BGC0001112: rhizoxin A biosynthetic gene cluster from Paraburkholderia rhizoxinica
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Location: 1 - 81,989 nt. (total: 81,989 nt).
This entry is originally from NCBI GenBank AM411073.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001112
Short description rhizoxin A biosynthetic gene cluster from Paraburkholderia rhizoxinica
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
AM411073.1
via Knock-out studies, Enzymatic assays
Compounds
  • rhizoxin A
Species Paraburkholderia rhizoxinica [taxonomy]
References
Chemical products information
rhizoxin A Evidence:
Copy SMILES
C35H47N1O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAL69886.1
  • rhiI
 1 - 867 (+) RhiI protein
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    • CAL69887.1
    • rhiG
    		 1066 - 3063 (-) acyltransferase
    • Scaffold biosynthesis
    • Knock-out
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    • CAL69888.1
    • rhiA
    		 3798 - 10880 (+) RhiA protein
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      • CAL69889.1
      • rhiB
      		 11310 - 31478 (+) RhiB protein
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        • CAL69890.1
        • rhiC
        		 31540 - 47247 (+) RhiC protein
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          • CAL69891.1
          • rhiD
          		 47298 - 59777 (+) RhiD protein
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            • CAL69892.1
            • rhiH
            		 59800 - 61257 (+) RhiH protein
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              • CAL69893.1
              • rhiE
              		 61823 - 74080 (+) RhiE protein
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                • CAL69894.1
                • rhiF
                		 74139 - 81989 (+) RhiF protein
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  1
                  Type
                  nrps-type1
                  Genes
                  rhiB
                  Substrates
                  serine (evidence: Structure-based inference)
                  Integrated Monomers
                  Domains
                  adenylation, oxidase
                  Name
                  0
                  Type
                  pks-trans-at
                  Genes
                  rhiA
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase
                  Name
                  1
                  Type
                  pks-trans-at
                  Genes
                  rhiB
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                  Name
                  2
                  Type
                  pks-trans-at
                  Genes
                  rhiB
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, carrier (ACP), carrier (ACP)
                  Name
                  3
                  Type
                  pks-trans-at
                  Genes
                  rhiB rhiC
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                  Name
                  4
                  Type
                  pks-trans-at
                  Genes
                  rhiC
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                  Name
                  5
                  Type
                  pks-trans-at
                  Genes
                  rhiC
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, ketoreductase, carrier (ACP)
                  Name
                  6
                  Type
                  pks-trans-at
                  Genes
                  rhiC
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, ketoreductase, carrier (ACP), carrier (ACP)
                  Name
                  7
                  Type
                  pks-trans-at
                  Genes
                  rhiD
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                  Name
                  8
                  Type
                  pks-trans-at
                  Genes
                  rhiD
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                  Name
                  9
                  Type
                  pks-trans-at
                  Genes
                  rhiE
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                  Name
                  10
                  Type
                  pks-trans-at
                  Genes
                  rhiE
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                  Name
                  11
                  Type
                  pks-trans-at
                  Genes
                  rhiE
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, branching, carrier (ACP)
                  Name
                  12
                  Type
                  pks-trans-at
                  Genes
                  rhiF
                  Substrates
                  Integrated Monomers
                  Domains
                  ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Corrected NRP module activity
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Corrected polyketide synthase gene entries
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Merged cross-CDS PKS modules
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Sorted modules by module number
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Corrected gene identifiers
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Changed amino acid substrates to lower case
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: ZUAEFEJPIFGA5SNZGJWBG3IU)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                  Detailed domain annotation
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