BGC0001116: virginiamycin S1 biosynthetic gene cluster from Streptomyces virginiae
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Location: 1 - 57,999 nt. (total: 57,999 nt).
This entry is originally from NCBI GenBank AB283030.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001116
Short description virginiamycin S1 biosynthetic gene cluster from Streptomyces virginiae
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AB283030.2
Compounds
  • virginiamycin S1
Species Streptomyces virginiae [taxonomy]
References
Chemical products information
virginiamycin S1
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C43H49N7O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAF50710.1
  • visF
 1 - 1192 (-) non ribosomal peptide synthetase for virginiamycin S
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  • BAF50711.1
  • visE
 1189 - 9204 (-) non ribosomal peptide synthetase for virginiamycin S
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  • BAF50712.1
  • vmsT
 9269 - 10102 (-) putative two component regulator
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  • BAF50713.1
  • virN
 10672 - 11892 (+) Favin-dependent oxidoreductase
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  • BAF50714.1
  • virM
 11846 - 13153 (+) Sarcosine oxidase
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  • BAF50715.1
  • vmsS
 13204 - 14193 (+) pathway specific regulatory protein
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  • BAF50716.2
  • varL
 14249 - 15922 (-) ABC-transporter protein
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  • BAF50717.1
  • virK
 15919 - 16827 (-) 4-phosphopantetheinyl transferase
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  • BAF50718.1
  • virJ
 16824 - 17627 (-) thioesterase
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  • BAF50719.1
  • virI
 17660 - 18547 (-) acyltransferase
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  • BAF50720.1
  • virH
 18576 - 26345 (-) hybrid non ribosomal peptide synthetase-polyketide synthase
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  • BAF50721.1
  • virG
 26368 - 29991 (-) hybrid non ribosomal peptide synthetase-polyketide synthase
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  • BAF50722.1
  • virF
 29985 - 32228 (-) polyketide synthase
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  • BAF50723.1
  • virE
 32614 - 33366 (-) enoyl-CoA hydratase
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  • BAF50724.1
  • virD
 33402 - 34142 (-) enoyl-CoA hydratase
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  • BAF50725.1
  • virC
 34157 - 35410 (-) HMG-CoA synthase-like protein
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  • BAF50726.1
  • virB
 35429 - 36769 (-) alpha-ketoacyl-acyl carrier protein
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  • BAF50727.1
  • virA
 37068 - 57962 (-) hybrid polyketide synthase-non ribosomal peptide synthetase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
visE
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: 2-aminobutyric acid
Evidence for specificity:
  • Structure-based inference
  • Homology
virH
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Sequence-based prediction
virA
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Knock-out studies
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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