BGC0001108: pederin biosynthetic gene cluster from Uncultured bacterium
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Location: 1 - 75,778 nt. (total: 75,778 nt).
This entry is originally from NCBI GenBank AY328023.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001108
Short description pederin biosynthetic gene cluster from Uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Pederin is most likely not released by the TE domain but by PedG."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
AY328023.1
via Enzymatic assays
Compounds
  • pederin
  • pseudopederin
  • pederone
Species Uncultured bacterium [taxonomy]
References
Chemical products information
pederin Evidence: NMR, Mass spectrometry, Chemical derivatisation
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C25H45N1O9
Chemical database entries
PubCHEM
pseudopederin Evidence: NMR, Mass spectrometry
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C24H43N1O9
Chemical database entries
PubCHEM
pederone Evidence: NMR, Mass spectrometry
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C25H43N1O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • AAS47548.1
1 - 520 (-) putative isocitrate dehydrogenase kinase/phosphatase
    AY328023 and AY850690\n together build up the pederin gene cluster (BGC0001108\n and BGC0000255\n) BGC0001109\n is not complete.
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    • AAS47549.1
    1911 - 2654 (+) putative dioxygenase
    • Tailoring
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    • AAS47557.1
    • pedA
    6372 - 7310 (-) putative methyltransferase
    • Tailoring
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    • AAS47558.1
    • pedB
    7324 - 8718 (-) putative FMN-dependent oxidoreductase
    • Tailoring
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    • AAS47559.1
    • pedC
    8894 - 9898 (-) putative acyltransferase
    • Scaffold biosynthesis
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    • AAS47563.1
    • pedD
    10062 - 11111 (+) putative acyltransferase
    • Scaffold biosynthesis
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    • AAS47560.1
    • pedE
    11341 - 12162 (+) putative methyltransferase
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    • AAS47564.1
    • pedF
    12407 - 38212 (+) mixed type I polyketide synthase/nonribosomal peptide synthetase
    • Scaffold biosynthesis
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    • AAS47561.1
    • pedG
    38240 - 39541 (+) putative FAD-dependent monooxygenase
    • Tailoring
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    • AAS47562.1
    • pedH
    39565 - 58365 (+) mixed type I polyketide synthase - peptide synthetase
    • Scaffold biosynthesis
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    • AAS47550.1
    61329 - 61637 (-) putative acyl carrier protein
    • Scaffold biosynthesis
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    • AAS47551.1
    66565 - 68511 (-) putative DNA helicase
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      • AAS47552.1
      69647 - 70096 (-) hypothetical protein
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        • AAS47553.1
        70095 - 70571 (+) putative RNA methylase
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          • AAS47554.1
          72053 - 72415 (-) hypothetical protein
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            • AAS47555.1
            72966 - 74459 (+) putative aldehyde dehydrogenase
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              Biosynthesis information

              Biosynthetic modules

              Name
              Unk01
              Type
              nrps-type1
              Genes
              pedH
              Substrates
              arginine (evidence: )
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk02
              Type
              nrps-type1
              Genes
              pedF
              Substrates
              glycine (evidence: )
              Integrated Monomers
              Domains
              adenylation
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              Removed gene names of 'No gene ID'
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Corrected duplicated gene annotation
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Removed duplicate gene name
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Added NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Fixed biosynthetic classes
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              Submitted
              • (ID: CUIZDUBUBVAF27VHF4OZXTI3)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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