BGC0001102: malleilactone biosynthetic gene cluster from Burkholderia thailandensis E264; ATCC 700388
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Location: 2,543,245 - 2,580,940 nt. (total: 37,696 nt).
This entry is originally from NCBI GenBank CP000085.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001102
Short description malleilactone biosynthetic gene cluster from Burkholderia thailandensis E264; ATCC 700388
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Putative gene functions: BurR: LuxR-type regulator, BurA: Gonyol-Synthetase (NRPS/PKS), BurB: methyltransferase, BurC: hydroxylase, BurD: aminotransferase, BurE: dehydrogenase, BurF: NRPS/PKS, BurG: reductoisomerase, BurH: FkbH-like protein, BurI: decarboxylase, BurJ: acyl-CoA ligase, BurK: unknown, BurL: acyltransferase, BurM: acyl-CoA ligase, BurN: efflux carrier protein"
Biosynthetic class(es)
  • NRP (Other)
  • Polyketide (Other)
Loci NCBI GenBank: CP000085.1
Compounds
  • malleilactone
Species Burkholderia thailandensis E264; ATCC 700388 [taxonomy]
References
Chemical products information
malleilactone [synonyms: burkholderic acid]
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C18H26O4
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_II2087
  • ABC34352.1
 2543245 - 2544522 (-) LuxR-type regulator
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  • BTH_II2088
  • ABC36203.1
 2545193 - 2553571 (+) Gonyol-Synthetase (NRPS-PKS hybrid)
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  • BTH_II2089
  • ABC34581.1
 2553671 - 2554189 (+) methyltransferase
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  • BTH_II2090
  • ABC35239.1
 2554346 - 2555740 (+) hydroxylase
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  • BTH_II2091
  • ABC35627.1
 2555749 - 2557170 (+) aminotransferase
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  • BTH_II2092
  • ABC35115.1
 2557164 - 2558576 (+) dehydrogenase
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  • BTH_II2093
  • ABC35796.1
 2558633 - 2570779 (+) NRPS-PKS hybrid
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  • BTH_II2094
  • ABC34926.1
  • ilvC-2
 2570785 - 2571846 (+) reductoisomerase
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  • BTH_II2095
  • ABC34723.1
 2571743 - 2574466 (+) FkbH-like protein
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  • BTH_II2096
  • ABC34346.1
 2574496 - 2576364 (+) acyl-CoA ligase
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  • BTH_II2097
  • ABC34855.1
 2576437 - 2576868 (+) Unknown
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  • BTH_II2098
  • ABC35574.1
  • fabD-2
 2576869 - 2577768 (+) acyltransferase
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  • BTH_II2099
  • ABC35922.1
 2577785 - 2579653 (+) acyl-CoA ligase
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  • BTH_II2100
  • ABC35961.1
 2580041 - 2580940 (+) efflux carrier protein
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Reductive release
Polyketide-synthases
Genes Properties Modules
BTH_II2088
+
BTH_II2093 		Synthase subclass: Modular type I/Trans-AT type I
Module 1
Genes: BTH_II2093
Core domains: Thiolation (ACP/PCP), Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 2
Genes: BTH_II2093
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 4
Specificity: Propionyl-CoA
Evidence for specificity: Structure-based inference
Genes: BTH_II2088
Core domains: Ketosynthase, Acyltransferase, Thioesterase, Ketoreductase
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass Other
Cyclic? yes
Release type
  • Reductive release
Thioesterase genes
  • BTH_II2088 (Type I)
NRP-synthases
Gene Modules
BTH_II2099
Module 0
Condensation domain type: Unknown
BTH_II2093
Module 3
Condensation domain type: LCL
BTH_II2088
Module 3
Specificity: propionic acid
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: WBX64IC5EUFODOV2ECKGLTGC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged burkholderic acid annotation
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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