BGC0001103: mycosubtilin biosynthetic gene cluster from Bacillus subtilis subsp. spizizenii ATCC 6633
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Location: 1 - 46,860 nt. (total: 46,860 nt).
This entry is originally from NCBI GenBank AF184956.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001103
Short description mycosubtilin biosynthetic gene cluster from Bacillus subtilis subsp. spizizenii ATCC 6633
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AF184956.1
via
Compounds
  • mycosubtilin
Species Bacillus subtilis subsp. spizizenii ATCC 6633 [taxonomy]
References
Chemical products information
mycosubtilin Evidence:
Copy SMILES
C55H86N14O16
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF08794.1
  • fenF
 1938 - 3140 (+) FenF
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    • AAF08795.1
    • mycA
    		 3161 - 15076 (+) MycA
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      • AAF08796.1
      • mycB
      		 15133 - 31242 (+) MycB
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        • AAF08797.1
        • mycC
        		 31340 - 39169 (+) MycC
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          • AAF08798.1
          • yngL
          		 39339 - 39731 (+) YngL
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            • AAF08799.1
            • yngK
            		 39886 - 41418 (+) YngK
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              • AAF08800.1
              • yngJ
              		 41925 - 43067 (+) YngJ
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                • AAF08801.1
                • yngI
                		 43110 - 44759 (+) YngI
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                  • AAF08802.1
                  • yngH
                  		 44769 - 46103 (+) YngH
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                    • AAF08803.1
                    • yngXX
                    		 46118 - 46339 (+) YngXX
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      mycA
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      mycB
                      Substrates
                      tyrosine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      mycB
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      mycB
                      Substrates
                      glutamine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      mycB
                      Substrates
                      proline (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      mycC
                      Substrates
                      serine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk07
                      Type
                      nrps-type1
                      Genes
                      mycC
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Update compound structure (SMILES) for mycosubtilin
                      • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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