Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001102.1:
Cluster 1NRP / Polyketide135748

BGC0001102, malleilactone biosynthetic gene cluster from Burkholderia thailandensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Malleilactone
SMILES string: Copy to clipboard
Molecular formula: C18H26O4
Exact molecular mass: 306.1831 Da (None)
Molecular activity: Siderophore

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Beta-lactam (linear)
Thioesterase type:
Type I
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
malJ (ABC35922.1)
Module 0
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Other
malF (ABC35796.1)
Module 3
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
malA (ABC36203.1)
Module 3
A specificity: Proprionate
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Polyketide subclass:
Polyene (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
None
Release / cyclization type:
Reductive release

Modular polyketide synthases:
malF (ABC35796.1)
Module 1
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module 2
Scaffold-modifying domain: None

malA (ABC36203.1)
Module 4
AT specificity: Propionyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Gene cluster description

malleilactone (BGC0001102). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000085, positions 2545193-2580940. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:John Biggins (The Rockefeller University)

Literature references

1. Biggins JB et al. (2012) Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. J Am Chem Soc 134(32):13192-5. doi: 10.1021/ja3052156. Epub 2012 Aug