Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001114.1:
Cluster 1NRP / Polyketide185738

BGC0001114, thailanstatin biosynthetic gene cluster from Burkholderia thailandensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Thailanstatin A
PubChem ID: 71665768
SMILES string: Copy to clipboard
Molecular formula: C28H41NO9
Average molecular mass: 535.634 Da
Molecular activity: Cytotoxic, Inhibitor
Molecular target: Spliceosome

Class-specific details

Biosynthetic class(es):
NRP / Polyketide

Gene cluster description

thailanstatin (BGC0001114). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank JX307851, positions 3438-81539. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Yi-Qiang (Eric) Cheng (University of North Texas Health Science Center)

Literature references

1. Liu X et al. (2013) Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod 76(4):685-93. doi: 10.1021/np300913h. Epub 2013 Mar 21.