BGC0001111: rhizopodin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
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Location: 1 - 92,218 nt. (total: 92,218 nt).
This entry is originally from NCBI GenBank FR854394.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001111
Short description rhizopodin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: FR854394.1
Compounds
  • rhizopodin
Species Stigmatella aurantiaca Sg a15 [taxonomy]
References
Chemical products information
rhizopodin
Copy SMILES
C78H124N4O22
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCA89321.1
176 - 895 (-) hypothetical protein
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  • CCA89322.1
898 - 2340 (-) hypothetical protein
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  • CCA89323.1
2636 - 3241 (+) hypothetical protein
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  • CCA89324.1
4014 - 5777 (+) hypothetical protein
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  • CCA89325.1
  • rizA
5788 - 6642 (+) acyltransferase
  • Activation / processing
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  • CCA89326.1
  • rizB
6639 - 43580 (+) mixed trans-AT type I polyketide synthase/nonribosomal peptide synthetase
  • Scaffold biosynthesis
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  • CCA89327.1
  • rizC
43574 - 49810 (+) trans-AT type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CCA89328.1
  • rizD
49812 - 73226 (+) mixed trans-AT type I polyketide synthase/nonribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CCA89329.1
  • rizE
73223 - 85105 (+) trans-AT type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CCA89330.1
  • rizF
85110 - 85970 (+) acyltransferase
  • Scaffold biosynthesis
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  • CCA89331.1
85993 - 86958 (-) hypothetical protein
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  • CCA89332.1
86973 - 88661 (-) hypothetical protein
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  • CCA89333.1
90897 - 91433 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
CCA89326.1
+
CCA89329.1
+
CCA89327.1
+
CCA89328.1
+
CCA89329.1
Synthase subclass: Trans-AT type I
Thioesterases:
  • CCA89329.1 (Type I)
Module 2
Genes: CCA89326.1
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Genes: CCA89326.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 4
Genes: CCA89326.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 5
Genes: CCA89326.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: CCA89326.1
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 7
Genes: CCA89326.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 8
Genes: CCA89326.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 9
Genes: CCA89326.1
Core domains: Ketosynthase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 9
Genes: CCA89327.1
Core domains: Thiolation (ACP/PCP)
Module 10
Genes: CCA89327.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: CCA89327.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 13
Genes: CCA89328.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 14
Genes: CCA89328.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 15
Genes: CCA89328.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 16
Genes: CCA89328.1
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 17
Genes: CCA89328.1
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 18
Genes: CCA89328.1
Core domains: Ketosynthase
Module 18
Genes: CCA89329.1
Core domains: Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 19
Genes: CCA89329.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 20
Genes: CCA89329.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 21
Genes: CCA89329.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
NRP-specific information
Subclass n/a
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
CCA89326.1
Module 1
Specificity: Glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Modification domains: Methylation
CCA89328.1
Module 12
Specificity: Serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Modification domains: Oxidation
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
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Detailed domain annotation
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