BGC0001112: rhizoxin A biosynthetic gene cluster from Paraburkholderia rhizoxinica
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Location: 1 - 81,989 nt. (total: 81,989 nt).
This entry is originally from NCBI GenBank AM411073.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001112
Short description rhizoxin A biosynthetic gene cluster from Paraburkholderia rhizoxinica
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Macrolide)
Loci NCBI GenBank: AM411073.1
Compounds
  • rhizoxin A
Species Paraburkholderia rhizoxinica [taxonomy]
References
Chemical products information
rhizoxin A
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C35H47N1O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAL69886.1
  • rhiI
 1 - 867 (+) RhiI protein
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  • CAL69887.1
  • rhiG
 1066 - 3063 (-) acyltransferase
  • Scaffold biosynthesis
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  • CAL69888.1
  • rhiA
 3798 - 10880 (+) RhiA protein
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  • CAL69889.1
  • rhiB
 11310 - 31478 (+) RhiB protein
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  • CAL69890.1
  • rhiC
 31540 - 47247 (+) RhiC protein
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  • CAL69891.1
  • rhiD
 47298 - 59777 (+) RhiD protein
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  • CAL69892.1
  • rhiH
 59800 - 61257 (+) RhiH protein
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  • CAL69893.1
  • rhiE
 61823 - 74080 (+) RhiE protein
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  • CAL69894.1
  • rhiF
 74139 - 81989 (+) RhiF protein
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Polyketide-specific information
Subclass Macrolide
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
rhiD
+
rhiF
+
rhiE
+
rhiG
+
rhiA
+
rhiB
+
rhiC 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: rhiG
Module 0
Genes: rhiA
Core domains: Ketosynthase
Module 1
Genes: rhiB
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 2
Genes: rhiB
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Genes: rhiB, rhiC
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 4
Genes: rhiC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 5
Genes: rhiC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Genes: rhiC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: rhiD
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Genes: rhiD
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 9
Genes: rhiE
Core domains: Ketosynthase, Dehydratase, Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 10
Genes: rhiE
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 11
Genes: rhiE
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Michael branching
Module 12
Genes: rhiF
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
NRP-specific information
Subclass N/A
Cyclic? no
Thioesterase genes
  • rhiF (Unknown)
NRP-synthases
Gene Modules
rhiA
Module 1
Condensation domain type: Unknown
rhiB
Module 1
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Modification domains: Oxidation
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZUAEFEJPIFGA5SNZGJWBG3IU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected polyketide synthase gene entries
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Sorted modules by module number
  • Corrected gene identifiers
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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