BGC0001116: virginiamycin S1 biosynthetic gene cluster from Streptomyces virginiae
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Location: 1 - 57,999 nt. (total: 57,999 nt).
This entry is originally from NCBI GenBank AB283030.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001116
Short description virginiamycin S1 biosynthetic gene cluster from Streptomyces virginiae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AB283030.2
via
Compounds
  • virginiamycin S1
Species Streptomyces virginiae [taxonomy]
References
Chemical products information
virginiamycin S1 Evidence:
Copy SMILES
C43H49N7O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAF50710.1
  • visF
 1 - 1192 (-) non ribosomal peptide synthetase for virginiamycin S
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    • BAF50711.1
    • visE
    		 1189 - 9204 (-) non ribosomal peptide synthetase for virginiamycin S
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      • BAF50712.1
      • vmsT
      		 9269 - 10102 (-) putative two component regulator
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        • BAF50713.1
        • virN
        		 10672 - 11892 (+) Favin-dependent oxidoreductase
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          • BAF50714.1
          • virM
          		 11846 - 13153 (+) Sarcosine oxidase
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            • BAF50715.1
            • vmsS
            		 13204 - 14193 (+) pathway specific regulatory protein
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              • BAF50716.2
              • varL
              		 14249 - 15922 (-) ABC-transporter protein
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                • BAF50717.1
                • virK
                		 15919 - 16827 (-) 4-phosphopantetheinyl transferase
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                  • BAF50718.1
                  • virJ
                  		 16824 - 17627 (-) thioesterase
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                    • BAF50719.1
                    • virI
                    		 17660 - 18547 (-) acyltransferase
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                      • BAF50720.1
                      • virH
                      		 18576 - 26345 (-) hybrid non ribosomal peptide synthetase-polyketide synthase
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                        • BAF50721.1
                        • virG
                        		 26368 - 29991 (-) hybrid non ribosomal peptide synthetase-polyketide synthase
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                          • BAF50722.1
                          • virF
                          		 29985 - 32228 (-) polyketide synthase
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                            • BAF50723.1
                            • virE
                            		 32614 - 33366 (-) enoyl-CoA hydratase
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                              • BAF50724.1
                              • virD
                              		 33402 - 34142 (-) enoyl-CoA hydratase
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                                • BAF50725.1
                                • virC
                                		 34157 - 35410 (-) HMG-CoA synthase-like protein
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                                  • BAF50726.1
                                  • virB
                                  		 35429 - 36769 (-) alpha-ketoacyl-acyl carrier protein
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                                    • BAF50727.1
                                    • virA
                                    		 37068 - 57962 (-) hybrid polyketide synthase-non ribosomal peptide synthetase
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      visE
                                      Substrates
                                      threonine (evidence: Structure-based inference, Homology)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      visE
                                      Substrates
                                      2-aminobutyric acid (evidence: Structure-based inference, Homology)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      virH
                                      Substrates
                                      serine (evidence: Structure-based inference, Homology, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk04
                                      Type
                                      nrps-type1
                                      Genes
                                      virA
                                      Substrates
                                      glycine (evidence: Structure-based inference, Sequence-based prediction, Knock-out studies)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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