioesterase.1" /evalue="2.50E-10" /label="lkcG_Thioesterase.1" /locus_tag="lkcG" /protein_end="830" /protein_start="711" /score="33.0" /tool="antismash" /translation="AWAQQIPALLRAGRTVYVPEYPGHNDTPFDEERFSFEALADEVAG FLRDTADGPADLVGWSLGGCVSTLTALRHPERVASLALVSCAPRYGEDAFERTLDLREE LRLHGGLLEAVFGEG" aSModule 7804..10254 /complete /domains="nrpspksdomains_lkcG_PKS_KS.1" /domains="nrpspksdomains_lkcG_PKS_PP.1" /domains="nrpspksdomains_lkcG_Thioesterase.1" /final_module /locus_tags="lkcG" /tool="antismash" /type="pks" CDS_motif complement(7957..8007) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcG_0003" /evalue="1.40E-05" /label="NRPS-te1" /locus_tag="lkcG" /protein_end="779" /protein_start="762" /score="17.6" /tool="antismash" /translation="DGPADLVGWSLGGCVST" aSDomain complement(8323..8559) /aSDomain="PKS_PP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcG_PKS_PP.1" /evalue="2.60E-11" /label="lkcG_PKS_PP.1" /locus_tag="lkcG" /protein_end="657" /protein_start="578" /score="35.6" /tool="antismash" /translation="APEAATDALARELCARLSALLGYDEDSDQVVPGTRIASLGLDSLS AVQLLSPYQKAGSAIKAHDLFRHETVADLAAAIG" aSDomain complement(9043..10254) /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcG_PKS_KS.1" /domain_subtype="Trans-AT-KS" /evalue="4.30E-125" /label="lkcG_PKS_KS.1" /locus_tag="lkcG" /protein_end="417" /protein_start="13" /score="409.7" /tool="antismash" /translation="VVGMACRFAGSDGLGEYWERLRLGRSALGTTGRWTEEEDAGSFTG GFLDGHQEFDARFFRISPNEAQCMDPQQRILLQTVQHAVDDGYLTAADLRDLDCGVFAA GLPGDYRTLVARRADLVYGTHSFLGNAPSTLSGRISYFYDVNGPSLTLDSACSSSLAAL HEAALNIRAGQCRAAIVGAVSVFSTPEVLRFAQRSRMSSPEGASLPFTDAADGFVPAEG AAALVVMRHDEARARGLRVYGAVQATGTNHNGTTNGLMAPSSKAQSRLIAELYDREKID ASQIAYLETHGTGTPLGDPIELEGLRSAFRRAGADGCHLGAVKPLIGHTLVASGLASVV KALLAFHHATIPPVAAAGEAVSYLDVAPFKVNREPLPWPEDKPLCAISAFGFTGSNGHV VLRRL" CDS_motif complement(9349..9396) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcG_0002" /evalue="3.80E-04" /label="PKSI-KS_m5" /locus_tag="lkcG" /protein_end="315" /protein_start="299" /score="12.6" /tool="antismash" /translation="YLETHGTGTPLGDPIE" CDS_motif complement(9769..9816) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcG_0001" /evalue="2.00E-05" /label="PKSI-KS_m3" /locus_tag="lkcG" /protein_end="175" /protein_start="159" /score="16.8" /tool="antismash" /translation="GPSLTLDSACSSSLAA" gene complement(10345..17385) /gene="lkcF" CDS complement(10345..17385) /NRPS_PKS="Domain: PKS_KR (200-369). E-value: 4.3e-40. Score: 129.4. Matches aSDomain: nrpspksdomains_lkcF_PKS_KR.1" /NRPS_PKS="Domain: ACP (455-526). E-value: 1.9e-12. Score: 39.2. Matches aSDomain: nrpspksdomains_lkcF_ACP.1" /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (606-1019). E-value: 1.7e-153. Score: 503.3. Matches aSDomain: nrpspksdomains_lkcF_PKS_KS.1" /NRPS_PKS="Domain: PKS_KR (1392-1573). E-value: 1.1e-55. Score: 180.2. Matches aSDomain: nrpspksdomains_lkcF_PKS_KR.2" /NRPS_PKS="Domain: PKS_PP (1647-1728). E-value: 4.9e-13. Score: 41.1. Matches aSDomain: nrpspksdomains_lkcF_PKS_PP.1" /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (1785-2191). E-value: 7.6e-144. Score: 471.5. Matches aSDomain: nrpspksdomains_lkcF_PKS_KS.2" /codon_start=1 /gene="lkcF" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: tra_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001:short-chain dehydrogenase/reductase SDR (Score: 58.2; E-value: 1.5e-17)" /gene_kind="biosynthetic" /note="ORF13 (2346 aa), lankacidin biosynthesis protein; similar to Z99113-15 Bacillus subtilis polyketide synthase, PksP (4930 aa)" /product="type I polyketide synthase LkcF" /protein_id="BAC76471.1" /sec_met_domain="PP-binding (E-value: 3.6e-13, bitscore: 39.9, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="tra_KS (E-value: 3.3e-171, bitscore: 559.7, seeds: 44, tool: rule-based-clusters)" /sec_met_domain="adh_short (E-value: 2.8e-44, bitscore: 141.2, seeds: 230, tool: rule-based-clusters)" /transl_table=11 /translation="MESLAPRYTDLAASDLPGAQAGATVVITDRQDIASAARSIGAECW HCDPATESDERIGRELGRYAARCTTLVVAWGDGHADGTPEYDAALRFARAGLALLQAVR GSGRPVRLVTLSRTGDTLPALLDGMARTAALECPLVHTAVEWSGTVTPRRLRAWIDAGA GRPGAVLRAEDDRIGLLEHTPRPLEGTGAREVFGDGDSVVVIGGAGGIGRQLCRYLSRH CGVRVFVLGRGTPGPRVREALKEAGVHSHLGAPADDPEALDGALRYLHDRFGPVKAVFN LAGVLDDCLLYHLTPDRLEHVLRPKVATGLNLAALTGPHRPGMVVHFSSLTSVTGNVGQ AAYAAANAFLDRLSAHRPDWYSINWGLWDTDGMRMPDDDGSGLRAMPPEQACDTLLRAL ATGTRQLVVYDGQPGLLATGTGAPDPSAPPRGAADAPAAGSRDGGPSADGLLVGTTRWL RELIVRHSGLRGLRDDENLLEQGLDSVGSIRVSRDIESCLGIAGSSRLSRAVLFEYPTV AALAAHLAETFAPELETFLTREDSPSPQPTAPPESAPPPESAASPEPVPAPAVRAAGTP PRPAGRQRASAPAAARSEDAPAADAYRPDDIAVIGMAGEFPGGADTEAFWQALLRGDDA VRVIPGDRWDWRENHSFAPDEPGTAYGRHGGFLDHALDFDPVFFNIAPLEARFMDPQER RFLQSVYHALEDAGYFARPTGDMGVFVAAMFGHYQDLTAADRVIGSSFAAIANRVSYAF DLHGPSIALDTMCSGGLTALHLAVRSIRAGDCALAVAGGVNLMTHPGKYRLLSEGRFLS PTGHCQAFGVEADGYVPGEGTAAVVLKPLSDALRDGDRVHAVIRATAVNSGGRTAGFTV PSERAQHRVIAAALAEAEIEPGAVTYVEAHGTGTRLGDPIEVRALSRAYGGPEQGRAYL GSVKSNIGHLESAAAMAGLVKVVKQLAHRTLAPTLHCTLENPDLHLADSRFALVKETLP WPKGSGPTRFAGLSSFGAGGANGHAIVQEFVAPPDTAPVPAFPCYFIALSGRDEAAVQR RADQLLAALRDAPDTASYLYGLSYTLCCARQHFRVRRGYWATSVAQLAERLEHAAGAAP AAPPADDAWAEAAAAYLAGERADFAALFPRPMLVDAPLYPFARERYVAETLDHANRPPA RTAPAAPQAGPAGDDTLLLTPVWRPHPAEEPAGAPPPCVLVLTDRGPRPPLPEPPAGLR LIRVTPGDTLVIEADRIELPEGDDTAARRALDHLTGDLGLDHLYWLDLRREVTAAAQLS FAKAVQGCRTPSTVLGVTRESEAAEARAWAGFLHGLAEENPHVRTVQARRAGDGPALAD GWGPLLDELRAARRPLTEVRWADGTRYTRELTELRLADGQRAGVRLRTGGTYLVTGGLG KVGRAITELLAERYRATVIAVGRSAPDAAQRQWIAGTPGLHYEQADVTSAARTRELVDT VRARFGGIDGVVHCAGVVRDALVQNKSAGDAEAVLAPKLRGTLNLDRCTADLPLDFFCV FSSISSVMGNTGQSDYIAANRFLDEFAAERARRVAAGERGGLSLSVNWPLWLDAEDERR EQYQALAAFLRGQFGMEPLSARRGAQLFLDLVDGLPATCHQVVPCVGDLARMRQRLLPG AAPAAARPAPRPGATQEELGARLLELVRAQTGLSAEDIAFDSRWGDLGYDSVMLQHLAR RLGPEFGVETPPNALFKYSSIASLSAYLRDQGAAGAPDTPGEDAAGAPQGPDRDAPDTP AAPDQGRAPAVPRPAPSGTAERSTGRGRYAVVGMSGIMPAGENLADFWRLLVENGSAIR PVERWKNRDRQYFAGTIDDHDAFDHSFFGLSAREAMLMDPQHRLFLQSAYNALLDAGYA PGSLREVGVFAGVQFSEYQTALQHSEDRAHPYTVTGNAHAMLANRVSHLLDFTGPSQTV DTACSSGLVALNRGVLSLAAGECDVALVGAVSVLVDPAATDAASELGVLSPDFRCATFD KDANGYVRAEGVGCVVVKRLDDARRDGDAVLAVIEAVAENHDGRSNSLTAPNPDAQVAL LNRVYTPELAERVSHIEAHGTGTNLGDPIEIGALRTAFGRLAPHREPGSITLGAVKTNV GHLEPAAGMAGLLKLLLCLRHRRLPANINFKELNPLVELAGSPFRLLLENEPWERGTPL VAGVSSFGFGGSNAHAVLSEAPAPASGPAASRPYWLIALSARSRASLTAMRDGLLEWLD GPEGRHAELGDIAHTLAVGRDHFEYRLAWVVSDTAELRRRLAQARPEEAAKCRSRRLTT HPVRLPAPTDPGHRAALDEVRARYAEGEEFAWESMFEGERFARLHLPGYAFEKNRFWFE " aSDomain complement(10813..12030) /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcF_PKS_KS.2" /domain_subtype="Trans-AT-KS" /evalue="7.60E-144" /label="lkcF_PKS_KS.2" /locus_tag="lkcF" /protein_end="2191" /protein_start="1785" /score="471.5" /tool="antismash" /translation="AVVGMSGIMPAGENLADFWRLLVENGSAIRPVERWKNRDRQYFAG TIDDHDAFDHSFFGLSAREAMLMDPQHRLFLQSAYNALLDAGYAPGSLREVGVFAGVQF SEYQTALQHSEDRAHPYTVTGNAHAMLANRVSHLLDFTGPSQTVDTACSSGLVALNRGV LSLAAGECDVALVGAVSVLVDPAATDAASELGVLSPDFRCATFDKDANGYVRAEGVGCV VVKRLDDARRDGDAVLAVIEAVAENHDGRSNSLTAPNPDAQVALLNRVYTPELAERVSH IEAHGTGTNLGDPIEIGALRTAFGRLAPHREPGSITLGAVKTNVGHLEPAAGMAGLLKL LLCLRHRRLPANINFKELNPLVELAGSPFRLLLENEPWERGTPLVAGVSSFGFGGSNAH AVLSEAP" CDS_motif complement(11032..11076) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0012" /evalue="7.80E-03" /label="PKSI-KS_m6" /locus_tag="lkcF" /protein_end="2118" /protein_start="2103" /score="9.2" /tool="antismash" /translation="GAVKTNVGHLEPAAG" CDS_motif complement(11143..11187) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0011" /evalue="6.40E-04" /label="PKSI-KS_m5" /locus_tag="lkcF" /protein_end="2081" /protein_start="2066" /score="12.1" /tool="antismash" /translation="IEAHGTGTNLGDPIE" CDS_motif complement(11377..11415) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0010" /evalue="2.60E-04" /label="PKSI-KS_m4" /locus_tag="lkcF" /protein_end="2003" /protein_start="1990" /score="14.0" /tool="antismash" /translation="FDKDANGYVRAEG" CDS_motif complement(11557..11604) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0009" /evalue="8.30E-06" /label="PKSI-KS_m3" /locus_tag="lkcF" /protein_end="1943" /protein_start="1927" /score="17.9" /tool="antismash" /translation="GPSQTVDTACSSGLVA" aSDomain complement(12202..12444) /aSDomain="PKS_PP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcF_PKS_PP.1" /evalue="4.90E-13" /label="lkcF_PKS_PP.1" /locus_tag="lkcF" /protein_end="1728" /protein_start="1647" /score="41.1" /tool="antismash" /translation="PRPGATQEELGARLLELVRAQTGLSAEDIAFDSRWGDLGYDSVML QHLARRLGPEFGVETPPNALFKYSSIASLSAYLRDQ" aSModule 12202..15567 /complete /domains="nrpspksdomains_lkcF_PKS_KS.1" /domains="nrpspksdomains_lkcF_PKS_KR.2" /domains="nrpspksdomains_lkcF_PKS_PP.1" /locus_tags="lkcF" /tool="antismash" /type="pks" aSDomain