BGC0001111: rhizopodin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 92,218 nt. (total: 92,218 nt).
This entry is originally from NCBI GenBank FR854394.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001111
Short description rhizopodin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: FR854394.1
Compounds
  • rhizopodin
Species Stigmatella aurantiaca Sg a15 [taxonomy]
References
Chemical products information
rhizopodin
Copy SMILES
C78H124N4O22
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCA89321.1
 176 - 895 (-) hypothetical protein
copy AA seq
copy Nt seq
  • CCA89322.1
 898 - 2340 (-) hypothetical protein
copy AA seq
copy Nt seq
  • CCA89323.1
 2636 - 3241 (+) hypothetical protein
copy AA seq
copy Nt seq
  • CCA89324.1
 4014 - 5777 (+) hypothetical protein
copy AA seq
copy Nt seq
  • CCA89325.1
  • rizA
 5788 - 6642 (+) acyltransferase
  • Activation / processing
Knock-out
copy AA seq
copy Nt seq
  • CCA89326.1
  • rizB
 6639 - 43580 (+) mixed trans-AT type I polyketide synthase/nonribosomal peptide synthetase
  • Scaffold biosynthesis
Knock-out
copy AA seq
copy Nt seq
  • CCA89327.1
  • rizC
 43574 - 49810 (+) trans-AT type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • CCA89328.1
  • rizD
 49812 - 73226 (+) mixed trans-AT type I polyketide synthase/nonribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • CCA89329.1
  • rizE
 73223 - 85105 (+) trans-AT type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • CCA89330.1
  • rizF
 85110 - 85970 (+) acyltransferase
  • Scaffold biosynthesis
Knock-out
copy AA seq
copy Nt seq
  • CCA89331.1
 85993 - 86958 (-) hypothetical protein
copy AA seq
copy Nt seq
  • CCA89332.1
 86973 - 88661 (-) hypothetical protein
copy AA seq
copy Nt seq
  • CCA89333.1
 90897 - 91433 (+) hypothetical protein
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
rizB
+
rizE
+
rizC
+
rizD
+
rizE 		Synthase subclass: Trans-AT type I
Thioesterases:
  • rizE (Type I)
Module 2
Genes: rizB
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Genes: rizB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 4
Genes: rizB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 5
Genes: rizB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: rizB
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 7
Genes: rizB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 8
Genes: rizB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 9
Genes: rizB, rizC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 10
Genes: rizC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: rizC
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 13
Genes: rizD
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 14
Genes: rizD
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 15
Genes: rizD
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 16
Genes: rizD
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 17
Genes: rizD
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 18
Genes: rizD, rizE
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 19
Genes: rizE
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 20
Genes: rizE
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 21
Genes: rizE
Core domains: Ketosynthase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
rizB
Module 1
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Modification domains: Methylation
rizD
Module 12
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Modification domains: Oxidation
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Remove leading/trailing whitespace in gene identifiers
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.