BGC0001118: endocrocin biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 54,334 - 75,724 nt. (total: 21,391 nt).
This entry is originally from NCBI GenBank CM000172.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001118
Short description endocrocin biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyphenol)
Loci NCBI GenBank: CM000172.1
Compounds
  • endocrocin
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
endocrocin
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C16H10O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_4G00200
  • EAL84398.1
 54334 - 55733 (+) F-box domain protein
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  • AFUA_4G00210
  • EAL84397.1
 55988 - 61485 (-) polyketide synthase
  • Precursor biosynthesis
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  • AFUA_4G00220
  • EAL84396.1
 61850 - 62856 (-) metallo-beta-lactamase
  • Scaffold biosynthesis
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  • AFUA_4G00225
  • EBA27176.1
 63169 - 63795 (+) monooxygenase
  • Tailoring (Monooxygenation)
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  • AFUA_4G00230
  • EAL84395.2
 64101 - 65225 (-) oxidoreductase
  • Tailoring (Unknown)
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  • AFUA_4G00235
  • EBA27175.1
 65900 - 66243 (+) conserved hypothetical protein
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  • AFUA_4G00240
  • EAL84394.2
 66688 - 68953 (-) amino acid transporter, putative
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  • AFUA_4G00250
  • EAL84393.2
 69578 - 73261 (+) WD40 repeat protein
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  • AFUA_4G00260
  • EAL84392.2
 73816 - 75724 (-) MFS transporter, putative
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Polyketide-specific information
Subclass Polyphenol
Starter unit Malonyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
AFUA_4G00210 Synthase subclass: Iterative type I
Iterative PKS type: Non-reducing, C6-C11 first
Iteration counts: 6
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AFUA_4G00210
Core domains: ACP transacylase, Ketosynthase, Acyltransferase, Product Template domain, Thiolation (ACP/PCP)
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: J4R6BDENZAM7XVDGVEEHZB2Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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