complement(12667..13209) /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcF_PKS_KR.2" /evalue="1.10E-55" /label="lkcF_PKS_KR.2" /locus_tag="lkcF" /protein_end="1573" /protein_start="1392" /score="180.2" /tool="antismash" /translation="GTYLVTGGLGKVGRAITELLAERYRATVIAVGRSAPDAAQRQWIA GTPGLHYEQADVTSAARTRELVDTVRARFGGIDGVVHCAGVVRDALVQNKSAGDAEAVL APKLRGTLNLDRCTADLPLDFFCVFSSISSVMGNTGQSDYIAANRFLDEFAAERARRVA AGERGGLSLSVNWPLWLD" CDS_motif complement(12736..12843) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0008" /evalue="1.40E-18" /label="PKSI-KR_m4" /locus_tag="lkcF" /protein_end="1550" /protein_start="1514" /score="59.4" /tool="antismash" /translation="LDFFCVFSSISSVMGNTGQSDYIAANRFLDEFAAER" CDS_motif complement(13108..13206) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0007" /evalue="2.30E-10" /label="PKSI-KR_m1" /locus_tag="lkcF" /protein_end="1426" /protein_start="1393" /score="33.1" /tool="antismash" /translation="TYLVTGGLGKVGRAITELLAERYRATVIAVGRS" aSDomain complement(14329..15567) /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcF_PKS_KS.1" /domain_subtype="Trans-AT-KS" /evalue="1.70E-153" /label="lkcF_PKS_KS.1" /locus_tag="lkcF" /protein_end="1019" /protein_start="606" /score="503.3" /tool="antismash" /translation="IAVIGMAGEFPGGADTEAFWQALLRGDDAVRVIPGDRWDWRENHS FAPDEPGTAYGRHGGFLDHALDFDPVFFNIAPLEARFMDPQERRFLQSVYHALEDAGYF ARPTGDMGVFVAAMFGHYQDLTAADRVIGSSFAAIANRVSYAFDLHGPSIALDTMCSGG LTALHLAVRSIRAGDCALAVAGGVNLMTHPGKYRLLSEGRFLSPTGHCQAFGVEADGYV PGEGTAAVVLKPLSDALRDGDRVHAVIRATAVNSGGRTAGFTVPSERAQHRVIAAALAE AEIEPGAVTYVEAHGTGTRLGDPIEVRALSRAYGGPEQGRAYLGSVKSNIGHLESAAAM AGLVKVVKQLAHRTLAPTLHCTLENPDLHLADSRFALVKETLPWPKGSGPTRFAGLSSF GAGGANGHAIVQEF" CDS_motif complement(14554..14595) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0006" /evalue="1.80E-03" /label="PKSI-KS_m6" /locus_tag="lkcF" /protein_end="944" /protein_start="930" /score="10.9" /tool="antismash" /translation="GSVKSNIGHLESAA" CDS_motif complement(14650..14697) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0005" /evalue="1.60E-04" /label="PKSI-KS_m5" /locus_tag="lkcF" /protein_end="912" /protein_start="896" /score="13.6" /tool="antismash" /translation="YVEAHGTGTRLGDPIE" CDS_motif complement(14890..14928) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0004" /evalue="2.30E-02" /label="PKSI-KS_m4" /locus_tag="lkcF" /protein_end="832" /protein_start="819" /score="8.3" /tool="antismash" /translation="FGVEADGYVPGEG" CDS_motif complement(15070..15117) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0003" /evalue="1.00E-03" /label="PKSI-KS_m3" /locus_tag="lkcF" /protein_end="772" /protein_start="756" /score="11.7" /tool="antismash" /translation="GPSIALDTMCSGGLTA" aSDomain complement(15808..16020) /aSDomain="ACP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcF_ACP.1" /evalue="1.90E-12" /label="lkcF_ACP.1" /locus_tag="lkcF" /protein_end="526" /protein_start="455" /score="39.2" /tool="antismash" /translation="RWLRELIVRHSGLRGLRDDENLLEQGLDSVGSIRVSRDIESCLGI AGSSRLSRAVLFEYPTVAALAAHLAE" aSModule 15808..16785 /domains="nrpspksdomains_lkcF_PKS_KR.1" /domains="nrpspksdomains_lkcF_ACP.1" /incomplete /locus_tags="lkcF" /tool="antismash" /type="pks" aSDomain complement(16279..16785) /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcF_PKS_KR.1" /evalue="4.30E-40" /label="lkcF_PKS_KR.1" /locus_tag="lkcF" /protein_end="369" /protein_start="200" /score="129.4" /tool="antismash" /translation="SVVVIGGAGGIGRQLCRYLSRHCGVRVFVLGRGTPGPRVREALKE AGVHSHLGAPADDPEALDGALRYLHDRFGPVKAVFNLAGVLDDCLLYHLTPDRLEHVLR PKVATGLNLAALTGPHRPGMVVHFSSLTSVTGNVGQAAYAAANAFLDRLSAHRPDWYSI NWGLWD" CDS_motif complement(16315..16413) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0002" /evalue="3.70E-16" /label="PKSI-KR_m4" /locus_tag="lkcF" /protein_end="357" /protein_start="324" /score="51.6" /tool="antismash" /translation="VVHFSSLTSVTGNVGQAAYAAANAFLDRLSAHR" CDS_motif complement(16690..16785) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcF_0001" /evalue="9.10E-06" /label="PKSI-KR_m1" /locus_tag="lkcF" /protein_end="232" /protein_start="200" /score="18.3" /tool="antismash" /translation="SVVVIGGAGGIGRQLCRYLSRHCGVRVFVLGR" gene complement(17438..18754) /gene="lkcE" CDS complement(17438..18754) /codon_start=1 /gene="lkcE" /note="ORF14 (438 aa), lankacidin biosynthesis protein; similar to AE004192-10 Vibrio cholerae conserved hypothetical protein (426 aa)" /product="amine oxidase LkcE" /protein_id="BAC76472.1" /transl_table=11 /translation="MTVVEAKSRIAVVGGGGSGSVAAWLLARRHDVTLFEADEYLGGHA YSHPVETDRGTLHVDMGVEHFNEKLSPNLFRLLTDFGIGTYVAPSSVHVDFPGEQQSWN NLDFLGELREELHEEFDRFHQEMNQLPTSGDDSYKQMSIGEYLDKHGYSKSFKYKAMNP ILSIYSGCHAPSLDYNLMYVALSFSMNLLSFFSAGYWRKAQGGIHSYLARIESDLGERV RLNTPVEAVVPTQSGVTVLAGGQEHHFDQVVFATHADVTLRLLRTSDQQYRDLLGDFAY VPVESVLHQDESWLSPAGGGAYCQFRMPEGFELARAEEQMGSLTRNCNVLHPYRKVSSP ILITFDPQEDVDPERVIVRREWKLPQLRPVDVRRKKRLHEIQGLNGLWFCGTDTSVTGH EGAIVSGMVIADRLGVPHPFPDDALAAAQFRGIKEFMGV" gene complement(18754..19635) /gene="lkcD" CDS complement(18754..19635) /NRPS_PKS="Domain: PKS_AT (6-285). E-value: 1.3e-57. Score: 187.2. Matches aSDomain: nrpspksdomains_lkcD_PKS_AT.1" /codon_start=1 /gene="lkcD" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: PKS_AT" /gene_functions="biosynthetic-additional (smcogs) SMCOG1021:malonyl CoA-acyl carrier protein transacylase (Score: 319.6; E-value: 7.2e-97)" /gene_kind="biosynthetic" /note="ORF15 (293 aa), lankacidin biosynthesis protein; similar to Z99113-3 Bacillus subtilis PksC protein (288 aa)" /product="acyltransferase LkcD" /protein_id="BAC76473.1" /sec_met_domain="PKS_AT (E-value: 3.6e-58, bitscore: 187.2, seeds: 1682, tool: rule-based-clusters)" /transl_table=11 /translation="MAGDVVMFPGQGSQRIGMGKEVFDAYPQLCDRADEIVGHSLRELC LKDPDGRLNETSRTQEAVYFVSCLMYLAYAEEHGAEQVRCLTGHSLGLYPALFAAGVFD LFEGLEIVSRRGALMQEARDGAMVAVLGPRASEIDDHLARLEFFDVDVANYNSPEQVVL SALKPRLEELVPRLEETGHRCVWLPVSGAFHSRHMEPARLRFAQFLRDRTFTPPTKPVV STTSGRTLGARHLLEEMVFQLVKPVRWWQTVTHLSRTGHKTFDEVGPGRVLTKLSAEIL GDEPSPQAEPRK" aSDomain complement(18781..19617) /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcD_PKS_AT.1" /evalue="1.30E-57" /label="lkcD_PKS_AT.1" /locus_tag="lkcD" /protein_end="285" /protein_start="6" /score="187.2" /tool="antismash" /translation="MFPGQGSQRIGMGKEVFDAYPQLCDRADEIVGHSLRELCLKDPDG RLNETSRTQEAVYFVSCLMYLAYAEEHGAEQVRCLTGHSLGLYPALFAAGVFDLFEGLE IVSRRGALMQEARDGAMVAVLGPRASEIDDHLARLEFFDVDVANYNSPEQVVLSALKPR LEELVPRLEETGHRCVWLPVSGAFHSRHMEPARLRFAQFLRDRTFTPPTKPVVSTTSGR TLGARHLLEEMVFQLVKPVRWWQTVTHLSRTGHKTFDEVGPGRVLTKLSAEILGDEP" CDS_motif complement(19276..19377) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcD_0002" /evalue="1.50E-11" /label="PKSI-AT-M_m3" /locus_tag="lkcD" /protein_end="120" /protein_start="86" /score="36.3" /tool="antismash" /translation="TGHSLGLYPALFAAGVFDLFEGLEIVSRRGALMQ" CDS_motif complement(19570..19623) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcD_0001" /evalue="1.20E-06" /label="PKSI-AT-mM_m1" /locus_tag="lkcD" /protein_end="22" /protein_start="4" /score="20.7" /tool="antismash" /translation="VVMFPGQGSQRIGMGKEV" gene complement(19647..25235) /gene="lkcC" CDS complement(19647..25235) /NRPS_PKS="Domain: PKS_KR (231-406). E-value: 8.7e-44. Score: 141.4. Matches aSDomain: nrpspksdomains_lkcC_PKS_KR.1" /NRPS_PKS="Domain: cMT (590-780). E-value: 1.9e-80. Score: 262.0. Matches aSDomain: nrpspksdomains_lkcC_cMT.1" /NRPS_PKS="Domain: ACP (821-889). E-value: 1.1e-16. Score: 52.8. Matches aSDomain: nrpspksdomains_lkcC_ACP.1" /NRPS_PKS="Domain: ACP (926-994). E-value: 1.1e-16. Score: 52.8. Matches aSDomain: nrpspksdomains_lkcC_ACP.2" /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (1043-1453). E-value: 4.2e-156. Score: 511.9. Matches aSDomain: nrpspksdomains_lkcC_PKS_KS.1" /codon_start=1 /gene="lkcC" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: tra_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (smcogs) SMCOG1047:phosphopantetheine-binding domain-containing protein (Score: 39.2; E-value: 1.1e-11)" /gene_kind="biosynthetic" /note="ORF16 (1862 aa), lankacidin biosynthesis protein; similar to AF239749 Xanthomonas albilineans albicidin multifunctional polyketide-peptide synthase (4801 aa)" /product="type I polyketide synthase LkcC" /protein_id="BAC76474.1" /sec_met_domain="PP-binding (E-value: 9.5e-11, bitscore: 32.2, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="tra_KS (E-value: 2.9e-171, bitscore: 559.9, seeds: 44, tool: rule-based-clusters)" /sec_met_domain="adh_short (E-value: 5e-40, bitscore: 127.3, seeds: 230, tool: rule-based-clusters)" /transl_table=11 /translation="MSRNEWRSGDSASGTARPDVPLVRRAAVDSMVFAPQWTHGRLERP RTGGDGPRTFLVPPGQHRLHQELTEQCPDSRVLLLDDAAIASLAAAPAADEHLVFVSRT SWADGIRDADLTAFLGLVHALDRWPRVRLDVFTDKAVPSPLFTAATHPVDGVYVGLAQA LAKERPDWSVRCFCLADLTAAALSEALERPLPTVPDKPVCVRGDEYAVASMEPASLPAW PARSAFRTGGTYVIVGGTGGLGGLLAEYLAAVHRAEVVVIGRRPAEDFAPAAQALREAG ARAVHYHQADLADGPALKRALDAHEVVHGVVHSALVLEDSALATMSERVLHDVLRPKLH GTRHLIEALRGRDLDFCLFFSSVQAYIASAGQGNYAAACVAKDACADLLDHALLIDAKV VNWGYWGGIGVVAKPEYRARMEGLGIGSIEPAEGLAVIERFLASEHRRITCVKGTEEAL ERMGITPHKPAATVSSADSATVLDDVVPAFRDEDTDVAHNRDLAERLEAYTRWRLAQVP LPATAIAKYAKLREAIAAMPPAHSLPLDELLRRYPELEGHCKLLDRCLKHLPDVLSGAT DAVEVLFPDGSFELVAPVYQSNPIADYFNRICARVVAAYQRRSAGRPLRVLEIGAGTGS TTGFVLPELDPHGVDYHFTDLSYAFLHKARDAFGADYPFLTYEICDIENPPEDYTGRFD VVVATNVLHATSNVPGTLRNVRKALREGGILVLNEITARQDYATLTFGLTDGWWLSNDP YRIEHSPLLSSDQWRSLMHEAGFGAVRPHGGDGQQVLVALAGPADEPSAAVPAPEAAGA VGVRGAVEGFVREVIAGTMRLDVSEVECDRPFRDMGIDSLISMELLKPLRERVGYVPAT VWFEYPTVDRLVEFLVTEYADAVAESFGAATATATAAVPASEAAGAVGVRGAVEGFVRE VIAGTMRLDVSEVECDRPFRDMGIDSLISMELLKPLRERVGYVPATVWFEYPTVDRLVE FLVTEYADAVAESFGATAATATAEEPVRPEQTEATAPAGQTALNQGEFAPRPGDIAVVG IAARLPQASDVRQFWENLLDGLDCTSTVPPERFATRLTDGAAPLSYTDRGAFVDDIDAF DHTFFGLTPHDAARMDPQERLVLEQTYLAMLDAGYSRARLAGSDTGVFVGVMNGGYAWH TTTEPGAQPPTSAFWSMANRASYHFDWHGPSMAVDTACSASLTALHLACQSLRTGECDR AVVSGVNLITHPRQYQLLCGLEMLSRAGECRPFGSGADGFVDGEGVISLMLRPAEDALR DGDRVYAVISGSAVNAGGRANGYTAPNPEAQSALVAKALAAARTSPEEVGYVEAHGTGT ALGDPIELRSLAKAYAAAGTGRIRLGSVKSNIGHLESAAGLSGVLKAVLQMRHGSLVPS LHAEPPNPHLDFDATPFTLAARTERWPADLPLVSAVSSYGAGGANAHVVLRGVPEPPAP AANATPRRDRYVIPLSHHTAAGLQLAMDGLREWLSGRRVDMDALAYTLACCRDSFAHRV AIVCRDQDELVRALERDLPRRPRRRTAPAPAAAELTSRTAEDIAALYESGGTPDWDRYY PRTTPVELPAYPFLRHRHWVDSAESGFRSLATLVSAHRIDGVAMAPAAWTLAVLADRAE GRALGNVLWQKPITDPGALEVRERGGEMSLVDRVTGDVYCTAEAGAPTPVGNPPDLPAA TRRQSRTEIYDAFRRLGYDYGEPLRGVRWAEVGPDTVRAFLHVDHDWGYGLSPALLDCG MQLSILLAAERTPDAPVFVPCHLGRLTVVRAPRTEAVYCHCVTRPGGSSPRTRTYDFFF TDENGDVLVALEEAVSVAIDGSAPAATRHGAPAPAPAAAPFTVLELN" aSDomain complement(20877..22106) /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcC_PKS_KS.1" /domain_subtype="Trans-AT-KS" /evalue="4.20E-156" /label="lkcC_PKS_KS.1" /locus_tag="lkcC" /protein_end="1453" /protein_start="1043" /score="511.9" /tool="antismash" /translation="IAVVGIAARLPQASDVRQFWENLLDGLDCTSTVPPERFATRLTDG AAPLSYTDRGAFVDDIDAFDHTFFGLTPHDAARMDPQERLVLEQTYLAMLDAGYSRARL AGSDTGVFVGVMNGGYAWHTTTEPGAQPPTSAFWSMANRASYHFDWHGPSMAVDTACSA SLTALHLACQSLRTGECDRAVVSGVNLITHPRQYQLLCGLEMLSRAGECRPFGSGADGF VDGEGVISLMLRPAEDALRDGDRVYAVISGSAVNAGGRANGYTAPNPEAQSALVAKALA AARTSPEEVGYVEAHGTGTALGDPIELRSLAKAYAAAGTGRIRLGSVKSNIGHLESAAG LSGVLKAVLQMRHGSLVPSLHAEPPNPHLDFDATPFTLAARTERWPADLPLVSAVSSYG AGGANAHVVLR" CDS_motif complement(21087..21131) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcC_0005" /evalue="4.30E-04" /label="PKSI-KS_m6" /locus_tag="lkcC" /protein_end="1383" /protein_start="1368" /score="12.6" /tool="antismash" /translation="GSVKSNIGHLESAAG" CDS_motif complement(21186..21233) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcC_0004" /evalue="1.40E-04" /label="PKSI-KS_m5" /locus_tag="lkcC" /protein_end="1350" /protein_start="1334" /score="13.8" /tool="antismash" /translation="YVEAHGTGTALGDPIE" CDS_motif complement(21606..21653) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcC_0003" /evalue="6.80E-06" /label="PKSI-KS_m3" /locus_tag="lkcC" /protein_end="1210" /protein_start="1194" /score="18.1" /tool="antismash" /translation="GPSMAVDTACSASLTA" aSDomain complement(22254..22457) /aSDomain="ACP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcC_ACP.2" /evalue="1.10E-16" /label="lkcC_ACP.2" /locus_tag="lkcC" /protein_end="994" /protein_start="926" /score="52.8" /tool="antismash" /translation="FVREVIAGTMRLDVSEVECDRPFRDMGIDSLISMELLKPLRERVG YVPATVWFEYPTVDRLVEFLVTE" aSDomain complement(22569..22772) /aSDomain="ACP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcC_ACP.1" /evalue="1.10E-16" /label="lkcC_ACP.1" /locus_tag="lkcC" /protein_end="889" /protein_start="821" /score="52.8" /tool="antismash" /translation="FVREVIAGTMRLDVSEVECDRPFRDMGIDSLISMELLKPLRERVG YVPATVWFEYPTVDRLVEFLVTE" aSModule 22569..24542 /domains="nrpspksdomains_lkcC_PKS_KR.1" /domains="nrpspksdomains_lkcC_cMT.1" /domains="nrpspksdomains_lkcC_ACP.1" /incomplete /locus_tags="lkcC" /tool="antismash" /type="pks" aSDomain complement(22896..23465) /aSDomain="MT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcC_cMT.1" /domain_subtype="cMT" /evalue="1.90E-80" /label="lkcC_cMT.1" /locus_tag="lkcC" /protein_end="780" /protein_start="590" /score="262.0" /tool="antismash" /translation="VAPVYQSNPIADYFNRICARVVAAYQRRSAGRPLRVLEIGAGTGS TTGFVLPELDPHGVDYHFTDLSYAFLHKARDAFGADYPFLTYEICDIENPPEDYTGRFD VVVATNVLHATSNVPGTLRNVRKALREGGILVLNEITARQDYATLTFGLTDGWWLSNDP YRIEHSPLLSSDQWRSLMHEAGFGAVR" aSDomain complement(24018..24542) /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcC_PKS_KR.1" /evalue="8.70E-44" /label="lkcC_PKS_KR.1" /locus_tag="lkcC" /protein_end="406" /protein_start="231" /score="141.4" /tool="antismash" /translation="GTYVIVGGTGGLGGLLAEYLAAVHRAEVVVIGRRPAEDFAPAAQA LREAGARAVHYHQADLADGPALKRALDAHEVVHGVVHSALVLEDSALATMSERVLHDVL RPKLHGTRHLIEALRGRDLDFCLFFSSVQAYIASAGQGNYAAACVAKDACADLLDHALL IDAKVVNWGYWG" CDS_motif complement(24078..24176) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcC_0002" /evalue="6.70E-10" /label="PKSI-KR_m4" /locus_tag="lkcC" /protein_end="386" /protein_start="353" /score="31.5" /tool="antismash" /translation="LDFCLFFSSVQAYIASAGQGNYAAACVAKDACA" CDS_motif complement(24441..24539) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcC_0001" /evalue="1.10E-08" /label="PKSI-KR_m1" /locus_tag="lkcC" /protein_end="265" /protein_start="232" /score="27.7" /tool="antismash" /translation="TYVIVGGTGGLGGLLAEYLAAVHRAEVVVIGRR" gene complement(25265..26095) /gene="lkcB" CDS complement(25265..26095) /NRPS_PKS="Domain: PKS_DH (31-170). E-value: 2.3e-17. Score: 55.7. Matches aSDomain: nrpspksdomains_lkcB_PKS_DH.1" /codon_start=1 /gene="lkcB" /note="ORF17 (276 aa), lankacidin biosynthesis protein; similar to Z99113-15 Bacillus subtilis PksP protein (4930 aa)" /product="dehydratase LkcB" /protein_id="BAC76475.1" /transl_table=11 /translation="MTTRADQTAGPAAVEPPRLLDTGEPDTFRVPVETGHPYLAQHLVQ GRRVLPGVACLEMALRGAARVRPGARPFAVRDAAWLRPVYGDEPLDELSVAFRTAPGAR ETDYTVTNRGALCAMGTLLFEPQDRAVAVGLEVRDEICAHTRSHLTRAEIYEEFSNMGI DYGPYFRRNSYVQRHGQRSLAWLSHNDGTRIGLVNLLDCAFQSGMAISIGEHRDSLMPF SMGHMVFHAPTRFPLGSAFVLTEKLSPFRTNFTLFDEDYEPLLSVFDLGVKPAL" aSDomain complement(25586..26002) /aSDomain="PKS_DH" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcB_PKS_DH.1" /evalue="2.30E-17" /label="lkcB_PKS_DH.1" /locus_tag="lkcB" /protein_end="170" /protein_start="31" /score="55.7" /tool="antismash" /translation="VETGHPYLAQHLVQGRRVLPGVACLEMALRGAARVRPGARPFAVR DAAWLRPVYGDEPLDELSVAFRTAPGARETDYTVTNRGALCAMGTLLFEPQDRAVAVGL EVRDEICAHTRSHLTRAEIYEEFSNMGIDYGPYFR" CDS_motif complement(25910..25984) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcB_0001" /evalue="2.00E-09" /label="PKSI-DH_m2" /locus_tag="lkcB" /protein_end="62" /protein_start="37" /score="29.9" /tool="antismash" /translation="YLAQHLVQGRRVLPGVACLEMALRG" gene complement(26092..30960) /gene="lkcA" CDS complement(26092..30960) /NRPS_PKS="Domain: Condensation_LCL (5-251). E-value: 6.2e-13. Score: 40.3. Matches aSDomain: nrpspksdomains_lkcA_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (439-830). E-value: 7.4e-78. Score: 253.7. Matches aSDomain: nrpspksdomains_lkcA_AMP-binding.1" /NRPS_PKS="Domain: PKS_PP (956-1033). E-value: 1.4e-08. Score: 26.8. Matches aSDomain: nrpspksdomains_lkcA_PKS_PP.1" /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (1065-1471). E-value: 6.5e-143. Score: 468.5. Matches aSDomain: nrpspksdomains_lkcA_PKS_KS.1" /codon_start=1 /gene="lkcA" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: tra_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS: PP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002:AMP-dependent synthetase and ligase (Score: 273.9; E-value: 3.5e-83)" /gene_kind="biosynthetic" /note="ORF18 (1622 aa), lankacidin biosynthesis protein; similar to Z99113-11 Bacillus subtilis PksK protein (4447 aa)" /product="multifunctional polyketide-peptide synthase LkcA" /protein_id="BAC76476.1" /sec_met_domain="Condensation (E-value: 6.1e-10, bitscore: 28.5, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 1.3e-80, bitscore: 260.9, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 4.8e-09, bitscore: 26.7, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="tra_KS (E-value: 3.4e-153, bitscore: 500.4, seeds: 44, tool: rule-based-clusters)" /transl_table=11 /translation="MTERQASAYERFQWYRYQRNPDDPGLTVGYVYALTGEVDTDRLED