BGC0001118 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001118 (Aspergillus fumigatus Af293)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	45,498	High	endocrocin	PKS:Iterative type I

BGC0001118 - Region 1 - T1PKS

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Location: 1 - 45,498 nt. (total: 45,498 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,499
Label		BGC0001118

Tailoring functions

Hydrolases: hydrolase

AFUA_4G00220: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthase

AFUA_4G00210: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

AFUA_4G00240: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001118.5	1.00	PKS	endocrocin	Aspergillus fumigatus Af293
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000013.3	0.68	PKS	alternariol	Aspergillus nidulans FGSC A4
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001118.5	1.00	PKS	endocrocin	Aspergillus fumigatus Af293
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000013.3	0.68	PKS	alternariol	Aspergillus nidulans FGSC A4
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 45498:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFUA_4G00210: mal

PKS_AT (921..1220): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.0
inactive: 59.5
Methoxymalonyl-CoA: 38.5
Methylmalonyl-CoA: 36.6
Isobutyryl-CoA: 13.5
2-Methylbutyryl-CoA: 9.8
Benzoyl-CoA: 7.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor