BGC0001105: onnamide A biosynthetic gene cluster from Uncultured bacterium
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Location: 1 - 36,513 nt. (total: 36,513 nt).
This entry is originally from NCBI GenBank AY688304.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001105
Short description onnamide A biosynthetic gene cluster from Uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The gene cluster encodes for all onnamides, theopederins and pseudoonnamides."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
AY688304.2
via
Compounds
  • onnamide A
Species Uncultured bacterium [taxonomy]
References
Chemical products information
onnamide A Evidence: NMR, Mass spectrometry
Copy SMILES
C39H63N5O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAV97868.1
 3 - 422 (+) putative transposase
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    • AAV97869.1
    • onnA
    		 459 - 1721 (+) OnnA
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      • AAV97870.1
      • onnB
      		 1783 - 14913 (+) OnnB
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        • AAV97871.1
        • onnC
        		 14930 - 16090 (+) OnnC
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          • AAV97872.1
          • onnD
          		 16120 - 17073 (+) OnnD
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            • AAV97873.1
            • onnE
            		 17124 - 18194 (+) OnnE
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              • AAV97874.1
              • onnF
              		 18213 - 19235 (+) OnnF
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                • AAV97875.1
                • onnG
                		 19409 - 20374 (+) OnnG
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                  • AAV97876.1
                  • onnH
                  		 20462 - 21268 (+) OnnH
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                    • AAV97877.1
                    • onnI
                    		 21358 - >36513 (+) OnnI
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      5
                      Type
                      nrps-type1
                      Genes
                      onnI
                      Substrates
                      glycine (evidence: Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      condensation (LCL), adenylation
                      Name
                      0
                      Type
                      pks-trans-at-starter
                      Genes
                      onnB
                      Substrates
                      Integrated Monomers
                      Domains
                      other (GNAT), carrier (ACP)
                      Name
                      1
                      Type
                      pks-trans-at
                      Genes
                      onnB
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                      Name
                      2
                      Type
                      pks-trans-at
                      Genes
                      onnB
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, other (Enoyl-CoA dehydratase), other (Enoyl-CoA dehydratase), carrier (ACP), carrier (ACP), carrier (ACP)
                      Name
                      3
                      Type
                      pks-trans-at
                      Genes
                      onnB
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, carrier (ACP)
                      Name
                      4
                      Type
                      pks-trans-at
                      Genes
                      onnI
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, carrier (ACP)
                      Name
                      6
                      Type
                      pks-trans-at
                      Genes
                      onnI
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP)
                      Name
                      7
                      Type
                      pks-trans-at
                      Genes
                      onnI
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, methyltransferase, carrier (ACP), carrier (ACP)
                      Name
                      8
                      Type
                      pks-trans-at
                      Genes
                      onnI
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, dehydratase, ketoreductase, other (Pyran synthase), carrier (ACP)
                      Name
                      9
                      Type
                      pks-trans-at
                      Genes
                      onnI
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP)
                      Name
                      10
                      Type
                      pks-trans-at
                      Genes
                      onnI
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                      Name
                      11
                      Type
                      pks-trans-at
                      Genes
                      onnI
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Update compound structure (SMILES) for onnamide A
                      • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Corrected NRP module activity
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Removed invalid PKS modules
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Sorted modules by module number
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Removed invalid NRPS modules
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Changed amino acid substrates to lower case
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: CUIZDUBUBVAF27VHF4OZXTI3)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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