ALREVVSTAFPRLLDYFTEVGGELIAKSRPLPRRILRRCERQDVLLDSGGIDPTGQELF RFRYCRVSPQKLLLRLDFSHVVFDGGCYAPFCAALSACWEGETPVLERQFGAAPRSGDG ADAAYWRSMLAGRPLHQPLPFSAAEPRRDGRRISVKETITGDQAEDIHRFLRRHELSLL QFVVGVTGALVHAYGDDDERGVVVAHTVDTRPYGAPYGCHTNLLPLWLDVRAERDALSL LEQVRAQRENLRDHQGFPVSDLLALAAGEHGRTVDQGGSALNLVVNASSAMLPTAVPRL SGLDVSWVRKPDTGSSSDLSVNFSSDEQGIHLSFDSATHVLSPEALSALAANFLRMARF VAADPHRPTAQCDLSRPLEPVAEGAVPAAGTGEGLGAALVRTARQNPDRVAVVDDHRSL TYGELLDAAHRLGQDLFGDATPARPGTAPVGVFLERSAAIPVAYLTALALRRTFVPMDP RLPDARLAYMAAAAEPGVILVDAATRDRAARLFPGIPRREVDGAPAPSAGPHRAGIRPS TPADGDRTAYVMFTSGSTGNPKGVAVSEGNLANFLHSVRQDPSMGPDDRIVALTPIGFD ISLLEILLPLLCGARLRMLSDETRSSGALLAEHIDAAGATVVQATPSTWRILKAAGWRA RRPMTLLCGGEALDRDLAEYLLSQSAAVYNMYGPTEATIWASWQRVTGAGHIHLGEPAL GTRFYVVDADGRSVAPGMAGELMIAGDCVAQGYLNAPATAFGSLPDGTPSYRTGDLVRY EGPARVTYVSRKDGQRKVNGHRIELDEVAAAVTARVPSATVVAVVRPEPEPHLRCFVWL PAGESFDAAAVRERLRDTLPYYMVPQAVHRLTRIPLTANGKTDVRKLSEAPLSALDLYP QDEASERPADAARAAVDTGAAGGPDTGAADGPDLLGELRRLVAAELGLPEPDADRPLGY QGVTSLGYNILAARIGERYGITVHAHDFYRMNTLRNVAETVARLSEGRTGERPEARPAT APRPGPADGRPGADGRLAIVGLSAVLPGGPDPDAFWQTLLDGRDCVTPAPAGRGLPGEF AGFLPGVRGFDARFFSISPREASWMDPRQRLLLQSAWHTLEDAGYAPSDLSGSRTGCYI AATGNDYALLQARADARQIPYSLVGHSLSLIANRVSSWFDWHGPSAVLDTACSGSLVAL VRACRDLRAGVCDAALVGGVNLILDSQINEGLHAARFLSPEHRCATFDAAADGYVRGEG YGTFLVKRLADALADGDDIRAVVESVAENHGGRANSLTAPNPNAQYRLLLDAYTPELAA RTGYIETHGTGTALGDAIEIDALKRAWRHLVPRSAGGRVRLGAVKSHIGHLEPAAGVAS LTKVVKAFEHRTLPANLHFQDPNPGIALEEGPFEAVRKTVPWGEDGGELVAGISSFGFG GSNAHVVLSAPPGRAARRPVSPRPRLVPLSARTPQALRRLTAALLDRVERSGPLSDHDL LDLSYTLCRREHLPCRLAWCPSSGEELLRALRTAGEPRHAPRTEREGGVWQATPESARD RFLAGGPVDTQALFAADAPRRLRLPGYPFEETDLWFTDEERTA" aSDomain complement(26548..27765) /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcA_PKS_KS.1" /domain_subtype="Trans-AT-KS" /evalue="6.50E-143" /label="lkcA_PKS_KS.1" /locus_tag="lkcA" /protein_end="1471" /protein_start="1065" /score="468.5" /tool="antismash" /translation="AIVGLSAVLPGGPDPDAFWQTLLDGRDCVTPAPAGRGLPGEFAGF LPGVRGFDARFFSISPREASWMDPRQRLLLQSAWHTLEDAGYAPSDLSGSRTGCYIAAT GNDYALLQARADARQIPYSLVGHSLSLIANRVSSWFDWHGPSAVLDTACSGSLVALVRA CRDLRAGVCDAALVGGVNLILDSQINEGLHAARFLSPEHRCATFDAAADGYVRGEGYGT FLVKRLADALADGDDIRAVVESVAENHGGRANSLTAPNPNAQYRLLLDAYTPELAARTG YIETHGTGTALGDAIEIDALKRAWRHLVPRSAGGRVRLGAVKSHIGHLEPAAGVASLTK VVKAFEHRTLPANLHFQDPNPGIALEEGPFEAVRKTVPWGEDGGELVAGISSFGFGGSN AHVVLSA" CDS_motif complement(26875..26922) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcA_0007" /evalue="7.80E-04" /label="PKSI-KS_m5" /locus_tag="lkcA" /protein_end="1362" /protein_start="1346" /score="11.8" /tool="antismash" /translation="YIETHGTGTALGDAIE" CDS_motif complement(27109..27147) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcA_0006" /evalue="8.10E-05" /label="PKSI-KS_m4" /locus_tag="lkcA" /protein_end="1284" /protein_start="1271" /score="15.5" /tool="antismash" /translation="FDAAADGYVRGEG" CDS_motif complement(27289..27336) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcA_0005" /evalue="5.50E-05" /label="PKSI-KS_m3" /locus_tag="lkcA" /protein_end="1224" /protein_start="1208" /score="15.5" /tool="antismash" /translation="GPSAVLDTACSGSLVA" aSDomain complement(27862..28092) /aSDomain="PKS_PP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcA_PKS_PP.1" /evalue="1.40E-08" /label="lkcA_PKS_PP.1" /locus_tag="lkcA" /protein_end="1033" /protein_start="956" /score="26.8" /tool="antismash" /translation="GAADGPDLLGELRRLVAAELGLPEPDADRPLGYQGVTSLGYNILA ARIGERYGITVHAHDFYRMNTLRNVAETVARL" aSModule 27862..30945 /complete /domains="nrpspksdomains_lkcA_Condensation_LCL.1" /domains="nrpspksdomains_lkcA_AMP-binding.1" /domains="nrpspksdomains_lkcA_PKS_PP.1" /locus_tags="lkcA" /tool="antismash" /type="nrps" CDS_motif complement(28441..28503) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcA_0004" /evalue="2.20E-07" /label="NRPS-A_a8" /locus_tag="lkcA" /protein_end="840" /protein_start="819" /score="23.3" /tool="antismash" /translation="YVSRKDGQRKVNGHRIELDEV" aSDomain complement(28471..29643) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcA_AMP-binding.1" /evalue="7.40E-78" /label="lkcA_AMP-binding.1" /locus_tag="lkcA" /protein_end="830" /protein_start="439" /score="253.7" /tool="antismash" /translation="RTARQNPDRVAVVDDHRSLTYGELLDAAHRLGQDLFGDATPARPG TAPVGVFLERSAAIPVAYLTALALRRTFVPMDPRLPDARLAYMAAAAEPGVILVDAATR DRAARLFPGIPRREVDGAPAPSAGPHRAGIRPSTPADGDRTAYVMFTSGSTGNPKGVAV SEGNLANFLHSVRQDPSMGPDDRIVALTPIGFDISLLEILLPLLCGARLRMLSDETRSS GALLAEHIDAAGATVVQATPSTWRILKAAGWRARRPMTLLCGGEALDRDLAEYLLSQSA AVYNMYGPTEATIWASWQRVTGAGHIHLGEPALGTRFYVVDADGRSVAPGMAGELMIAG DCVAQGYLNAPATAFGSLPDGTPSYRTGDLVRYEGPARVTYVSRKDGQRKV" CDS_motif complement(28588..28656) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcA_0003" /evalue="4.20E-09" /label="NRPS-A_a6" /locus_tag="lkcA" /protein_end="791" /protein_start="768" /score="28.7" /tool="antismash" /translation="PGMAGELMIAGDCVAQGYLNAPA" CDS_motif complement(29152..29208) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcA_0002" /evalue="6.00E-09" /label="NRPS-A_a3" /locus_tag="lkcA" /protein_end="603" /protein_start="584" /score="28.0" /tool="antismash" /translation="AYVMFTSGSTGNPKGVAVS" aSDomain complement(30208..30945) /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_lkcA_Condensation_LCL.1" /domain_subtype="Condensation_LCL" /evalue="6.20E-13" /label="lkcA_Condensation_LCL.1" /locus_tag="lkcA" /protein_end="251" /protein_start="5" /score="40.3" /tool="antismash" /translation="ASAYERFQWYRYQRNPDDPGLTVGYVYALTGEVDTDRLEDALREV VSTAFPRLLDYFTEVGGELIAKSRPLPRRILRRCERQDVLLDSGGIDPTGQELFRFRYC RVSPQKLLLRLDFSHVVFDGGCYAPFCAALSACWEGETPVLERQFGAAPRSGDGADAAY WRSMLAGRPLHQPLPFSAAEPRRDGRRISVKETITGDQAEDIHRFLRRHELSLLQFVVG VTGALVHAYGDDDERGVVVAHTVD" CDS_motif complement(30808..30879) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_lkcA_0001" /evalue="1.90E-05" /label="C2_LCL_024-062" /locus_tag="lkcA" /protein_end="51" /protein_start="27" /score="17.0" /tool="antismash" /translation="VGYVYALTGEVDTDRLEDALREVV" ORIGIN 1 tcacaggacg agttcgctgc cgtccggcag cacttccacg ccggcctcgc gcaccgccgc 61 gtgggcggcg gaggaggggt cgaggagggg gttggtgttg ttgaggtggg tgtagatccg 121 gcgcagtccc cggtggcggg cgagggcggc gaggctgccg ccgggtccgg ccaccggcag 181 atggcccatc agggactgcc cggcgcccgc ggaggaggtc gccgtgccca gttcgccggc 241 gctgaagaag gtcccgtcca gcagggcgca ggtcgccgag gccagcaggt cgtcgaagcc 301 gtccggccag gtggccaggc agggggcgta gaccagggcg ccgccggtcg ccgggtcctc 361 gatgcggtag gcgcacaccc agggggcgtc cgggtccggg gcgtgcgcgt acttgggggc 421 cttggtaccg accgggtgcg cggtgacggt gagcccgccg gccaccgcga agccgccggg 481 tgcggtggcg tcccgccagt cccagggggc gtagcggtcc agcaggccgc gcacgggcag 541 ctcggcactg agcgcgccgc gcaccggggg cgcggcgtac acggtcagac cggtggcgcc 601 gcgcaggacg gccagcccca gcgcgtggtc gacctcggcg tcggtgagca gcacgccgcg 661 cacgggggtg tcgcgcgggc cggggccggg cgtcagggcg ggcgcggcga ggagttgggt 721 gcggatgtcg ggggaggcgt tgagcagcca ccagtcgcgt ccgtcgccgc tgacggcgac 781 gcattcctgg gagcgcgcgg gcagttcgcc gcgccggccg cgggcgcaca gggcacaggc 841 gcagttccac tgggggaagc cgccgcccgc ggcggtgccg agcaggatca ccttcacgcc 901 ggcaccggac cccgagggac gaacgccggt accgggccgt cggtgacctc cgccagtgcc 961 gcgtccacca gcgaccggtg cggggacagg ccgcaggccg ggtcggtggc ggcggcgtcg 1021 ccggtcagct ggaacgcctg gcagcggcag ccgccgtggt cggcgtggcg ctccgggcag 1081 gtacggcacg gttcgcgcat ccagccggtg ccgcggtagg cgttgaagga tcgcgaggcg 1141 taccagatct ccgacagggg gcggcgcagc gcgttctcca ccgggagggt ggtgatggcg 1201 tacgcggcgg ggcacggcag tacgtcgcct gcgggggtga cggtcagctg ggtgctgccc 1261 cagccgtcca tacagggttt gggccggtcg tcgtagtagt cggccgccac gtagaccagt 1321 tcggggccgc ccgcgtaccg cgtgcgggcg tgccgcacgg cctcgcgggc ggcggcgagc 1381 tgggcggcgg tgggcatcag cgcggcgcgg ttgcgcagcc cccagccgta gtactgggtg 1441 ttggccagct cgatccggtc ggcgcccagg tcgacggcga ggtcgaccat ccgcccggtg 1501 cggtcgatgt tgccgcggtg caggacgatg ttcaccgtga gcgggagccc ggcggcggtg 1561 accgcccgcg ccgcctccag tttggcggtg tgcacgcggg cgccggcgat ggcctggccg 1621 gcggccgggt cggcgtcctg gagcgagagc tggacgtggt cgacaccgcg ccgcgccagg 1681 tcgtgtgcgc gttcggcggt caggccgacg ccgctggtga ccaggttgac gtaggcgccg 1741 agccgccggg cgtggccgac gaggtcgggc aggtccgggc gggccagcgg ctcgccgccg 1801 gagaagtgca tctgtacgac gccgagttcg cgggcctggg tgaggatgtc cgtccactgc 1861 tcgcaggtca gttccgcctc gcggcgcacg agttcgaggg ggttggagca gtaggggcag 1921 tgcagcgggc agcggtgggt cagttcgatc agcatccccg cgggggcgcc gacggcgggg 1981 tcagccatgc aggtccacca cccggcgctg cgccaggcgc aggagcagtt cgcggacgtc 2041 ttcggcgctg acgccctcgt actcctcggc gaggcgctcg acgatgccgg cgaggctggt 2101 ggtgccgtcg cagtgggcga gcaccgccgc ggcggtgtcg ttgaggacga cgacgcgctc 2161 gggcagcagg gccagttcgc cgcgtgcggg gtcgcgggtc agccggactc cgggccgcag 2221 ccggggcacg gtgggttcgg gcaggccggt catgaccgcg tggctccgtt tccggtgtgg 2281 tagtcgagcg