Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001113.1:
Cluster 1NRP / Polyketide193443

BGC0001113, spliceostatin / FR901464 biosynthetic gene cluster from Burkholderia sp. FERM. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: spliceostatin
PubChem ID: 16204481
SMILES string: Copy to clipboard
Molecular formula: C51H82N6O12S
Average molecular mass: 1003.307 Da

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Polyketide synthase subclass:
Trans-AT type I

Gene cluster description

spliceostatin / FR901464 (BGC0001113). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank KJ461964. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Eustaquio AS et al. (2014) Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/alpha-ketoglutarate-dependent dioxygenase. Proc Natl Acad Sci U S A 111(33):E3376-85. doi: