BGC0001119: divergolide A biosynthetic gene cluster from Streptomyces sp. HKI0576
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Location: 1 - 72,571 nt. (total: 72,571 nt).
This entry is originally from NCBI GenBank HF563079.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001119
Short description divergolide A biosynthetic gene cluster from Streptomyces sp. HKI0576
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Ansamycin)
Loci NCBI GenBank: HF563079.1
Compounds
  • divergolide A
  • divergolide B
  • divergolide C
  • divergolide D
Species Streptomyces sp. HKI0576 [taxonomy]
References
Chemical products information
divergolide A
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C31H39N1O8
Chemical database entries
PubCHEM
ChemSpider
divergolide B
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C31H37N1O7
Chemical database entries
PubCHEM
ChemSpider
divergolide C
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C31H35N1O8
Chemical database entries
PubCHEM
ChemSpider
divergolide D
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C31H35N1O8
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCP20037.1
  • divA
 138 - 1454 (+) divA protein
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  • CCP20038.1
  • divB
 1491 - 2507 (-) divB protein
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  • CCP20039.1
  • divC
 2758 - 3720 (-) divC protein
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  • CCP20040.1
  • divD
 3729 - 5108 (-) divD protein
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  • CCP20041.1
  • divE
 5221 - 6759 (-) divE protein
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  • CCP20042.1
  • divF
 6780 - 7214 (-) divF protein
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  • CCP20043.1
  • divG
 7362 - 8525 (+) divG protein
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  • CCP20044.1
  • divH
 8522 - 9586 (+) divH protein
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  • CCP20045.1
  • divI
 9610 - 10236 (+) divI protein
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  • CCP20046.1
  • divJ
 10220 - 11278 (+) divJ protein
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  • CCP20047.1
  • divK
 11548 - 27195 (+) divK protein
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  • CCP20048.1
  • divL1
 27192 - 33833 (+) divL1 protein
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  • CCP20049.1
  • divL2
 33830 - 39217 (+) divL2 protein
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  • CCP20050.1
  • divL3
 39214 - 45816 (+) divL3 protein
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  • CCP20051.1
  • divM
 45813 - 54056 (+) divM protein
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  • CCP20052.1
  • divN
 54094 - 54849 (+) divN protein
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  • CCP20053.1
  • divO
 54849 - 56075 (+) divO protein
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  • CCP20054.1
  • divP
 56203 - 56967 (+) divP protein
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  • CCP20055.1
  • divQ
 57034 - 58221 (-) divQ protein
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  • CCP20056.1
  • divR
 58361 - 59722 (+) divR protein
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  • CCP20057.1
  • divS
 59729 - 60730 (+) divS protein
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  • CCP20058.1
  • divT
 60727 - 61587 (+) divT protein
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  • CCP20059.1
  • divU
 61988 - 64771 (+) divU protein
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  • CCP20060.1
  • divV
 64820 - 65449 (+) divV protein
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  • CCP20061.1
  • divW
 66216 - 66890 (+) divW protein
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  • CCP20062.1
  • divGNAT
 67568 - 68314 (+) divGNAT protein
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  • CCP20063.1
  • divX
 68640 - 69839 (+) divX protein
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  • CCP20064.1
  • divY
 69859 - 71235 (+) divY protein
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  • CCP20065.1
  • divZ
 71232 - 72503 (+) divZ protein
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Polyketide-specific information
Subclass Ansamycin
Starter unit 3,5-AHBA-CoA
Cyclic? yes
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
divK
+
divL3
+
divL1
+
divM
+
divL2 		Synthase subclass: Modular type I
Module 0
Genes: divK
Core domains: Ketoreductase, CoA-ligase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Inactive
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: divK
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: divK
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 3
Specificity: Malonyl-CoA
Genes: divK
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 4
Specificity: Ethylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: divL1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: divL2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Genes: divL3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 7
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: divM
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 8
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: divM
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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