BGC0001111: rhizopodin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
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Location: 1 - 92,218 nt. (total: 92,218 nt).
This entry is originally from NCBI GenBank FR854394.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001111
Short description rhizopodin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
FR854394.1
via Knock-out studies
Compounds
  • rhizopodin
Species Stigmatella aurantiaca Sg a15 [taxonomy]
References
Chemical products information
rhizopodin Evidence:
Copy SMILES
C78H124N4O22
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCA89321.1
 176 - 895 (-) hypothetical protein
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    • CCA89322.1
    		 898 - 2340 (-) hypothetical protein
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      • CCA89323.1
      		 2636 - 3241 (+) hypothetical protein
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        • CCA89324.1
        		 4014 - 5777 (+) hypothetical protein
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          • CCA89325.1
          • rizA
          		 5788 - 6642 (+) acyltransferase
          • Activation / processing
          • Knock-out
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          • CCA89326.1
          • rizB
          		 6639 - 43580 (+) mixed trans-AT type I polyketide synthase/nonribosomal peptide synthetase
          • Scaffold biosynthesis
          • Knock-out
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          • CCA89327.1
          • rizC
          		 43574 - 49810 (+) trans-AT type I polyketide synthase
          • Scaffold biosynthesis
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          • CCA89328.1
          • rizD
          		 49812 - 73226 (+) mixed trans-AT type I polyketide synthase/nonribosomal peptide synthetase
          • Scaffold biosynthesis
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          • CCA89329.1
          • rizE
          		 73223 - 85105 (+) trans-AT type I polyketide synthase
          • Scaffold biosynthesis
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          • CCA89330.1
          • rizF
          		 85110 - 85970 (+) acyltransferase
          • Scaffold biosynthesis
          • Knock-out
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          • CCA89331.1
          		 85993 - 86958 (-) hypothetical protein
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            • CCA89332.1
            		 86973 - 88661 (-) hypothetical protein
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              • CCA89333.1
              		 90897 - 91433 (+) hypothetical protein
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                Biosynthesis information

                Biosynthetic modules

                Name
                1
                Type
                nrps-type1
                Genes
                rizB
                Substrates
                glycine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation, adenylation, methyltransferase
                Name
                12
                Type
                nrps-type1
                Genes
                rizD
                Substrates
                serine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (Heterocyclization), adenylation, oxidase
                Name
                2
                Type
                pks-trans-at
                Genes
                rizB
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                Name
                3
                Type
                pks-trans-at
                Genes
                rizB
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                Name
                4
                Type
                pks-trans-at
                Genes
                rizB
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, methyltransferase, carrier (ACP)
                Name
                5
                Type
                pks-trans-at
                Genes
                rizB
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, carrier (ACP)
                Name
                6
                Type
                pks-trans-at
                Genes
                rizB
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, dehydratase, enoylreductase, methyltransferase, carrier (ACP)
                Name
                7
                Type
                pks-trans-at
                Genes
                rizB
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, carrier (ACP)
                Name
                8
                Type
                pks-trans-at
                Genes
                rizB
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, methyltransferase, carrier (ACP)
                Name
                9
                Type
                pks-trans-at
                Genes
                rizB rizC
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                Name
                10
                Type
                pks-trans-at
                Genes
                rizC
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, carrier (ACP)
                Name
                11
                Type
                pks-trans-at
                Genes
                rizC
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, carrier (ACP)
                Name
                13
                Type
                pks-trans-at
                Genes
                rizD
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, carrier (ACP)
                Name
                14
                Type
                pks-trans-at
                Genes
                rizD
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, carrier (ACP)
                Name
                15
                Type
                pks-trans-at
                Genes
                rizD
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, methyltransferase, carrier (ACP)
                Name
                16
                Type
                pks-trans-at
                Genes
                rizD
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, dehydratase, carrier (ACP)
                Name
                17
                Type
                pks-trans-at
                Genes
                rizD
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                Name
                18
                Type
                pks-trans-at
                Genes
                rizD rizE
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, carrier (ACP)
                Name
                19
                Type
                pks-trans-at
                Genes
                rizE
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, methyltransferase, carrier (ACP)
                Name
                20
                Type
                pks-trans-at
                Genes
                rizE
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, carrier (ACP)
                Name
                21
                Type
                pks-trans-at
                Genes
                rizE
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Remove leading/trailing whitespace in gene identifiers
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Merged cross-CDS PKS modules
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Changed amino acid substrates to lower case
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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