BGC0001126: 12-epi-hapalindole J isonitrile biosynthetic gene cluster from Fischerella ambigua UTEX 1903
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Location: 1 - 41,745 nt. (total: 41,745 nt).
This entry is originally from NCBI GenBank KF664586.1.

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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001126
Short description 12-epi-hapalindole J isonitrile biosynthetic gene cluster from Fischerella ambigua UTEX 1903
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Monoterpene)
  • other (other)
Loci
KF664586.1
via Enzymatic assays
Compounds
  • 12-epi-hapalindole J isonitrile
  • ambiguine A isonitrile
  • ambiguine B isonitrile
  • ambiguine C isonitrile
  • ambiguine D isonitrile
  • ambiguine E isonitrile
  • ambiguine K isonitrile
  • ambiguine L isonitrile
  • ambiguine I isonitrile
  • ambiguine J isonitrile
Species Fischerella ambigua UTEX 1903 [taxonomy]
References
Chemical products information
12-epi-hapalindole J isonitrile Evidence:
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C21H24N2
Chemical database entries
NPAtlas
ambiguine A isonitrile Evidence:
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C26H31Cl1N2
Chemical database entries
PubCHEM
ChemSpider
ambiguine B isonitrile Evidence:
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C26H31Cl1N2O1
Chemical database entries
PubCHEM
ambiguine C isonitrile Evidence:
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C26H32N2O1
Chemical database entries
PubCHEM
ambiguine D isonitrile Evidence:
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C26H29Cl1N2O3
Chemical database entries
PubCHEM
ambiguine E isonitrile Evidence:
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C26H29Cl1N2O2
Chemical database entries
PubCHEM
ambiguine K isonitrile Evidence:
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C26H29Cl1N2O1
Chemical database entries
NPAtlas
PubCHEM
ambiguine L isonitrile Evidence:
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C26H30N2O1
Chemical database entries
NPAtlas
PubCHEM
ambiguine I isonitrile Evidence:
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C26H30N2O2
Chemical database entries
NPAtlas
ChEBI
ambiguine J isonitrile Evidence:
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C26H30N2O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHB62752.1
 257 - 712 (+) conserved membrane hypothetical protein (possible transporter)
  • Transport
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  • AHB62753.1
 720 - 1913 (+) ABC exporter membrane fusion protein, DevB family
  • Transport
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  • AHB62754.1
 1937 - 3103 (+) DevC protein
  • Transport
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  • AHB62755.1
 3510 - 4460 (-) halogenase, 2OG-Fe(II) oxygenase family
  • Tailoring
  • Activity assay
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  • AHB62756.1
 4585 - 5442 (-) rieske oxygenase
  • Tailoring
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  • AHB62757.1
 5880 - 6587 (-) unknown function
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    • AHB62758.1
    		 6960 - 7652 (-) AmbU3
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      • AHB62759.1
      		 7982 - 8698 (-) AmbU2
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        • AHB62760.1
        		 8992 - 9711 (-) AmbU1
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          • AHB62761.1
          		 9766 - 10857 (-) rieske oxygenase
          • Tailoring
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          • AHB62762.1
          		 11166 - 12248 (-) rieske oxygenase
          • Tailoring
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          • AHB62763.1
          		 12336 - 13415 (-) rieske oxygenase
          • Tailoring
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          • AHB62764.1
          		 13715 - 14683 (-) aromatic prenyl transferase
          • Scaffold biosynthesis
          • Activity assay
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          • AHB62765.1
          		 14911 - 16113 (-) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH)
          • Precursor biosynthesis
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          • AHB62766.1
          		 16186 - 17226 (-) geranyl diphosphate synthase
          • Precursor biosynthesis
          • Activity assay
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          • AHB62767.1
          		 19791 - 20489 (+) LuxR family transcriptional regulator
          • Regulation
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          • AHB62768.1
          		 20721 - 21455 (-) LuxR family transcriptional regulator
          • Regulation
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          • AHB62769.1
          		 22948 - 23526 (+) dephospho-CoA kinase-like protein
          • Precursor biosynthesis
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          • AHB62770.1
          		 23591 - 24811 (+) 1-deoxy-D-xylulose 5-phosphate reductoisomerase (IspC, Dxr)
          • Precursor biosynthesis
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          • AHB62771.1
          		 25117 - 26076 (+) isonitrile indole synthase A (IsnA)
          • Scaffold biosynthesis
          • Activity assay
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          • AHB62772.1
          		 26268 - 27260 (+) isonitrile indole synthase A (IsnA)
          • Scaffold biosynthesis
          • Activity assay
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          • AHB62773.1
          		 27260 - 28081 (+) isonitrile indole synthase B (IsnB)
          • Scaffold biosynthesis
          • Activity assay
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          • AHB62774.1
          		 28558 - 29487 (+) aromatic prenyl transferase
          • Scaffold biosynthesis
          • Activity assay
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          • AHB62775.1
          		 29744 - 31687 (+) 1-deoxy-D-xylulose-5-phosphate synthase (DXS)
          • Precursor biosynthesis
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          • AHB62776.1
          		 31760 - 32986 (+) 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG)
          • Precursor biosynthesis
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          • AHB62777.1
          		 33201 - 34106 (+) 3-deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase
          • Scaffold biosynthesis
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          • AHB62778.1
          		 34160 - 36364 (+) anthranilate synthase (TrpE)
          • Precursor biosynthesis
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          • AHB62779.1
          		 36609 - 37460 (+) indole-3-glycerol phosphate synthase (TrpC)
          • Precursor biosynthesis
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          • AHB62780.1
          		 37512 - 38324 (+) tryptophan synthase subunit alpha (TrpA)
          • Precursor biosynthesis
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          • AHB62781.1
          		 38486 - 39736 (+) tryptophan synthase subunit beta (TrpB)
          • Precursor biosynthesis
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          • AHB62782.1
          		 39772 - 40869 (+) anthranilate phosphoribosyltransferase (TrpD)
          • Precursor biosynthesis
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          • AHB62783.1
          		 40894 - 41538 (+) phosphoglycerate mutase family protein
          • Precursor biosynthesis
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          Biosynthesis information
          Annotation changelog

          Entry version: 3

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2019-10-16
          Migrated from v1.4
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2019-10-16
          Updated compound(s) information (NPAtlas curation)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2015-06-12
          Submitted
          • (ID: XU7PTWDFW5UJ7GLIWVSFLQRF)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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