Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001118.1:
Cluster 1Polyketide121391

BGC0001118, endocrocin biosynthetic gene cluster from Aspergillus fumigatus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: endocrocin
PubChem ID: 160483
SMILES string: Copy to clipboard
Molecular formula: C16H10O7
Average molecular mass: 314.249 Da
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyphenol (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Non-reducing
Number of iterations:
-1
C6-C11 first
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
XP_746435.1
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

endocrocin (BGC0001118). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank CM000172, positions 55988-65225. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Philipp Wiemann, Nancy Keller (University of Wisconsin-Madison)

Literature references

1. Lim FY et al. (2012) Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Appl Environ Microbiol 78(12):4117-25. doi: 10.1128/AEM.07710-11. Epub
2. Berthier E et al. (2013 TI) Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog 9(4):e1003289. doi: 10.1371/journal.ppat.1003289. Epub 2013 Apr