BGC0001124 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001124 (Aspergillus niger ATCC 1015)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	31,240	pyranonigrin E	PKS	100%

BGC0001124 - Region 1 - T1PKS

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Location: 1 - 31,240 nt. (total: 31,240 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,241
Label		BGC0001124

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001124	1.00	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000046	0.33	Polyketide	depudecin	Alternaria brassicicola
BGC0002180	0.31	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4
BGC0002227	0.29	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002266	0.29	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002228	0.29	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001340	0.28	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001913	0.27	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001264	0.27	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002211	0.26	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001124	1.00	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000046	0.66	Polyketide	depudecin	Alternaria brassicicola
BGC0002180	0.64	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4
BGC0002227	0.63	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002266	0.63	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002228	0.62	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001340	0.62	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001913	0.60	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001264	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002211	0.60	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30318:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPNIDRAFT_179585

PKS_AT (566..879): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 88.5
Methoxymalonyl-CoA: 85.2
Isobutyryl-CoA: 79.1
Malonyl-CoA: 68.2
Ethylmalonyl-CoA: 47.5
Propionyl-CoA: 45.7
Benzoyl-CoA: 39.1
inactive: 38.5
3-Methylbutyryl-CoA: 30.4
trans-1,2-CPDA: 26.0
2-Methylbutyryl-CoA: 24.2
Acetyl-CoA: 23.4
CHC-CoA: 11.7
fatty_acid: 10.7