Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001121.1:
Cluster 1Polyketide19908

BGC0001121, orsellinic acid biosynthetic gene cluster from Aspergillus nidulans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: orsellinic acid
PubChem ID: 68072
ChemSpider ID: 61385
SMILES string: Copy to clipboard
Molecular formula: C8H8O4
Average molecular mass: 168.148 Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AN7909,XP_681178
Iterative PKS subtype:
Non-reducing
Number of iterations:
3
C2-C7 first
Thioesterase type:
Unknown
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
AN7909
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: None
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

orsellinic acid (BGC0001121). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank BN001302, positions 206866-213367. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Yuta Tsunematsu (University of Shizuoka)

Literature references

1. Schroeckh V et al. (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34):14558-63. doi:
2. Sanchez JF et al. (2010) Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans. Mol Biosyst 6(3):587-93. doi: 10.1039/b904541d. Epub 2009 Dec 16.