agtccaggac cgcgttcagc acgcggcact tgaacgcgag ggcgcggacg 2341 caggcttcct gctgttcccg gctgacggcg tgccgggcga ccagatcgag cagggaacgg 2401 ccttcggggc ccaccacctc gatgcgcgcg gtgaagtact cgaagccctc ctccgcgatc 2461 cacgggtagt gctccctgag gcggcccagc cggtgggcga gcaggcccgg cgagaacagc 2521 tcggtcagtc cggaggcggc cgcctccagc caggggcggc ggcgggcgaa gtccacgtag 2581 gcgtccacgg cgaagcgggt gcccgcgagg acgaggcgct cgtcgtgcac ctcgtccctg 2641 cgcagcccga ccgcctcggc cagacgcagc catttctccg caccgcccgc gcaggcgtcc 2701 gccccgtcgt ggtagacgat cctggacagc cactgccgcc gcacttcggg cagcgggcag 2761 ttggccacga tcgccgcgtc cttctgcggc agacagcgct ggtagtacca gcggttggcc 2821 gcccacagcc gcaactcccc ctcgtccagg agtccttcgt gcatccgccg gtgaaacggg 2881 tgccggtccc agtaggacga ctccagtgcg tggaggcgct gccggaattc ggcctcgctc 2941 cagggggcgg ccacctcgcg cgtcacggac atcgacatgc ctgcgtcctt ttctcagcgg 3001 cgggtcagcg gctgaagtag gcggtgactt ccatgccggt gtcgatggtg acgaaatcgg 3061 gacggtgcca tgccttcttg gcgggcagtt ccttgccgga ggtccgcatg ccggtgctcc 3121 ttttcacaga acggatttca cagtgaacga ggggacggta acgacgccgg ggaaaggcac 3181 acaatgtctc tccggttttc ctcaagcggt tcacgaatcg ggcccgttga ggcaccggtc 3241 ctgtcgcgtc cgtggccgaa cagcgcctgt ggggagggat cttttctggt accgtgaagc 3301 acggatggtg tagacgaagg agagggagcc gtggttatcg cgggtgacga cgacatcacc 3361 gggtgatccc cggatgtcga ctgccaccgc tgcgcgccgt gcgtgcgcgg tgccgtggcc 3421 gtacccccac gcgctctgac cttcccatcc tttgggcgcg ccgctgcgcg cccgcatctt 3481 cttgcgaggc ctgcgtacat gaccgacgcc agcatcgtct gctcgaatct ctccttctcc 3541 tggcccgacg gcaccccggt gttccacgac ctgtcctggt ccgtcggcga aggccacacc 3601 ggcctggtcg cgccgaacgg cgcgggcaag tccaccctgc tcaagctgat cacgggcgcg 3661 ctgcgcccga accgcggctc ggtgaccgtg cagggcctgg tcggctacct gccccagacc 3721 ctcccgctga ccggcgacct caccgtggcc gaggtgctgg gcatcgcccc ggtcatcgag 3781 gcgctggacg cgatcgcgtc cggggacgtg agcgaggagc acttcgccac catcggcgac 3841 gactgggaca tcgaggaacg cagccgggcc cagctcgacc gcctggggct cggcgacatc 3901 gcgctgaccc ggcggctgca cgacctcagc ggcggccagg tcgtctcgct gggcctggcg 3961 acccagctgc tcaagcggcc cgacgtactg ctgctggacg aaccgaccaa caacctcgac 4021 ctggacgccc gccgccggct ctaccaggtg ctggagagct tcggcggctg cctgctggtg 4081 gtcagccacg accgggcgct gctcgacctg atggacacca tcgccgaact cgaatcgggt 4141 gagatgcggc tgtacggcgg caactacacc gactacgaag aggccgtacg cgccgagcag 4201 gagaccgccg agaagaacat ccgcaccgcc gagcagcagg tcaagcggga gaagcgggag 4261 atgcagcagg cgcgggagcg ggcggtgcgc cgggccggca tcggggccag ggcgtaccgc 4321 aagggcagca tgtccaagat ggccgcgggc acgctcaaac ggcgcgccca ggaatcggcg 4381 ggcaagtcga acgacacgca cggccagcgc ctcgccgacg ccaaggcacg gctggacgac 4441 gcgagccgga tgctgcggga cgaccgcagg atcgcgctgg agctgcccga caccaatgtg 4501 ccggccggcc gcaccgtctt cctcggcgag gggatcaacg tgcgctacgg cgggcgggag 4561 atcttcgccg gcgacggggt cagcctcacc atccgggggc cggagcggat cgcgctgacc 4621 ggcagcaacg gcgtcggcaa gtccaccctg ctgcgcgtga tcagcggtga actcgaggcg 4681 gaccgcggcg agttcaagcg ggccgacggc cgcatcgcct acctctcgca gcgcctggac 4741 accctgccgc tcgaccgtac cgtcgcgcag tgcctggccg actacgcgcc gctcaagccg 4801 gaggcggagc ggatgaacct gctcgcccgc ttcctcttcc gcggcgccgc ggcgcacctt 4861 ccggtcggcg ccctgtcggg gggtgagcgc ctgcgcgcga ccctggcctg tgtcctgggt 4921 gccgagccgg cgccgcagct gctgctgctc gacgagccca ccaacaacct cgacctggac 4981 agcgtcgagc agctggaggg agccctgaac tcctacgagg gcgcgttcat cgtggtcagc 5041 cacgacgagc ggttcgtcaa ggagatcggg gtggaccgct ggctgcggct ggcggacggc 5101 cggctgctgg agaccggggg gcccgccgat gagtgatgcc cccgcaccgc ccgaccacgg 5161 gcaggacgtc ctgtccgccg accaccgctc ggcgcacctg ctcgccgagg acctgcgctg 5221 cgtgctgggg gaccgggtgg tgctgcacga cgtgtcgctc tcggtctccc gcggcgagcg 5281 ggtgggactg atcggcgaga acggccgggg caagtccacc ctgctgcgcg ccctcgccgg 5341 cgagctggcc ccgcagcgcg gccgggtggt gcgcgcggtg acgggccggg tgggcttcct 5401 ggcgcagcag ccggacttcc cgccgggctc caccatcgag gacgtgctcg cacaggcgac 5461 ggcggagttc cgggagctgt ccgcgcgcat gcacgccgcg gaggagcgga tgtcgtccga 5521 gtcgggcgat ctcgatgccg tgatggagga atacggccgt ctccaggagg agttcacccg 5581 gcgcggcggc tgggagctgg gtgcccgcgt cggtgaggtg ctggacgtct tcgggctggc 5641 cgggctggac cgggaccgcc gcatcgggac cctgtcggga ggcgagcggg cccggctggc 5701 gctggcctgc ctggtcctgg acgaaccggc cgggctgctg ctcgacgagc ccaccaacca 5761 cctggacgac cgggcggtgg actggctcgt gcggtggctc gcggcctacc agggaccgtg 5821 tctgatcgcc tcccacgacc gggcgctgct cgacacggcc gtcaccgcca tcgtcgacct 5881 ggacggcccc agcggtgcca ccgtgcgcta cggcggcggc taccgggact acctggccga 5941 gcgggcggcg gcccaggagc gctggtggca gcggtaccgc gagtggagcc gggaggtggc 6001 cgaggcccgg cggcggctgg agcgggcgca cgcgggcggc cgggtgttcg cgggccgcgc 6061 cgacaacgac aagctgtcgt acaacgccat gggcagcgcc gccgaggcgg ccgtcgcgcg 6121 ccggacccgt gccgcccagc agcatcttcg ggagctgctg ggcgaggcgg tgccgcgtcc 6181 gccggagccc ctggacttcg ctcccccggc gcccgaccag gagaccgacg gcgtcgcgga 6241 gccggccggc ggtgtgctgc tgcgggccgc cggtctgctg gccggggagg tgctgcgggg 6301 ggcggagctg acgctggccg ccggcagccg ctatgtgatc agcgggccga acggcgcggg 6361 caagtcgacc ttgctgtcgg tgctcgcggg tgagcgggag ccggacgccg gggtggtgga 6421 gcgggcgccg gggctgcgca tcggatacct gccgcaggac agcgacttcg gtgcggagcg 6481 gcgcgggctg ctggaggcct tcgccgcgcg tcgcgagacc catctcgacg acgcagcggc 6541 cgagttgacc cggttcgggc tgttcgctcc gcgggacttc gccaccccgg cgaaccggct 6601 gtcggtaggc cagtggcggc gcctggacct cgcgctgctt ttcgcccggc gcccgcatct 6661 gctgctgctc gacgaaccca ccaaccacct cagcctggtg ctggtggagc aactgctggc 6721 ggcggtcgag cgtttcacgg gtccggtcgt gatggtcacc cacgaccggg cgctgcgcga 6781 gcgccaccgc gaccggctcc tggagctggc cggcgggcgg ctggtgccct ccgggtgagg 6841 gccgggccgc ccgctggcgg ggggtccggg gcgggcgccc cggacccgcc cggtcagcgg 6901 atgtaccggc cgtccaggta cttcttggcc agttcgaggt agcggccgtc ctcggagttg 6961 cggatcagtt cgaagaagaa catctcccgc gtgatcaggt gcaccccgag ctgccgcagc 7021 cgggccagtc ccagctcgtg gtccgcctgg ttgcgggcgg agacggtgtc ggccagcacg 7081 aagaccgtct tgccctgctc cagcaggctc agcgcggact ggaggacgac cacatgggtc 7141 tccgctccgg ccagcacata ctgctcccgg ccggtgtcgg ccacatgccg cgcgatgggc 7201 tcctcgcgca ggaagtcgaa gtgctccttg ggcagccggg gcgcgtcctc ggccgcctcg 7261 tgcagcgaca gggagagtcc gcccagcttc ttgtgctcgg tcagcagcag cgggaggtcg 7321 aactcccgcg ccacctccgc gacccagcag gtgttgtgca gcagttgcgt gccctccagc 7381 agcagcggaa tgagctccag ctgcatgtcg aagaggacga ccgccgtctt gtccgcgcgt 7441 accagcatgt tccgcgaccg atccaatccc gtgagtaggt gtgttcccgg atgtcgtacg 7501 gcgttcgcgg ggtcagcccc gcccggccca gaacgcggcc agcgtcctgt tgacggcgcg 7561 cgccgcggtg aggggcacat agtgcccgtg gtcctcgaac tcgcgcaccc gcactccggg 7621 gatcctggag tacagctcga ccgcttcggc gtcgaggacg cagtcgccga cgccgcgcag 7681 caccaggcag tccgccgtga tgtccgggag ccggtcgacg acgtcgaagg cggtcaggtc 7741 cgtgtagtag cagcgcagca cgtccatgga ggcgttcccg ccgaacttct cggccaggtt 7801 gccgccctcg ccgaacaccg cttccagcag ccccccgtgc agccgcagct cctcgcgcag 7861 gtcgagggtg cgctcgaagg cgtcctcgcc gtagcggggt gcgcagctga cgagggccag 7921 cgaggcgacg cgctccgggt gccgcagggc ggtcagggtc gagacgcagc cgcccaggga 7981 ccagccgacc aggtcggccg ggccgtcggc ggtgtcccgc aggaagccgg ccacctcgtc 8041 cgcgagcgcc tcgaaggaga agcgctcctc gtcgaagggg gtgtcgttgt gccccggata 8101 ctccgggacg tagaccgtgc gtcccgcccg gagcagggcc gggatctgct gggcccaggc 8161 ccgctcgtcg cagttgagcg ggggcagcag cagggtgggc cggcccgcgt cgccgtacgc 8221 cgaccaccgg atcagcggcg cgtggtccgg cccggcgcct cccctgcggg tcgtgccggg 8281 ctcgcgggcc gggggcgtcg gcggcggggc gagcggccgg ccgccgatgg ccgcggcgag 8341 atcggccacc gtctcgtggc ggaagaggtc gtgcgccttg atggcgcttc cggccttctg 8401 gtaggggctg agcaactgga cggcggagag cgagtccagg ccgagcgagg cgatcctggt 8461 gccgggtacg acctggtcgc tgtcctcgtc gtagcccagc agggcggaca gccgggcgca 8521 cagttcgcgg gcgagggcgt cggtcgccgc ttccggggcg tccgggaccg gcggcgcggc 8581 cggttccggt gcttcgccgg tcagccagtg ccgccggccg tcgaaggggt aggcgggcag 8641 cgtgatccgg gccaggtcgg ccggtgcgtc gagccgccgc tgcacggcgg gcatgtcctg 8701 tgcccgccag cgggtgacca gctcgcgcag gtcgtcgtcg agacgggcgg tgtccgcgct 8761 ccggggtgcc gggccctcgg acccgccgtg ggccaacgcc tcgagggcgg tgcccagttc 8821 gtctcgggta cgggccacga ccaccgactc gtgggcgagc ctcgggcggc gcagcagcag 8881 ctgggagagg tcccagagcc ggtctccggg cagctcggcg accagcgtcc ggcagcggtc 8941 ggccagcgcc gcgaggctgt ccggtgactc ggccgacagg cagaagggca gcgcccgccc 9001 cggccggcgg tccaccgcgt ccgcggtcgg cggcgcgtcc ggcagccggc gcagcaccac 9061 gtgtccgttg gagccggtga acccgaaggc gctgatcgcg cacagcggct tgtcctcggg 9121 ccacggcagc ggttcccggt tgaccttgaa cggcgcgacg tcgaggtagg agaccgcctc 9181 gccggcggcg gccaccggcg ggatcgtcgc gtggtggaag gcgagcagcg ccttgacgac 9241 gctcgccagg cccgaggcca cgagggtgtg cccgatgagc ggcttcacgg cgccgaggtg 9301 gcagccgtcg gcgccggccc ggcggaaggc ggagcgcagg ccctccagct cgatggggtc 9361 gccgagcggg gtcccggtgc cgtgcgtctc caggtaggcg atctgcgagg cgtcgatctt 9421 ctcgcggtcg tacagctcgg cgatcagccg ggactgggcc ttcgaactcg gcgccatcag 9481 gccgttggtg gtgccgttgt ggttggtgcc ggtcgcctgg accgctccgt