Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001120.1:
Cluster 1NRP / Polyketide137696

BGC0001120, burkholderic acid biosynthetic gene cluster from Burkholderia thailandensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: burkholderic acid
ChemSpider ID: 28536046
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial, Cytotoxic, Siderophore, Other

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
Type II
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
burA (ABC36203)
Module A1
A specificity: Unknown
Evidence for specificity: Other
C domain subtype: None
burF (ABC35796)
Module B3
A specificity: None
Evidence for specificity: Unknown
C domain subtype: Other
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Unknown
Thioesterase type:
None
Release / cyclization type:
Reductive release

Modular polyketide synthases:
burA (ABC36203)
Module A2
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Inactive
Scaffold-modifying domain: Hydroxylation

burF (ABC35796)
Module B0
Module B1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation
Module B2

Gene cluster description

burkholderic acid (BGC0001120). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000086, positions 2543245-2580940. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Proven expression in natural host
MIxS-compliance:Unknown
Contact for this cluster:Keishi Ishida (Leipniz Institute for Natural Product Research and Infection Biology)

Literature references

1. Franke J et al. (2012) Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. Angew Chem Int Ed Engl 51(46):11611-5. doi: 10.1002/anie.201205566.
2. Biggins JB et al. (2012) Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. J Am Chem Soc 134(32):13192-5. doi: 10.1021/ja3052156. Epub 2012 Aug