BGC0001105: onnamide A biosynthetic gene cluster from Uncultured bacterium
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Location: 1 - 36,513 nt. (total: 36,513 nt).
This entry is originally from NCBI GenBank AY688304.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001105
Short description onnamide A biosynthetic gene cluster from Uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The gene cluster encodes for all onnamides, theopederins and pseudoonnamides."
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AY688304.2
Compounds
  • onnamide A
Species Uncultured bacterium [taxonomy]
References
Chemical products information
onnamide A
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C39H63N5O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAV97868.1
 3 - 422 (+) putative transposase
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  • AAV97869.1
  • onnA
 459 - 1721 (+) OnnA
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  • AAV97870.1
  • onnB
 1783 - 14913 (+) OnnB
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  • AAV97871.1
  • onnC
 14930 - 16090 (+) OnnC
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  • AAV97872.1
  • onnD
 16120 - 17073 (+) OnnD
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  • AAV97873.1
  • onnE
 17124 - 18194 (+) OnnE
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  • AAV97874.1
  • onnF
 18213 - 19235 (+) OnnF
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  • AAV97875.1
  • onnG
 19409 - 20374 (+) OnnG
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  • AAV97876.1
  • onnH
 20462 - 21268 (+) OnnH
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  • AAV97877.1
  • onnI
 21358 - >36513 (+) OnnI
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
onnI
+
onnB 		Synthase subclass: Trans-AT type I
Module 0
Genes: onnB
Core domains: Thiolation (ACP/PCP)
Scaffold-modifying domains: GNAT
Module 1
Genes: onnB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 2
Genes: onnB
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: 2x Crotonase / Enoyl-CoA dehydratase
Module 3
Genes: onnB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 4
Genes: onnI
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: onnI
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: onnI
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 8
Genes: onnI
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Pyran synthase
KR-domain stereochemistry: D-OH
Module 9
Genes: onnI
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 10
Genes: onnI
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: onnI
Core domains: Ketosynthase
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
onnI
Module 5
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for onnamide A
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Removed invalid PKS modules
  • Sorted modules by module number
  • Removed invalid NRPS modules
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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