agacgcgcag 9541 tccgcgggcc cgtgcctcgt cgtggcgcat gacgacgagc gcggcggcgc cctcggccgg 9601 tacgaagccg tcggccgcat cggtgaaggg cagcgaggcg ccctcggggg aactcatcct 9661 ggaacgctgg gcgaagcgca gcacctccgg ggtgctgaac accgacacgg cgccgacgat 9721 cgcggcacgg cactgtccgg cccggatgtt gagcgccgcc tcgtgcagcg ccgccagcga 9781 cgaggagcag gcgctgtcca gcgtcaggga cgggccgttg acgtcgtaga agtaggagat 9841 gcggcccgac agcgtcgagg gcgcgttgcc caggaagctg tgggtgccgt agaccaggtc 9901 ggcgcgccgc gccaccaggg tgcggtagtc gccgggcagc ccggcggcga ataccccgca 9961 gtccaggtcg cgcaggtccg cggccgtcag atagccgtcg tcgacggcgt gctgcaccgt 10021 ttgcagcagg atgcgctgct gcgggtccat gcactgcgcc tcgttcggcg agatgcggaa 10081 gaaccgcgcg tcgaactcct ggtgtccgtc caggaagccg ccggtgaagg acccggcgtc 10141 ctcctcttcc gtccagcggc cggtggtgcc cagggcgctg cggccgagcc gcaggcgctc 10201 ccagtactcc cccaggccgt cgctgccggc gaaccggcag gccatgccga ccacgaccgg 10261 ggtgtcgtcc tcaagcagct cgtccattcc cactctcgat tccctggccg gttcgccggc 10321 gcgccgttgc cttgccggtg ccggtcactc gaaccagaac cggttcttct cgaaggcgta 10381 gcccggcaga tggagccggg cgaaccgctc gccttcgaac atcgattccc atgcgaactc 10441 ctcgccctcg gcgtagcggg cccgtacctc gtccagcgcc gcgcggtggc cggggtccgt 10501 cggggccggc agccgcaccg ggtgtgtggt cagccgccgg gaccggcact tggccgcctc 10561 ctcgggccgg gcctgcgcca gccgccggcg cagttccgcg gtgtcggaga cgacccaggc 10621 caggcggtac tcgaaatggt cgcggccgac cgccagggtg tgggcgatgt ccccgagctc 10681 cgcgtgccgg ccctccgggc cgtccagcca ctccagcaga ccgtcgcgca tcgcggtgag 10741 cgaggcacgg gagcgggcgc tgagggcgat gagccagtac ggccgcgacg ccgccggccc 10801 ggacgccggg gcgggtgcct cggagaggac cgcgtgcgcg ttggacccgc cgaacccgaa 10861 ggagctgacg ccggccacca ggggggtgcc ccgctcccac ggctcgttct ccagcagcag 10921 ccggaagggc gaaccggcca gctccaccag cgggttgagc tccttgaagt tgatgttcgc 10981 cggcaggcgg cggtggcgca ggcacagcag cagcttcagc agccccgcca tgccggcggc 11041 cggctccagg tggcccacgt tggtcttcac cgcgcccagg gtgatgctgc ccggctcgcg 11101 gtgcggggcc agccggccga acgcggtgcg cagcgcgccg atctcgatgg ggtcgcccag 11161 gttggtgccg gtgccgtgcg cctcgatgtg agagacccgc tcggccagct ccggggtgta 11221 gacccggttc agcagggcga cctgcgcgtc ggggttgggt gcggtgagcg agttcgagcg 11281 gccgtcgtgg ttctcggcca ccgcctcgat caccgcgagc acggcgtcac cgtcgcgccg 11341 ggcgtcgtcg agccgtttga cgaccacgca ccccacgccc tccgcgcgca cgtagccgtt 11401 ggcgtccttg tcgaaggtgg cgcagcggaa gtcgggggag agcacgccca gttcgctcgc 11461 cgcgtcggtg gcggccgggt cgacgagcac gctgacggcg cccacgagag cgacgtcgca 11521 ctccccggcc gccagcgaga gcacgccccg gttcagcgcg accaggccgc tggagcaggc 11581 cgtgtcgacc gtctggctcg gtccggtgaa gtcgagcagg tgggacacgc ggttggcgag 11641 catggcgtgc gcgttgccgg tgacggtgta cgggtgggcg cggtcctcgc tgtgctgcag 11701 ggccgtctgg tactcgctga actgcactcc ggcgaagacg cccacctccc gcagcgatcc 11761 cggcgcgtag ccggcgtcca gcagagcgtt gtaggcgctc tggaggaaga gccggtgctg 11821 cgggtccatc agcatcgctt cgcgggcgga gagtccgaag aaggagtggt cgaaggcgtc 11881 atggtcgtcg atggtgcccg cgaagtactg ccggtcgcgg ttcttccagc gttccacggg 11941 acggatggcg ctgccgttct cgacgagcag ccgccagaag tccgcgaggt tctcgcccgc 12001 gggcatgatg ccgctcatgc cgaccacggc gtaccggccg cgtccggtgc tccgctccgc 12061 cgtgccggag ggcgcgggcc gcggcacggc cggcgcccgg ccctggtccg gggcagccgg 12121 tgtgtccggt gcgtcccggt ccggcccctg cggtgcgccc gccgcgtcct cgcccggcgt 12181 gtccggtgcg ccggccgcgc cctggtcccg cagataggcg ctcagcgagg cgatgctgct 12241 gtacttgaac agggcgttgg gcggggtctc cacgccgaac tcggggccga gccgccgggc 12301 caggtgctgg agcatgaccg agtcgtagcc gaggtcgccc cacctgctgt cgaaggcgat 12361 gtcctcggcg ctcaggccgg tctgagcgcg caccagttcc aggagccgtg cgccgagctc 12421 ctcctgcgtc gcgccggggc ggggggccgg gcgcgcggcg gccggggcgg cgcccggcag 12481 cagccgctgc cgcatccgcg cgaggtcgcc gacgcagggg acgacctgat ggcatgtcgc 12541 cggcaggccg tcgaccaggt cgaggaacaa ctgcgcgccg cggcgcgcgg agagcggctc 12601 catcccgaac tggccgcgca ggaaggcggc gagcgcctgg tactgctcgc gccgttcgtc 12661 ctcggcgtcc agccacagcg gccagttgac cgacaggctg aggccgccgc gctcgcccgc 12721 cgccacgcgc cgggcgcgct cggcggcgaa ctcgtccagg aaccggttgg cggcgatgta 12781 gtcgctctgc ccggtgttgc ccatgacgct ggagatggag gagaagacgc agaagaagtc 12841 cagcggcagg tcggcggtgc accggtccag gttcagcgtg ccgcgcagct tgggggcgag 12901 caccgcctcg gcgtccccgg ccgacttgtt ctgcaccagg gcgtcgcgca cgacaccggc 12961 gcagtggacg acgccgtcga tgccgccgaa gcgcgcgcgg acggtgtcga ccagttcgcg 13021 ggtccgggcc gcggaggtga cgtccgcctg ctcgtagtgc agccccggtg tgccggcgat 13081 ccactgccgc tgcgcggcgt ccggcgcgga gcggcccacg gcgatcaccg tggcgcggta 13141 ccgctcggcg aggagttcgg tgatggcccg gccgaccttg cccaggccgc cggtgacgag 13201 ataggtcccc ccggtgcgca gccggacgcc ggcgcgctgc ccgtccgcga ggcggagttc 13261 ggtcagctcg cgcgtgtacc gggtgccgtc ggcccaccgg acctcggtga gcggccggcg 13321 ggcggcgcgc agctcgtcca gcagcggccc ccagccgtcg gcgagcgccg gaccgtcgcc 13381 ggcgcggcgc gcctggaccg tgcggacatg cgggttctcc tccgccagtc cgtgcaggaa 13441 tccggcccag gcgcgcgcct cggccgcctc gctctcgcgg gtcacgccga ggacggtgga 13501 cggggtacgg cagccctgca ccgccttggc gaaggacagc tgggccgccg ccgtcacctc 13561 gcgccgcagg tcgagccagt acaggtggtc caggcccaga tcgccggtga ggtggtccag 13621 ggcccgccgg gcggcggtgt cgtcgccctc gggcagttcg atccggtccg cctcgatcac 13681 cagcgtgtca ccgggggtga cccggatcag ccggagtccg gcgggcggtt cgggcagcgg 13741 gggccgcggg ccgcggtcgg tgagcacgag gacgcagggc ggcggggcac cggccggctc 13801 ctcggccggg tgcggccgcc acaccggggt gagcagcagg gtgtcgtccc ccgccgggcc 13861 ggcctgcggt gcggctgggg ccgtgcgggc gggcggccgg ttggcgtggt cgagcgtctc 13921 ggccacgtac cgctcgcggg cgaaggggta gagcggggcg tccaccagca tgggccgcgg 13981 gaacagcgcc gcgaagtcgg cccgctcgcc ggccaggtag gcggctgccg cttcggccca 14041 ggcgtcgtcg gccggcggtg cggccggggc ggcgccggcc gcgtgctcca gccgctcggc 14101 cagctgcgcg acgctggtcg cccagtagcc gcgccggacc cggaagtgct ggcgggcgca 14161 gcacagggtg tagctcagcc cgtacaggta cgacgccgtg tcgggggcgt cgcgcagggc 14221 ggcgagcagt tggtccgcgc gccgctgcac ggcggcctcg tcgcgcccgg agagcgcgat 14281 gaagtagcac gggaacgcgg ggacgggggc ggtgtcgggg ggtgccacga actcctggac 14341 gatcgcgtgc ccgttggcgc cgcccgcgcc gaacgagctg agtccggcga accgcgtggg 14401 accgctgccc ttgggccagg gcagggtctc cttgaccagg gcgaaacgcg agtccgccag 14461 gtgcaggtcg ggattctcca gcgtgcagtg cagggtgggc gccagggtcc ggtgggcgag 14521 ctgcttgacg accttgacga gtccggccat cgccgcggcg gactccaggt ggccgatgtt 14581 gcttttcacc gagcccaggt aggcgcggcc ctgttcgggt ccgccgtagg cccggctcag 14641 ggcgcgcacc tcgatcgggt cgccgagccg ggtgcccgtg ccgtgggcct cgacgtaggt 14701 caccgcgccc ggttcgatct ccgcctcggc cagggccgcg gcgatcaccc ggtgctgggc 14761 ccgttccgag ggcacggtga aaccggccgt gcggccgccg gagttcaccg ccgtcgcccg 14821 gatgacggcg tgcacccggt cgccgtcccg cagcgcgtcg gacagcggct tgaggaccac 14881 ggcggcggtt ccctcgccgg ggacgtagcc gtccgcctcc acgccgaagg cctggcagtg 14941 gccggtgggg ctgaggaatc tgccctcgga cagcaggcgg tacttgccgg ggtgcgtcat 15001 caggttcacc ccgccggcca cggccagcgc gcagtccccg gcgcggatgc tgcgcacggc 15061 gaggtgcagg gcggtgaggc cgccggagca catggtgtcc agggcgatgc tggggccgtg 15121 caggtcgaag gcgtacgaga cccggttggc gatggcggcg aacgagctgc cgatcacccg 15181 gtcggcggcg gtgaggtcct ggtagtggcc gaacatggcg gccacgaaga cgcccatgtc 15241 gccggtcggc cgggcgaagt acccggcgtc ctccagggcg tggtagacgg attgcaggaa 15301 gcggcgctcc tgcgggtcca tgaaacgggc ttccaggggc gcgatgttga agaagacggg 15361 gtcgaagtcc agggcgtggt cgaggaatcc gccgtggcgg ccgtaggcgg tgcccggctc 15421 gtcgggggcg aaggagtggt tctcgcgcca gtcccagcgg tcgccgggga tcacccgtac 15481 cgcgtcgtca ccccgcagca gcgcctgcca gaacgcctcg gtgtcggcgc cgccggggaa 15541 ctccccggcc atcccgatga cggcgatgtc gtcggggcgg taggcgtccg ccgcgggagc 15601 gtcctcggac cgggccgccg cgggagcgga cgcccgctgc cgcccggcgg gccggggcgg 15661 tgtcccggcc gcgcggaccg ccggtgccgg cacgggctcc ggggaggcgg cggactccgg 15721 gggcggggcg gattccgggg gcgcggtggg ctgcggggag ggcgagtcct cgcgggtgag 15781 gaaggtctcc agttccgggg cgaaggtctc ggccaggtgg gcggcgagcg cggcgaccgt 15841 cgggtactcg aagaggaccg cgcggctcag ccgggacgag ccggcgatgc ccaggcagct 15901 ctcgatgtcc ctgctgacgc ggatgctgcc gacgctgtcc agcccctgtt ccagcaggtt 15961 ctcgtcgtcg cgcagccccc gcagcccgct gtggcggacg atcagctccc gcagccaccg 16021 ggtcgtgccg accaggaggc cgtcggcgga cggcccgccg tcgcgggagc ccgccgcggg 16081 cgcgtccgcg gcgccgcggg gcggcgcgga ggggtcgggg gccccggtcc cggtggcgag 16141 gaggcccggc tgtccgtcgt agacgaccag ctggcgcgtc cccgtggcga gggcccgcag 16201 cagcgtgtcg caggcctgct cgggcggcat cgcccgcagc ccggagccgt cgtcgtccgg 16261 catccgcatg ccgtcggtgt cccacaggcc ccagttgatg ctgtaccagt cgggccggtg 16321 cgcgctcagc cggtcgagga aggcgttggc cgccgcgtag gccgcctggc ccacattgcc 16381 cgtgacgctc gtcagcgagc tgaagtgcac caccatgccg ggccggtgcg gcccggtgag 16441 ggccgccagg ttgaggccgg tggccacctt cggccgcagg acgtgctcca ggcggtcggg 16501 ggtgaggtgg tacagcaggc agtcgtcgag cactccggcg aggttgaaca ccgccttgac 16561 gggcccgaac cggtcgtgga ggtagcgcag ggcgccgtcg agcgcctcgg ggtcgtcggc 16621 gggggcaccg agatggctgt gcacgcccgc ttccttcagc gcctcccgca cccgcgggcc 