BGC0001120: burkholderic acid biosynthetic gene cluster from Burkholderia thailandensis E264
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Location: 2,543,245 - 2,580,940 nt. (total: 37,696 nt).
This entry is originally from NCBI GenBank CP000086.1.

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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001120
Short description burkholderic acid biosynthetic gene cluster from Burkholderia thailandensis E264
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: CP000086.1
Compounds
  • burkholderic acid
Species Burkholderia thailandensis E264 [taxonomy]
References
Chemical products information
burkholderic acid [synonyms: malleilactone]
Copy SMILES
C18H26O4
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_I2260
  • ABC36863.1
2543312 - 2544238 (+) carbohydrate kinase, PfkB family
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  • BTH_I2261
  • ABC37581.1
2544338 - 2545522 (+) beta-ketothiolase
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  • BTH_I2262
  • ABC38748.1
2545539 - 2546144 (+) hypothetical protein
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  • BTH_I2263
  • ABC39448.1
  • metC
2546405 - 2547589 (+) cystathionine beta-lyase
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  • BTH_I2264
  • ABC39314.1
2547819 - 2548664 (-) phosphoserine phosphatase
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  • BTH_I2265
  • ABC38375.1
2549326 - 2549871 (+) conserved hypothetical protein
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  • BTH_I2266
  • ABC37205.1
2550151 - 2550969 (-) membrane protein, putative
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  • BTH_I2267
  • ABC36682.1
2550966 - 2551796 (-) ABC transporter, ATP-binding protein
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  • BTH_I2268
  • ABC39026.1
2551795 - 2554251 (+) AsmA family protein
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  • BTH_I2269
  • ABC38495.1
2554703 - 2556295 (+) ABC transporter, ATP-binding protein
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  • BTH_I2270
  • ABC37540.1
2556751 - 2557911 (-) outer membrane porin OpcP
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  • BTH_I2271
  • ABC36740.1
2558091 - 2559584 (+) aldehyde dehydrogenase
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  • BTH_I2272
  • ABC39474.1
2559689 - 2560963 (+) oxidoreductase, 2-nitropropane dioxygenase family
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  • BTH_I2273
  • ABC37264.1
2561036 - 2561680 (+) outer membrane protein, OmpW family
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  • BTH_I2274
  • ABC38497.1
2561809 - 2562048 (-) Protein of unknown function (DUF1289) family
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  • BTH_I2275
  • ABC38269.1
2562181 - 2563743 (-) manganese/iron transporter, NRAMP family
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  • BTH_I2276
  • ABC37002.1
2563872 - 2564966 (+) putrescine ABC transporter, periplasmic putrescine-binding protein
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  • BTH_I2277
  • ABC37732.1
2565057 - 2566217 (+) putrescine ABC transporter, ATP-binding protein
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  • BTH_I2278
  • ABC38093.1
2566214 - 2567143 (+) putrescine ABC transporter, permease protein
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  • BTH_I2279
  • ABC38819.1
2567140 - 2567958 (+) putrescine ABC transporter, permease protein
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  • BTH_I2280
  • ABC37446.1
2568169 - 2568975 (-) membrane protein, putative
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  • BTH_I2281
  • ABC37566.1
2569015 - 2570685 (-) pyridine nucleotide-disulphide oxidoreductase
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  • BTH_I2282
  • ABC39027.1
2570735 - 2571628 (-) metallo-beta-lactamase family protein
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  • BTH_I2283
  • ABC36658.1
2571887 - 2573242 (+) sigma-54 dependent transcriptional regulator
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  • BTH_I2284
  • ABC37439.1
2573447 - 2574010 (+) conserved hypothetical protein
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  • BTH_I2285
  • ABC36525.1
2574021 - 2574245 (+) transcription regulator, Cro/CI family -related protein
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  • BTH_I2286
  • ABC37131.1
2574235 - 2575035 (+) conserved hypothetical protein
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  • BTH_I2287
  • ABC39547.1
2575130 - 2576737 (-) RND efflux system, outer membrane lipoprotein, NodT family
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  • BTH_I2288
  • ABC39009.1
2576740 - 2579913 (-) AcrB/AcrD/AcrF family protein
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Reductive release
Polyketide-synthases
Genes Properties Modules
ABC36203
+
ABC35796
Synthase subclass: Modular type I
Module A2
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ABC36203
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Hydroxylation
KR-domain stereochemistry: Inactive
Module B0
Genes: ABC35796
Core domains: Thiolation (ACP/PCP)
Module B1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ABC35796
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module B2
Genes: ABC35796
Core domains: Ketosynthase, Thiolation (ACP/PCP)
NRP-specific information
Subclass n/a
Cyclic? yes
NRP-synthases
Gene Modules
ABC36203
Module A1
ABC35796
Module B3
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
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