BGC0001122 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001122 (Aspergillus terreus NIH2624)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	43,663	dihydroisoflavipucine/isoflavipucine	NRPS:Type I+PKS:Iterative type I	100%

BGC0001122 - Region 1 - NRPS,T1PKS

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Location: 1 - 43,663 nt. (total: 43,663 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,664
Label		BGC0001122

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001122	2.00	NRP, Polyketide	dihydroisoflavipucine, isoflavipucine	Aspergillus terreus NIH2624
BGC0002538	0.52	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0000977	0.43	NRP, Polyketide	cyclopiazonic acid	Aspergillus oryzae
BGC0001264	0.42	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001255	0.41	NRP, Polyketide	equisetin	Fusarium heterosporum
BGC0002268	0.41	Polyketide, NRP	CJ-16,173, CJ-15,696, citridone B, citridone A, citridone B'	Penicillium sp.
BGC0002492	0.41	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0001268	0.40	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0002304	0.40	Polyketide, NRP	varicidin A	Talaromyces variabilis
BGC0000064	0.40	NRP, Polyketide	fusarin	Fusarium verticillioides

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001122	1.00	NRP, Polyketide	dihydroisoflavipucine, isoflavipucine	Aspergillus terreus NIH2624
BGC0002538	0.59	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0000977	0.54	NRP, Polyketide	cyclopiazonic acid	Aspergillus oryzae
BGC0001264	0.54	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001255	0.53	NRP, Polyketide	equisetin	Fusarium heterosporum
BGC0002268	0.53	Polyketide, NRP	CJ-16,173, CJ-15,696, citridone B, citridone A, citridone B'	Penicillium sp.
BGC0002492	0.53	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0001268	0.53	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0002304	0.53	Polyketide, NRP	varicidin A	Talaromyces variabilis
BGC0000064	0.53	NRP, Polyketide	fusarin	Fusarium verticillioides

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 43663:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATEG_00325

PKS_AT (551..867): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 85.6
Methoxymalonyl-CoA: 66.2
Ethylmalonyl-CoA: 56.9
Malonyl-CoA: 45.8
Isobutyryl-CoA: 44.7
Benzoyl-CoA: 40.1
Propionyl-CoA: 30.2
2-Methylbutyryl-CoA: 17.9
fatty_acid: 17.7
trans-1,2-CPDA: 17.1
CHC-CoA: 15.5
Acetyl-CoA: 15.4
inactive: 13.9
3-Methylbutyryl-CoA: 12.2

AMP-binding (2935..3344): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASLLGAIMK
Nearest Stachelhaus code(s):: bOH-Tyr DASTLGAICK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)