16681 cggcgtgccg cggccgagga cgaacacccg gacgccgcag tgccggctca gataccggca 16741 cagctgccgt ccgatgcccc cggccccgcc gatgaccacg acggagtcgc cgtcgccgaa 16801 cacctcgcgc gccccggtgc cctccagcgg gcggggcgtg tgctccagga gcccgatccg 16861 gtcgtcctcg gcgcgcagca ccgcgcccgg ccggccggca ccggcatcga tccacgcgcg 16921 cagccgccgt ggggtgacgg tgccgctcca ctcgaccgcc gtgtgcacga gcgggcactc 16981 cagcgccgcc gtcctggcca tgccgtcgag cagcgcgggc agtgtgtccc cggtgcggga 17041 cagcgtgacg agacggaccg ggcgccccga cccgcgcacg gcctggagca gggccagacc 17101 ggcgcgggcg aaccggagcg ccgcgtcgta ctcgggtgtg ccgtccgcgt gcccgtcgcc 17161 ccatgccacc accagggtgg tgcaccgggc ggcgtaccgg cccagttccc gcccgatccg 17221 ttcgtcgctc tcggtggcgg ggtcgcagtg ccagcactcg gcgccgatgg agcgggccgc 17281 cgacgcgatg tcctgccggt cggtgatcac caccgtggct ccggcctgcg cgccgggcag 17341 gtccgaggcg gcgaggtcgg tgtatcgagg tgctagcgat tccatgggtc atccccgtga 17401 gagaaagtga ggctgcgaca ggcgggcggg tgctggctca cacgcccatg aattccttga 17461 tgccgcggaa ctgcgcggcg gcgagggcgt cgtccgggaa ggggtgcggg acacccagcc 17521 ggtccgcgat caccatgccg gagacgatcg ctccctcgtg gccggtgacg ctggtgtcgg 17581 tgccgcagaa ccagaggccg ttcagaccct ggatctcgtg cagccgcttc ttgcggcgca 17641 cgtccaccgg ccggagctgg gggagcttcc actcgcggcg gacgatgacc cgctcggggt 17701 cgacgtcctc ctgcgggtcg aaggtgatca ggatgggcga ggagaccttc cggtaggggt 17761 ggagcacgtt gcagttgcgg gtcaggctgc ccatctgctc ctcggcgcgg gcgagttcga 17821 agccctccgg catccggaac tggcagtagg cgccgccgcc ggccgggctc agccagctct 17881 cgtcctggtg cagcacgctc tcgaccggca cgtaggcgaa gtccccgagc aggtcccggt 17941 actgctggtc ggaggtacgc agcagccgca gcgtcacgtc cgcgtgcgtg gcgaacacga 18001 cctggtcgaa gtggtgctcc tgcccgccgg ccagcacggt caccccggac tgcgtcggta 18061 cgacggcctc gacgggcgtg ttcaggcgga cccgctcgcc caggtcgctc tcgatcctgg 18121 ccaggtagga gtggattccg ccctgcgcct tgcgccagta cccggcggag aagaaggaga 18181 gcaggttcat gctgaacgac agcgcgacgt acatgaggtt gtagtcgagc gacggcgcgt 18241 ggcagcccga gtagatgctc aggatggggt tcatcgcctt gtacttgaag ctcttggagt 18301 acccgtgctt gtccaggtac tcgccgatgc tcatctgctt gtacgagtcg tcgcccgagg 18361 tgggcagctg gttcatctcc tggtggaacc ggtcgaactc ctcgtgcagt tcctcgcgca 18421 gttcgccgag gaagtcgagg ttgttccacg actgctgctc gccggggaag tccacgtgca 18481 ccgaggacgg ggcgacatag gtgccgatgc cgaagtcggt cagcagccgg aacaggttgg 18541 gcgagagctt ctcgttgaag tgttccacgc ccatgtcgac gtggagggtg ccccggtccg 18601 tctcgaccgg gtggctgtag gcgtggccgc ccaggtactc gtccgcctcg aagagggtga 18661 cgtcgtgcct gcgggccagc agccaggccg cgacggaccc ggagccgccg ccgccgacaa 18721 cggcgatcct gctttttgct tctaccacgg tcatcacttc ctgggctcgg cctgcggcga 18781 gggttcgtcg ccgaggatct ctgcgctcaa tttggtcagc acccggccgg gaccgacctc 18841 gtcgaaggtc ttgtgtccgg tacgggacag atgggtcacg gtctgccacc accgcaccgg 18901 tttgacgagc tggaagacca tctcctccag caggtgacgg gctcccagcg tccggccgct 18961 cgtcgtggag acgacgggct tggtgggcgg cgtgaacgtg cggtcccgca ggaactgcgc 19021 gaaccggagc cgggccggct ccatgtggcg ggagtggaag gccccgctga ccggcagcca 19081 cacacagcgg tggccggtct cctccagccg cggcaccagc tcctccaggc gcggcttcag 19141 ggcgctgagc acgacctgct ccgggctgtt gtagttggcc acgtccacgt cgaagaactc 19201 cagccgggcg aggtggtcgt cgatctcgct cgcccgcggt ccgaggaccg ccaccatcgc 19261 cccgtcccgc gcctcctgca tcagggcgcc gcgccgggag acgatctcca gtccctcgaa 19321 gaggtcgaag acgccggccg cgaagagagc cgggtacagc ccgaggctgt ggcccgtcag 19381 gcagcgcacc tgctccgcgc cgtgctcctc ggcgtacgcc aggtacatca ggcagctgac 19441 gaaatagacc gcctcctggg tgcgggaggt ctcgttgagc cgtccgtccg ggtccttcag 19501 gcacagctcg cgcagcgagt ggccgacgat ctcgtcggcc ctgtcgcaca gctgcggata 19561 ggcgtcgaac acctccttgc ccatgccgat gcgctgcgag ccctgtccgg ggaacatcac 19621 gacatcgccg gccatcgccg cccccctcag ttcagttcga ggacggtgaa cggcgcggcg 19681 gccggcgcgg gcgccggggc gccgtgccgg gtcgccgccg gggcgctgcc gtcgatcgcc 19741 acggacaccg cttcctccag ggccacgagg acgtcgccgt tctcgtcggt gaagaagaag 19801 tcgtaggtgc gggtcctcgg ggaggagccg cccggccggg tcacgcagtg gcagtacacc 19861 gcctcggtgc gcggggcccg gaccacggtc agccggccca ggtggcaggg gacgaacacc 19921 ggggcgtccg gcgtccgttc ggccgccagc aggatggaca gctgcattcc gcagtccagc 19981 agcgcgggcg acaggccgta cccccagtcg tggtccacgt ggaggaaggc ccgtaccgtg 20041 tccggtccga cctcggccca gcgcacaccg cgcagcggtt cgccgtagtc gtagccgagc 20101 cgccggaagg cgtcgtagat ctccgtcctg gactgcctgc gcgtggcggc gggcaggtcg 20161 ggcgggttcc cgaccggtgt gggcgcccct gcctcggcgg tgcagtacac gtcgccggtg 20221 acgcggtcga cgagcgacat ctcgccgccg cgctcgcgga cttcgagggc accggggtcg 20281 gtgatcggct tctgccacag cacgttgccc agcgcccggc cctccgcccg gtcggcgagg 20341 acggcgagcg tccaggccgc cggcgccatg gccacgccgt cgatccggtg ggcggacacc 20401 agcgtggcga gggaacggaa gccggactcc gcggagtcga cccagtggcg gtggcgcagg 20461 aacgggtagg cgggcagttc gacgggggtg gtcctcgggt agtagcggtc ccagtccggg 20521 gtgccgccgg actcgtacag ggccgcgatg tcctcggccg tgcgggaggt cagttccgcc 20581 gccgccggtg ccggcgcggt ccggcgccgg ggccggcgcg gcaggtcccg ctccagggcg 20641 cggaccagct cgtcctggtc gcggcagacg atcgcgacgc ggtgcgcgaa gctgtcgcgg 20701 cagcacgcga gcgtgtaggc cagggcgtcc atgtccacgc gccgcccgct cagccactcc 20761 cgcagcccgt ccatggccaa ctggagcccc gcggcggtgt ggtgggagag cgggatgacg 20821 tagcggtccc gccgcggggt ggcgttcgcc gcgggcgcgg ggggctcggg cactccgcgc 20881 aggacgacgt gggcgttggc cccgcccgcg ccgtaggagc tgacggcgga caccaggggg 20941 aggtccgcgg gccagcgctc ggtccgtgcg gcgagcgtga acggggtggc gtcgaagtcc 21001 aggtgcgggt tggggggctc cgcgtgcagc gagggcacca gggagccgtg gcgcatctgg 21061 agcaccgcct tgagcacccc gctcaggccg gccgccgact ccaggtggcc gatgttggac 21121 ttcaccgagc ccagccggat gcggccggtg ccggccgccg cgtaggcctt ggccagggac 21181 cgcagctcga tggggtcgcc cagcgcggtg ccggtgccgt gggcctcgac gtaccccact 21241 tcctcgggag aggtccgggc cgcggcgagg gccttggcga cgagcgcgga ctgggcctcg 21301 ggattgggcg cggtgtagcc gttcgcccgg ccgcccgcgt tgaccgccga accgctgatg 21361 accgcgtaga cccggtcgcc gtcgcgcagg gcgtcctcgg cgggcctgag catcaggctg 21421 atgacgccct cgccgtccac gaagccgtcg gctccggagc cgaagggacg gcactccccg 21481 gcgcgcgaga gcatctccag cccgcacagg agctggtact ggcgggggtg cgtgatgagg 21541 ttgacgccgc tgacgacggc gcggtcgcac tcgccggtgc gcagcgactg gcaggcgagg 21601 tgcagcgcgg tcagggacgc cgagcacgcg gtgtcgacgg ccatgctggg cccgtgccag 21661 tcgaagtggt acgaggcgcg gttggccatc gaccagaacg ccgaggtggg tggctgcgca 21721 ccgggctcgg tggtcgtgtg ccaggcgtat ccgccgttca tgacgccgac gaacactccc 21781 gtgtcgctgc cggcgagcct ggcccggctg tagccggcgt ccagcatcgc caggtaggtc 21841 tgctccagga cgaggcgttc ctgggggtcc atgcgggccg catcgtgcgg ggtgaggccg 21901 aagaaggtgt ggtcgaaggc gtcgatgtcg tcgacgaagg caccgcggtc ggtgtacgac 21961 aggggtgcgg cgccgtccgt caggcgggtg gcgaagcgct ccgggggcac ggtggaggtg 22021 cagtccaggc cgtcgagcag gttctcccag aactgccgga cgtccgacgc ctgcggcagc 22081 cgcgcggcga tgccgacgac ggcgatgtcg ccggggcgcg gcgcgaactc gccctggttc 22141 agggcggtct gcccggccgg cgcggtggcc tcggtctgct ccggccgtac cggctcctcg 22201 gcagtggcgg tggcggcggt ggcgccgaag gactcggcca ccgcgtcggc gtactcggtg 22261 accaggaact ccaccagccg atccaccgtc ggatactcga accacaccgt cgcgggcaca 22321 taccccaccc gctcacgcaa cggcttcagc aactccatcg agatcagcga atcgatcccc 22381 atgtcacgga acggccggtc gcactccacc tccgacacat ccagccgcat cgtccccgcg 22441 atcacctcac gcacgaaccc ctccaccgca ccccgcacac cgacggcccc cgccgcctcg 22501 gaagccggga cggcggcggt ggcggtggca gtggcggcgc cgaaggactc ggccaccgcg 22561 tcggcgtact cggtgaccag gaactccacc agccgatcca ccgtcggata ctcgaaccac 22621 accgtcgcgg gcacataccc cacccgctca cgcaacggct tcagcaactc catcgagatc 22681 agcgaatcga tccccatgtc acggaacggc cggtcgcact ccacctccga cacatccagc 22741 cgcatcgtcc ccgcgatcac ctcacgcacg aacccctcca ccgcaccccg cacaccgacg 22801 gcccccgccg cctcgggagc cgggacggcg gcggacggct cgtccgccgg gccggccagc 22861 gcgaccagga cctgctggcc gtcgccgccg tggggccgca ccgcgccgaa gccggcctcg 22921 tgcatgagcg aacgccactg gtcgctggag agcagggggc tgtgctcgat gcggtacggg 22981 tcgttgctga gccaccagcc gtcggtgagg ccgaaggtga gcgtggcgta gtcctgccgt 23041 gccgtgatct cgttgaggac caggatcccg ccctcgcgca gcgccttgcg cacgttgcgc 23101 agcgtgccgg ggacgttcga cgtcgcgtgc aggacgttgg tggcgacgac gacgtcgaag 23161 cggccggtgt agtcctcggg cgggttctcg atgtcgcaga tctcgtaggt gaggaacggg 23221 tagtcggcgc cgaaggcgtc ccgcgccttg tgcaggaacg cgtaggacag gtcggtgaag 23281 tgatagtcga cgccgtgcgg gtccagctcc ggcagcacga acccggtggt gctgccggtg 23341 ccggcgccga tctccaggac gcgcagcggg cgccccgccg agcggcgctg gtaggcggcg 23401 accacgcggg cgcagatccg gttgaagtag tcggcgatgg ggttgctctg gtagacgggc 23461 gcgaccagtt cgaaggaccc gtcgggaaag agcacctcca ccgcgtcggt ggcgccgctc 23521 agcacgtccg gcaggtgttt caggcaccgg tcgagcagct tgcagtggcc ctccagctcc 23581 gggtaccggc gcaggagttc gtccagcggc agggagtgcg ccggcggcat ggccgcgatg 23641 gcctcccgca gcttggcgta tttggcgatc gccgtcgccg gcagcggcac ctgcgccagc 23701 cgccaccggg tgtacgcctc cagccgctcg gcgaggtccc ggttgtgcgc gacgtccgtg 23761 tcttcgtccc tgaaggccgg caccacgtcg tcgaggacgg tcgcggaatc ggcggacgac 