BGC0001126: 12-epi-hapalindole J isonitrile biosynthetic gene cluster from Fischerella ambigua UTEX 1903
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Location: 1 - 41,745 nt. (total: 41,745 nt).
This entry is originally from NCBI GenBank KF664586.1.

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General
Compounds
Genes
Terpene
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001126
Short description 12-epi-hapalindole J isonitrile biosynthetic gene cluster from Fischerella ambigua UTEX 1903
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Terpene (Monoterpene/Unknown)
  • Alkaloid (Indole/benzopyrrole)
Loci NCBI GenBank: KF664586.1
Compounds
  • 12-epi-hapalindole J isonitrile
  • ambiguine A isonitrile
  • ambiguine B isonitrile
  • ambiguine C isonitrile
  • ambiguine D isonitrile
  • ambiguine E isonitrile
  • ambiguine K isonitrile
  • ambiguine L isonitrile
  • ambiguine I isonitrile
  • ambiguine J isonitrile
Species Fischerella ambigua UTEX 1903 [taxonomy]
References
Chemical products information
12-epi-hapalindole J isonitrile
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C21H24N2
Chemical database entries
NPAtlas
ambiguine A isonitrile
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C26H31Cl1N2
Chemical database entries
PubCHEM
ChemSpider
ambiguine B isonitrile
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C26H31Cl1N2O1
Chemical database entries
PubCHEM
ambiguine C isonitrile
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C26H32N2O1
Chemical database entries
PubCHEM
ambiguine D isonitrile
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C26H29Cl1N2O3
Chemical database entries
PubCHEM
ambiguine E isonitrile
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C26H29Cl1N2O2
Chemical database entries
PubCHEM
ambiguine K isonitrile
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C26H29Cl1N2O1
Chemical database entries
NPAtlas
PubCHEM
ambiguine L isonitrile
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C26H30N2O1
Chemical database entries
NPAtlas
PubCHEM
ambiguine I isonitrile
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C26H30N2O2
Chemical database entries
NPAtlas
ChEBI
ambiguine J isonitrile
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C26H30N2O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHB62752.1
 257 - 712 (+) conserved membrane hypothetical protein (possible transporter)
  • Transport
Sequence-based prediction
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  • AHB62753.1
 720 - 1913 (+) ABC exporter membrane fusion protein, DevB family
  • Transport
Sequence-based prediction
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  • AHB62754.1
 1937 - 3103 (+) DevC protein
  • Transport
Sequence-based prediction
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  • AHB62755.1
 3510 - 4460 (-) halogenase, 2OG-Fe(II) oxygenase family
  • Tailoring (Halogenation)
Activity assay
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  • AHB62756.1
 4585 - 5442 (-) rieske oxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AHB62757.1
 5880 - 6587 (-) unknown function
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  • AHB62758.1
 6960 - 7652 (-) AmbU3
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  • AHB62759.1
 7982 - 8698 (-) AmbU2
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  • AHB62760.1
 8992 - 9711 (-) AmbU1
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  • AHB62761.1
 9766 - 10857 (-) rieske oxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AHB62762.1
 11166 - 12248 (-) rieske oxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AHB62763.1
 12336 - 13415 (-) rieske oxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AHB62764.1
 13715 - 14683 (-) aromatic prenyl transferase
  • Scaffold biosynthesis
Activity assay
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  • AHB62765.1
 14911 - 16113 (-) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62766.1
 16186 - 17226 (-) geranyl diphosphate synthase
  • Precursor biosynthesis
Activity assay
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  • AHB62767.1
 19791 - 20489 (+) LuxR family transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AHB62768.1
 20721 - 21455 (-) LuxR family transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AHB62769.1
 22948 - 23526 (+) dephospho-CoA kinase-like protein
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62770.1
 23591 - 24811 (+) 1-deoxy-D-xylulose 5-phosphate reductoisomerase (IspC, Dxr)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62771.1
 25117 - 26076 (+) isonitrile indole synthase A (IsnA)
  • Scaffold biosynthesis
Activity assay
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  • AHB62772.1
 26268 - 27260 (+) isonitrile indole synthase A (IsnA)
  • Scaffold biosynthesis
Activity assay
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  • AHB62773.1
 27260 - 28081 (+) isonitrile indole synthase B (IsnB)
  • Scaffold biosynthesis
Activity assay
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  • AHB62774.1
 28558 - 29487 (+) aromatic prenyl transferase
  • Scaffold biosynthesis
Activity assay
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  • AHB62775.1
 29744 - 31687 (+) 1-deoxy-D-xylulose-5-phosphate synthase (DXS)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62776.1
 31760 - 32986 (+) 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62777.1
 33201 - 34106 (+) 3-deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHB62778.1
 34160 - 36364 (+) anthranilate synthase (TrpE)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62779.1
 36609 - 37460 (+) indole-3-glycerol phosphate synthase (TrpC)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62780.1
 37512 - 38324 (+) tryptophan synthase subunit alpha (TrpA)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62781.1
 38486 - 39736 (+) tryptophan synthase subunit beta (TrpB)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62782.1
 39772 - 40869 (+) anthranilate phosphoribosyltransferase (TrpD)
  • Precursor biosynthesis
Sequence-based prediction
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  • AHB62783.1
 40894 - 41538 (+) phosphoglycerate mutase family protein
  • Precursor biosynthesis
Sequence-based prediction
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Terpene-specific information
Carbon count subclass Monoterpene
Structural subclass Unknown
Isoprenoid precursor GPP
Prenyltransferases AHB62774.1, AHB62766.1
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: XU7PTWDFW5UJ7GLIWVSFLQRF, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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