Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001123.1:
Cluster 1NRP143743

BGC0001123, aspirochlorine biosynthetic gene cluster from Aspergillus oryzae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: aspirochlorine
PubChem ID: 44559211
ChemSpider ID: 23326711
SMILES string: Copy to clipboard
Molecular formula: C12H9ClN2O5S2
Average molecular mass: 360.783 Da
Molecular activity: Antifungal, Cytotoxic

Class-specific details

Biosynthetic class(es):
Other (cyclic)
Thioesterase type:
Release / cyclization type:

Nonribosomal peptide synthetases:
AOR_1_68164, XP_001818608
Module 1
A specificity: Phenylalanine
Evidence for specificity: Activity assay
C domain subtype: Unknown
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

aspirochlorine (BGC0001123). Gene Cluster 1. Biosynthetic class = NRP. GenBank AP007154, positions 59595-103337. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays
Contact for this cluster:Yuta Tsunematsu (University of Shizuoka)

Literature references

1. Chankhamjon P et al. (2014) Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angew Chem Int Ed Engl 53(49):13409-13. doi: 10.1002/anie.201407624.