BGC0001117: himastatin biosynthetic gene cluster from Streptomyces himastatinicus ATCC 53653
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Location: 1 - 51,421 nt. (total: 51,421 nt).
This entry is originally from NCBI GenBank FR823394.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001117
Short description himastatin biosynthetic gene cluster from Streptomyces himastatinicus ATCC 53653
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FR823394.1
via
Compounds
  • himastatin
Species Streptomyces himastatinicus ATCC 53653 [taxonomy]
References
Chemical products information
himastatin Evidence:
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C72H104N14O20
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBZ42132.1
 1 - 807 (+) hypothetical protein
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    • CBZ42133.1
    		 821 - 1417 (-)
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      • CBZ42134.1
      		 1473 - 2300 (+)
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        • CBZ42135.1
        • hmtA
        		 2356 - 3099 (+) putative MerR family transcriptional regulator
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          • CBZ42136.1
          • hmtB
          		 3468 - 4451 (-) acetylglutamate kinase
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            • CBZ42137.1
            • hmtC
            		 4675 - 5319 (+) putative negative regulator
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              • CBZ42138.1
              • hmtD
              		 5391 - 6074 (-) regulator
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                • CBZ42139.1
                • hmtE
                		 6632 - 7189 (-) hypothetical protein
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                  • CBZ42140.1
                  • hmtF
                  		 7255 - 10242 (-) non-ribosomal peptide synthetase
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                    • CBZ42141.1
                    • hmtG
                    		 10325 - 11155 (-) Acyl-Co Adehydrogenase
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                      • CBZ42142.1
                      • hmtH
                      		 11170 - 11868 (-) putative thioesterase
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                        • CBZ42143.1
                        • hmtI
                        		 12303 - 18479 (+) putative non-ribosomal peptide synthetase
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                          • CBZ42144.1
                          • hmtJ
                          		 18495 - 19274 (+) putative thioesterase
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                            • CBZ42145.1
                            • hmtK
                            		 19271 - 23056 (+) non-ribosomal peptide synthetase
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                              • CBZ42146.1
                              • hmtL
                              		 23076 - 38321 (+) putative non-ribosomal peptide synthetase
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                                • CBZ42147.1
                                • hmtM
                                		 38387 - 39685 (+) peptide monooxygenase
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                                  • CBZ42148.1
                                  • hmtN
                                  		 39920 - 41119 (+) P450-like enzyme
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                                    • CBZ42149.1
                                    • hmtO
                                    		 41281 - 41802 (+) hypothetical protein
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                                      • CBZ42150.1
                                      • hmtP
                                      		 41843 - 42694 (+) hypothetical protein
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                                        • CBZ42151.1
                                        • hmtQ
                                        		 42754 - 43707 (+) putative ABC-2 transporter
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                                          • CBZ42152.1
                                          • hmtR
                                          		 43704 - 44546 (+) putative ABC-2 type transporter
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                                            • CBZ42153.1
                                            • hmtS
                                            		 44738 - 45931 (+) putative P450-like enzyme
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                                              • CBZ42154.1
                                              • hmtT
                                              		 45979 - 47172 (+) putative P450-like enzyme
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                                                • CBZ42155.1
                                                		 47249 - 48259 (+)
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                                                  • CBZ42156.1
                                                  		 48275 - 51421 (-)
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                                                    Biosynthesis information

                                                    Biosynthetic modules

                                                    Name
                                                    Unk01
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    hmtF
                                                    Substrates
                                                    piperazic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk02
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    hmtI
                                                    Substrates
                                                    valine (evidence: Structure-based inference, Sequence-based prediction)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk03
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    hmtK
                                                    Substrates
                                                    2-ketoisovaleric acid (evidence: Structure-based inference, Sequence-based prediction)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk04
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    hmtL
                                                    Substrates
                                                    leucine (evidence: Structure-based inference, Sequence-based prediction)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk05
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    hmtL
                                                    Substrates
                                                    threonine (evidence: Structure-based inference, Sequence-based prediction)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk06
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    hmtL
                                                    Substrates
                                                    tryptophan (evidence: Structure-based inference, Sequence-based prediction)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Annotation changelog

                                                    Entry version: 4

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Updated bioactivity data
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Added NRP substrate specificities
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated reference publication(s) (MIBiG Annotathon)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated compound(s) information (NPAtlas curation)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2015-06-12
                                                    Submitted
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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