23821 accgtggcgg cgggcttgtg cggcgtgatt cccatgcgct ccaacgcctc ttccgttcct 23881 ttcacacagg tgatccgtcg gtgctcggac gcgaggaacc gctcgatgac ggccagcccc 23941 tcggcaggct cgatcgagcc gatccccagc ccttccatgc gcgcgcggta ctccggtttc 24001 gcgacgacgc ctatcccgcc ccagtagccc cagttgacga ccttggcgtc gatcagcagg 24061 gcgtggtcga gcaggtccgc gcaggcgtcc ttggccacgc acgcggcggc gtagttgccc 24121 tgcccggcgc tggcgatgta ggcctgcacg gaggagaaga agaggcagaa gtcgaggtcc 24181 cggccgcgca gcgcctcgat cagatggcgg gtgccgtgca gcttcgggcg cagtacgtcg 24241 tgcagcaccc gctcgctcat ggtggcgagg gcggagtcct ccagcaccag cgcggagtgc 24301 accacgccgt ggacgacctc gtgggcgtcg agcgcgcgct tgagtgccgg gccgtcggcc 24361 aggtcggcct ggtggtagtg gaccgcgcgg gcacccgcct cgcgcagggc ctgcgcggcc 24421 ggggcgaagt cctcggccgg gcggcgcccg atgacgacca cctcggcccg gtggacggcg 24481 gccaggtact cggcgagcag cccgcccagt ccgccggtgc cgcccacgat gacgtacgtg 24541 cccccggtgc ggaacgccga gcgggcgggc caggccggga gggacgccgg ttccatggac 24601 gcgacggcgt actcgtcgcc gcggacgcac acgggcttgt ccggcacggt cggcaggggc 24661 cgctccaggg cctcggacag cgcggccgcg gtgaggtccg cgaggcagaa gcagcgcacc 24721 gaccagtcgg gccgctcctt ggcgagggcc tgtgccaggc cgacgtacac gccgtccacc 24781 ggatgcgtgg cggcggtgaa cagcgggctg ggcaccgcct tgtcggtgaa gacgtcgagg 24841 cggacccgcg gccagcggtc gagggcgtgc acgaggccga ggaacgccgt gagatcggcg 24901 tcccggatgc cgtcggccca ggaggtgcgg ctgacgaaca ccaggtgctc gtcggcggcc 24961 ggagcggcgg cgagcgaggc gatcgccgcg tcgtcgagca gcagcaccct gctgtccggg 25021 cactgctccg tcagctcctg gtgcagccgg tgctgtccgg gcggcaccag gaaggtgcgc 25081 ggtccgtccc cgccggtgcg cggccgctcc agccggccgt gcgtccactg cggggcgaac 25141 accatcgagt ccacggcggc acggcgaacc agcgggacat cggggcgcgc tgtaccggac 25201 gcggaatctc cgcttcgcca ttcgttgcga ctcaacaaaa tcccctatgc ctaggacgcc 25261 ggattcaaag agcgggtttc acaccgaggt cgaataccga cagaagcggt tcgtaatcct 25321 cgtcgaacaa ggtgaagttg gtcctgaagg gggagagttt ttccgtcagg acgaaagcgg 25381 aaccgagcgg aaagcgcgtc ggcgcgtgaa agaccatatg gcccatggag aagggcatca 25441 agctgtcacg gtgctctccg atggagatcg ccatgccgga ctggaaggcg cagtcgagaa 25501 ggttgaccag cccgatccgg gtgccgtcgt tgtgcgagag ccaggcgagc gaccgctgtc 25561 cgtgccgctg cacatagctg ttgcggcgga aatacgggcc gtagtcgatg cccatgttcg 25621 agaattcttc gtagatttcc gctcgggtga gatgggaccg ggtgtgcgcg cagatctcgt 25681 cgcgtacctc cagtcccacc gcgaccgcgc ggtcctgcgg ttcgaaaagg agggtgccca 25741 tggcgcagag cgcgccgcgg ttggtgacgg tgtagtccgt ctcccgagcg ccgggtgcgg 25801 tgcggaaggc gacggacagc tcgtccagcg gctcgtcgcc gtagacggga cgcagccagg 25861 cggcgtcgcg gacggcgaac ggccgcgcgc cggggcggac ccgggcggcc ccgcgcagtg 25921 ccatctccag gcaggcgacg ccgggcagca cgcgccggcc ctgaaccagg tgttgagcga 25981 ggtaggggtg gccggtctcg accggcaccc ggaaggtgtc cggttcgccg gtgtcgagca 26041 gccgcggcgg ctccaccgcc gccgggccgg cggtctggtc ggctcgggtc gtcatgccgt 26101 ccgctcctcg tccgtgaacc acaggtccgt ctcctcgaac gggtagccgg gcagccgcag 26161 ccggcggggg gcgtcggcgg cgaacagggc ctgcgtgtcg accgggccgc cggccaggaa 26221 ccggtcgcgg gccgactcgg gggtcgcctg ccacacgccg ccttcccgct ccgtgcgcgg 26281 cgcgtggcgc ggttcgccgg ccgtgcgcag tgcgcgcagg agttcctcgc cggaggacgg 26341 gcaccacgcc aggcggcacg gcaggtgctc ccggcggcac agggtgtacg agaggtcgag 26401 caggtcgtgg tccgagagcg gaccggaccg ctcgacacgg tcgagcagcg cggccgtcag 26461 acggcgcagc gcctgcgggg tgcgcgccga cagcgggacc agccgggggc gcggggagac 26521 cgggcgccgg gcggcgcggc ccggcggcgc ggacaggacg acgtgcgcgt tggacccgcc 26581 gaagccgaag gagctgatgc ccgcgacgag ttcgccgccg tcctcgcccc aggggaccgt 26641 cttgcgcacc gcctcgaagg gcccctcctc cagggcgatg ccggggttgg ggtcctggaa 26701 gtgcaggttg gccggcagcg tccggtgttc gaacgccttg accaccttgg tcagggaggc 26761 gacgcccgcg gcgggctcca ggtgcccgat gtgggacttg accgcgccga gccggacccg 26821 gccgcccgcg gaccgcggca ccaggtgccg ccaggcccgc ttcagcgcgt cgatctcgat 26881 cgcgtcgccc agtgccgttc cggtgccgtg ggtctcgatg tacccggtgc gggcggcgag 26941 ttcgggcgtg taggcgtcca ggagcaggcg gtactgggcg ttggggttgg gcgcggtgag 27001 cgagttggcg cggccgccgt ggttctccgc cacgctctcg acgaccgccc ggatgtcgtc 27061 gccgtcggcg agcgcgtccg ccagccgctt gaccaggaag gtgccgtagc cctcgccgcg 27121 cacatagccg tcggcggcgg cgtcgaaggt ggcgcagcgg tgctccgggg agaggaaccg 27181 cgcggcgtgc agtccctcgt tgatctggga gtcgaggatg aggttcacgc cgccgaccag 27241 ggccgcgtcg cacaccccgg cgcgcaggtc gcggcaggcc cggaccagcg ccaccaggga 27301 accggagcag gcggtgtcga ggaccgcgga ggggccgtgc cagtcgaacc aggaggagac 27361 gcggttggcg atgaggctca gcgagtgccc caccagcgag tacgggatct gccgggcgtc 27421 cgcgcgggcc tggagcagcg cgtagtcgtt gccggtggcc gcgatgtagc acccggtgcg 27481 cgagccgctc aggtcggagg gtgcgtaccc agcgtcctcc agggtgtgcc aggcggactg 27541 gagcagcagc cgctggcggg ggtccatcca gctcgcctcg cgtggcgaga tggagaagaa 27601 cctggcgtcg aatcccctga cgccggggag gaatccggcg aactcgccgg gcaggccgcg 27661 cccggccggt gcgggtgtga cgcagtccct gccgtcgagc agggtctgcc agaacgcgtc 27721 ggggtccggg ccgccgggca ggaccgccga gaggccgacg atggccagcc ggccgtcggc 27781 gccgggccgg ccgtcggccg gtcccggtcg cggcgcggtg gccggccggg cctccggccg 27841 ttccccggtc cgcccctcgg acagccgtgc gacggtctcg gcgacgttgc gcagggtgtt 27901 catccggtag aagtcgtgcg cgtggacggt gatcccgtac cgctcgccga tccgcgcggc 27961 gaggatgttg tagccgagcg aggtgacgcc ctggtaaccc aggggccggt cggcgtccgg 28021 ctccggcagg cccagttcgg cggcgacgag ccggcgcagc tcgccgagga ggtccggccc 28081 gtccgccgca cccgtgtccg ggccgcccgc cgcgccggtg tccaccgcgg cgcgcgccgc 28141 gtcggccggc cgctcggacg cctcgtcctg cgggtacagg tccagcgcgg acaggggggc 28201 ctcgctcagc tttctgacgt cggtcttgcc gttggccgtc agcgggatcc gggtcagccg 28261 gtgcacggcc tgcggcacca tgtagtacgg cagggtgtcc cgcaggcgtt cccggacggc 28321 ggcggcgtcg aagctctcgc cggccggcag ccacacgaag cagcgcaggt gcggctcggg 28381 ttcgggccgt acgacggcga cgacggtcgc ggacggcacc cgtgccgtca ccgcggcggc 28441 cacctcgtcc agttcgatcc ggtggccgtt gaccttgcgc tggccgtcct tgcgcgagac 28501 gtaggtgaca cgcgcggggc cctcgtagcg gaccaggtcg ccggtccggt aggacggcgt 28561 tccgtcgggc aggctgccga aggccgtcgc cggggcgttg aggtacccct gggccacaca 28621 gtcgccggcg atcatcagct cgcccgccat gccgggtgcc acggagcggc cgtcggcgtc 28681 cacgacgtag aaccgggtgc ccagcgcggg ctcccccagg tgaatgtggc ccgcgccggt 28741 cacgcgctgc cagctcgccc agatggtcgc ctcggtcggg ccgtacatgt tgtagacggc 28801 cgcgctctgg ctcagcaggt actccgcgag gtcgcggtcc agcgcctccc cgccgcacag 28861 cagggtcatg ggccgccggg cccgccagcc ggccgccttc aggatgcgcc aggtggaggg 28921 ggtggcctgg acgacggtgg cgccggcggc gtcgatgtgc tcggccagca gggccccgct 28981 gctcctggtc tcgtcggaga gcatccgcag gcgcgcgccg cacagcagcg gcagcaggat 29041 ctccagcagg gagatgtcga agccgatcgg ggtcagggcc acgatgcggt cgtccgggcc 29101 catcgagggg tcctggcgca cggagtgcag gaagttggcg aggttgccct cgctcaccgc 29161 cacgcccttg gggttcccgg tcgagcccga ggtgaacatc acgtaggcgg tgcggtcgcc 29221 gtcggccggg gtggagggcc ggatgccggc acggtgcggg ccggcggacg gggcgggtgc 29281 gccgtccacc tcccgcctgg gtatgccggg gaacagccgc gccgcccggt cacgggtcgc 29341 cgcgtccacc aggatgacgc ccggttccgc ggccgcggcc atgtacgcga gtcgggcgtc 29401 cggcagccgg gggtccatcg gtacgaacgt ccgccgcagc gccagcgcgg tcagataggc 29461 gacggggatc gccgccgagc gctccaggaa cacgccgacg ggcgccgtgc cgggccgggc 29521 cggggtggcg tcgccaaaga ggtcctggcc gagccggtgt gcggcgtcga gcagttcgcc 29581 gtaggtgagc gagcggtggt cgtccacgac ggccacccgg tccgggttct gccgggcggt 29641 ccggaccagc gccgcgccca ggccctcgcc ggtcccggcg gccgggaccg ccccctcggc 29701 caccggctcc agggggcgcg acaggtcgca ctgtgccgtg gggcggtgcg gatcggcggc 29761 cacgaaccgg gccatgcgca ggaagttggc cgccagcgcg gacagggcct cgggcgagag 29821 cacgtgcgtg gcggagtcga aggagaggtg gatgccctgc tcgtcggagc tgaagttgac 29881 gctcaggtcg ctggagctgc cggtgtcggg cttgcggacc caggagacgt ccagcccgct 29941 cagccgcgga accgcggtcg gcagcatcgc cgaggacgcg ttcaccacga ggttgagcgc 30001 gctgccgccc tggtccaccg tgcggccgtg ctcgcccgcg gccagggcga gcagatcgga 30061 caccgggaag ccctggtggt cccggaggtt ctcgcgctgg gcgcgcacct gctccagcag 30121 cgacagcgcg tctcgctccg cccggacgtc cagccacagc ggcagcagat tggtgtggca 30181 gccgtacggg gctccgtacg gccgggtgtc cacggtgtgc gcgacgacga cgccgcgctc 30241 gtcgtcgtcg ccgtaggcgt gcacgagcgc gccggtgacg cccaccacga actgcagcag 30301 gctcagctcg tgccggcgca ggaaccggtg gatgtcctcg gcctggtcgc cggtgatcgt 30361 ctccttgacc gagatgcgcc ggccgtcgcg ccggggctcc gcggcggaga agggcagcgg 30421 ctggtgcagg gggcggccgg ccagcatcga acgccagtag gcggcgtccg cgccgtcgcc 30481 ggagcgcggc gccgcgccga actgcctttc gagcaccggg gtttcgccct cccagcaggc 30541 gctgagcgcg gcgcagaacg gcgcgtagca gccgccgtcg aacaccacgt ggctgaagtc 30601 cagacggagc agcagcttct gcggggacac ccggcagtac cggaagcgga acagctcctg 30661 tccggtgggg tcgatgccac cggagtcgag gagcacgtcc tgccgctcgc accgccgcaa 30721 tatccgccgg ggcagcggac gactcttcgc gatcagttcc ccgccgactt cggtgaaata 30781 gtcgagaagg cgcgggaaag ccgtggaaac cacttcccga agtgcgtctt cgagccggtc 30841 ggtgtcgact tctccggtca gcgcgtacac atagccgacg gtgagtcccg gatcatcggg 30901 attccgctgg taccgatacc attgaaagcg ctcgtaggcg cttgcctgac gctccgtcat //