BGC0001125: puwainaphycin A biosynthetic gene cluster from Cylindrospermum alatosporum CCALA 988
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Location: 1 - 56,729 nt. (total: 56,729 nt).
This entry is originally from NCBI GenBank KM078884.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001125
Short description puwainaphycin A biosynthetic gene cluster from Cylindrospermum alatosporum CCALA 988
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
KM078884.1
via
Compounds
  • puwainaphycin A
  • puwainaphycin B
  • puwainaphycin C
  • puwainaphycin D
Species Cylindrospermum alatosporum CCALA 988 [taxonomy]
References
Chemical products information
puwainaphycin A Evidence:
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C58H98N12O17
Chemical database entries
PubCHEM
puwainaphycin B Evidence:
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C59H100N12O16
Chemical database entries
PubCHEM
puwainaphycin C Evidence:
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C56H95Cl1N12O16
Chemical database entries
NPAtlas
PubCHEM
puwainaphycin D Evidence:
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C57H97Cl1N12O15
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIW82276.1
  • orf1
 1 - 1980 (-) ORF1
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    • AIW82277.1
    • puwA
    		 2060 - 10672 (-) PuwA
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      • AIW82278.1
      • orf2
      		 10848 - 14198 (-) ORF2
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        • AIW82279.1
        • puwB
        		 16099 - 23703 (+) PuwB
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          • AIW82280.1
          • puwC
          		 23707 - 25500 (+) PuwC
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            • AIW82281.1
            • puwD
            		 25762 - 26067 (+) PuwD
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              • AIW82282.1
              • puwE
              		 26336 - 35569 (+) PuwE
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                • AIW82283.1
                • puwF
                		 35566 - 42678 (+) PuwF
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                  • AIW82284.1
                  • puwG
                  		 42729 - 53207 (+) PuwG
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                    • AIW82285.1
                    • puwH
                    		 53421 - 56729 (+) PuwH
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      puwA
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      puwA
                      Substrates
                      proline (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      puwE
                      Substrates
                      valine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      puwF
                      Substrates
                      threonine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      puwF
                      Substrates
                      asparagine, glutamine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      puwG
                      Substrates
                      threonine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk07
                      Type
                      nrps-type1
                      Genes
                      puwG
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk08
                      Type
                      nrps-type1
                      Genes
                      puwG
                      Substrates
                      alanine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk09
                      Type
                      nrps-type1
                      Genes
                      puwH
                      Substrates
                      threonine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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