Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001111.1:
Cluster 1NRP / Polyketide192218

BGC0001111, rhizopodins biosynthetic gene cluster from Stigmatella aurantiaca. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Rhizopodin
SMILES string: Copy to clipboard
Molecular formula: C78H124N4O22
Exact molecular mass: 1469.8779 Da ([M+H]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
rizB (CCA89326.1)
Module 1
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: Unknown
Scaffold-modifying domain: Methylation
rizD (CCA89328.1)
Module 12
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
rizB (CCA89326.1)
Module 2
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 3
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 4
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 5
AT specificity: None
Evidence for specificity: Unknown
Module 6
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 7
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 8
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 9
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation

rizC (CCA89327.1)
Module 9
AT specificity: None
Evidence for specificity: Unknown
Module 10
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 11
AT specificity: None
Evidence for specificity: Unknown

rizD (CCA89328.1)
Module 13
AT specificity: None
Evidence for specificity: Unknown
Module 14
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 15
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 16
AT specificity: None
Evidence for specificity: Unknown
Module 17
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 18
AT specificity: None
Evidence for specificity: Unknown

rizE (CCA89329.1)
Module 18
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 19
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 20
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 21
AT specificity: None
Evidence for specificity: Unknown

Gene cluster description

rhizopodins (BGC0001111). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank FR854394, positions 1-92218. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Pistorius D, Muller R. (2012) Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining. Chembiochem 13(3):416-26. doi: 10.1002/cbic.201100575. Epub 2012 Jan