Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001119.1:
Cluster 1Polyketide172571

BGC0001119, divergolide biosynthetic gene cluster from Streptomyces sp. HKI0576. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: divergolide A
ChemSpider ID: 27026593
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Ansamycin (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
3,5-AHBA-CoA
Thioesterase type:
None
Release / cyclization type:
Macrolactamization

Modular polyketide synthases:
divK (CCP20047.1)
Module 0
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: Inactive
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown
KR stereochemistry: A-group

divL1 (CCP20048.1)
Module 4
AT specificity: Ethylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group

divL2 (CCP20049.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group

divL3 (CCP20050.1)
Module 6
AT specificity: Other
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

divM (CCP20051.1)
Module 7
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Module 8
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group

Gene cluster description

divergolide (BGC0001119). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank HF563079. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Keishi Ishida (Leipniz Institute for Natural Product Research and Infection Biology)

Literature references

1. Xu Z et al. (2014) Biosynthetic code for divergolide assembly in a bacterial mangrove endophyte. Chembiochem 15(9):1274-9. doi: 10.1002/cbic.201402071. Epub 2014 May
2. Li SR et al. (2014) Identification and characterization of the biosynthetic gene cluster of divergolides from Streptomyces sp. W112. Gene 544(1):93-9. doi: 10.1016/j.gene.2014.04.052. Epub 2014 Apr 24.
3. Ding L et al. (2011) Divergolides A-D from a mangrove endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis. Angew Chem Int Ed Engl 50(7):1630-4. doi: 10.1002/anie.201006165.
4. Xu Z et al. (2011) A branched extender unit shared between two orthogonal polyketide pathways in an endophyte. Angew Chem Int Ed Engl 50(20):4667-70. doi: 10.1002/anie.201008265.